Targeting the Lung: Preclinical and Comparative Evaluation of Anticancer Aerosols in Dogs with Naturally Occurring Cancers

Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Current Cancer Drug Targets (Impact Factor: 3.52). 09/2003; 3(4):265-73. DOI: 10.2174/1568009033481903
Source: PubMed


Pet dogs with naturally occurring cancers offer a novel opportunity for the study of both cancer biology and therapy. The following review will provide the rationale for the use of these spontaneous cancer models in translational research, particularly in the development of anticancer aerosols. A summary of work involving pet dogs with primary and metastatic cancers to the lung and the investigation of therapeutic chemotherapy and cytokine immunotherapy aerosols will be presented.

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    • "Chemotherapy for the dog has been largely unrewarding, with minimal responses to vindesine, cisplatin, and partial responses to vinorelbine [7,8]. No responses were seen in dogs with primary cpAC treated with the inhaled antineoplastic drugs paclitaxel or doxorubicin [9,10]. A dog with the diagnosis of primary bronchogenic carcinoma was treated with the TKI, toceranib, and was reported to have stable disease of 34+ weeks [11]. "
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