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Synthesis and Characterization of New Heterocyclic Compounds Derived from 4- Amino Antipyrine and Study of Biological Activity

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Dhurgham Aziz
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The target of this work involves synthesis of different new macrocyclic derivatives utilizing two different strategies. The first one involved prepare new azo derivative for (4- amino antipyrine), Through reaction between (4-amino antipyrine) with antipyrine in suitable solvent to form (A1), while the second step involved reaction prepared azo compound with several compounds such as ( urea , thiourea , quanidine and o- phenylene diamine ) to form ( A2, A3, A4 and A5 ) compounds, Finally, the biological activity of some final products (A1, A2, A3, A4 and A5) has been tested through its effect on one type of bacteria and the results were compared with some standard antibiotics such as tetracycline ciprofloxacin and cefoxitin..etc