Preclinical and Clinical study on “MATHUMEGAM” (Type-2 Diabetes Mellitus) and the drug of choice is “ATTHIPPATTAIYATHI KASAYAM” (Internal).

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In South India, indigenous remedies have been used in the treatment of Diabetes mellitus since the time of Agathiyar and Thirumoolar. Plants have always been an exemplary source of drugs and many of the currently available drugs have been derived directly or indirectly from them. The ethnobotanical information reports that about 800 plants may possess anti-diabetic potential. Atthippattaiyathi kasayam, a polyherbal antidiabetic Siddha formulation containing 22 ingredients of plants origin. They are Ficus recemosa, Cassia fistula, Cassia auriculata, Salacia reticulate, Madhuca longifolia, Tamarindus indica, Terminalia arjuna, Hemidesmus indicus, Amaranthus tricolor , Phyllanthus reticulates, Aloe barbadensis, Cyperus rotundus, Tinospora cordifolia, Zingiber officinale, Piper nigrum, Piper longum, Myristica fragrans, Syzygium aromaticum, Spermacoce hispida and Ferula asafetida. Overall, this review presents the profiles of plants of Atthippattaiyathi kasayam with hypoglycemic properties, reported in the literature.
Atthippattaiyathi kasayam (APK), a polyherbal Siddha formulation intended to use for diabetic patients, has been screened for toxic effects. For acute toxicity studies, Atthippattaiyathi kasayam was administered orally in single dose of 270 mg/kg to the mice. For sub-acute toxicity studies, different doses of Atthippattaiyathi kasayam (270, 1350 and 2700 mg/kg) were administered orally to the rats once daily for 28 days. Animals were observed for physiological and behavioral responses, mortality, food and water intake and body weight changes. All the animals were sacrificed on 29th day and changes in organ weights and histology were examined. No mortality was observed up to 270 mg/kg of Atthippattaiyathi kasayam in acute toxicity study. Daily administration of as high as 2700 mg/kg dose of Atthippattaiyathi kasayam did not result in any mortality or changes in gross behavior, body weight, weight and histology of different organs. Therefore such doses may be safe for daily administration without causing any serious side effects.