Association of consumption of products containing milk fat with reduced asthma risk in pre-school children: The PIAMA Birth Cohort Study

University of Groningen, Groningen, Groningen, Netherlands
Thorax (Impact Factor: 8.29). 08/2003; 58(7):567-72. DOI: 10.1136/thorax.58.7.567
Source: PubMed


Environment and lifestyle contribute to the development of asthma in children. Understanding the relevant factors in this relationship may provide methods of prevention. The role of diet in the development of asthma in pre-school children was investigated.
Data from 2978 children participating in a prospective birth cohort study were used. Food frequency data were collected at the age of 2 years and related to asthma symptoms reported at the age of 3 years.
The prevalence of recent asthma at age 3 was lower in children who consumed (at age 2) full cream milk daily (3.4%) than in those who did not (5.6%) and in those who consumed butter daily (1.5%) than in those who did not (5.1%). The prevalence of recent wheeze was lower in children who consumed milk products daily (13.7%) than in those who did not (18.4%) and in children who consumed butter daily (7.7%) than in those who did not (15.4%). These effects remained in a logistic regression model including different foods and confounders (adjusted odds ratio (CI) for recent asthma: full cream milk daily v rarely 0.59 (0.40 to 0.88), butter daily v rarely 0.28 (0.09 to 0.88)). Daily consumption of brown bread was also associated with lower rates of asthma and wheeze, whereas no associations were observed with the consumption of fruits, vegetables, margarine, and fish.
In pre-school children, frequent consumption of products containing milk fat is associated with a reduced risk of asthma symptoms.

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Available from: Marjan Kerkhof, Nov 26, 2015
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    • "It is also possible that women consumed fat-free or low-fat cheeses that would not have been high in saturated fat. There is evidence, however, from a pediatric prospective cohort study that both brown bread and milk fat are protective against asthma symptoms [64]. "
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    ABSTRACT: Background There is abundant research relevant to genetic and environmental influences on asthma and hayfever, but little is known about dietary risk factors in Australian adults. This study’s purpose was to identify dietary factors associated with lifetime asthma (AS) and asthma or hayfever (AS/HF) diagnosis in Australian middle-aged and older adults. Methods From The 45 and Up Study baseline self-report data, this study included 156,035 adult men and women. Participants were sampled from the general population of New South Wales, Australia in 2006–2009. About 12% of participants reported ever receiving an AS diagnosis (men 10%; women 14%) and 23% reported AS/HF diagnosis (men 19%; women 26%). Following principle components factor analysis, dietary items loaded onto one of four factors for men (meats/cheese; fruits/vegetables; poultry/seafood; grains/alcohol) or five factors for women (meats; fruits/vegetables; poultry/seafood; cereal/alcohol; brown bread/cheese). Logistic regression was used to analyze the associations between dietary factors and AS or AS/HF diagnosis. Results For men, the meats/cheese factor was positively associated with AS (AOR = adjusted odds ratio for highest versus lowest quintile = 1.18, 95%CI = 1.08, 1.28; Ptrend = 0.001) and AS/HF (AOR for highest versus lowest quintile = 1.22, 95%CI = 1.14, 1.29; Ptrend < 0.001). Poultry/seafood was also associated with AS/HF in men (AOR for highest versus lowest quintile = 1.11, 95%CI = 1.04, 1.17; Ptrend = 0.002). For women, significant risk factors for AS/HF included meats (AOR for highest versus lowest quintile = 1.25, 95%CI = 1.19, 1.31; Ptrend = 0.001), poultry/seafood (AOR for highest versus lowest quintile = 1.06, 95%CI = 1.01, 1.12; Ptrend = 0.016), and fruits/vegetables (AOR for highest versus lowest quintile = 1.07, 95%CI = 1.02, 1.12; Ptrend = 0.011). In contrast, the cheese/brown bread dietary factor was protective against AS in women (AOR for highest versus lowest quintile = 0.88, 95%CI = 0.82, 0.94; Ptrend < 0.001). Conclusions Generally, diets marked by greater intakes of meats, poultry, and seafood were associated with diagnosed AS and AS/HF. Taken together, these findings suggest that adherence to a more meat-based diet may pose risk for AS and AS/HF in Australian adults.
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    • "Several studies have also suggested that specific foods might have an impact on asthma and allergies. Vegetables [9,27,28], fruits [9,27-29], dairy products [9,28,30,31] and fish [9,29,32,33] have been associated with reduced asthma risk in children, whereas fast food [34] and dietary fats [31] have been associated with an increased risk. Because foods can interact with one another, it has been suggested that dietary patterns derived from cluster or factor analysis [35] or the use of diet scores [35] are a useful approach for characterizing the diet of individuals and providing nutritional recommendations. "
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    • "An increase in the ratio of dietary polyunsaturated fatty acids (PUFAs) to saturated fatty acids (SFA), named P/S ratio, has been observed in westernized diet over the last few decades [1] [5] [6]. This event is associated with asthma susceptibility, as demonstrated by some studies that related consumption of PUFA with higher, and consumption of SFA with lower susceptibility to asthma [7] [8] [9] [10]. It was hypothesized that an increase in n-6 PUFA/n-3 PUFA ratio, instead of the increase in P/S ratio, could raise the susceptibility to the development of asthma [5], but this hypothesis is not supported by epidemiological studies [1]. "
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