Bartonella schoenbuchensis Isolated from the Blood of a French Cow

Unité des Rickettsies CNRS UMR-A 6020, IFR 48, Faculté de Médecine, Université de la Méditerranée, 13385 Marseilles Cedex 05, France.
Annals of the New York Academy of Sciences (Impact Factor: 4.38). 07/2003; 990(1):236-8. DOI: 10.1111/j.1749-6632.2003.tb07370.x
Source: PubMed
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    • "(B. chomelii and B. schenobuensis) are occasionally found in cattle [17,25]. Although Bartonella spp. "
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    ABSTRACT: Bartonella bovis is commonly detected in cattle. One B. bovis strain was recently isolated from a cow with endocarditis in the USA, suggesting its role as an animal pathogen. In the present study, we investigated bartonella infections in 893 cattle from five countries (Kenya, Thailand, Japan, Georgia, and Guatemala) and 103 water buffaloes from Thailand to compare the prevalence of the infection among different regions and different bovid hosts. We developed a multi-locus sequence typing (MLST) scheme based on nine loci (16S rRNA, gltA, ftsZ, groEL, nuoG, ribC, rpoB, ssrA, and ITS) to compare genetic divergence of B. bovis strains, including 26 representatives from the present study and two previously described reference strains (one from French cows and another from a cow with endocarditis in the USA). Bartonella bacteria were cultured in 6.8% (7/103) of water buffaloes from Thailand; all were B. bovis. The prevalence of bartonella infections in cattle varied tremendously across the investigated regions. In Japan, Kenya, and the Mestia district of Georgia, cattle were free from the infection; in Thailand, Guatemala, and the Dusheti and Marneuli districts of Georgia, cattle were infected with prevalences of 10-90%. The Bartonella isolates from cattle belonged to three species: B. bovis (n=165), B. chomelii (n=9), and B. schoenbuchensis (n=1), with the latter two species found in Georgia only. MLST analysis suggested genetic variations among the 28 analyzed B. bovis strains, which fall into 3 lineages (I, II, and III). Lineages I and II were found in cattle while lineage III was restricted to water buffaloes. The majority of strains (17/28), together with the strain causing endocarditis in a cow in the USA, belonged to lineage I. Further investigations are needed to determine whether B. bovis causes disease in bovids.
    Full-text · Article · Nov 2013 · PLoS ONE
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    • "B. bovis is also reported in other ruminant species, including mule deer and elk (Chang et al., 2000). Bartonella schoenbuchensis was first isolated from wild roe deer (Capreolus capreolus) in Germany (Dehio et al., 2001) and was later reported in French cattle (Rolain et al., 2003) as well as deer keds (Lipoptena cervi) collected from roe deer and red deer in Germany (Dehio et al., 2004). Bartonella capreoli, a species that is genetically close to B. schoenbuchensis , was also first isolated from wild roe deer in France (Bermond et al., 2002) and was found recently in ticks (Ixodes ricinus) collected from roe deer in Poland (Bogumiła and Adamska, 2005). "
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    ABSTRACT: The aim of the present study was to investigate the presence of Bartonella infections in elk populations. We report the isolation of four Bartonella strains from 55 elk blood samples. Sequencing analysis demonstrated that all four strains belong to Bartonella capreoli, a bacterium that was originally described in the wild roe deer of Europe. Our finding first time demonstrated that B. capreoli has a wide geographic range, and that elk may be another host for this bacterium. Further investigations are needed to determine the impact of this bacterium on wildlife.
    Full-text · Article · Sep 2010 · Veterinary Microbiology
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    • "The establishment of a chronic intra-erythrocytic bacteremia takes place exclusively in the mammalian reservoir host(s). Most Bartonella species appear to be restricted to cause intra-erythrocytic infection in a single mammalian species, e.g., B. bacilliformis in humans or B. henselae in domestic cats, while other species have several, but typically closely related mammalian reservoir hosts, e.g., B. bovis or B. schoenbuchensis infecting various ruminant hosts, such as roe deer, red deer [47], mule deer, elk and cattle [31, 114]. Depending on the level of host adaptation, these infections in the reservoir host range from an asymptomatic or sub-clinical (most animal-specific species) to clinical manifestations with low morbidity and limited mortality (such as human-specific B. quintana infections), or even to life-threatening disease, such as severe hemolytic anemia associated with the human-specific infection by B. bacilliformis. "
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    ABSTRACT: Bartonella spp. are facultative intracellular bacteria that cause characteristic hostrestricted hemotropic infections in mammals and are typically transmitted by blood-sucking arthropods. In the mammalian reservoir, these bacteria initially infect a yet unrecognized primary niche, which seeds organisms into the blood stream leading to the establishment of a long-lasting intra-erythrocytic bacteremia as the hall-mark of infection. Bacterial type IV secretion systems, which are supra-molecular transporters ancestrally related to bacterial conjugation systems, represent crucial pathogenicity factors that have contributed to a radial expansion of the Bartonella lineage in nature by facilitating adaptation to unique mammalian hosts. On the molecular level, the type IV secretion system VirB/VirD4 is known to translocate a cocktail of different effector proteins into host cells, which subvert multiple cellular functions to the benefit of the infecting pathogen. Furthermore, bacterial adhesins mediate a critical, early step in the pathogenesis of the bartonellae by binding to extracellular matrix components of host cells, which leads to firm bacterial adhesion to the cell surface as a prerequisite for the efficient translocation of type IV secretion effector proteins. The best-studied adhesins in bartonellae are the orthologous trimeric autotransporter adhesins, BadA in Bartonella henselae and the Vomp family in Bartonella quintana. Genetic diversity and strain variability also appear to enhance the ability of bartonellae to invade not only specific reservoir hosts, but also accidental hosts, as shown for B. henselae. Bartonellae have been identified in many different blood-sucking arthropods, in which they are typically found to cause extracellular infections of the mid-gut epithelium. Adaptation to specific vectors and reservoirs seems to be a common strategy of bartonellae for transmission and host diversity. However, knowledge regarding arthropod specificity/restriction, the mode of transmission, and the bacterial factors involved in arthropod infection and transmission is still limited.
    Full-text · Article · Apr 2009 · Veterinary Research
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