The Sexual Sensation Seeking Scale (SSSS; Kalichman & Rompa, 1995) is a measure of the propensity to seek out novel or risky sexual stimulation. This measure has been consistently related to HIV-risk behavior in several different samples of gay men and with behavioral correlates of sexual permissiveness in college students. Five hundred twenty-eight college students completed the SSSS and several other sexuality and personality measures. The results reveal significant gender differences on the SSSS and similar (although stronger among women) patterns of significant correlations with sexually permissive characteristics and behaviors. Furthermore, SSSS scores were more highly correlated with sexual measures, whereas a more general measure of sensation seeking was more highly correlated with general personality measures. We discuss implications for use of the SSSS by sexuality educators and sex therapists.