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PRESENTATION
This second book on Person-Centered Medicine (PCM), written by the theory author- the first was published in 2001 by the same author- introduces the PCM paradigm applied in the Milan School of Medicine since 1998, and the first results of the Person-Centered Clinical Method application in clinical practice. The book is essential to understand the institution of the Person-Centered Medicine paradigm of Medicine and Medical science, the first extrinsic in Medicine history, its scientific bases, and the revolutionary change of the health concept. The book introduces the "Health Relativity theory" (HRT) and its indeterministic epistemological construct, with a revolution of the deterministic current one, posing the basis of the People and Person-Centered new model of prevention (PPCP). The book's second significant scientific contribution introduces the MCP-derived general theory of SARS-COV 2 infection and COVID-19 clinical complications like ARDS, highlighting the WHO and countries' scientific committees' omissions. By introducing PPCP, the book reverses, in an irrefutably way, the health policy to date promoted in the world against COVID-19. The book constitutes part of the teaching theory of the International master in Person-Centered Medicine of the Milan School of Medicine. The book ( 131pg.-123 ref.) is structured in 10 chapters as follows:
1. The epistemological and scientific basis of Person-Centered Medicine ( Scientific bases of the paradigm );
2. Person-Centered Medicine teaching in the Milan School of Medicine ( First institutional MCP teaching in the world since 1998);
3. The Person-Centered Medicine Clinical Method (Step by step the Person-Centered Medicine Clinical Method);
4. Results of the Person-Centered Medicine clinical application: the first PCM pilot study (2002);
4.1. Analysis of the PCM pilot study results (2003);
5. Person-Centered Medicine learning and the PCM pilot study results;
6. The COVID-19 mechanic primary prevention defeat is the result of a guilty omission of secondary prevention.; This chapter introduces the general theories of SARS-COV 2 allostasis and its complications and the derived Copernican revolution of the mechanic prevention perspective through the "People and person-centered prevention" model. The chapter highlights the reasons for the secondary prevention omission and failure of primary prevention;
7. The health relativity theory. The chapter introduces the "Health Relativity Theory," derived by PCM, that revolutions the current deterministic health concept and poses the epistemological basis of PPCP
8. The PCCM resilience induction (The PCCM orientation to promote protective factors );
9. The need for Person-Centered Medicine for a "People and Person-Centered Prevention";
10. Opening remarks The chapter introduces the PCM and PPCP's necessary impact in the world of public health and medical education;
11. THE PCCM LEARNING EVALUATION PROTOCOL-PCCMLEP-);
12. References ;
The PCM paradigm is derived from medical science and humanities-induced person-centered advances, which during the last 40 years changed the health concept and clinical method, starting from the epistemological innovation of the determinate and indeterminate relativity of biological reactions written by the same author in 1996. Part of this book and its figures correspond to the person-centered theory and its teaching procedures highlighted by prof. Giuseppe R. Brera in an invited presentation at WHO on 4 May 2011. The book explains the scientific basis of the medical science and person-centered medicine paradigm, corresponding to the shift from the dominant Medicine and health mechanistic-deterministic intrinsic hidden paradigm to the extrinsic Person-centered indeterministic one. This change is similar to that from mechanistic to quantum physics at the beginning of the last century
147 pages, $ 28
Distributed worldwide by Amazon
Person-Centered Medicine and Person-Centered Medicine Clinical Method: Clinical results of the first Medicine unitary paradigm teaching and the SARS-COV 2 entry relativity inducing COVID-19 Person-Centered Prevention.
147 pag, $ 28
Distributed by Amazon worldwide
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SARS-COV 2, like HIV, induces an NK, CD4+, CD8+-based immune-depression proportional to the COVID-19 severity and immune-anergy after the seventh day from the beginning of clinical symptoms, which is the principal cause of fatalities in older people affected by atherosclerosis-based comorbidities. Since the 2003 SARS-COV pandemic, this clinical evidence did not orient WHO and anti-COVID 19 scientific committees to a natural innate and adaptive active immunity boosting-based primary and secondary prevention and immune-therapy in anergy. It represents a guilty omission, only orienting countries to mass vaccination with experimental vaccines of limited validity with unknown but clinical and scientific evidence of short term and probable long-term adverse effects. Beta-glucans, structural polysaccharides present in Baker’s Yeast, cereals, algae, or exo-polysaccharides in the wall of mushrooms or fungi like Ganoderma Lucidum (Reishi), Grifola Frondosa (Maitake), and Lentinula Edodes (Shitake), Coriolus Versicolor, in evolution responsible of the defense from massive pandemics, are powerful innate and adaptive immunity boosters. Extensively studied in cancer prevention and therapy, they boost innate humoral immunity, neutralize immunosuppression, and induce an active humoral adaptive one, representing an easy, cheap, formidable weapon against SARS-COV 2 accessible for all worldwide, for primary and secondary prevention, and therapy, at zero costs, inducing the pandemic shut-down, and cross prevention against cancer and other communicable diseases.
The Ambrosiana University has edited a treatise on SARS-COV 2 by Professor Giuseppe R.Brera, director of the Milan School of Medicine and President of the International Committee for the change of the paradigm of health and medicine. The treatise introduces into virology the revolutionary physiological concept of "Allostasis", hitherto unknown to most virologists, clinicians, and researchers, and recently the subject of an international conference on its importance for the paradigmatic change of medicine. The treatise, the first in the world, addresses the scientific and clinical approach to infection in a new multifactorial perspective, integrating the experimental and clinical investigations of SARS-COV and SARS-COV 2 in virology, immunology, epidemiology biochemistry. This impressive theoretical work on more than 1000 experimental and clinical investigations since 2002, forms the basis of a new approach to the pandemic called: "Person-Centered Prevention and Infection Early Treatment according to "Person-Centered Medicine", which since 1999 has revolutionized medicine and medical science and since then taught at the School of Medicine in Milan.
In the treatise, Prof. Brera introduces the theory of relativity of virus entry into cells through an alteration of the membrane structure induced by cholesterol and the consequences, even fatal, of infection, due to atherosclerosis resulting in innate and adaptive immunity depression and an abnormal reaction induced by the immune phenotype to viral antigens’ stimuli. The theory explains the vulnerability of patients with co-morbidity characterized by atherosclerosis and the innate immune protection of children and young people (up to 30 ) who do not need any vaccination.
The entry of the virus into cells is conditioned by the "lipid rafts" where the virus with the ACE 2 and other receptors transmigrates for endocytosis..
The signal deviation induced by LDL cholesterol in the "lipid rats" of atherosclerotic patients induces an immune phenotype favoring the fatal immune anergy after the seventh day easily detectable and preventable, a strategy so far omitted with a fatal error of the WHO and most health governments of the countries, error paid by millions of people.
The theory of the relativity of SARS-COV 2 infection is crucial to change the prevention strategy and free humanity from the nightmare of SARS-COV 2 and its variants. It allows for the preventive detection of people vulnerable to infection and directs to primary and secondary prevention based on the reinforcement of immunity, a strategy omitted by the fatal ignorance of public health managers that caused more than a million deaths. Epistemological and scientific illiteracy has been paid by the world and Italian population but has been well supported and practiced by most of the world governments and the WHO. In Italy, this is the main cause of the request of the "National Health Committee" for determined action to induce the resignation of the Minister of Health Roberto Speranza.
The treatise was preceded by another book by the same author, Person-Centered Medicine and Person-Centered Clinical Method, the application of which leads to saving people’s suffering and the health costs of countries in a meaningful way as it appears from the data published in the book. Here the author also presented the epistemological basis of the new concept of health, and a chapter highlights the necessary pathways of entry of SARS-COV and the development of COVID-19, also discussing the scientific probability of induction of cancer of vaccines against SARS-COV mRNA. This essay and the treatise are a crucial contribution to addressing any prevention and treatment of any pandemic, underpinning the strategy of the "Person-Centred Prevention Programme", which orients public health to health promotion, education, health education, self-treatment, and induced cross-prevention with other communicable and non-communicable diseases.
These books indicate that the most dangerous pandemic seems to be epistemological ignorance of the changing paradigm of Medicine.. This delay has led to a mono-dimensional, failed virological approach to the pandemic, aimed only at inducing mechanistic prevention-wrong biotechnology and human rights violations and an economic failure of the countries that are causing the poverty of millions of people. The establishment by Europe and some European countries of a "Green Pass" for vaccinated people is without any scientific foundation because vaccination does not prevent infections and contagion. Vice versa, from 2002 to 2020, multinational vaccines have not produced any vaccine because of the frequent mutations of the virus. The theory of relativity SARS-COV 2 refutes the erroneous mechanistic-determinist and linear causality model, in coping to COVID-19 promoted by the WHO and many countries, omitting secondary prevention. This wrong approach caused more than a million deaths because it pushed primary prevention only to biotechnological measures, excluding people’s health education to an immuno-empowering and anti-viral quality of life. This omission based on ignorance gets to expose children and young people, completely protected by innate immunity, or elderly immunosenescent, with innate and adaptive immunity depression, to experimental vaccines with limited validity over time and completely useless against variants, with short and long-term risks of adverse effects until death.
The treatise is edited at the same time as the International Conference: for the 26th anniversary of the opening of the Ambrosiana University:
The paradigm shift centered on the person’s health and medicine paradigms and COVID-19- Proceedings :
http://www.unambro.it/html/pdf/ATTIWEBsuUnambro-en.pdf
where the most significant scientists contributors of the paradigms change of medicine and health explained the scientific basis of the transition from the dominant deterministic and one-dimensional paradigm-mechanistic to the new and its omission related to the development of the SARS-COV 2 pandemic.
Before the treatise the author published the book:
Giuseppe R.Brera: Person-Centered Medicine and Person-Centered Clinical Method- practical results of the paradigm of unitary medicine and the theory of prevention COVID-19 people and person-centered" - 131 p. -132 references euro 25 - e-book and print ISBN: 9798726465432
Both the books are distributed worldwide by Amazon and the editorial staff of the Ambrosiana University editorialdepartment@unambro.it
Person-Centered Medicine is the first extrinsic paradigm of medical science instituted owing to the last forty years of biomedical science and human sciences advance. Their epistemological bases are interactionism and the human nature teleonomy allowing the freedom and dignity-based "being-person" identity. The Medicine indeterministic epochal shift is similar to the discovery of quantum physics, which is allowed to constitute the "Person-centered clinical method" that integrates the obsolete one and reassesses the physician's role as maieutic of the being person. The lecture introduces the PCM health-derived concept relativity theory and the People and Person-Centered Prevention paradigm (PPCP), whose application in the light of the SARS-COV 2 infection and complication general theory discoveries, only can shutdown the COVID-19 and other communicable and non-communicable diseases
Person-Centered Medicine is the first extrinsic paradigm of medical science instituted owing to the last forty years of biomedical science and human sciences advance. Their epistemological bases are interactionism and the human nature teleonomy allowing the freedom and dignity-based "being-person" identity. The Medicine indeterministic epochal shift is similar to the discovery of quantum physics, which is allowed to constitute the "Person-centered clinical method" that integrates the obsolete one and reassesses the physician's role as maieutic of the being person. The lecture introduces the PCM health-derived concept relativity theory and the People and Person-Centered Prevention paradigm (PPCP), whose application in the light of the SARS-COV 2 infection and complication general theory discoveries, only can shutdown the COVID-19 and other communicable and non-communicable diseases
1 Person-Centered Medicine is the first paradigm of Medicine and Medical Science, enunciated in 1999 in the " Person-Centered Medicine Epistemological Manifesto" a change from the dominant intrinsic bio-molecular one. 2 The paradigm kew words are: Being person", Teleonomy, Objective ethics, Interactionism, Indeterminism". The paradigm change event is similar to the Physic's paradigm change from mechanistic to quantum one at the beginning of the last century. 3 Being person-teleonomy and ethics-Epistemological and teleological roots of the PCM paradigm at philosophical level are the ancient Greece philosophy: the Socrates epistemology, Hippocrates ethics and epistemology, Aristotle's metaphysics, the Aristotle's based Roman culture and philosophy: Boetius, (first Person's definition) ,the Tommaso d'Aquino's medieval philosophy, the Husserl's and Edith Stein's phenomenology, the modern personalism of Iosef Seifert, Kairol Woitila and Kairology. 4 The scientific theoretical base of interactionism are: at Physiological level : "Allostasis theory", at genetic level "Epigenetics", at clinical level "The Relativity of Biological Reaction to coping possibilities and quality" based on the Psycho-Neuro-Endocrine-Immunology and on the "Affects science " which introduce the concept of "Biological reaction" and " Resilience" like action of protective factors determined by the person's health possibilities and resources. The philosophical and existential words "possibility" and "resource" enter into labotarory medical science and it become demarcated by clinics. 5 In the light of the scientific revolution the health concept has been reformulated like a music played by a person who reading a score (DNA) pushes three orders of keys belonging to three interacting fields of knowledge and existence: Subjectivity (symbolic level: empathy, affects, emotions, values ,Biology (empirical variables at physical or molecular levels), Environment (interpersonal relations, physic environment). (S-BE Person-Centered Health System) 1. To date health appears to be related to more or less person-dependent indeterminate interpretation driven by a deep soul research of unity, harmony, love, truth, and beauty, expression of the human being research of a fulfilled meaning (Tommaso d'Aquino's "Actus humanus"), latent protective factor, constituting the concepts of resilience and vulnerability, depending on the result of the person's quality of life ,result of its interpretation and integration of environmental, subjective, biological possibilities 6. A new scientifically and existentially based new Health definition is possible: " The best possibilities for the best being" 7 in Italy to the aim to apply and teach PCM clinical applications and form clinical teachers' Starting from the Medical Counselling structure (1991) in 1998-1999 AY at the Milan School of Medicine, the Person-Centered Medicine Clinical Method (PCCM) and its teaching method was theorized and taught with standardized quality procedures realized in the Ambrosiana University quality system. From 1995 many international and national conferences and workshop s were promoted on the matter. The most important was addressed to change the paradigm in Medical Education toward Person Centered Medicine. in 2003 the first investigation on PCCM effects in clinical resulted in a better comprehension of patients (95%) improvement of the health and life quality of patients (75%), in avoiding useless examinations and drug prescriptions, (70%) sparing unnecessary hospitalizations (55%) but requesting more time to dedicate topatients (55%). PCCM effectiveness in saving useless examinations and drug prescription is significantly associated to the medical role (P=0,02). MP (100%) and Paediatricians (85%) declare that PCCM is effective in sparing useless examinations, drug prescription and unnecessary hospitalizations. There is general agreement about the necessity and importance of learning and spreading PCCM. With the data assessments by Lombardia Region about drugs prescription, data about a trained pediatrician's prescriptions were measured. Data confirmed the described reduction of drug prescription in an amazing way, such us to suppose that the spreading of Person-Centered Medicine, could lead not only to the improvement of the patient's wellbeing but also to an important save of money for health systems.
Medical science and health paradigm change
Background
The first and unique Book-to date- in Person Centered Medicine (pg 153) which introduced in Medical Science and Clinics Person Centered Medicine, the Paradigm Change in Medical Science, the Person Centered Clinical Method, Medical Education in Person Centered Medicine, the Person Centered Medicine clinical sheet
It is the result of the application of the Person Centered Medicine Paradigm (born in 1998) in clinics and medical education made in the University Ambrosiana since 1995 and institutionalized in 1998 in the opening ceremony of the Academic Year of the University Ambrosiana of Milan
Chapters
Ist Part THE PERSON CENTERED MEDICINE
1. The seven aims of Medicine as object of the physicians free choice (by Iosef Seifert)
2 The Person Centered Medicine
3 The Person Centered Medicine Epistemological Manifesto
4 A revolution for the Clinical Method and the bio-medical research: the determinate and the undeterminated relativity of biological reactions to coping possibility and quality
IInd part THE PERSON CENTERED MEDICINE CLINICAL METHOD
1. The Person Centered Clinical Method
2. Dignity and clinical method : the kairological interactionism (clinical report)
3. Person Centered Medicine: a clinical report ; “The Alessandra’s history (by Cristina Morelli)
III° Part MEDICAL EDUCATION IN THE THIRTH CENTURY
1. Medical Education in the thirth century, the Milan school of Medicine , physicians’ and humanity school
2. Skills for Person Centered Medicine and its teaching
3. The MD degree oriented to Person Centered Medicine and the Medicine Superior Normal School of the University Ambrosiana
Appendix
1. Letter to the prospective medical student
2. The Medicine Superior Normal School
3. The clinical sheet according Person Centered Medicine
Summary of the book
“La medicina centrata sulla persona e la Formazione dei medici nel terzo Millennio”
IEPI Pisa 2001. ISBN 88-8147-245-7
Person Centered Medicine is the change of Paradigm of Medicine and Medical Science born in Italy in 1998 and officially instituted in Postgraduate Courses of the University Ambrosiana of Milan with quality procedures in system quality.
The book, the first to be published on Person Centered Medicine and written in Italian, after an ethical epistemological introduction of the philosopher Iosef Seifert, at the light of realistic phenomenology whose he is the most important interpreter in the world (chap 1),introduces the Person Centered Medicine Paradigm (chap 2), and the epistemological basis of the Person Centered Medicine: the theory of the Determinate and the Indeterminate Relativity of Biological Reactions. (Chap.3).In Chap 4 is presented the Person Centered Clinical method and its differences from the traditional one. In Chap 5 is presented the kairological interactionism where the mysterious teleology of human nature, is presented, starting from a clinical case. In Chap 6 is presented a clinical report of a clinical case treated with the Person centered clinical method. In chap 7 is presented the necessity to re-orient medical education to Person centered Clinical Method starting from a definition of limits of clinical method applied to date and its incoherence on base sciences. Chap 8 introduces the necessary skills for teaching Medicine and Person Centered Medicine and its learning objectives and the results of the fists investigation of a new method for giving evidence to a personal reliability for entering into a Medical Faculty for an health profession.
At the end the clinical sheet according Person Centered Medicine is presented.
he Human nature has a relative value in agreement with hermeneutics which interprets it . The interpretative theory consequently is at the origin of the epistemology , its objects and methods of knowing reality. Therefore the progress of science and humanity is entrusted to hermeneutics of the human symbolic world. In the study of Adolescence, the models currently practised reflect the influence of deterministic and mechanistic theories both in medicine and in psychology. Adolescence appears closed between biology , drivers and social behaviour which influence clinics, health education and research. These epistemologies have the effect of forming a cultural image of adolescents which are adaptive to the theories that design it, closing them in something like an epistemological cage. In clinical sciences these theories reduce adolescents to the problem that they report, to biological knowledge and to techniques, while profound questions, resources and possibilities which find expression also in suffering, require "qualitative" epistemology more than "quantitative," as appears from the results of the interactionist experimental epistemology and from the relativity of biological reactions. The study of Adolescence, with a phenomenological approach, allows to characterise this period of life like a specific revelation of the mystery of human existence that, with a likewise mysterious development of new logical, emotional, affective, existential structures, is asking a real sense to give to the new "words" of life discovered during this time: "love," "truth" and "beauty." In this perspective Adolescence means: entrance into the mystery of existence discovering possibilities and limits, its teleonomy and its pathos. The human being , starting with Adolescence feels himself called to build a unitary "theory" , that unconsciously and/or consciously could orientate him in planning, knowing, feeling, perceiving, building reality. A positive existential reality is an arrival point and it is coherent with a new concept of health. Existence is designed like the construction of time and space "opportune" (kairos), the man and the "Other" could create as possible answers ( self possible) to the fundamental questions of existence in order ( genetic self/ideal self ) to build a human "realised" identity (real self ) capable of hoping, willing and choosing. "Kairology", the hermeneutics born in 1993 for a non reductionist interpretation of Adolescence and human nature, is applied with noteworthy results to research, clinics and medical education in the Adolescentology Dept of Ambrosiana University, the first University department dedicated to Adolescence, Kairology has been seen proved of giving more dignity to clinical and scientific work and to adolescents as human persons.
« Persona est Individua substantia rationalis naturae ». This definition, that filled the Middle Age philosophy, makes relative the person ontology to his/her acts and functions and it is wrong, because also persons without intelligence, at the first or final stage of their life, or unable of a human relation like schizophrenics or suffering from autism, have the person dignity. Being person is the primary ontological status of the human nature introduced by Jesus Christ, who gave a substance quality to the being and whose contribution to the humanity, is more than a religious one as also Nietzche and Hengel stated. This person founded an ontological revolution of the human nature determining the birth of an anthropology of human nature, changing the humanity history, (e.g the birth of hospitals and the concept of " Taking care of sick abandoned and emarginated people", complementary and new , compared to the Greek Therapy" and determinant for the philosophy, theology and clinical science history. To date, the world time is measured from his birth. Christian Theology first decidedly oriented towards a relational interpretation of the person from the Trinitarian relation among three individual persons but omitted to consider that before a relation the identity of "being the person" is necessary. In the same way, the Christian revolution has given to the person the necessity of a relationship with himself and the world for assuming the attribute of "human". In this unique perspective, existence could be defined as possibility for being a human person. Possibility of being a human person, the self-possible, starts in adolescence from the awareness to establish relationships, constituting a " self" and a "you". The possibility of being a human person is the second ontological status of human nature. Higher faculties of the being person such as intelligence and will, quests for natural freedom that calls for a choice among the possibilities of desires, intentions and behavior-the Self-possible". These are addressed to follow a deep natural question of truth, love, and beauty-the Self ideal-revealed from the adolescence time, for interpreting possibilities giving to these a true or wrong meaning for the internal and external world construction. This is the necessary passage for realizing him/herself , the "Self-real", the person's liberty and dignity as Kairology teaches. This is the " Real ontological status" corresponding to the "being a human person", the realization of the self-possible in truth, love and beauty. "Self-ideal" isn't the psychoanalytic " ego ideal" a tool of the self-possible and indifferently addressed to life or death, according to the ideal quality. Self-ideal, Self-possible, Self-real correspond to the ontological structure of the human person, but the possibility of being a human person does not give an answer to the natural question about the meaning of the being person, posed by the Self possible. It requests for knowledge, impossible to humanity, for answering the question: " What's the truth, what's the love, what's the beauty". Only a true answer allows human dignity as Socrates intuited with his "Ti esti"? What is this) , through the invitation to introspection written on the Delphi temple: " Man know yourself", that means: "The truth about yourself" as Augustin of Hippo had developed: " Noli foras ire, redi in te ipsum, in interiore homine habitat veritas" , founding introspection psychology ..............( see the extended summary)
The identification of two new clinical syndrome: “The Post Hexavalent Vaccination Sudden Infant Death Syndrome ”, (PHVSIDS) and the Post Vaccination ASIA Syndrome (PVAS), irrefutably confirmed by the scientific literature and for PHVSIDS from autopsies of newborns died without pathologies inducing a life risk, calls for an urgent revision of the criticized WHO AEFI algorithm for assessing adverse reactions to vaccines. PVAS syndrome , taking in account the delayed auto-immunity reactions, is a risk also for adult population. Moreover a multiple antigens’ inoculation induces depression of the natural and adaptive immunity via the NK cells suppressing antigen presenting cells (APC), inducing the inhibition of TCell effectors priming . In Italy from 1999 to 2004 there has been a slaughter of 52 new-borns after hexavalent vaccination without taking in account 55 (44%) deaths of immunized children for cardiac arrest of 121 SIDS. The PHVSIDS and PVAS call public health for a new person-centered vaccination schedule, submitted to the paediatrician’s clinical evaluation , reducing the vaccines number within the first year of life to the essence with a distanced mono-antigenic inoculation and starting a health policy promoting breast feeding ,natural immunity and a healthy life quality for all.
The contribution is a partial summary of the prof Brera’s invited presentation at World Health Organization in the IVth Geneva Conference in Medical Education Proceedings in the Symposium: Person Centered Medicine and Medical Education - May 4 2011, , pg 39-41
This is a descriptive pilot study. 20 Physicians (7 medical practitioners, 6 Paediatricians, 3 hospital doctors, 4 private doctors) accepted to fill out a questionnaire on “ PCCM Quality in Medical Practice” and e-mail it upon completion. Questionnaire items, positive answer rates on the perception of change in medical practice, associations with the role of the physicians were studied with descriptive statistics and cross tabulations. A sample of physicians’ drug prescriptions in the Lombardia Region health district, was compared with the trained physician’s one,
This is a descriptive pilot study. 20 Physicians (7 medical practitioners, 6 Paediatricians, 3 hospital doctors, 4 private doctors) accepted to fill out a questionnaire on “ PCCM Quality in Medical Practice” and e-mail it upon completion. Questionnaire items, positive answer rates on the perception of change in medical practice, associations with the role of the physicians were studied with descriptive statistics and cross tabulations. A sample of physicians’ drug prescriptions in the Lombardia Region health district, was compared with the trained physician’s one,
This is a descriptive pilot study. 20 Physicians (7 medical practitioners, 6 Paediatricians, 3 hospital doctors, 4 private doctors) accepted to fill out a questionnaire on “ PCCM Quality in Medical Practice” and e-mail it upon completion. Questionnaire items, positive answer rates on the perception of change in medical practice, associations with the role of the physicians were studied with descriptive statistics and cross tabulations. A sample of physicians’ drug prescriptions in the Lombardia Region health district, was compared with the trained physician’s one,
THE HEXAVALENT VACCINATION RUSSIAN ROULETTE
THE HEXAVALENT VACCINATION RISK FOR CHILDREN AND ADULTS' LIFE . THE INTRODUCTION OF THE POST HEXAVALENT VACCINATION SUDDEN DEATH SYNDROME (PHVSIDS) AND THE POST VACCINATION ASIA SYNDROME( PVAS).
REVIEW UNDER THE PATRONAGE OF THE ITALIAN SOCIETY OF ADOLESCENTOLOGY AND ADOLESCENCE MEDICINE, THE MILAN SCHOOL OF MEDICINE AND THE PERSON CENTERED MEDICINE INTERNATIONAL ACADEMY
Giuseppe R.Brera
Summary
The review of the international literature on the hexavalent vaccination adverse effects, documents, without doubt, the existence of a new clinical syndrome: “The Post Hexavalent Vaccination Sudden Infant Death Syndrome ”, (PHVSIDS) without concurrent pathologies inducing a life risk confirmed by autoptic investigation, with an enhancement of the infant mortality and hospital admissions rates correlated to the number of vaccines before the first year of life.From 1999 to 2004, in Italy, there has been a slaughter of 52 infants, directly associated to hexavalent vaccination , 8 before 24 hours (RR= 1,5, RR= 2,3 with the Infarix Hexa vaccine- 0,7 with Hexavac ) , 34 within 7 days (RR=1,8- RR 1,5 with Infarix Hexa- 2,8 with Hexavac, with all the hexavalent products RR =2) 52 within 14 days (RR 1,5, RR= 1,5 with Infarix Hexa,1,6 with Hexavac). Children' deaths notifications continued after this date. The hexavalent vaccination appears like a Russian Roulette in children with an unknown vulnerability. In addition to PHVSDS, there is the clinical and scientific evidence of auto-immune diseases, associated to vaccinations that derive from minerals added to vaccines as adjuvants, preservatives and stabilizers, like Aluminum , inoculated in enormous quantities, and Mercurium, that allows to define a new clinical Syndrome: the Post Vaccination ASIA Syndrome-PVAS). ASIA is the depicted Autoimmunity Syndrome Induced by Adjuvants . Autoimmunity can derive also from DNA recombination in the host of the DNA from human cell lines of abortion fetuses used for the MMRV vaccine production also associated with autism. Moreover, there is an irrefutable documentation that hexavalent vaccination determines immunosuppression well depicted by immunology, a consequent cause of death from other infections, as happened. The WHO AEFI algorithm (Causality Assessment of Adverse Event following vaccination) built on an epistemological mechanistic obsolete linear causality ,showed a well explained fallacy. These scientific and clinical observations give evidence to the fact that children cannot be treated as battery chickens and to the necessity of a person centered approach to vaccination according Person centered Medicine, the change of the medical science paradigm. The paper reveals that the Italian Health Ministry has spread in 2017 a 2009 a guide written in 2009 to the vaccination adverse effects, with ridiculous and dangerous suggestions , like “ Do not visit healthy children before vaccination nor take temperature ” and it was informed about a true Italian children’s slaughter and serious adverse effects from hexavalent vaccination ( 9-20,3 % from 2014-2016) and another signaled 5 children' deaths from PHVSDS . The philosophy “ Let few deaths for saving much more lives “ is unacceptable for a physician who risks to see a newborn death caused by his act, within few hours from a preventive vaccination, and at the same time, parents cannot be obliged to expose their children to a Russian Roulette. The possible solution is to entrust to the pediatrician the choice of vaccination time, after a necessary clinical evaluation, reducing the number of vaccines to essential, with a health policy that could be named “Person centered vaccination”. Infectious diseases can be more prevented enhancing natural immunity, also with a public health policy promoting breastfeeding, a strong immune protective factor with also vaccine power, maternal care quality and educating to a healthy immune stimulating diet and life conditions, all resiliency factors for natural immunity, more powerful than adaptive immunity
Review in Italian
Proceedings of the Conference : Medical science and health paradigm change
13-14-15 October 2017.Milan,Italy
THE EPISTEMOLOGICA MANIFESTO OF PERSON-CENTERED MEDICINE
*Giuseppe Rodolfo Brera
1Abstract“Person -centred medicine” represents a new epistemologic orientation for medical science. The components of the paradigm derive firstly from an acknowledgement of the impact of Christianity on the History of medicine, secondly from kairological introspection, which, starting from phenomenological and anthropo-analytical premises, provides evidence of teleonomy in human nature, thirdly from the indeterminate relation between biological reactions and the quality of coping, the epistemological foundation of the interactivity shown by biological research, and finally from the emergence in the epistemological field of a new concept of health based on quality of life and the individual person’s resources.Person-centred medicine is a new medical concept based on the acknowledgement of the fact that valuing and giving value to human life from conception to natural death is the ultimate justification of medical knowledge. The individual human being can never be the tool of science or of economic or political interests, laws, ideologies, theories or religious dogma.The basis of this philosophy, of which I had the honour and the responsibility of being maieuta, rests on a theoretical synthesis between the quality of knowledge derived from experimental research and that derived from humanistic clinical research.This approach has already been extensively evaluated in the postgraduate medical courses of the Ambrosiana University in Milan and has been validated by the extraordinary improvements in the quality of medical profession. The Manifesto represents the Epistemological programme of the Ambrosiana University Milan Medical School “Scuola Normale Superiore di Medicina”.Person-centred medicine aims to modify the bio-molecular reductionist approach to medical science in favour of an integration which makes doctors, nurses and patients true protagonists of the health scenario.In science and education, “The person-centred paradigm” represents a challenge to develop research and education methods based, not on conjectures, but on the interactionism and on the teleonomic theory, which is founded on the relativity of biological reactions to the quality of coping as has been confirmed by numerous experimental studies.In the second millennium jubilee of the birth of Jesus Christ, we affirm our hope that “Person –centred medicine” may complement thevalues of Hypocratic medicine by the concept of the sanctity of human life and the individual human being as God’s gift to the World, which through the dominion of Christ has constituted occidental cultureCorrespondence to: Giuseppe R. Brera, Università Ambrosiana, V.le Romagna 51, 20133 Milano (Italy). E-mail:gbrera@unambro.it.Availablealsoon line: http://www.unambro.it/html/manifesto.htm
Medicine, Mind and Adolescence 1999, XIV, 1-2
(PDF) The Epistemological Manifesto of Person Centered Medicine. Available from: https://www.researchgate.net/publication/320730620_The_Epistemological_Manifesto_of_Person_Centered_Medicine [accessed Nov 27 2018].
The epistemological principles of Person Centered Medicine
(published in 1999)
In the last forty years there has been a great change of medical science through the progress of neurobiology, the birth of quantum biology, the development of epigenetics, the change of physiology with the concept of “Allostasis instead of “Homeostasis”, the opening of new interactionist investigation fields like Psycho-neuro-endocrine-immunology and the consequent formulation of the Theory of the relativity of biological reactions. At the same time there has been the integration of Medicine with human sciences such as cognitive psychology, psychoanalysis, counseling allowing to discovery a teleology of human nature. The change can be considered an indeterminist revolution of medical science, similar to the shift to quantum physics, from the Newtonian determinism and mechanism happened in Physics at the beginning of the last century. The epistemological change of Medicine is based on an irrefutable interactionism of three orders of variables belonging to subjectivity, biology and environment and to a natural tendency to give an objective meaning to life, giving importance to quality of life and lifestyle for the health construction. The concept of health appears related before its expression in the human biology, in a symbolic work made by the person addressed to interpret the quality of possibilities perceived in the external and internal experience in analogy to the interpretation work of biological information made by the membrane cell for answering to the adaptation requests. Disease, suffering, physicians are a personal experience of life that call for a meaning and a question for an answer that can’t be explained by empirical variables but that interact with these. The health definition introduced to WHO in 2011 in such a way appears:” The choice of the best possibilities for the best being a human person”. There is a true risk that Medicine could be developed on schizophrenic epistemology dissociated from the progress of the basic sciences. The Milan Conference held on 13-14-15 October 2017 wants to formalize a determinant shift for Clinics, clinical investigation, medical education and public health policy.
Socrates…… Well then, could we ever know what an art makes the man himself better, if we were ignorant of what we are ourselves ? Alcibiades: Impossible ! (Plato)
Medical science is changed because of the epistemological revolution of basic sciences in the last 40 years through the birth of Epigenetics, Allostasis, Psycho-Neuro-Endocrine-Immunology (PNEI), Affect science, Neurobiology and Quantum biology, resumed by the Relativity Theory of Biological Reactions (RBR theory). The progress and the birth of these theories, determined the fall of positivism and deterministic mechanism in Medicine and Medical Science similar to the historical shift to quantum physics. RBR Theory allowed in 1998 the development and application in clinics and medical education of the first full paradigm of Medical Science :”Person Centered Medicine” (PCM), proposed to WHO in 2011 where a new conception of health based on the Biology and human sciences progress: “The choice of the best possibilities for the best being a human person” , was presented on invitation. The “Person centered health” paradigm is based on two main epistemological principles: “Interactionism” among subjective, biological and environmental variables, piloted by the person and the “teleology”, a natural call for a meaning, whose existence finds its roots in the Aristotle’s philosophy and in human sciences and whose answering quality is linked to biological variables and determines life style and culture transmission through epigenetics. This change allows to submit medicine and health sciences to a “Person Centered Health Anthropology” thank to the progress in clinical application made by the Person Centered Medicine Clinical Method, which introduced new knowledge objects like empathy and person diagnosis addressed to construct resilience rendering patients subjects and not tools, improving the clinical relationship
Abstract
Studies on the interactions between the central nervous, immunitary and endocrinological systems, the mind and behaviour, permit a theory of medical science to be formulated . The variability of immunitary reactions to the experimental possibility offered to animals to escape - or otherwise - conditions of stress determined the obsolescence of Selye’s concept of stress and permitted the formulation of a theory on «the determinate relativity of animal coping» while, for the indeterminate human world, a theory on «the indeterminate relativity of human coping» was developed, where biological variables were related to psycho-sociological, anthropological and existential ones. The results of such studies made it possible to introduce a new theoretical paradigm of research and practice to medical epistemology, refounding it on new key words such as «biological reactions», «possibility of coping» and «quality of coping», and overcoming such concepts of the philosophy of science as « biological laws» only definable a posteriori by the greater or lesser variability of biological reactions.
Biological reactions in non-humans appear to be subject to a foreseeable determinism that is explained by a theory of «general determinate relativity«, while human biological reactions appear to be subject to a theory of «general indeterminate relativity».
These new theories seem to suggest that research, clinics and medical
1 Correspondence to: Prof. Giuseppe R. Brera MD, Milan School of Medicine, Università Ambrosiana, Vle Romagna 51, 20133 Milano (Italy)
E-mail: gbrera@unambro.it
Summary of the book
A Revolution for the Clinical Method and Biomedical Research : the Determinate and the Quality Indeterminate Relativity of Biological Reaction
Giuseppe R.Brera ©Copyright Università Ambrosiana 1996
The book introduces the concept of "Relativity of Biological Reactions" separating these from "Biological constants" necessary for survival., leading Medicine to an indeterministic paradigm against determinism and mechanism and limiting for clinics results of experimental investigations on animals. The book is the epistemological basis of Person Centered Medicine and introduces in Medicine the interactionist paradigm, causing the end of the Stimulus-Answer model, mechanistic and deterministic one of the Selye’s stress theory centered only on animals’ biological variables change determined by bio-chemical stimula . Humans differently through subjective symbolic affective ,cognitive resources related to emotions elaborate and interpret internal and external stimula, that are influent on the gene expression.
The theory has been based on experimental studies on the interactions between central nervous, immunitary and endocrinological systems, mind and behavior.
The core of this theory is expressed in 4 equations, A-B-C-D.
The base of the theory has been the experimental evidence about the variability of immunitary reactions in relation to the experimental possibility offered to animals to escape - or otherwise - conditions of stress determining the obsolescence of Selye’s concept of stress and permitted the formulation of a theory on «The determinate relativity of animal coping» called “Equation C” . Equation C (Rb = Bc x Pt (a)) draws the relativity of animal biological reactions to coping possibilities determined by the probability of positive or negative social and/or environmental conditions in relation to drives, Individual genotype and biological homeostasis. Equation D differently draws for humans a different relativity.
Equation D
Pt x Qc
HmRb = --------------------
Bc
HmRB = Human biological Reactions
PT= Possibilities of coping
AC = Quality of coping
The equation introduces the concept of the “Quality” of coping related to the indeterminate subjective possibilities of humans ( values, emotions, affects, relations, behaviors) which determine a “ Coping quality” (Qc) related to choices in experience. This unforeseeable possibility (Pt) of choice but like animals related to genotype, biological homeostasis, social and environmental conditions but in a only human way to cognitive and psycho-sexual structural stage of development, is the indetermination constant of the Equation D. Biological constants (Bc) appear inversely related to possibilities of choices. Less possibilities of coping there are more biological reactions are determined by a direct actions of biological constants on life, how physicians and surgeons know when they work in emergency.
Different epistemological models for human and animals are dependent from the presence in humans of self-determined, cognitive and psychosexual levels, and indeterministic factors ( eg. : moral and religious thinking, hypothetic-deductive reasoning, meaning awareness and will, creativity, parents’ education ). which determine a ” quality” in cognitive and affective symbolic processes, emotions, behaviors, coping and consequently different biological reactions. These qualitative and subjective factors are strictly related to neuromodulators, hormones and immunitary system actions in a bidirectional way through a new gene expression and receptors synthesis. Quality of coping is caused by the only human quality to choose among perceived and interpreted possibilities according the cognitive and psychosexual level, like Piaget and Freud showed., but possibility of an experience is unforeseeable like a dream or an encounter. Persons give a meaning to these showing a transcendent not empirical teleology existent in human nature well described by kairological theory. Mechanistic theory of human nature is obsolete and wrong and introduces necessarily new variables in medical research, clinics and medical education if wants arrive to true results. A new concept of health related to protective factors played by human possibilities, quality of the interpretation of reality, existential choices corresponding to affective and cognitive processes and neuromodulations, hormones transduced messages to cell membranes, that is a new indeterministic universe to be explored and related to person is born. Health to date can be interpreted and defined in a new way : “ Possibilities and qualities for being an human person based on a balance between protective and risk factors, that is resilience vs/ vulnerability”
The theory of the relativity of biological reactions to possibilities and quality of coping (RBR theory) appears to introduce a new epistemological chapter in human biology and medical science allowing a reformulation of the scientific method applied to human nature and a new clinical method based on
a. the necessity of introducing into human biology and clinical research variables belonging to the subjective world of humans determining quality of life : values,beliefs,emotions, affects, coping, behaviour and level of cognitive and psychosexual development.
b. the existence of a teleology in human nature and the importance of affective and cognitive symbolic world in a culture determining possibilities and qualities in reality interpretation, choices and behaviours.
c. the impossibility to directly transfer and apply to humans experimental inferences, based only on results of experimental studies because of the difference between Equation C and Equation D
d the change of the health concept and the introduction in Medicine and Medical education the concepts of Resilience and Vulnerability.
e the necessity to change clinical method according RBR equations B and D
f the necessity of introducing in the experimental method new RBR variables according equation A and C
d. the existence in humans of a mysterious indetermination constant
The RBR (Relativity of Biological Reaction) theory opens new perspectives in Medical Science and Medicine and at clinical level constitutes the basis of the Person Centered Medicine Clinical Method.
Dignity has not generally been seen as something that can be applied to clinical medicine. There are instances, however, where this has direct application. An adolescent with phobic problems and “at risk” behaviors who seemed not to change with a normal psychodynamic approach, quickly solved his problems when his counselor utilized a method that involves the client’s “dignity as a human being”. This appeal to dignity solved a problem of a clinical nature. In this case, the kairological approach to clinical problems during the process of enhancement of the adolescent’s resources and possibilities enabled him to discover and experience his dignity as a necessity in order to be a person.
This kind of clinical approach requires that the doctor does not consider his profession just as a job, but as the practical side of his human feeling
Person Centered Medicine (PCM) is a new inter-actionist, indeterministic, extrinsic Paradigm of Medicine, born in 1999, based on the Theory of the determinate and the quality indeterminate relativity of biological reactions” (1996). Structuring a new health epistemological model, developed from Medical Science base interactionist investigations, consistent with the Allostasis and Epigenetics epistemological changes in Physiology and Genetics and with a new phenomenological hermeneutics of the human nature: Kairology, defining the person’s mystery and destiny. A complete epistemological definition of a “Person Centered Health inter-actionist and indeterministic health model” was presented by the author in 2005. Person Centered Medicine in 1998 was officially presented as the leading epistemological structure of the Milan School of Medicine, priority addressed to Physicians medical education in postgraduate courses, starting from the previous foundation of Medical Counselling and its teaching method. Since 1998 the Person Centered Clinical Method (PCCM), born as the PCM clinical application, was inserted and taught in all the PG courses and in the University Ambrosiana Quality system and applied to the physician’s preparation. Person Centered Clinical Method structure changes Clinics introducing a three dimensional, indeterministic structured work on the person, “ Diacrisis ” which in the “Person diagnosis” and the “Cross ratio” structured assessment of resilience and vulnerability, in the interlocutory physical examination, in the clinical objectives assessment and in a literary clinical synthesis and portrait, ensures that information about the subjective and objective person’s and hypothesis about their relations are depicted together. Learning objective of PCM and PCCM are theoretical and practical and PCM teaching requests a structured training in Università Ambrosiana organized in International Masters and in “Licentia Docendi” courses.
In 2002 the first investigation on PCCM teaching effects on clinical practice by 20 trained physicians who assisted 16.000 persons was made. Results documented an amazing save in drug prescriptions, hospital admission requests, technical examinations and physicians professional gratification.
Person Centered Medicine (PCM) is a new inter-actionist, indeterministic, extrinsic Paradigm of Medicine, born in 1999, based on the Theory of the determinate and the quality indeterminate relativity of biological reactions” (1996). Structuring a new health epistemological model, developed from Medical Science base interactionist investigations, consistent with the Allostasis and Epigenetics epistemological changes in Physiology and Genetics and with a new phenomenological hermeneutics of the human nature: Kairology, defining the person’s mystery and destiny. A complete epistemological definition of a “Person Centered Health inter-actionist and indeterministic health model” was presented by the author in 2005. Person Centered Medicine in 1998 was officially presented as the leading epistemological structure of the Milan School of Medicine, priority addressed to Physicians medical education in postgraduate courses, starting from the previous foundation of Medical Counselling and its teaching method. Since 1998 the Person Centered Clinical Method (PCCM), born as the PCM clinical application, was inserted and taught in all the PG courses and in the University Ambrosiana Quality system and applied to the physician’s preparation. Person Centered Clinical Method structure changes Clinics introducing a three dimensional, indeterministic structured work on the person, “ Diacrisis ” which in the “Person diagnosis” and the “Cross ratio” structured assessment of resilience and vulnerability, in the interlocutory physical examination, in the clinical objectives assessment and in a literary clinical synthesis and portrait, ensures that information about the subjective and objective person’s and hypothesis about their relations are depicted together. Learning objective of PCM and PCCM are theoretical and practical and PCM teaching requests a structured training in Università Ambrosiana organized in International Masters and in “Licentia Docendi” courses.
In 2002 the first investigation on PCCM teaching effects on clinical practice by 20 trained physicians who assisted 16.000 persons was made. Results documented an amazing save in drug prescriptions, hospital admission requests, technical examinations and physicians professional gratification.
