Article

An eye on insulin

Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
Journal of Clinical Investigation (Impact Factor: 13.22). 07/2003; 111(12):1817-9. DOI: 10.1172/JCI18927
Source: PubMed

ABSTRACT

Diabetic retinopathy, the most frequent complication of diabetes and leading cause of vision loss, involves vascular and neural damage in the retina. Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators.

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    • "In diabetic retinopathy, abnormal glucose metabolism and hyperglycemia-associated neo-and hypervascularization are hallmark features. Such vascular pathologies are known to cause neuronal damage in the retina and induce ocular hemorrhage-induced vision loss [17] [18]. The retina is separated from the general circulation by the blood-retinal barrier (BRB), which in many ways, exhibits an ultrastructure similar to the BBB. "
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