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... SeS2 reduces scales, itching, irritation and redness of the scalp. Moreover, it rebalances the skin microbiome [21,22]. We hereafter present results from 2 studies showing the clinical benefits of a shampoo containing SeS2 (Dercos ® Anti-Dandruff Shampoo, Laboratoires Vichy, France) on dandruff scalp and its impact on the fungal and bacterial scalp microbiota and surface squalene. ...
... SeS2 is a well-known active ingredient to manage dandruff [22]; however, only limited clinical work has been carried out to confirm its efficacy and mode of action [21,29,30]. We herewith report results from 2 studies that, in addition to the assessment of clinical parameters, also assessed the impact of SeS2 on the scalp full microbiota and sebum in subjects with dandruff. ...
Background:
Dandruff is a chronic and relapsing scalp condition characterized by flaky scalp. Environmental and host factors (exposome) may alter the sebaceous gland activity, sebum composition, epidermal barrier function, and scalp microbiome balance, resulting in dandruff. Selenium disulfide (SeS2) improves the clinical signs of dandruff.
Objectives:
To investigate the mode of action of SeS2 shampoo during treatment and relapse phases.
Materials & methods:
Two single-center studies assessed dandruff severity, subjective efficacy perception, microbial balance, microbiota diversity and sebum lipids.
Results:
SeS2 significantly (p≤0.01) reduced scaling and led to a significant decrease of Malassezia and Staphylococcus spp. counts in both lesional and non-lesional areas, compared to the vehicle at D28 returning to baseline levels at D56. Cutibacterium spp. levels were not different between the SeS2 and the vehicle treatment groups but had significantly increased with SeS2 (p<0.001) in the lesional zone at D56. The ratio Malassezia spp./Cutibacterium spp. decreased significantly in lesional zones compared to baseline levels, at both D28 and D35 (p<0.001). The total squalene content significantly increased (p<0.05), whereas peroxided squalene had significantly decreased by almost 50% at D31. The ratio triglycerides/free fatty acids significantly (p<0.0001) increased, almost 5-fold, between D0 and D31. SeS2 shampoo was very well tolerated.
Conclusion:
SeS2 is beneficial in scalp dandruff, even after treatment interruption. It is well tolerated, rebalances the equilibrium between the main bacterial and fungal populations, and improves sebum quality.
... Selenium disulfide (SeS 2 ) is a recognized ingredient to manage both dandruff and SD efficiently. It reduces flakes, pruritus, irritation, and scalp redness [4][5][6]. The aim of this study was to assess the efficacy of a SeS 2 -based shampoo after 4 weeks of use in subjects with dandruff or SD, in a real-life setting. ...
Unlabelled:
Seborrheic Dermatitis (SD) is a chronic and relapsing inflammatory condition accompanied by erythema, flaking and itching. Dandruff is a milder form of SD. Selenium disulfide (SeS2) is beneficial in both conditions.
Objectives:
to assess the efficacy of SeS2-based shampoo in dandruff/SD.
Materials & methods:
an international, multicenter, observational study was conducted in 1407 adult subjects. SeS2- based shampoo was used 2 to 3 times per week for 4 weeks. Clinical efficacy criteria included improvement of hair, flaking, erythema and irritation on a scale from 0 to 5; investigator satisfaction was assessed at month 3 from 0 to 10. The subjects rated the impact of their hair problem (0 to 5), efficacy and satisfaction with SeS2-based shampoo at month 3. Tolerance was assessed throughout the study.
Results:
At baseline, 68.2% had a flake severity score of 3-5, 49.9% an erythema severity score of 3-5, and 46.2% an irritation severity score of 3-5; 28.2% were bothered and 41.5% were very bothered. At study end, SD/D had at least clearly improved in 89.6% of subjects. All clinical signs had significantly (p<0.001) improved. 95.6% of subjects reported less pruritus. Significantly fewer (15.4%, p<0.0001) subjects were still bothered. The overall subject satisfaction score was 8.9±1.4; 97.6% of investigators were satisfied or very satisfied. Tolerance was good or very good in 98.8% of subjects.
Conclusion:
A SeS2-based shampoo applied 2 to 3 times per week is efficient and well tolerated in dandruff and SD.
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