*This is a fictional document (external prop) created for a fictional academic world in a fiction novel about religion, science and magic in West Africa. The author, designation, email address, research center and university are all fictional. Please do not cite.* A heuristic about the structural topography of reality (as biblically portrayed) is presented which proposes that nature and supernature are macro-systemically integrated within 'hypernature', but in such a way as to each possess their own unique subsystems which are operatively and constitutively autonomous and mechanically coherent to a robust, yet not thorough degree. Their integration implies the existence of nexuses/points of structural interaction which are unavoidably detectable from the natural standpoint. This structural topography also explains such intelligibility and why materialist-assumptive science is able to make such ample and extensive progress in understanding the natural system without the need to invoke extra-natural notions. However, the points where elements of nature and supernature interact (Nature-Supernature Nexuses-NSNs) should have observable effects on the nature-side, and due to the materialist assumption of conventional science, 'holes of explanatory inadequacy' are met in some cases. Due to psycho-intellectual frictions preventing relaxation of materialist assumptions, there is thus a mandate for religious scientists to explore these nature-supernature nexuses using the scientific method as a form of Nexus-Empirical Theology (NET) to correlate scriptural indications of the structural nexuses with scientific explorations of these holes. Three examples of nexus-empirical theology and rough frameworks for their investigation are proposed: the use of low-level psychokinesis experimental data as a means of estimating demonic inhabitance in samples; comparatively detecting the statistical influence of the Holy Spirit in the Christian conversion process; and the building of a prophecy database and use of conditional prophecy data to detect supernatural influence in world events.