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Cognitive-Behavioral Therapy for Social Anxiety Disorder: Supporting Evidence and Future Directions

Authors:

Abstract

The present paper examines the role of cognitive-behavioral therapy (CBT) in the treatment of social anxiety disorder (SAD). A cognitive-behavioral model of SAD is first presented. Different modalities of CBT for SAD are then described, including exposure, cognitive restructuring, relaxation training, and social skills training, and evidence supporting their efficacy is reviewed. The comparative and combined impact of CBT and pharmacotherapeutic interventions is also explored. CBT appears to be an efficacious treatment for SAD. However, the overall efficacy CBT may be increased by closer examination of the active ingredients of treatment. Such analyses may also enable more successful integration of the different CBT techniques and of CBT and pharmacotherapy in the treatment of SAD.
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373
FOCUS POINTS
• Cognitive-behavioral theory (CBT) suggests that patients’
distorted perceptions of social situations and their own
physical arousal lead to behaviors that enable them to
avoid anxiety-provoking situations in the short term, but
which act to generate and maintain disabling levels of
anxiety in social situations in the long term.
CBT targets these beliefs in a variety of forms, including
exposure, cognitive restructuring, relaxation training, and
social skills training.
Exposure therapy and cognitive restructuring have
tended to show results most comparable to pharma-
cotherapeutic interventions.
• Future research should continue to explore the effective-
ness of CBT and ways in which CBT and medication can
be partnered to achieve optimal outcomes for patients
with social anxiety disorder.
ABSTRACT
The present paper examines the role of cognitive-behav-
ioral therapy (CBT) in the treatment of social anxiety disor-
der (SAD). A cognitive-behavioral model of SAD is first
presented. Different modalities of CBT for SAD are then
described, including exposure, cognitive restructuring, relax-
ation training, and social skills training, and evidence sup-
porting their efficacy is reviewed. The comparative and
combined impact of CBT and pharmacotherapeutic interven-
tions is also explored. CBT appears to be an efficacious treat-
ment for SAD. However, the overall efficacy CBT may be
increased by closer examination of the active ingredients of
treatment. Such analyses may also enable more successful
integration of the different CBT techniques and of CBT and
pharmacotherapy in the treatment of SAD.
CNS Spectr 2003;8(5):373-381
THE IMPACT OF SOCIAL ANXIETY DISORDER
Social anxiety disorder (SAD) is the pathologic fear of
negative evaluation in one or more social or performance
situation(s).
1
Estimates of the 1-year prevalence of SAD
run as high as 8%,
2
although recent evidence suggests that
the rate of clinically significant SAD in the general popu-
lation is closer to 4%.
3
Despite its high prevalence, SAD
has only begun to receive substantial attention in the last
few years.
4
The social and personal consequences of SAD
are now known to be far-reaching. SAD disrupts an indi-
vidual’s relationships, resulting in fewer friendships,
greater difficulty getting along with friends, and less satis-
faction with one’s available network of social support.
5,6
Persons with SAD are also less likely to be married and
more likely to live alone than persons without mental dis-
order
7,8
and persons with other anxiety disorders.
9
Unemployment, underemployment (working at a level
below one’s abilities), reduced work productivity, and
increased dependence on public assistance are all charac-
teristic of individuals with SAD.
10-14
SAD also appears to
be a risk factor for other disorders and symptoms, includ-
ing major depression, alcoholism, and suicidal ideation.
8
Fortunately, pharmacologic interventions and cogni-
tive-behavioral therapy (CBT) have demonstrated efficacy
in treating this disorder and in helping patients reduce
their level of symptoms and disability and improve the
quality of their lives. This paper will focus on the impact
of CBT on the potentially catastrophic consequences of
SAD. We begin with a presentation of a cognitive-behav-
ioral model of SAD, which suggests how maladaptive pat-
terns of thought and behavior can maintain anxiety over
time and may be used to help explain how CBT can ame-
liorate anxiety in social situations. Next, we review the
major modalities of CBT for SAD, focusing on exposure,
cognitive restructuring, relaxation training, and social
skills training, as well as evidence in support of their effi-
cacy. Third, we examine the relationship between CBT
and pharmacologic interventions for SAD, first reviewing
research comparing the relative effectiveness of CBT and
medication and then considering the combined effects of
these two treatment approaches. Finally, we consider
future directions and current shortcomings in our under-
standing of the effectiveness of CBT for SAD.
Mr. Hambrick, Mr. Weeks, and Ms. Harb are all doctoral students in clinical psychology in the Department of Psychology at Temple University in
Philadelphia, Pennsylvania. Dr. Heimberg is professor of psychology, director of clinical training, and director of the Adult Anxiety Clinic in the
Department of Psychology at Temple University.
Disclosures: This work has been funded in part by a National Institute of Mental Health grant (44119) to Dr. Heimberg.
Acknowledgement: The authors wish to dedicate this article to the memory of Robert A. Gould, PhD.
Please direct all correspondence to: Richard G. Heimberg, PhD, Adult Anxiety Clinic of Temple University, Department of Psychology, Temple University,
Weiss Hall, 1701 North 13th Street, Philadelphia, PA 19122-6085; Tel: 215-204-1575, Fax: 215-204-5184; Email: heimberg@temple.edu.
Review Article
Cognitive-Behavioral Therapy for
Social Anxiety Disorder: Supporting
Evidence and Future Directions
By James P. Hambrick, MA, Justin W. Weeks, BA, Gerlinde C. Harb, MS
and Richard G. Heimberg, PhD
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THE COGNITIVE-BEHAVIORAL MODEL
OF SOCIAL ANXIETY DISORDER
A number of cognitive-behavioral models of SAD exist,
focusing on different aspects of how individuals with SAD
process social-evaluative information and how biases in infor-
mation processing may affect their emotional and behavioral
responses in social situations. The model discussed here was
first presented by Rapee and Heimberg
15
and later elaborated
by others.
16,17
The model is depicted in the Figure.
Rapee and Heimberg
15
argue that the experience of anxi-
ety in social situations is induced by the threat of a poten-
tially critical audience (ie, another person or persons
who may observe and evaluate the individual in the social
situation). An individual develops an image or mental rep-
resentation of him or herself as perceived by that audience,
reflecting a combination of memories or images of past
experiences in similar situations, appraisals of his or her
current physical state, and appraisal of negative or ambigu-
ous audience cues (eg, yawning or other displays of lack of
interest). This mental representation of the self as perceived
by the audience is compared to the person’s prediction of
audience expectations. That is, the person asks him or her-
self “Am I doing as well as the audience expects of me?”
The more negative the person’s response to this question,
the greater the perceived likelihood of negative evaluation
and cost of social failure. As shown in Figure 1, this judg-
ment subsequently gives rise to thoughts about how the per-
son is performing (particularly negative thoughts), physical
symptoms (eg, sweating, blushing, ormuscle tension), and
anxious behaviors (eg, social withdrawal or reduction of eye
contact). These thoughts, physiologic symptoms, and behav-
iors feed back into the person’s impressions of the situation,
driving the perception of the self as seen by the audience
downward, augmenting the person’s anxiety and reinforcing
his or her belief that he or she is performing poorly. The
channeling of the person’s attentional resources toward
signs of threat (eg, increasing physiologic arousal) instead of
sources of positive feedback (eg, displays of interest from
the audience) further exacerbates this process.
Although there is not a clear delineation between normal
shyness and SAD,
18
social anxiety may become more perva-
sive or extreme as a result of a number of factors. Biological
and temperamental factors can shape a person’s overall ten-
dencies to engage with or disengage from social situations.
These factors are reflected in Kagan and Snidman’s
19
find-
ings that infants who had initial difficulty engaging with new
stimuli (ie, new toys or unfamiliar people) tended to be more
shy later in life and more likely to meet criteria for a diagno-
sis of SAD,
20
and in twin studies finding evidence for the
heritability of shyness
21
and SAD.
22
Another potential factor in the development of SAD is
the distortion of the person’s self-image in long-term mem-
ory, sensitizing him or her to negative experiences in social
situations. Early or critical experiences can inform a per-
son’s image of him or herself, distorting the person’s
impression of his or her performance in the current
situation. Although data in support of distorted and biased
memory in SAD are mixed,
23
Hackmann and colleagues
24
showed that more than three-fourths of a sample of individ-
uals with SAD reported recurrent visual images of past
social catastrophes. These images were typically viewed
from the perspective of an outside observer rather than
through the eyes of the person and may be best described
as representations of the person’s worst fears of how they
appeared to others rather than accurate depictions of past
events. Importantly, these situations often occurred during
the period of onset of social anxiety and were sponta-
neously imaged in anticipation of current social situations.
Beliefs about the relative likelihood and potentially cata-
strophic consequences of failure in a social situation can
also have an impact on the person’s willingness to engage
with those situations. Foa and colleagues
25
found that prior
to CBT, individuals with SAD were much more likely to
make inaccurate assessments of the probability of negative
outcomes in social situations and to make dire predictions
about the consequences of social failures. CBT had some-
what of a normalizing effect on these evaluations.
If early experiences have an impact on current experi-
ence, then it stands to reason that current experiences will
have an impact on future experiences. Clark and Wells
26
Review Article
Volume 8 – Number 5 CNS Spectrums - May 2003
FIGURE. A MODEL OF THE GENERATION AND MAIN-
TENANCE OF ANXIETY IN SOCIAL/EVALU-
ATIVE SITUATIONS.
15
Reprinted with permission from Rapee RM, Heimberg RG. A cognitive-
behavioral model of anxiety in social phobia. Behav Res Ther. 1997;35:743.
Copyright by Elsevier Science Ltd. Used with permission of the publisher.
Hambrick JP, Weeks JW, Harb GC, Heimberg RG. CNS Spectr. Vol 8, No 5.
2003.
373-381_0503CNS_Hambrick 5/18/03 9:26 AM Page 374
375
point out that strategies the socially anxious person uses to
avoid the present situation may decrease anxiety in the short
term, but ultimately leave the person with an accumulation
of negative beliefs about the situation, as well as shame that
they were unable to perform as well as they hoped.
A full review of the evidence supporting this cognitive-
behavioral model is beyond the scope of this paper but is
available in the papers by Rapee and Heimberg,
15
Turk and
colleagues,
16
and Roth and Heimberg.
17
The model delin-
eates the interactive effect of physiologic arousal, interac-
tions with the environment, and distorted appraisals of the
impact and consequences of those experiences on the per-
son’s anxiety experience. In the next section, we discuss
how CBT attempts to address these aspects of SAD to lessen
the person’s distress in social situations.
COGNITIVE-BEHAVIORAL THERAPY
FOR SOCIAL ANXIETY DISORDER
Although there are differences among the CBT tech-
niques, they share a set of fundamental assumptions. CBT is
a time-limited and present-oriented approach that strives to
empower the patient to act as his or her own agent of
change.
27
In CBT, the therapist and patient work together as
a collaborative team. The therapist acts as observer and
coach, teaching coping skills and, in some types of CBT,
pointing out logical contradictions in the patient’s patterns
of thinking and behavior. The therapist’s roles as teacher
and coach vary according to the type of CBT being adminis-
tered and the relative emphasis of each on learning skills
versus encouragement to see situations in new ways and
permitting oneself to experience anxiety until it attenuates.
Meanwhile, the patient learns to move toward and engage
his or her anxiety and employs skills used in therapy to
cope with it on a daily basis between sessions. The four
modalities to be considered here are the most widely stud-
ied in the treatment of SAD: exposure, cognitive restructur-
ing, relaxation training, and social skills training.
Exposure to Feared Social Situations
Exposure to feared situations is essential for fear reduc-
tion. When the individual is exposed to the feared situation
but does not encounter the feared outcome (eg, outright
rejection in a social interaction), natural conditioning
processes involved in fear reduction (habituation and
extinction) take place. The individual is also confronted
with information that contradicts negative distorted beliefs.
The first stage of exposure treatment is the collaborative
development of a rank-ordered list of situations that provoke
anxiety for the patient (often referred to as the fear and
avoidance hierarchy). Patients put themselves into these
feared situations, starting with situations low on this rank-
ordered list. They are typically asked to engage the situation
fully (ie, maintaining a focus on the situation and all its vari-
ous aspects rather than attempting to filter the distressing
aspects of the situation from awareness or engage in some
other form of distraction). They are also asked to remain in
the situation until their anxiety naturally begins to subside.
As a sense of mastery in the lesser situation is obtained and
it no longer elicits distressing levels of fear, patients
approach increasingly more anxiety-evoking situations and
gradually work towards the social situations they find most
difficult. Exposure to feared situations may be administered
by means of imagery; role-play with the therapist or therapy
assistants; confronting feared situations in everyday life out-
side of session; or by a combination of these methods.
In addition, exposure protocols may differ in the amount
of therapist involvement (ie, self-exposure or clinician-
accompanied in vivo exposure), as well as the length, num-
ber, and interval between exposure sessions. Furthermore,
exposure is often combined with other treatment compo-
nents, such as applied relaxation or cognitive techniques.
Exposure exercises are most effective when patients’ psy-
chological engagement in the feared situation is maximized,
that is, when they pay full attention to the situation and
allow the inevitable rush of anxiety and arousal to occur.
28
However, anxious patients may try to distract themselves
from the feared situation as it unfolds, or their tendency to
focus attention on the threatening aspects of the situation
may prevent them from attending to what is actually hap-
pening. Therefore, instructions to maintain focus on the
feared situation are an important component of, and
increase the efficacy of, exposure techniques.
29
Cognitive Restructuring
Findings suggest that it is important for patients to exam-
ine thoughts related to feared situations and the beliefs that
underlie them. Indeed, current cognitive-behavioral models
of SAD
15,26
are based on the premise that the disorder devel-
ops due to inaccurate beliefs about potential dangers
encountered during social situations, negative outcome pre-
dictions of these situations, and biased perceptual process-
ing of events occurring within social situations. The goal of
cognitive restructuring is to help the patient evaluate feared
situations more realistically.
The first step in cognitive restructuring is the identifica-
tion of negative thoughts that occur prior to, during, or after
a confrontation with feared situations. Next, the patient and
therapist evaluate the accuracy of these thoughts using evi-
dence obtained from Socratic dialogue and/or from planned
“behavioral experiments.”
30
The goal is to develop evalua-
tions based on data that is more objective and rational than
the patient’s anxiety-driven perceptions.
By utilizing these rational thoughts in lieu of their cus-
tomary negative interpretations in exposures to anxiety-pro-
voking situations, patients are provided with a
cognitive-coping strategy, which, over time and repetition,
will allow them to modify their habitual negative beliefs
about social situations.
Most cognitive approaches to the treatment of social
anxiety are closely tied to exposure. Exposure to anxiety-
provoking situations is central to cognitive restructuring, for
helping patients access their negative thoughts and to
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obtain evidence to evaluate these thoughts. Behavioral
experiments are designed to provide patients with opportu-
nities to treat their thoughts as hypotheses and test whether
their beliefs (eg, “I will not be able to speak” or “Everyone
will laugh at me”) are realistic appraisals.
Behavioral experiments may require patients to enter
anxiety-provoking situations without engaging in their usual
“safety behaviors.”
31,32
Patients often hold erroneous beliefs
that engaging in safety behaviors allows him or her to man-
age their anxiety successfully and that the implementation
of safety behaviors will prevent feared catastrophes.
For example, individuals with SAD may attempt to con-
trol shaking of their arms in anxiety-provoking encounters
by stiffening muscles or by tightly holding on to objects.
Other individuals may be reticent in social situations and
choose not to contribute to conversations for fear of saying
the wrong thing and being criticized by others. Thereafter,
she or he may believe that they “survived” the feared situa-
tion only because they engaged in the safety behavior.
However, they may have denied themselves the opportunity
to learn that they could have managed the situation ade-
quately without doing so. Safety behaviors often interfere
with the execution of competent social behaviors and inad-
vertently lead to the very negative consequences that
patients seek to avoid.
31
The socially anxious individuals who speak little in
social situations, fearing they might say the wrong words if
they fully engage the conversation, are likely to evoke nega-
tive reactions in their conversation partners and thus miss
opportunities for future positive social interactions and the
development of meaningful relationships. It is therefore
important to design behavioral experiments that require the
abandonment of these behaviors in order to give patients the
opportunity to be exposed to corrective information about
their false beliefs.
Thus, most cognitive techniques include an exposure
component and are rarely purely cognitive. In fact, several
treatment protocols have combined exposure with other
treatment components, most notably, cognitive-behavioral
group therapy (CBGT).
33
In CBGT, groups of 4–7 patients,
balanced with regard to age and sex, are led by male and
female cotherapists and typically meet for 12 weekly
2.5-hour sessions. The first two sessions are devoted to pro-
viding patients with a cognitive-behavioral model of SAD
and to introducing the concepts of exposure, homework, and
cognitive restructuring. Structured exercises are used to
teach patients the concepts and procedures involved in the
identification, logical analysis, and disputation of negative
automatic thoughts. During the remaining 10 sessions, ther-
apists plan graduated individualized exposure role-plays for
patients that allow them to examine and modify their nega-
tive thoughts before, during, and after exposure to feared
situations. Therapist-directed cognitive-restructuring exer-
cises and coaching are integrated with exposure to feared
situations to provide opportunities for testing the veracity
of patients’ negative thoughts. Furthermore, homework
assignments are developed for each patient at the end of each
session; these usually consist of exposures to real-life situa-
tions. When approaching feared situations outside of group
sessions, patients are encouraged to utilize cognitive-restruc-
turing skills before, during, and after the homework event.
Relaxation Training
Individuals with SAD often experience excessive physio-
logic arousal when confronted with, or in anticipation of,
feared social situations, and this arousal may interfere with
optimal social performance. Effective relaxation strategies
provide patients with a means of coping with these physio-
logic manifestations of social anxiety.
Current approaches to relaxation training are derived
from the work of Wolpe,
34
Bernstein and Borkovec,
35
and
Bernstein and colleagues,
36
and involve exercises aimed at
the relaxation of different muscle groups (both in-session and
as homework assignments). Progressive muscle relaxation
practices involve focusing on particular muscle groups, tens-
ing for 5–10 seconds, releasing the tension, and noticing the
difference between sensations accompanying tension and
relaxation. Progressive muscle relaxation begins by working
on 16 muscle groups, Its focus is on progressively larger
muscle groups in order to achieve relaxation rapidly. Further,
patients may be taught cue-controlled relaxation, which
involves the repeated pairing of a word (eg, “relax”) with a
relaxed bodily state, and then using the word as a cue to
achieve a relaxed state during everyday activities. These
relaxation strategies are most effective in the treatment of
SAD if ultimately applied in feared social situations.
Applied relaxation involves three skills to be acquired in
treatment: recognition of the early sensations of anxiety and
physiologic arousal; proficiency in achieving a relaxed state
quickly while engaging in daily activities; and use of relax-
ation strategies in anxiety-provoking situations. Applied
relaxation for socially anxious individuals combines relax-
ation techniques with exposure to feared situations.
37
Social Skills Training
Social skills training for SAD is based on the premise
that socially anxious patients exhibit behavioral deficien-
cies (eg, poor eye contact, poor conversation skills) that
elicit negative reactions from others, thereby causing social
interactions to be punishing and anxiety-inducing for the
patient. Social skills training is comprised of several tech-
niques designed to reduce these deficiencies. These tech-
niques include therapist modeling, behavioral rehearsal,
corrective feedback, social reinforcement, and homework
assignments. Research on this phenomenon has produced
conflicting results, with some studies finding performance
deficits among socially anxious persons
38,39
and others fail-
ing to do so.
40,41
It is important to note that any therapeutic efficacy of
social skills training is not necessarily attributable to the
remediation of deficiencies in the patient’s repertoire of
social skills, although this possibility is equally viable.
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Alternatively, social skills training may yield therapeutic
effects due to the training aspects (eg, repeated practice of
feared social behaviors), the exposure aspects (eg, con-
frontation of feared situations) or the cognitive elements (eg,
corrective feedback about the adequacy of one’s social
behavior) inherent in the instruction of such skills.
Regardless, social skills training may be easily combined
with other techniques, such as cognitive restructuring or
exposure. For instance, Social Effectiveness Training
42
is a
multicomponent treatment package that combines exposure
with social skills training and education in a mixture of
group and individual formats.
EFFICACY OF COGNITIVE-BEHAVIORAL
THERAPY FOR SOCIAL ANXIETY DISORDER
A large number of outcome studies have been conducted
in the last 2 decades. In order to evaluate the efficacy of
CBT for SAD, meta-analytic strategies have been increas-
ingly used to examine this large and growing literature.
Meta-analyses reduce the results of each study to a common
quantitative metric, the effect size (ES). The within-group
ES (also referred to as “uncontrolled”) denotes the number
of standard deviation units of improvement for patients
within a particular treatment group. An average within-
group ES of 1.0 for a specific treatment method signifies an
average improvement of one standard deviation unit for
patients in all studies who received a particular treatment.
These ESs should be interpreted with caution, however,
because they do not control for the influence of non-specific
factors or sample differences which may affect treatment.
43
In contrast, between-group ESs, also known as controlled
ESs, index the degree to which patients who receive a par-
ticular treatment improve more than patients in a control
condition, expressed in standard deviation units. An aver-
age between-group ES of 1.0 indicates that the treatment
group improved one standard deviation unit more than the
control group. Guidelines for the interpretation of the mag-
nitude of ESs are provided by Cohen,
44
who states that 0.20,
0.50, and 0.80 correspond to small, medium, and large
effects, respectively.
Five meta-analytic investigations have examined the effi-
cacy of CBT for SAD
43,45-48
and have provided very promising
findings. The overall within-group ES for CBT has been large.
For example, Chambless and Hope
45
meta-analyzed 8 con-
trolled CBT studies that compared the relative efficacies of
CBGT, exposure and anxiety management, and applied relax-
ation training. CBT demonstrated an average within-group ES
of 0.94. Thus, patients receiving CBT demonstrate substantial
improvement in social anxiety symptoms after treatment.
Furthermore, in comparison with control groups, CBT
appears to be an effective treatment, more beneficial than
placebo, supportive counseling, and wait-list control groups
(average within-group ES of 0.3). The overall controlled ES
for CBT was reported to be 0.74 by Gould and colleagues.
47
CBT has not only been found efficacious in the short-
term but also in follow-up investigations. Uncontrolled pre-
treatment to follow-up ESs indicate that treatment gains are
maintained after CBT ends (average ESs ranging from
0.78–1.31 for various types of CBT, with average follow-up
intervals ranging from 3.65–4.75 months).
43,45,46,48
These ESs
are generally larger than pre- to posttreatment ESs, suggest-
ing that most patients either maintained their gains or made
additional improvements. The one uncontrolled ES calcu-
lated for change between posttreatment and follow-up
(0.23)
47
supports this assertion, indicating a small effect for
additional improvement during follow-up.
CBT appears to be an efficacious treatment for SAD in
both the short- and long-term. However, the aforementioned
analyses do not speak to the relative efficacy of the variety
of CBT types. Many CBT treatments are comprised of het-
erogeneous procedures, often including more or less focus
on behavioral techniques (eg, exposure, relaxation, social
skills training), and/or cognitive strategies. Research has
attempted to elucidate what components may be important
in achieving treatment success, that is, which types of CBT
may be more or less important than others.
All five meta-analyses have addressed this question by
comparing the average ESs of different types of CBT. In a
meta-analysis of 24 studies, Feske and Chambless
43
investi-
gated the differential effects of treatments combining expo-
sure with cognitive restructuring and treatments using only
exposure. Mean uncontrolled ESs were generally indicative
of large treatment effects and were similar for the two groups
of treatments (exposure and combined, 0.99 and 0.90,
respectively); controlled ESs, however, suggested a better
treatment response for exposure-only treatments (1.06 and
0.38, respectively). The combined treatments, however,
were compared with more stringent control groups than the
exposure treatments. Of the seven combined treatment stud-
ies, two included placebo and educational support group
control conditions, whereas exposure-only treatments were
all compared with wait-list control groups. Thus, this differ-
ence in control conditions may have attenuated controlled
ESs for the combined treatment group. The authors of this
meta-analysis excluded several studies supportive of the
use of cognitive techniques in combination with exposure,
and thus, the results may be somewhat skewed toward
greater efficacy of exposure-only treatments.
In contrast to Feske and Chambless,
43
Gould and col-
leagues
47
meta-analyzed 27 trials of CBT and found the
largest controlled ESs for both exposure therapy (0.89) and
the combination of exposure and cognitive restructuring
(0.80). Treatments involving cognitive restructuring alone
(0.60) and social skills training (0.60) were moderately effi-
cacious. Similarly, among psychological treatments for SAD
recently meta-analyzed by Fedoroff and Taylor,
46
combined
(cognitive restructuring and exposure) therapy, cognitive
restructuring alone, social skills training, and applied relax-
ation demonstrated significant effects at posttreatment (the
average within-group ESs were 0.84, 0.72, 0.64, and 0.51,
respectively). For studies of exposure treatment alone, the
average ES (1.08) was large, but there was a great deal of
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variability among studies, and the confidence interval
around this figure overlapped with zero, suggesting a non-
significant average treatment effect.
Finally, Taylor
48
examined the relative efficacy of cogni-
tive restructuring, exposure therapy, combined cognitive
restructuring and exposure, and social skills training in a
meta-analysis of 42 treatment-outcome trials for SAD. For
all active CBT treatments, improvements in social anxiety
were similar and superior to those of wait-list control
groups. However, when compared with placebo-controlled
groups (pill placebo or attention placebo), only the treat-
ments combining cognitive restructuring and exposure were
significantly better.
Thus, these results suggest that combined and pure expo-
sure treatments do not consistently result in different treat-
ment outcomes, and the addition of cognitive techniques
may neither deter nor increase the efficacy of exposure
treatments. Analyses of follow-up data show that all active
treatments result in maintenance of gains. In the meta-
analysis by Feske and Chambless,
43
improvements were
maintained in both exposure-only and combined treatments,
resulting in similar average within-group ESs for both
groups at follow-up (1.04 and 1.10, respectively). Fedoroff
and Taylor
46
report that there were no differences between
the four reviewed CBT treatments (exposure, cognitive-
restructuring, combined exposure and cognitive restructur-
ing, and social skills training) at follow-up.
In summary, while research clearly supports CBT as an
efficacious treatment for SAD, the question of which vari-
eties of CBT are most beneficial has not been resolved.
Evidence points to exposure and treatments using both cog-
nitive strategies and exposure as the most efficacious. Social
skills training or relaxation training do not appear to be
indicated for every patient and may have less impact on the
patient who is socially facile or who reports little physiologic
arousal, respectively. However, the question of whether the
addition of cognitive strategies increases treatment gains
above those achieved by exposure alone is still unresolved.
Several possible explanations have been suggested for the
general lack of difference in comparisons of exposure and
combined treatments. First, it is possible that these overall no-
difference results are due to the actual implementation of
exposure and combined interventions overlap. For example,
exposure treatments often include therapist feedback about
the patient’s performance or the (lack of) visibility of anxiety
symptoms.
49
Such interventions may not be labeled as cogni-
tive, yet they share common features with cognitive interven-
tions, which may increase the frequency of no-difference
findings. Second, those studies that have found an added ben-
efit of cognitive procedures may reflect chance findings.
50
Finally, it is possible that, for some patients, exposure-only
treatments are sufficient to produce significant improvements,
whereas other individuals may require the addition of cogni-
tive-restructuring to achieve optimal outcomes. Unfortunately,
it is not yet known which variables may identify those groups
of patients.
51
Whether or not cognitive techniques are shown to
be necessary in the treatment of SAD, it appears that individu-
als who demonstrate more cognitive change (as assessed with
measures of rational thinking, positive and negative self-state-
ments, or thought listing procedures after behavior tests and
the like) show greater improvements in social anxiety.
52,53
Although cognitive change is an important or even necessary
part of reduction in social anxiety, it is not clear whether
changes in maladaptive thinking require the use of cognitive
techniques. Furthermore, the correlational nature of the rela-
tionship between cognitive and clinical change leaves open
the possibility that greater cognitive change may either lead to
or be a consequence of clinical improvement.
45
COGNITIVE-BEHAVIORAL THERAPY
AND PHARMACOTHERAPY FOR
SOCIAL ANXIETY DISORDER
A number of medications have demonstrated superiority
to placebo in at least one published double-blind study of
the treatment of SAD, including the selective serotonin
reuptake inhibitors paroxetine, sertraline, and fluvoxamine;
the monoamine oxidase inhibitor phenelzine; the reversible
inhibitors of monoamine oxidase brofaromine; the high-
potency benzodiazepine clonazepam; and the anticonvul-
sant gabapentin.
54
Few studies have directly compared the
relative efficacy of CBT and pharmacotherapy for SAD.
However, many published studies have examined either the
efficacy of CBT or the efficacy of pharmacotherapy. Thus,
we turn again to the meta-analyses that summarized and
compared these treatment methods statistically.
Two of the meta-analyses discussed earlier also examined
the relative efficacy of CBT and pharmacotherapy for SAD.
Gould and colleagues
47
reported similar controlled effect
sizes for cognitive-behavioral (0.74) and pharmacologic
(0.62) interventions on measures of social anxiety. Federoff
and Taylor,
46
however, report superior effect sizes for acute
pharmacotherapy. Benzodiazepines were superior to most
cognitive-behavioral interventions, but this was not the case
for either the monoamine oxidase inhibitors or selective sero-
tonin reuptake inhibitorss. It was not possible to examine
whether pharmacotherapy was associated with maintenance
of gains as reported earlier for CBT because these data were
not generally reported for medication treatments.
As previously mentioned, there are few studies directly
investigating the relative efficacy of medication and CBT
approaches. Of the few studies which have been conducted to
date, two used medication treatments, buspirone and atenolol,
which have not demonstrated superiority to placebo in con-
trolled trials.
55,56
Other studies included specific instructions
to engage in exposure to feared situations for patients receiv-
ing medication or placebo, making results difficult to inter-
pret.
57,58
One of these studies found that both clonazepam with
exposure instructions and CBGT produced significant and
similar improvements on clinician-rated measures.
58
In this
study, some self-report measures indicated greater improve-
ment for the medication/exposure condition among treatment
completers, but not in intent-to-treat analyses.
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Heimberg and colleagues
59
compared the relative effi-
cacy of group CBT and phenelzine with two control condi-
tions in a sample of 133 patients with SAD. The first was a
pill placebo, the second an educational supportive therapy
designed to resemble group CBT in credibility and genera-
tion of positive outcome expectations. In a conservative
analysis of the impact of the treatments, individuals who
dropped out of treatment were counted as nonresponders.
After 12 weeks of treatment, 58% of the patients treated
with group CBT and 65% of those patients treated with
phenelzine were classified as responders by independent
assessors, not significantly different from each other, but
significantly better than the placebo conditions. Individuals
on phenelzine typically responded faster, but showed much
greater rates of relapse after 6 months of maintenance treat-
ment and a 6-month follow-up period than did individuals
treated with group CBT.
60
Finally, we examine whether combining CBT and pharma-
cotherapy increases treatment gains. There are at least three
possible outcomes of combining medication and CBT: syner-
gistic effects on improvements, preservation of an equivalent
treatment response, or reduced efficacy. Synergistic effects
might occur if the combination of treatments increases an
individual’s likelihood for a positive response or it increases
the magnitude of improvements across individuals. There
would be little benefit to combining treatments if both med-
ication and CBT target the same aspects of SAD. The combi-
nation of interventions may result in decreased treatment
efficacy if patients receiving both medication and CBT
believe that the medication is the primary agent of change
and they consequently invest less in the activities involved in
CBT. This phenomenon has been studied in patients with
agoraphobia who received the combination of alprazolam and
exposure or relaxation treatment.
61
In this investigation,
patients who attributed improvements more to medication
than to their own efforts and who felt less confident in coping
without medication after 8 weeks of treatment showed higher
relapse rates and more withdrawal symptoms during drug
taper and follow-up periods.
Although common in clinical practice of the treatment of
SAD, empirical investigations of a combined treatment
strategy are lacking. Two published studies that have exam-
ined this issue used medications which were not superior to
placebo in controlled studies.
55,62
In another study,
63
expo-
sure combined with sertraline was not more efficacious than
sertraline and placebo. The follow-up investigation of the
Heimberg-Liebowitz collaborative study
64
includes a
phenelzine/CBGT combination condition. Preliminary
results show some evidence of superior treatment response
in the combined treatment. However, knowledge in this area
of research on the treatment of SAD is still lacking.
In summary, research supports the efficacy of both phar-
macotherapy and CBT for SAD. Pharmacotherapy may show
somewhat greater acute efficacy and may be associated with
quicker response. CBT may confer greater protection
against relapse. The evidence is also extremely limited for
how CBT and pharmacotherapeutic interventions might
work together in the treatment of SAD.
FUTURE DIRECTIONS IN TREATMENT
FOR SOCIAL ANXIETY DISORDER
Stein
65
has made a case for “cognitive-behaviorally
informed pharmacotherapy,” emphasizing the best possible
integration of resources to produce the best possible level of
care for the patient. Looking at how medication and therapy
respectively contribute to improvement can inform which
patients benefit from which intervention, and even if both
modalities are necessary. It should not be automatically
assumed that a combination of two effective treatments is
better than one intervention alone. However, we know little
about the specific characteristics of the patient that will
allow us to make this prediction. We also need to keep in
mind that not all cognitive-behavioral techniques may com-
bine equally well with medications and may do so better
with some medications than others. For instance, medica-
tions that inhibit the experience of anxiety, such as benzodi-
azepines or β-blockers, may be relatively poorer candidates
for combination with exposure techniques.
Future investigators of the combination of CBT and med-
ication may need to think outside the box when considering
how best to combine these two treatment modalities.
27
We
should not automatically think of the simultaneous adminis-
tration of both treatments. It would be of great interest to
know the relative efficacy of different methods of starting
and sequencing these aspects of treatment. For instance,
one might start a patient on medication first to take the edge
off his or her fears and promote quicker entry into feared sit-
uations. The medication might be phased out as the patient
learns cognitive-behavioral skills for coping with anxious
arousal. Cognitive-behavioral interventions might also be
used to help patients with SAD discontinue medications on
which they have become psychologically or physically
dependent, as has been done quite successfully with panic
disorder patients.
66
A similar strategy might be utilized with
patients who have used medications successfully but who
may be likely to relapse on medication discontinuation.
CBT might also be used to augment gains in partial respon-
ders to pharmacotherapy.
CONCLUSION
SAD is a prevalent, often debilitating fear of participating
in one or more social or performance situations. Cognitive-
behavioral models of SAD suggest that it is based, in part,
on distorted, catastrophic appraisals of the consequences of
physiologic and behavioral reactions to social situations.
Both CBT and pharmacologic interventions have been
shown to have efficacy in the treatment of SAD. What is less
clear is the active mechanisms of change in these cases and
how these treatments can be most effectively integrated to
provide the patient the best quality care. As yet, little is
known about the ways in which specific CBT techniques are
best combined with specific pharmacotherapies. In fact,
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380
there remains much to learn about the best methods of com-
bining the different techniques of CBT. These are clearly
important agenda for future research.
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... Os indivíduos com PAS, em comparação com os pares saudáveis, têm maiores dificuldades no que diz respeito a aspetos relacionais, apresentando menor número de relações de amizade menor satisfação com a rede de suporte social e maior tendência a não casar e a habitar com os pais ou outras pessoas com perturbação mental (Hambrick et al., 2003). Frequentemente não são capazes de participar com todo o seu potencial nas atividades escolares ou laborais, culminando em menor produtividade, maior taxa de absentismo e maior dependência dos serviços de assistência social. ...
... Existe ainda um elevado risco de comorbilidade com outras perturbações psiquiátricas, maioritariamente com outras patologias do espectro da ansiedade, perturbação depressiva major, doença bipolar e surgimento de ideação suicida (Fink et al., 2009;Hambrick, 2003;Westenberg, 2009). A comorbilidade frequente com abuso de substâncias pode refletir uma tentativa de automedicação para mascarar os sintomas da doença (Fink et al., 2009). ...
... Neste modelo considera-se que a sucessão de eventos que leva à ansiedade social tem início em situações nas quais o indivíduo é exposto a um público que é percepcionado como potencialmente crítico, ou seja, com potencial para elaborar uma avaliação negativa acerca do sujeito (Hambrick et al., 2003). Os indivíduos com PAS têm tendência à generalização, assumindo que a maioria das pessoas são críticas, e a maximizar os aspetos competitivos das relações interpessoais, minimizando os aspetos cooperativos e de interajuda (Hofmann, 2007). ...
Article
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Social Anxiety Disorder (SAD) is a highly prevalent and incapacitating disorder, manifested by marked fear or anxiety in situations in which the individual might be negatively evaluated by others Current investigations suggest that Cognitive-Behavioral Therapy (CBT) is an effective treatment strategy. The objective of this work was to provide a structured review of the role of CBT in SAD, addressing cognitive-behavioral models and their effectiveness. Thus, a non-systematized review of the literature was carried out through a bibliographic research at PubMed. CBT models for SAD suggest that these patients focus their attention selectively in interoceptive processes and in threatening cues perceived in the interaction with others. They develop maladaptive schemas that result in negative self-representations that don’t coincide with their overestimation of other’s expectations. This leads to negative emotions and symptoms of anxiety. In order to reduce these symptoms, patients tend to develop safety or avoidant behaviours that function as a negative reinforcement and perpetuate their dysfunctional beliefs. The main TCC approaches for SAD are: cognitive reconstructing and exposure techniques. To date, studies show that TCC is an effective treatment for SAD, but more investigation is necessary to improve treatment strategies for these patients.
... Recent meta-analyses have suggested that iCBT may be as effective as face-to-face treatment for SA (Guo et al., 2021), although investigation of iCBT's engagement in exposure has received less attention. Repeated exposure to fear-eliciting targets is a central component to the efficacy of CBT for SA (Hambrick et al., 2003) and engagement with exposure during iCBT has been associated with greater symptom reduction (Dryman et al., 2017). ...
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... Even though cognitive behavioral therapy is an effective solution for the treatment of SAD, it has limitations concerning the individual costs and the timing of the therapy (Pilling et al., 2013;Mayo-Wilson et al., 2014;Scaini et al., 2016;Dos Santos et al., 2019). Evidence suggests that pharmacological medications could complement a psychological approach, especially in cases when the severity of the impairment could cause other psychological and health risks, such as depression and suicide attempts (Hambrick et al., 2003;Vitiello, 2009;Kelly et al., 2014;Rao and Andrade, 2017). Unfortunately, current pharmacological treatments are based on serotonin and norepinephrine reuptake inhibitors, presenting multiple collateral effects and requiring at least some weeks to obtain a therapeutic response (Dos Santos et al., 2019). ...
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Social avoidance in rodents arises from a complex interplay between the prefrontal cortex and subcortical structures, such as the ventromedial hypothalamus and the dorsal periaqueductal gray matter. Experimental studies are revealing the contribution of these areas, but an integrative view and model of how they interact to produce adaptive behavior are still lacking. Here, we present a computational model of social avoidance, proposing a set of integrated hypotheses on the possible macro organization of the brain system underlying this phenomenon. The model is validated by accounting for several different empirical findings and produces predictions to be tested in future experiments.
... Together with prior work indicating that AS cognitive and physical concerns are associated with tobacco dependence severity in treatment-seeking smokers, [19] current findings suggest that it may be beneficial to focus more on addressing AS cognitive concerns in individuals with tobacco-alcohol problem comorbidity, whereas it may be beneficial to focus on addressing both AS physical and cognitive concerns in males with tobaccocannabis problem comorbidity. Also, together with prior research evidencing that AS social concerns are the only AS component associated with positive reinforcement-related cigarette smoking, [19] current findings may have additional implications for assisting high-AS cigarette smokers who want to quit smoking and curb their drinking habits: Individuals high in AS social concerns, who may smoke and drink for pleasure and to increase positive affect in social situations, may additionally benefit from relaxation training aimed at lessening social anxiety [72] and behavioral activation aimed at enhancing positive affect. [73] 23. ...
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... Specifically, given the relationship between all three AS components and negative reinforcement-related smoking variables, it is likely that standard tobacco cessation treatment for high-AS smokers (e.g., interoceptive exposure with cognitive restructuring, [64] which focuses on habituating and cognitively inoculating individuals to panic/anxiety-related symptoms) would be effective in reducing AS and ultimately smoking behavior regardless of which AS components are elevated. However, individuals high in AS social concerns, who may also smoke to increase PA and relax in social situations, may additionally benefit from relaxation training [65] (a cognitive-behavioral therapy technique developed for individuals with social anxiety disorder) as well as alternative methods of obtaining sensory satisfaction that are devoid of nicotine (e.g., nicotine-free chewing gum, [66,67] nicotine-free inhalator, [68] or nicotine-free e-cigarette [69] ...
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Anxiety sensitivity (AS)—fear of anxiety-related experiences—has been implicated in smoking motivation and maintenance. In a cross-sectional design, we examined AS facets (physical, cognitive, and social concerns) in relation to tobacco use, abstinence-related problems, and cognitions in 473 treatment-seeking smokers. After controlling for sex, race, age, educational attainment, hypertension status, and neuroticism, linear regression models indicated that AS physical and cognitive concerns were associated with tobacco dependence severity (β = .13–.14, p < .01), particularly the severity of persistent smoking regardless of context or time of day (β = .14–.17, p < .01). All three AS facets were related to more severe problems during past quit attempts (β = .23–.27, p < .001). AS cognitive and social concerns were related to negative affect reduction smoking motives (β = .14, p < .01), but only the social concerns aspect of AS was related to pleasurable relaxation smoking motives and positive and negative reinforcement-related smoking outcome expectancies (β = .14–.17, p < .01). These data suggest that AS physical and cognitive concerns are associated with negative reinforcement-related smoking variables (e.g., abstinence-related problems), whereas the social concerns aspect of AS is associated with positive and negative reinforcement-related smoking variables. Together with past findings, current findings can usefully guide AS-oriented smoking cessation treatment development and refinement.
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Introduction : Social anxiety disorder (SAD) and major depressive disorder (MDD) often co-occur; however, there is limited research evaluating how cognitive-affective and behavioral factors maintain SAD and MDD for specific individuals. Evidence suggests that individuals exhibit symptom-level heterogeneity, necessitating a person-specific approach to assessment and intervention. We compared group and person-specific models of SAD-MDD comorbidity and hypothesized that individuals would demonstrate person-specific patterns of comorbidity factors that differed from the group. Methods : Cisgender women (N = 35) with SAD and a current or past major depressive episode were recruited. Ages ranged from 18-37 years old and a majority of women were White (n = 18; 51.43%). Brief ecological momentary assessment surveys related to SAD-MDD comorbidity were administered five times a day for a month (T = 4,357). Results : Multilevel and person-specific network analyses were used to examine between-, within-, and person-specific patterns. Intra-daily depressed mood demonstrated the strongest connections to other variables and exhibited additional, unexpected temporal effects. All models demonstrated person-specific patterns relevant to SAD-MDD comorbidity. Limitations : These results are descriptive in nature from women with a similar psychiatric profile. Future research integrating intensive EMA and personalized modeling within the context of experimental design is needed to determine the extent to which individuals truly differ from the group. Conclusions : Patterns of SAD-MDD comorbidity varied substantially across women, underscoring the potential for results from person-specific (idiographic) networks to inform the development and implementation of personalized directives for clinical assessment and intervention.
Book
This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.
Chapter
Evidence-based treatments are suggested for generalized anxiety disorder (GAD) and social anxiety disorder (SAD). Pharmacological treatments such as selective serotonin reuptake inhibitors (SSRIs) and psychological treatment including cognitive-behavioral treatment (CBT) have been used as first-line treatments. However, many patients do not improve despite successful delivery of standard therapeutic interventions. The definition of treatment resistance is that standard treatments have been effectively delivered, but the results are ineffective. Overcoming treatment resistance requires reevaluation of the diagnosis and optimization of the treatments. Options for treatment-resistant GAD and SAD include augmentation with other antidepressants, atypical antipsychotics, benzodiazepines, and pregabalin. A partial NMDA agonist D-cycloserine was studied as a newer treatment option with exposure therapy in anxiety disorders.
Chapter
Interventions that address social communication abilities are of key importance in the rehabilitation of persons with traumatic brain injury (TBI), due to the impact of social competence on social and occupational outcomes. This chapter will review various interventions that have been utilized to address social communication difficulties after TBI. The first section of the chapter outlines the typical social communication changes observed in TBI and will clarify the scope of skills encompassed by the term social communication abilities. This will be followed by a brief review of the extant literature linking social communication to social and occupational functioning. A review of the interventions that have been used and evidence of their effectiveness is then presented, followed by a case illustration to outline clinical applications of social communication interventions for persons with TBI. © 2014, Springer Science+Business Media, LLC. All rights reserved.
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This chapter examines how obsessive-compulsive disorder (OCD) may be effectively treated using biologic approaches. Early recognition and intervention with combined cognitive behavioral and medication therapy limit its subsequent morbidity. Selective serotonin reuptake inhibitors (SSRIs) and clomipramine are central in acute and maintenance pharmacotherapy of OCD, often requiring high dosage. Augmenting agents include low-dose typical and atypical antipsychotic agents, among others. As OCD appears to be a chronic waxing and waning illness, effective medications should be continued for at least 1 to 2 years. Relapse rates tend to be high following medication discontinuation, although a history of cognitive behavioral therapy limits this risk. In severe treatment-refractory cases, surgical and somatic therapies such as deep brain stimulation have been used.
Chapter
IntroductionAntidepressant or Antiobsessional?Clomipramine (CMI)Selective Serotonin Reuptake Inhibitors (SSRIs)Drug DosageSide Effects of Antiobsessional MedicationsOnset of Treatment ResponseLong-term ApproachSpecial ConditionsTreatment-resistant OCDSummaryReferences Pharmacotherapy of Obsessive-compulsive Disorder: Accomplishment, Unanswered Questions and New Directions. Authored by Teresa A. PigottBeyond Serotonin Reuptake Inhibitors: Do We Have Our Second Wind? Authored by Christopher J. McDougleFuture Pharmacotherapy for Obsessive-compulsive Disorder: 5-HT2 Agonists and Beyond. Authored by Pedro L. DelgadoComments on the Pharmacological Treatment of Obsessive-compulsive Disorder. Authored by Matig R. MavissakalianThe Expanding Obsessive-compulsive Disorder Evidence Base. Authored by Lorrin M. KoranThe Heterogeneity of Obsessive-compulsive Disorder and Its Implications for Treatment. Authored by Laura BellodiPharmacotherapy of Obsessive-compulsive Disorder: Questions for the Next Decade. Authored by Mihaly AratoRecent Progress and Open Issues in the Pharmacological Approach to Obsessive-compulsive Disorder. Authored by José A. Yaryura-TobiasTreatment and Neurobiology of Obsessive-compulsive Disorder. Authored by Johan A. den BoerObsessive-compulsive Disorder: Pharmacological Decision. Authored by Jambur AnanthSerotonergic Antidepressants in Obsessive-compulsive Personality Disorder. Authored by M. AnsseauDrug Treatment of Obsessive-compulsive Disorder: Dark Past, Bright Present, but Glowing Future. Authored by Pierre Blier
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Seventy-two social phobics were Tandomly assigned to behavioral (flooding) or drug treatment with atenolol or placebo. Treatment was administered over a 3-month period of time, and duration of treatment effects was determined at a 6-month follow-up assessment. Multiple measures of outcome were used, including self-report, clinician ratings (including assessment by independent evaluators), behavioral assessment, and performance on composite indexes. The results indicated that flooding consistently was superior to placebo, whereas atenolol was not. Flooding also was superior to atenolol on behavioral measures and composite indexes. Those subjects who improved during treatment maintained gains at the 6-month follow-up regardless of whether they received flooding or atenolol. The variability of outcome on different measures in social phobia research is discussed, and the need for broad-based treatment strategies to address the pervasive deficits associated with social phobia is noted.
Chapter
Cognitive behavioral therapy (CBT) involving exposure and ritual prevention (EX/RP) is a well-established treatment for obsessive-compulsive disorder (OCD) in adults. Support for its efficacy is derived from many Type 1 and Type 2 studies; more recently the literature on more cognitively based treatments for OCD has provided further empirical support for this approach as well. Combined treatment studies examining EX/RP plus serotonin reuptake inhibitors or clomipramine have provided some advantages for the combined regimen over the monotherapies, but equivocal findings have emerged as well. In recent years there has been increased attention paid to the treatment of pediatric OCD using CBT, and now there are several Type 1 studies documenting the efficacy of this approach for youth with OCD. Further research is needed to examine predictors of outcome and to examine the effectiveness of CBT for OCD in a variety of clinical settings.
Chapter
Explanations of the variation in human behavior, especially those qualities that a culture regards as prototypic of the ideal, are high on the list of preoccupations of the citizen as well as those whose role it is to provide scientifically valid interpretations. The philosophical premises of each culture direct, often in subtle ways, the preferred interpretations, whereas available evidence, no matter how primitive, constrains theorists from generating potentially valid explanations that few will accept because the mind needs scaffolding for arguments that rest on novel or unpopular premises.
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Progress in treating OCD has accelerated in recent years. Effective first-line treatments include behavior therapy and medications, with overwhelming evidence supporting the efficacy of serotonergic reuptake inhibitors (SRIs). Second-line medication treatments for OCD include augmentation of SRIs with neuroleptics, clonazepam, or buspirone, with limited support for other strategies at present. Alternative monotherapies (e.g., buspirone, clonazepam, phenelzine) have more limited supporting data and require further study. Behavior therapy, and perhaps cognitive therapy, is as effective as medication and may be superior in risks, costs, and enduring benefits. Future rigorous research is needed to determine which patients respond preferentially to which medications, at what dose, and after what duration. Emerging treatments include new compounds acting via serotonergic, dopaminergic, glutamatergic, and opioid systems.
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Social phobia is increasingly recognized as a prevalent and socially impairing mental disorder. However, little data is available regarding the general and disease-specific impairments and disabilities associated with social phobia. Furthermore, most studies have not controlled for the confounding effects of comorbid conditions. This study investigates: (a) the generic quality of life; (b) work productivity; and, (c) various other disorder-specific social impairments in current cases with pure (n = 65), comorbid (n = 51) and subthreshold (n = 34) DSM-IV social phobia as compared to controls with no social phobia (subjects with a history of herpes infections). Social phobia cases reported a mean illness duration of 22.9 years with onset in childhood or adolescence. Current quality of life, as assessed by the SF-36, was significantly reduced in all social phobia groups, particularly in the scales measuring vitality, general health, mental health, role limitations due to emotional health, and social functioning. Comorbid cases revealed more severe reductions than pure and subthreshold social phobics. Findings from the Liebowitz self-rated disability scale indicated that: (a) social phobia affects most areas of life, but in particular education, career, and romantic relationship; (b) the presence of past and current comorbid conditions increases the frequency of disease-specific impairments; and, (c) subthreshold social phobia revealed slightly lower overall impairments than comorbid social phobics. Past week work productivity of social phobics was significantly diminished as indicated by: (a) a three-fold higher rate of unemployed cases; (b) elevated rates of work hours missed due to social phobia problems; and, (c) a reduced work performance. Overall, these findings underline that social phobia in our sample of adults, whether comorbid, subthreshold, or pure was a persisting and impairing condition, resulting in considerable subjective suffering and negative impact on work performance and social relationships. The current disabilities and impairments were usually less pronounced than in the past, presumably due to adaptive behaviors in life style of the respondents. Data also confirmed that social phobia is poorly recognized and rarely treated by the mental health system.
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• Selected sociodemographic and clinical features of social phobia were assessed in four US communities among more than 13 000 adults from the Epidemiologic Catchment Area study. Rates of social phobia were highest among women and persons who were younger (age, 18 to 29 years), less educated, single, and of lower socioeconomic class. Mean age at onset was 15.5 years, and first onsets after the age of 25 years were uncommon. Lifetime major comorbid disorders were present in 69% of subjects with social phobia and usually had onset after social phobia. When compared with persons with no psychiatric disorder, uncomplicated social phobia was associated with increased rates of suicidal ideation, financial dependency, and having sought medical treatment, but was not associated with higher rates of having made a suicide attempt or having sought treatment from a mental health professional. An increase in suicide attempts was found among subjects with social phobia overall, but this increase was mainly attributable to comorbid cases. Social phobia, in the absence of comorbidity, was associated with distress and impairment, yet was rarely treated by mental health professionals. The findings are compared and contrasted with prior reports from clinical samples.