The BON domain: A putative membrane-binding domain

ArticleinTrends in Biochemical Sciences 28(7):352-5 · August 2003with4 Reads
Impact Factor: 11.23 · DOI: 10.1016/S0968-0004(03)00115-4 · Source: PubMed


    A novel conserved protein region – the BON (bacterial OsmY and nodulation) domain – is found in the bacterial osmotic-shock-resistance protein OsmY, a family of haemolysins, a group of nodulation specificity proteins and secretory channels, and several hypothetical proteins. Functional annotation in the literature suggests that it interacts with phospholipid membranes. A lack of catalytic residues in the sequence alignment supports the hypothesis that it is a binding domain.