Project

RISK-HUNT3R

Goal: RISK-HUNT3R is the new European effort hosting world-leading experts from many different disciplines aiming to develop a novel and modular framework for animal-free next generation risk assessment (NGRA).

Launched in June 2021 and coordinated by the University of Leiden (NL), the project will run for 5 years with a budget of €23M granted by Europe’s Horizon 2020 program. It unites 37 partners, including academic researchers, regulatory authorities, and safety scientists from key industry sectors, to prove that NGRA can be put into practice.

The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient, and cost-effective chemical safety assessment approach, entirely based on non-animal methods. Integrating cutting-edge in silico (computational) and in vitro (experimental testing) technologies, RISK-HUNT3R will establish, optimize and assemble all essential safety testing elements: exposure assessment, information on chemical distribution in the body, hazard characterization, adverse outcome prediction and determination of actual risk in defined scenarios.

This project receives funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 964537.

More details can be found at https://www.risk-hunt3r.eu.

Date: 1 June 2021

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Project log

Johanna Mahélé
added an update
From 4 to 8 July 2022, the General Assembly Meeting of RISK-HUNT3R took place in Egmond aan Zee, the Netherlands.
This event was an opportunity for the project members to discuss together progress and challenges towards NGRA, during the general assembly and parallel sessions.
Young researchers presented their work through posters and short oral presentations and took part in different training sessions and workshops organised in connection with the consortium meeting.
The video below presents pictures taken during the event. Check it out to know more about the meeting.
 
Johanna Mahélé
added an update
The ASPIS Cluster (ONTOX, PrecisionTox, and RISK-HUNT3R) has published a reaction to the ongoing consultation hosted by the European Commission on the revision of the Regulation on the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH Regulation).
More information is available on the RISK-HUNTER website: https://www.risk-hunt3r.eu/nams-aspis-safe-environment/
The complete statement is herewith attached.
 
Johanna Mahélé
added an update
The first RISK-HUNT3R Newsletter has been published on the project's public website. To consult the document, please click on the following link : https://www.risk-hunt3r.eu/wp-content/uploads/RH3R_newsletter_issue1_FV.pdf .
 
Johanna Mahélé
added an update
The RH3R mini-symposium “Orienteering for regulatory needs” is scheduled on March 14 (virtual, 3:30 – 6:00 PM CET). The mini-symposium aims to summarize the workshop discussion and engage a broader audience on this crucial topic. If you are interested in attending this event, you can register here : https://zoom.us/meeting/register/tJEpc-yvpjkvE9eZjqHjEtDJp1xkMuiNbJBx.
Please find the agenda in the attached document.
 
Adeline Paul
added an update
Johanna Mahélé
added an update
A new postdoctoral position has opened at the German Federal Institute for Risk Assessment (BfR). The available position is in the department Safety of Pesticides of the BfR and especially in the unit „Testing and Assessment Strategies“.
The activities includes:  modeling of Adverse Outcome Pathways (AOP) in silico, bioinformatic preparation and statistical analysis of omics data, contributing to the development of regulatory concepts for ab initio testing using in silico based NAMs, and also the publication of the acquired results.
The unit is looking for a person with a degree preferably in bioinformatics, chemoinformatics, computer science or a comparable discipline who has experience with modeling omics data is an advantage in the field of toxicology.
Applications are open until March 2nd. To have a look at the full job description and apply, please open the attached PDF document.
 
Johanna Mahélé
added an update
A new postdoctoral position has opened at Lund University, Sweden. The position is in the field of Uncertainty Analysis in Scientific Assessment, with a specific focus on NAMs and AOPs used for chemical safety assessment.
The research group is looking for a person with a degree in mathematics or statistics, with knowledge about Bayesian inference, and a person who is interested in the possibility of measuring uncertainty with probability.
Applications are open until December 20th. To apply, click on the following link : https://lu.varbi.com/what:job/jobID:454310/?lang=en.
 
Johanna Mahélé
added an update
A new short video presenting the RISK-HUNT3R project is now available. You can view the video by clicking on the following link : https://www.youtube.com/watch?v=gA4FznJl3X4 .
 
Johanna Mahélé
added an update
RISK-HUNT3R's lastest Corner in Altex is now avaible. To consult the article, click on the following link (page 690) : https://www.altex.org/index.php/altex/article/view/2363/2301
 
Johanna Mahélé
added an update
On the 3rd and 4th of November 2021, the Final Symposium of the EU-ToxRisk project was held in Brussels, Belgium, and online. The purpose of this event was for the EU-ToxRisk consortium partners to present their results, and to discuss the different strategies and methods developed within the project with external stakeholders.
This meeting was a way for the EU-ToxRisk project to pass the torch to the RISK-HUNT3R consortium. and to formally introduce, the ASPIS cluster, which is a collaboration of the H2020 funded projects ONTOX, PrecisionTOX and RISK-HUNT3R.
During the ASPIS Kick-off meeting, which constituted the fourth part of the event, each project was presented as well as the purpose and planned implementation of the ASPIS Cluster. It was an opportunity for cluster members to meet each other in person and to exchange about how the projects can collaborate together.
 
Johanna Mahélé
added an update
On the 12th and 13th of October 2021 happened the face-to-face Kick-off Meeting of the European project RISK-HUNT3R in Egmond an Zee, the Netherlands. This meeting was organised in connection with the Final General assembly of the EU-ToxRisk project, held on 11-22 October.
RISK-HUNT3R being the continuation of the research made during the EU-ToxRisk project, it was an opportunity for all consortium members to finally meet in person, after a first online meeting in June.
All partners had the occasion to introduce themselves, discuss the progress made so far in each work package, and to learn more about the results obtained by the EU-ToxRisk consortium.
 
Adeline Paul
added an update
You can download the project flyer below to learn more about our approach, vision and consortium.
 
Adeline Paul
added an update
During the next Plenary session, MEPs will vote on an important text for non-animal testing. The project coordinators of PrecisionTox, ONTOX and RISK-HUNT3R welcome this initiative: animal testing is too long to enable the safety assessment of the growing number of chemicals whose toxicity is still unknown.
Related declaration attached and article available here:
 
Adeline Paul
added an update
Meet RISK-HUNT3R, ONTOX & PrecisionTox at the ASPIS cluster kick-off meeting on 4th November 2021 at Le Square, Brussels (BE).
 
Adeline Paul
added an update
Our project partner Vrije Universiteit Amsterdam is recruiting a PhD student with strong background on metabolism and metabolomics.
 
Adeline Paul
added an update
The RISK-HUNT3R project will be presented in the afternoon of 04 November 2021, at Le Square convention centre, in Brussels (BE), in the framework of the ASPIS cluster Kick-off meeting.
The ASPIS cluster comprises of three related EU projects – RISK-HUNT3R, ONTOX, and PrecisionTOX – focussing on different aspects of toxicology and safety testing strategies. The three projects will work together and organise joint dissemination and communication activities over the next 5 years. At the ASPIS kick-off meeting you can become acquainted with the RISK-HUNT3R, ONTOX and PrecisionTOX projects, and their projected collaborations.
The ASPIS cluster Kick-off meeting itself will be embedded in yet another big event: the Final Symposium of the EU-ToxRisk project, the predecessor of RISK-HUNT3R. We would thus be delighted to welcome you also to this public event, where you can discover the main results, developed tools and learnings of EU-ToxRisk, all which constitute the basis of the RISK-HUNT3R  project.
More details soon available at: https://www.risk-hunt3r.eu/
 
Adeline Paul
added a project goal
RISK-HUNT3R is the new European effort hosting world-leading experts from many different disciplines aiming to develop a novel and modular framework for animal-free next generation risk assessment (NGRA).
Launched in June 2021 and coordinated by the University of Leiden (NL), the project will run for 5 years with a budget of €23M granted by Europe’s Horizon 2020 program. It unites 37 partners, including academic researchers, regulatory authorities, and safety scientists from key industry sectors, to prove that NGRA can be put into practice.
The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient, and cost-effective chemical safety assessment approach, entirely based on non-animal methods. Integrating cutting-edge in silico (computational) and in vitro (experimental testing) technologies, RISK-HUNT3R will establish, optimize and assemble all essential safety testing elements: exposure assessment, information on chemical distribution in the body, hazard characterization, adverse outcome prediction and determination of actual risk in defined scenarios.
This project receives funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 964537.
More details can be found at https://www.risk-hunt3r.eu.