Article

A new acetylated glucoside of luteolin and two flavone glucosides from Lavandula stoechas ssp. stoechas

Laboratory of Pharmacognostics, Aristotle University of Thessaloniki, Saloníki, Central Macedonia, Greece
Pharmazie (Impact Factor: 1.05). 07/2003; 58(6):426-7.
Source: PubMed

ABSTRACT

Fractionation of ethyl acetate extract of Lavandula stoechas aerial parts revealed the presence of a novel acetylated glucoside (1) together with apigenin 7-O-glucoside (2) and luteolin 7-O-glucoside (3). The structures of these compounds were elucidated by spectroscopic analyses, notably UV, MS, and NMR.

  • Source
    • "Presence of multiple chemical constitutes such as monoterpenes and sesquiterpene including linalool, linalyl acetate and flavnoids such as L. uteolin in the other species of this plant (L. vera) reinforces the possibility of its effect on different parts of the central nervous system (14, 15). Shaw et al (2007) showed that the effects of Lavandula on rat are the same as chlordizpoxide (16) "
    [Show abstract] [Hide abstract]
    ABSTRACT: Many herbs have been used to treat psychiatric disorders including anxiety and depression in traditional medicine. This study was carried out to determine the effect of using Lavandula angustifilia infusion on depression in patients taking Citalopram. Among all patients referred to the Hajar Hospital psychiatric clinic, Shahrekord, Iran, 80 patients who met the criteria of major depression according to the structured interviews and the Hamilton questionnaire for Depression were included in the study. They were randomly assigned into two groups of experimental treatment group and standard treatment group at this study. In standard treatment group, the patients were given Citalopram 20 mg. In experimental treatment group, the patients took 2 cups of the infusion of 5 g dried Lavandula angustifilia in addition to tablet Citalopram 20 mg twice a day. The patients were followed up for four and eight weeks of the study onset using Hamilton Scale questionnaire and treatment side effects form. Data were analyzed using student t-test, pair t-test and chi square. After four weeks of the trial onset, the mean depression score according to the Hamilton Scale for Depression was 17.5 ± 3.5 in the standard treatment group and 15.2 ± 3.6 in the experimental treatment group (P < 0.05). After eight weeks, it was 16.8±4.6 and 14.8±4 respectively (P < 0.01). In addition, the most commonly observed adverse effects were nausea (12.8 %) and confusion (10%). In terms of side effects, there were no significant differences between two groups. Considering the results of this study, Lavandula angustifilia infusion has some positive therapeutic effects on depressed patients most importantly decreases mean depression score and might be used alone or as an adjunct to other anti-depressant drugs.
    Full-text · Article · Aug 2013
  • Source
    • "The saponins were also detected by Küpeli et al. (2006) in E. ilicifolium. Previous phytochemical investigations of L. stoechas revealed the presence of acetylated glucoside of luteolin and flavone glucoside in ethylacetate extracts of the aerial parts (Gabrieli and Kokkalou, 2003). "
    [Show abstract] [Hide abstract]
    ABSTRACT: In Morocco, most people particularly in rural areas use medicinal plants to treat diseases. In order to find new antipneumococcal extracts, an ethnobotanical survey has been conducted in different regions of Marrakesh (south of Morocco). Four plants often cited by traditional practitioners (Marrubium vulgare, Thymus pallidus, Eryngium ilicifolium and Lavandula stoechas) are tested against Streptococcus pneumoniae responsible for pharyngitis, rhinitis, otitis and sinusitis infections. Aqueous and methanol extracts have been prepared and tested on S. pneumoniae collected in four regions of Marrakesh. A significant activity has been observed with methanol extracts of three plants; M. vulgare, T. pallidus and L. stoechas (MIC= 256 μg/ml).
    Full-text · Article · Mar 2009 · African journal of pharmacy and pharmacology
  • Source
    • "Jatropha cilliata Euphorbiaceae isoorientin and orientin [385] Kitaibelia vitifolia Malvaceae luteolin [386] Kummerowia striata Leguminosae luteolin 4'-O-glucopyranoside [82] Lactuca indica Asteraceae luteolin, luteolin 7-O-glucuronide [387] Lactuca sativa Asteraceae luteolin 7-O-glucuronide [388] Lactuca scariola Asteraceae luteolin-7-O-beta-D-glucopyranoside, luteolin [389] Lamiophlomis rotata Lamiaceae luteolin-7-O-glucoside, luteolin [390] Lavandula stoechas Lamiaceae luteolin 7-O-glucoside [391] Lawsonia inermis Lythraceae luteolin [44] Leandra lacunosa Melastomataceae luteolin [227] Leontodon croceus Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide, luteolin 4'-O-beta-D-glucoside [392] Leontodon duboisii Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide, luteolin 4'-O-beta-D-glucoside [392] Leontodon helveticus Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide, luteolin 4'-O-beta-D-glucoside [392] Leontodon montaniformis Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide [392] Leontodon autumnalis Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide, luteolin 4'-O-beta-D-glucoside [392] Leontodon pyrenaicus Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide, luteolin 4'-O-beta-D-glucoside [392] Leontodon rilaensis Asteraceae luteolin, luteolin 7-O-beta-D-gentiobioside, luteolin 7-O-beta-D-glucoside, luteolin 7-O-beta-D-glucuronide, luteolin 4'-O-beta-D-glucoside [392] Leontopodium alpium Asteraceae luteolin-7-O-beta-D-glucoside, luteolin-3'-O-beta-D-glucoside, luteolin-4'- O-beta-D-glucoside, 6-hydroxy-luteolin-7-O-beta-D-glucoside, luteolin-7,4'- di-O-beta-D-glucoside, [393] Lepechinia graveolens Lamiaceae luteolin-7-O-glucuronide [394] Leucanthemum adjustum Asteraceae luteolin-7-glucoside, luteolin-7-glucuronide [263] Leucanthemum vulgare Asteraceae luteolin-7-glucuronide [263] Leucas cephalotes Lamiaceae luteolin 4'-O-beta-D-glucuronopyranoside [395] Ligustrum vulgare Oleaceae luteolin, luteolin 7-O-glucoside [396] Lippia alba Verbenaceae luteolin-7-diglucuronide [397] Lisianthius nigrescens Gentianaceae luteolin 8-C-glucoside [398] Lobelia chinensis Campanulaceae luteolin [399] Lonicera confusa Caprifoliaceae luteolin [400] Lonicera japonica Caprifoliaceae luteolin, luteolin 7-O-beta-D-glucopyranoside [35] [401] Lophira alata Ochnaceae luteolin [402] Luffa cylindrica Cucurbitaceae luteolin-7-O-beta-D-glucuronide methyl ester [403] "
    [Show abstract] [Hide abstract]
    ABSTRACT: Epidemiological evidence suggests that flavonoids may play an important role in the decreased risk of chronic diseases associated with a diet rich in plant-derived foods. Flavonoids are also common constituents of plants used in traditional medicine to treat a wide range of diseases. The purpose of this article is to summarize the distribution and biological activities of one of the most common flavonoids: luteolin. This flavonoid and its glycosides are widely distributed in the plant kingdom; they are present in many plant families and have been identified in Bryophyta, Pteridophyta, Pinophyta and Magnoliophyta. Dietary sources of luteolin include, for instance, carrots, peppers, celery, olive oil, peppermint, thyme, rosemary and oregano. Preclinical studies have shown that this flavone possesses a variety of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial and anticancer activities. The ability of luteolin to inhibit angiogenesis, to induce apoptosis, to prevent carcinogenesis in animal models, to reduce tumor growth in vivo and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid has cancer chemopreventive and chemotherapeutic potential. Modulation of ROS levels, inhibition of topoisomerases I and II, reduction of NF-kappaB and AP-1 activity, stabilization of p53, and inhibition of PI3K, STAT3, IGF1R and HER2 are possible mechanisms involved in the biological activities of luteolin.
    Full-text · Article · Feb 2009 · Mini Reviews in Medicinal Chemistry
Show more