Behrens, T. E. et al. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nature Neurosci. 6, 750-757

Department of Engineering Science, University of Oxford, Oxford, England, United Kingdom
Nature Neuroscience (Impact Factor: 16.1). 08/2003; 6(7):750-7. DOI: 10.1038/nn1075
Source: PubMed


Evidence concerning anatomical connectivities in the human brain is sparse and based largely on limited post-mortem observations. Diffusion tensor imaging has previously been used to define large white-matter tracts in the living human brain, but this technique has had limited success in tracing pathways into gray matter. Here we identified specific connections between human thalamus and cortex using a novel probabilistic tractography algorithm with diffusion imaging data. Classification of thalamic gray matter based on cortical connectivity patterns revealed distinct subregions whose locations correspond to nuclei described previously in histological studies. The connections that we found between thalamus and cortex were similar to those reported for non-human primates and were reproducible between individuals. Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter.

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Available from: Paul M Matthews, Jan 11, 2015
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    • "The detailed description of WM modifications was made possible using the development of Diffusion Tensor Imaging (DTI). DTI is an established method for studying in vivo the WM pathways and has the ability to reveal structural properties of the WM (Basser et al., 2000; Le Bihan et al., 2001; Behrens et al., 2003) by measuring water diffusion at mesoscopic resolution in brain tissue. It has been shown that axonal structure, cell membrane, and myelin sheath strongly influence water diffusion. "
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    Full-text · Article · Feb 2016 · Frontiers in Aging Neuroscience
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    • "The thalamic nuclei are connected with the cerebral cortex via reciprocal connections in a topographically organized fashion. This has been portrayed in the classical anatomical literature (e.g.,Parent, 1996) and recently with the advent of diffusion imaging (Behrens et al., 2003;Johansen Berg et al., 2005;Makris et al., 1999). Cortico-striatal Tracts. "
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    • "Although the VIM-related FC networks identified in the ET patients and the HCs are highly consistent with the individual anatomical connectivity networks revealed by invasive tract-tracing and noninvasive DTI studies of normal non-human primates [Asanuma et al., 1983a; Yamamoto et al., 1983] and healthy humans [Behrens et al., 2003; Johansen-Berg et al., 2005; Kincses et al., 2012], we must use caution when interpreting these findings, especially when applying them at an individual level. Additionally , to reveal the characteristic profiles of ET, a homogenous entity is necessary because growing evidence has suggested that ET is not a single disease but rather is a family of diseases or a syndrome [Louis et al., 2014]. "
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