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- Maksim Davydov
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- Sergei Ya Kilin
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- Anatoly Osipov
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- Vladimir A. Kulchitsky
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One of the unresolved issues in the problem of artificial intelligence is the question of the desirability of introducing elements of motivation and emotions into artificial neural networks. The attitude to this issue is still controversial. The coding system in the interfaces is based on the binary system of the "on-off" type. In the case that an emotional component is included into the artificial intelligence system, it is advisable to introduce, along with binary coding system, a positive or negative attitude to the decision which is being made by implementing a feedback system. Thus, the “on” or “off” due to the feedback can, at a certain level of “noise” or emotional disturbances, decline or turn into appropriate opposite. This article presents an attempt to critically understand the existing problem of an effective result of artificial intelligence in the presence of positive or negative emotional component of varying intensity and duration. It is important that all events associated with artificial intelligence functioning should be considered not as static ones, but as events developing simultaneously in time and space.
The article briefly describes advantages of autologous mesenchymal stem cells (MSCs) use in clinical conditions to correct structure and function of damaged areas in organs and tissues of humans and animals. The effectiveness of MSCs migration via per-ineural nerve spaces to inner organs was confirmed. Such method of cell therapy allows avoiding major surgeries and achieving more effective result in combination of classic treatment techniques with MSCs perineural delivery to damaged organs and tissues.
The problem of the functional reparation of injured internal organs, especially vital ones (heart, lungs) is socially significant, since it has not been solved until now. What body reserves and practical skills of clinicians are the bases for new ideas aimed at preventing and/or restoring impaired functions of internal organs? For the authors of the study, the postulate was the well-known idea that stem cells (SCs) are the foundation for the development of cells during ontogenesis and the implementation of reparative processes in organs and tissues of living organisms. Unfortunately, the endogenous potential of SCs in reality turns out to be insufficient with the development of pathological processes in a living organism. The existing methods of classical therapy, as well as the systemic administration of SCs for the purpose of additional activation of regenerative processes in the body, often turn out to be palliative and insufficient for restoring the working capacity of patients. It is advisable to find new technologies for the activation of reparative processes in the body during the development of pathological processes. The authors propose to supplement the existing technologies for the reparation of the functions of internal organs after their damage with the help of a fundamentally new method of introducing autologous SCs. The technique is based on the natural perineural migration of autologous SCs along the cranial, somatic or autonomic nerves to the site of destruction in the internal organs. As a result, an intensive reparative process is initiated in the damaged tissues. In order to initiate a regenerative process in tissues, a miniature surgery is required under local anesthesia, which is necessary for the perineural administration of autologous SCs. After perineural implantation of SCs, targeted and natural migration of SCs develops to the area of internal organ damage (heart, lungs, liver, pancreas, stomach, spleen, kidneys).
Perineural migration of stem cells (SCs) is the basis for the development of new ap-proaches for internal organ diseases treatment. The authors have previously proved in ex-perimental and clinical conditions the effectiveness of perineural migration of SCs through the cranial nerves in strokes and brain injury conditions. In recent studies, the feasibility of SCs delivery through the vagus nerve to heart, liver, pancreas has been confirmed. Thus, the use of nerve trunks as a migration pathway network for the delivery of SCs to the in-ternal organs is promising in the treatment of socially significant diseases (stroke, heart attack, diabetes, gastric ulcer) since they avoid complex surgical interventions.
Keywords: Stem Cells; Perineural Transport; Cell migration; Nervous System; Diseases; Treatment
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ARTICLE INFO Hypothesis on reality of perineural migration of stem cells (SCs) along vagus nerve fibers to injured heart and brain stem regions was experimentally verified on ten Wistar rats. Heart injuries were simulated using unilateral vagotomy. Vagotomy led to degeneration of vagus nerve fibers in heart and brain stem. These destructive processes in tissues were the basis for SCs migration. FITC-labeled SCs were revealed in cardiac ganglions and nucleus tractus solitarii of brain stem. Experimental results should be used to test the technique in clinical conditions in patients with impaired cardiac function, namely with acute heart failure after myocardial infarction.
Kulchitsky Vladimir, Zamaro Alexandra, Koulchitsky Stanislav. Perineural Migration of Stem Cells in the Model of Damaged Heart Nodes. Biomed J Sci & Tech Res 14(4)-2019. BJSTR. MS.ID.002578.
Unilateral vagotomy (n=15) with simultaneous injection of 10 thousand stem cells in 10µl of culture medium to intact vagus nerve (n=9) was performed on Wistar rats an-esthetized with ketamine-xylazine-acepromazine. Migration of stem cells to atriums and ventricles was tracked by fluorescent markers. Also protective role of perineural injection of stem cells was established in relation to development of destructive processes in heart ganglions. Unilateral vagotomy and injection of stem cells to intact vagus nerve resulted in preservation of cell structure in sinoatrial ganglion and recovery of cardiac rhythm. It was assumed that technique of perineural migration of stem cells along vagus nerve fibers to heart is promising for prevention of arrhythmias and heart failure development in pa-tients with impaired heart function.
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- Agha H Amin
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CHINESE STRATEGIC COUNTER MEASURES TO REDUCE DEPENDENCE ON IMPORTS FROM USA AND ITS SATTELLITES
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- Agha H Amin
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CHINA HEAVILY RELIANT ON USA AND ITS SATTELLITES SOUTH KOREA TAIWAN AND SINGAPORE FOR IMPORT OF SEMI CONDUCTORS SO THIS IS WHERE PRESIDENT TRUMP IS HITTING CHINA-BUT
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- Agha H Amin
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STRATEGIC INCOMPETENCE- AND NOT EVEN TACTICALLY SOUND !
Manhole in Pakistan army maintained and owned DHA Lahore not repaired since last 6 years- these johnnies cannot maintain dha Lahore , how on earth they can dominate Afghanistan as they claim ! My foot !
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- Agha H Amin
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Western mercenaries ready for Syria; Russians already there
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ABSTRACT.
In fact, it is proposed to bring in key element in the vision of pathological mechanisms of somatic diseases development – functional state of intestinal microbiota. The grade of intestinal dysbiosis affects formation of conditions for endotoxemia initiation and manifestation of pathological processes accompanied with development of systemic and local sites of inflammation in blood vessel walls and various organs. Confirmation of this hypothesis will allow creating reasonable methods of pathological processes correction at the stage of human intestine. Positive effects of different diets, e.g. Mediterranean one, significance of Chinese traditions of tea-drinking, relevance of products’ quality in food retail chains, parenting of nutrition ritual from an early age, etc. should be reviewed once again.
Kulchitsky V., Zamaro A., Huo Po, Li Junbo, Chen X, Koulchitsky S. (2018) Association of Intestinal Dysbiosis Problem with Initiation and Development of Somatic Diseases. Biomed Sci&Tech Res 8(2): 1-3.
BJSTR MS.ID.001630.
DOI: 10.26717/ BJSTR.2018.08.001630
Abstract
Zamaro A, Krivenchuk D, Denisov A, Koulchitsky S, Kulchitsky V. Topical Issues of Bioprinting Technology. Biomed J Sci & Tech Res. 2018; 12(1) 1-3. BJSTR. MS.ID.002195. DOI: 10.26717/ BJSTR.2018.12.002195.
Brief analysis of positive and negative aspects of bioprinting was performed. Bioprinting has technical deficiencies and a range of unresolved issues, including the absence of bioprinting protocol strategy. It is necessary to develop bioprinting protocols as well as technologies of 4D production of biological tissues and techniques of formed organs and tissues combination with tissues of living organism to successfully resolve biocompatibility issues.
Keywords: brain structure, brain functions, brain plasticity, brain reparation, bioprinting prospects.
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Kletskov AV, Potkin VI, Kolesnik IA, Petkevich SA, Kvachonak AV, Dosina M.O., Loiko DO, Larchenko MV, Pashkevich SG, Kulchitsky VA (2018) Synthesis and Biological Activity of Novel Comenic Acid Derivatives Containing Isoxazole and Isothiazole Moieties. Natur. Product Communication (NPC) 13(11):1507-1510.
Abstract:
Methyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate was synthesized by esterification of methanol with comenic acid under acidic catalysis. The obtained ester was alkylated with 3-(chloromethyl)-5-phenylisoxazole and 4,5-dichloro-3-(chloromethyl)isothiazole to afford corresponding conjugates containing isoxazole and isothiazole moieties which then were transformed into water-soluble Li-salts. During the bioassays of synthesized isoxazole and isothiazole derivatives of comenic acid in mixtures with first-line antitumor drug Temobel (Temozolomid) used in brain tumors chemotherapy, a synergetic effect was observed.
Keywords: Comenic acid, Isoxazole, Isothiazole, Esterification, Alkylation, Biological activity.
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Kulchitsky V., Zamaro A., Zaykina N., Yaromenka Y., Hudny G., Krivenchuk D., Semenik-Philipovich T., Koulchitsky S., Andrianova T., Dosina M., Kaliadzich Z. (2018) The Role of Feedback in Breathing Self-Regulation in Health and Obstructive Sleep Apnea Syndrome Development. Biomed J Sci & Tech Res 11(3): 1-3. BJSTR. MS.ID.002103. DOI: 10.26717/ BJSTR.2018.11.002103.
Abstract
Hypothesis on efficiency of feedback from medullary chemoreceptors (MCh) which react to carbon dioxide excess in the organism was tested in patients with obstructive sleep apnea syndrome (OSAS). Attenuation of feedback from MCh to respiratory center was established in 62.5% of patients with OSAS and 43.8% of healthy volunteers after “rebreathing” test. Obtained data correspond to significant variability of MCh sensitivity to CO2 content in brain stem in health and disease which is accompanied with increase of CO2 content in the organism. It was concluded that revealed decreased sensitivity of MCh to hypercapnic stimulus in patients with OSAS is one of diagnostic criteria which will allow substantiating reasonability of CPAP (Continuous Positive Airway Pressure) and BiPAP (Biphasic Positive Airway Pressure)-therapy use in patients with OSAS to prevent fatal breathing stop during sleep.
Keywords: Medullary Chemoreceptors; Breathing Regulation; Obstructive Sleep Apnea; “Rebreathing” Test; Patients.
Abbreviations: BiPAP: Biphasic Positive Airway Pressure; СО2: Carbon dioxide; CPAP: Continuous Positive Airway Pressure; MCh: Medullary chemoreceptors; OSAS: Obstructive Sleep Apnea Syndrome; Qco2: Parameter Reflecting Degree of Central Chemoreceptors Functioning.
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- Agha H Amin
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AN ATTACK WITH NO RATIONALE ALTHOUGH IN ACTUAL EXECUTION IT TURNED OUT TO BE A GRAND STRATEGIC LEVEL SPOILING ATTACK THAT THREW INTO WINDS INDIAN ATTACK PLAN ON RAHIMYARKHAN
RATIONALE OF THE LONGANEWALA
JAISALMER ATTACK
The Pakistan Army tank attack at Longanewala has always intrigued and bewildered military historians.
This is a short graphic examination of that battle.
Brigadier ZA Khan in his autobiography published in 1999 justified the attack.In 2002 in an interview with this scribe , he again justified it in following words :--
“After the operation ‘Labbaik’ ended in fiasco everyone claimed that they were not privy to the operation though 206 Brigade commander was removed from command for objecting to the operation. The mission assigned to 18 Division was “Defend the area of responsibility in order to ensure the security of the main line of communications Karachi-Multan and be prepared to carry out the war into the enemy territory under favourable conditions.” This implied the guarding of 600 miles road and rail communications close to the border, 18 Division successfully carried out its mission. It was a classical spoiling attack which put the Indians off balance, the division’s mission was achieved.”
Major General Fazal Muqeem Khan who wrote Pakistan Armys first official sanctioned account in 1973 had a totally different opinion from ZA Khans views expressed as late as 1999 :--
“In the overall plan the mission of the division was defensive by virtue of the paucity of resources compared to its task.It seems, however, that at a later stage the Army Chief of Staff, on a visit to the formation, somewhat peremptorily and without due process of staff study,conceived the idea of an offensive mission for this division as well.What purpose was to be achieved by this offensive is not clear.If the idea was to keep the Indian forces in that area fixed,this could have been done by other methods.In any case the time and space factors would not have enabled the Indian troops deployed in this area being withdrawn in time to influence the battle in the plains of Punjab.In the event this decision turned out to be an unfortunate one, as the division, with a brigade detached as it was to look after the Khokhropar Umarkot approach, was not equal to the allotted task of capturing Ramgarh 40 miles deep in enemy territory, leave alone aspiring to capture Jaisalmer, another 40 miles away.”
Pakistans second officially sanctioned historian Major General Shaukat Riza was totally blank, although he had complete access to all archives and had nothing to state about the rationale of Longanewala attack in his book.Thus Shaukat Riza merely stated as follows:--
“18 Division had the mission to defend Karachi sector.In November it was given an additional mission i.e capture Jaisalmer”.
Lieutenant General Gul Hassan Khan in his autobiography published in 1993 was more straightforward and stated as below :--
“Another formation that failed to achieve its mission was 18 Division in the desert area south of Bahawalpur.But then the episode falls in a different category in that the commander, who had a vast area to defend including Hyderabad, had been wheedled or coerced by the COS during his countless trips to Karachi to plan to seize objectives that were beyond the means at his disposal”.
True that Longanewala attack in its final outcome turned out to be a classic strategic spoiling attack that derailed the planned Indian attack on Rahimyarkhan , but this certainly was not the intention of the attacks planners.
MAJOR A.H AMIN (RETIRED)
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Kulchitsky V, Zamaro A, Shanko Y, Koulchitsky S. Prospects of Perineural Implantation of Stem Cells in Recovery of Neural Networks’ Functions in Brain Diseases. Biomed J Sci&Tech Res. 2018. 10(3):1-4. BJSTR. MS.ID.001959. DOI:10.26717/ BJSTR.2018.10.001959
Abstract
Background: The question on prospects of additional use of cellular therapy in standard protocols of brain neural networks recovery after neurodestructive processes of various etiology was analyzed. Data on low efficiency of existing methods of neurodestructive processes treatment gave a boost to authors to conduct series of studies related to brain diseases and cellular technologies. Existing treatment principles now should be updated with new methods – in particular, cellular technologies. This statement was based on stem cells (SC) presence in human brain. Nature has formed basis for neural network formation in the process of training and for recovery therapy in case of pathology. Unfortunately, recovery potential of brain SC appeared to be ineffective in neurodestructive processes. Therefore, SC should be additionally injected into brain. It is advisable to use autologous SC in order to avoid possible side effects, such as malignization of allogeneic and other SC. But in certain cases use of allogeneic SC can be approved.
Methods: Autologous mesenchymal SC (MSC) are usually administered to patients in experimental and clinical conditions. Two ways of MSC delivery to brain are preferred: with cerebral blood flow after MSC injection into bloodstream and MSC implantation close to damaged area after additional skull trepanation. Authors experimentally developed and clinically evaluated new technique of perineural implantation of MSC. This method is based on natural ability of SC to migrate. MSC are implanted into the area of cranial nerve endings (mainly olfactory and trigeminal) and then they migrate along cranial nerves to cranial cavity.
Results: The area of vomeronasal complex (VC) is preferred for MSC implantation because its mucosa has nerve endings of both olfactory and trigeminal nerves. Such technique of MSC implantation was substantiated by authors and was named perineural implantation of MSC when used in neurodestructive processes.
Discussion and Conclusion: The article contains critical analysis and prospects of cellular technologies development for therapy of brain diseases. Special attention is paid in discussion to technology of perineural implantation of MSC in experimental and clinical conditions.
Key words: neurodestructive processes, stem cells, mesenchymal stem cells, reparation of neural network functions, recovery of brain functions control, vomeronasal complex
Abbreviations: SC, Stem Cells; MSC, Mesenchymal Stem Cells; VC, Vomeronasal Complex
The article analyzes the problem of side effects of antitumor therapy. Professional knows the two principal goals of any medical treatment: increase of its effectiveness, and reduction of the costs. Combination of the chemotherapy with adjuvants (nanoparticles, HC) will allow reducing the doses of cytostatic while preserving or even improving the efficacy of treatment. This approach should also minimize the adverse effects of the chemotherapy and let on the cost savings.
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- Agha H Amin
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the thick headed
will attack thickest part of the hedge USA Reinforcing failure in Syria (AND A CORRUPT CIA AND PENTAGON PROXY CONTRACT OF OBAMA ERA)
US Coalition transports over 250 trucks filled weapons to Euphrates River Valley
https://www.almasdarnews.com/article/us-coalition-transports-over-250-trucks-filled-weapons-to-euphrates-river-valley-monitor/?utm_medium=ppc&utm_source=push&utm_campaign=push+notifications&utm_content=English
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- Agha H Amin
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FAR SIGHTEDNESS AND LONG TERM FORESIGHT OF BRITISH ADMINISTRATORS OF INDIA
- Agha H Amin
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Mere Religion is not enough for a strategic Victory
Allah or God is neither with Muslims or Christians or Jews or Hindus or Communists-What matters is superior strategy,leadership and technology
Agha H Amin
Excerpts from my book " Islamic Bravery and Martial Superiority Myths and History"
Allah or God is neither with Muslims or Christians or Jews or Hindus or Communists-What matters is superior strategy,leadership and technology
ISLAMIC EXTREMISTS BASIC IDEAS ABOUT EXPANSIONISM AND CONTROL ARE FLAWED
MERE SUICIDE BOMBINGS OR LOW INTENSITY CONFLICT ARE MINOR IRRITANTS BUT CANNOT WIN A WAR
Conceptual Blocks
· The central point that has been a self imposed block in Muslim history is that human personality and character is not formed by religion totally.Khalid Bin Waleed who was early Islams greatest general was a great general not because he was a Muslim but because he was great as an individual with or without Islam.Thus Khalid Bin Waleed defeated the Muslims at Battle of Uhad while he was a Pagan. When Khalid Bin Waleed was dismissed by the second caliph Omar he justified it stating "You have done; And no man has done as you have done. But it is not people who do; It is Allah who does..." . This line of thought is fallacious because Allah has made every man differently and mere absence or presence of a man can lead to defeat or victory in battle.No Muslim army at least in the Arab Empire after Khalid Bin Waleed ever succeeded in defeating the Byzantine Empire , despite all the so called Islamic fervor. Machiavelli brilliantly summed up this issue as " God was neither with us nor with them" . If this was not so the Muslims would not have repeatedly failed to capture Constantinople , or at Tours or against Khazars in Caucasus.
· Poor strategy cannot compensate for religious martial fervor :-- The early Muslim Caliphs wasted a great deal of energy in capturing North Africa and in campaigns in Central Asia but failed to deal with the Byzantine Empire which was the strongest Muslim foe and occupied the most fertile lands as well as blocking Muslim advance into Europe. In addition poor mountain warfare ability and poor siege warfare ability doomed the Muslim cause in Byzantine wars of early Islam. The early Arab Muslim invasions of Byzantine Empire to capture Constantinople were undertaken via sea route as the Arab Muslims lacked the capability to invade via the land route across Taurus Mountains, as they were not well versed in mountain warfare and lacked the siege warfare capability to reduce Byzantine fortresses.Similarly at Constantinople Ummayad Muslims failed because of poor siege artillery.
THE CONSTANTINOPLE THAT TURKS FINALLY CAPTURED WAS A 1000 TIMES WEAKER CITY MUCH DETERIORATED AND WEAKENED BY 750 YEARS PLUS OF BATTLE WITH COUNTLESS BARBARIANS.
THERE NEVER WAS AN EMPIRE LIKE EASTERN OR WESTERN ROMAN EMPIRE !
I think it was Machiavelli who brilliantly summed it up as " God was neither with us nor with them "
Agha H Amin
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- Agha H Amin
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BRITISH REALISE THE NEED FOR CAVALRY AFTER DEFEAT IN FIRST ANGLO MYSORE AND A DRAW IN SECOND ANGLO MYSORE WAR -1769-1784
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- Agha H Amin
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they had not read and digested carl von clausewitz
- Agha H Amin
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Journal of Book Reviews-Drones and Terrorism: Asymmetric warfare and the threat to Global Security
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- Agha H Amin
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THINGS CAN LOOK GOOD IN STRATEGY
WHILE IN REALITY THEY MAY NOT BE THAT
GOOD-OCTOBER 1768
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- Agha H Amin
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Perles de non-sens stratégique gonflés de ce qu'on appelle la réputation de
réflexion international
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- Agha H Amin
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STRATEGIC POSITION -COLONEL SMITH
VERSUS HYDER ALI- AUGUST 1768
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Principles of eco-logic democracy are being elaborated by geonomic argumentation.
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- Agha H Amin
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BRIGADIER IQBAL NAZIR WARRAICH MUSHARRAFS COMMANDING OFFICER IN THE THREE COMMANDO BATTALION IN 1971 INDIA PAKISTAN WAR , CATEGORICALLY DENIED THAT MUSHARRAF SAW ANY ACTION IN 1971 WAR-HOWEVER STEVE COLL REPEATED THIS CHRONIC LIE IN HIS 2018 NEW BOOK DIRECTORATE “S”
- Agha H Amin
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THE WESTS TWISTED LOGIC ABOUT ATTACKING OR NOT ATTACKING IRAN
Agha H Amin
A rather naieve logic is being advanced by so called brilliant western geopolitical thinkers about USA , attacking or not attacking Iran !
That USA attacking Iran would only benefit (1) Russia (2) Sunni Jihadists and (3) Turkey.
A rather twisted and illogical logic of seeing things .
First – Sunni Jihadists have been no threat to the USA at all , nor have these clowns been a threat to Russia . Sunni Jihadists are 95 % state proxies and the states that use them as proxies include Pakistan , USA , KSA ,Turkey etc.
Second- USA has been one of the main employers of Sunni Jihadists starting from Soviet Afghan war , Libya , Syria ,Iraq etc .
Third Iran is not a serious rival of Turkey and both Iran and Turkey have clear cut defined spheres of influence.
Fourthly Iran and Russia have been natural allies and reducing Iranian power would not help Russia in any way.
Lastly Iran has never been a threat to the USA. Irans rivalries are local and sectarian rather than geopolitical .
The most serious obstacle to the west dealing with Iran is not Iran at all but a wide variety of divergent western intellectuals who represent some mickey mouse local agenda like Saudi financed , Israel financed , simple banker financed etc. Thus total confusion and lack of clarity about the western powers devising any coherent Iran policy.
28 March 2018, Wednesday
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