Project

New Homeopathic Medicines: use of modern drugs according to the principle of similitude

Goal: The homeopathic method of healing is grounded on the application of the principle of therapeutic similitude (similia similibus curentur) by using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism against its own disturbs. Such vital, homeostatic or paradoxical reaction of the organism can be scientifically explained on the basis of the rebound effect of modern drugs. This work presents the conclusion of a study aiming at a method to use modern drugs with homeopathic criteria. This claim is epistemologically justified by the fact that a definite class of adverse events described by experimental pharmacology represents actual pathogenetic symptoms of drugs. On these grounds it was possible to elaborate a homeopathic materia medica and repertory comprising 1,251 modern drugs to be employed according to the principle of similitude and the individualizing symptomatic totality. Besides supplying a basis for homeopathy as a medical rationality regarding scientific pharmacology, this study makes available a method that may broaden the scope of intervention of homeopathy in present day diseases. Available at: www.newhomeopathicmedicines.com

O método de tratamento homeopático se baseia na aplicação do princípio da similitude (similia similibus curentur), utilizando medicamentos que causam efeitos semelhantes aos sintomas da doença, com o objetivo de estimular uma reação do organismo contra seus próprios distúrbios. Essa reação vital, homeostática ou paradoxal do organismo está cientificamente embasada no estudo do efeito rebote das drogas modernas. Nesse trabalho, estamos concluindo uma proposta antiga, na qual sugerimos um método para a utilização homeopática das drogas modernas. Apoiados na justificativa epistemológica de que determinada classe de eventos adversos descritos na farmacologia experimental são sintomas patogenéticos das substâncias, foi elaborada uma Matéria Médica e um Repertório Homeopático com 1251 drogas modernas, sugerindo sua utilização segundo o princípio da similitude e a totalidade sintomática individualizante. Além de embasar a racionalidade homeopática perante a farmacologia científica, estamos disponibilizando uma metodologia que poderá ampliar o espectro de ação da homeopatia nas doenças atuais. Disponível em: www.novosmedicamentoshomeopaticos.com

Date: 31 December 2002

Updates
0 new
0
Recommendations
0 new
0
Followers
0 new
15
Reads
2 new
602

Project log

Marcus Zulian Teixeira
added a research item
Objective: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). Study design: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score≥5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI).
Marcus Zulian Teixeira
added a research item
When Samuel Hahnemann systematized homeopathy and the effects of drugs on the state of human health, he described the primary action of drugs and the following secondary and opposite reaction of the body. Seeking to apply this secondary action or vital reaction of the body as therapeutic method, he postulated the “principle of cure by similars”, i.e. the prescription to ill individuals of drugs that cause similar symptoms in the healthy (similia similibus curentur). In modern pharmacology, this secondary action (vital reaction) of the body is known as rebound effect or paradoxical reaction. It has been observed after discontinuation of several classes of palliative drugs, namely those that act according to the “principle of cure by contraries” (contraria contrariis curentur). Since 1998, we have been bridging the gap between homeopathic and conventional pharmacology through the systematic study of rebound effect of modern drugs, scientifically confirming the homeopathic postulate (primary action of the drug followed by secondary and opposite reaction of the body) and the homeopathic healing principle. Following the homeopathic premises, conventional drugs can be employed according to the principle of therapeutic similitude provided they cause primary symptoms (therapeutic, adverse and side effects) similar to the symptomatic manifestations of sick individuals. Since 2003, we are proposing the use of the rebound effect of modern drugs in a curative manner, administering to patients, in ultra-diluted doses, drugs that cause a set of similar adverse events. Since 2021, these two decades of studies are made available in three free-access digital books.
Marcus Zulian Teixeira
added 2 research items
Homeopathic treatment is based on the principle of similitude ('like cures like') administering to sick individuals substances that cause similar symptoms in healthy individuals, employing the paradoxical or biphasic action of the organism as therapeutic response. This homeostatic, vital or secondary action of the organism is scientifically explained by the rebound effect of drugs, resulting in worsening of symptoms after enantiopathic treatment withdrawal. Natalizumab reduces relapses in patients with active multiple sclerosis (MS), but recent studies report severe worsening of MS after suspension of treatment, as a consequence of the rebound effect. Extending this source of evidence, this work reviews research that demonstrates secondary worsening of MS after discontinuation of natalizumab, a human monoclonal antibody that suppresses the disease inflammatory activity as primary action. Several studies refer to the immune reconstitution inflammatory syndrome (IRIS) as a plausible explanation of reactivation of MS after withdrawal of natalizumab: a rebound effect or secondary action of the organism in response to the primary immunosuppression caused by the drug. Relapses of MS after discontinuation of natalizumab treatment indicate rebound of disease activity, supporting the homeopathic principle and warning healthcare professionals about this serious iatrogenic event.
Homeopathy employs the so-called ‘principle of similars’ as therapeutic method - which consists in administering medicines that cause certain primary symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curantur) – in order to induce a secondary and healing reaction of the body against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the body is based on the ‘rebound effect’ of modern drugs, a type of adverse event that occurs following discontinuation of several classes of drugs prescribed according to the ‘principle of contraries’ (contraria contrariis curantur). Since 1998, we have been bridging the gap between homeopathic and conventional pharmacology through the systematic study of the rebound effect of modern drugs, scientifically confirming the homeopathic postulate (primary action of the drug followed by secondary and opposite reaction of the organism) and the homeopathic healing principle. Following the homeopathic premises, conventional drugs can be employed according to the therapeutic similitude principle provided they cause primary symptoms (therapeutic, adverse and collateral effects) similar to the symptomatic manifestations of sick individuals. Since 2003, we are proposing the use of the rebound effect of modern drugs in a curative manner, administering to patients, in ultra-diluted doses, the drugs that cause a set of similar adverse events. Entitled “New Homeopathic Medicines: use of modern drugs according to the principle of similitude”, this proposal are been made available in a database composed of three free-access bilingual digital books.
Marcus Zulian Teixeira
added 23 research items
Using the empirical or phenomenological research method by observing the effects of drugs in the human physiology, Samuel Hahnemann proposed the homeopathic treatment. He synthesized modern pharmacodynamic in the ‘primary action’ of the drugs and in the consequent and opposite ‘secondary action’ or ‘vital reaction’ of the organism. Noting that drugs with ‘contrary’ primary action to the symptoms of the diseases caused worsening of the symptoms after its withdrawal, as a result of secondary action of the organism, Hahnemann proposed using this vital reaction (secondary action) in a curative way, administering to sick individuals the drugs that caused ‘similar’ symptoms in healthy individuals (therapeutic use of the similitude principle). According to the clinical and experimental pharmacology, this secondary action (vital reaction) of the organism is observed in the ‘rebound effect’ or ‘paradoxical reaction’ of several classes of drugs, which is the scientific basis of the ‘homeopathic pharmacology’. In the last decade, exponents of modern pharmacology have suggested the therapeutic use of the paradoxical reaction (‘paradoxical pharmacology’), proposing the use of drugs that cause an exacerbation of the disease in the short term to treat these same diseases in the long-term. In this review, we compare the various aspects between the ‘homeopathic pharmacology’ and the ‘paradoxical pharmacology’, reinforcing the validity of homeopathic assumptions and expanding the knowledge to optimize both proposals.
Using the empirical or phenomenological research method by observing the effects of drugs in the human physiology, Samuel Hahnemann proposed the homeopathic treatment. He synthesized modern pharmacodynamic in the ‘primary action’ of the drugs and in the consequent and opposite ‘secondary action’ or ‘vital reaction’ of the organism. Noting that drugs with ‘contrary’ primary action to the symptoms of the diseases caused worsening of the symptoms after its withdrawal, as a result of secondary action of the organism, Hahnemann proposed using this vital reaction (secondary action) in a curative way, administering to sick individuals the drugs that caused ‘similar’ symptoms in healthy individuals (therapeutic use of the similitude principle). According to the clinical and experimental pharmacology, this secondary action (vital reaction) of the organism is observed in the ‘rebound effect’ or ‘paradoxical reaction’ of several classes of drugs, which is the scientific basis of the ‘homeopathic pharmacology’. In the last decade, exponents of modern pharmacology have suggested the therapeutic use of the paradoxical reaction (‘paradoxical pharmacology’), proposing the use of drugs that cause an exacerbation of the disease in the short term to treat these same diseases in the long-term. In this review, we compare the various aspects between the ‘homeopathic pharmacology’ and the ‘paradoxical pharmacology’, reinforcing the validity of homeopathic assumptions and expanding the knowledge to optimize both proposals.
Marcus Zulian Teixeira
added 6 research items
Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses ultradiluídas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma "Matéria Médica Homeopática dos Fármacos Modernos", agrupando os efeitos adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas clássicas, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um "Repertório Homeopático dos Fármacos Modernos", dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos clássicos, descrito na terceira obra desta série.
Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in homeopathic doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a "Homeopathic Materia Medica of Modern Drugs" was elaborated, where the adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a "Homeopathic Repertory of Modern Drugs", where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in the third book of this series.
Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses ultradiluídas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma "Matéria Médica Homeopática dos Fármacos Modernos", agrupando os efeitos adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas clássicas, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um "Repertório Homeopático dos Fármacos Modernos", dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos clássicos, descrito nessa obra.
Marcus Zulian Teixeira
added 2 research items
Since ancient Greece, Hippocrates had already taught that there were two forms of treatment: by the principle of contrary and by the principle of similar. Treatment based on the principle of contrary uses substances that act in a contrary or palliative manner (“anti-”) to the symptoms of the disease (eg: anti-inflammatory, antacids, antidepressants, etc.). This is the main form of treatment used by conventional medicine or 'allopathy'. The treatment by the principle of similar or similitude, employed by homeopathy, uses substances that cause symptoms similar (“homeo”) to the symptoms of diseases, in order to stimulate a reaction of the organism against the own disturbances or diseases (Ex .: coffee that causes insomnia is used homeopathically to treat insomnia, chamomile that causes colic is used to treat colic, belladonna that causes fever is used to treat fever, etc.). When Samuel Hahnemann instituted homeopathy in 1796, he bases this homeopathic principle on the detailed observation of the effect of drugs of his time on the human organism, stipulating a "universal mechanism of action of drugs”: “Every agent that acts upon the vitality, every medicine, deranges more or less the vital force, and causes a certain alteration in the health of the individual for a longer or a shorter period. This is termed primary action. [...] To its action our vital force endeavors to oppose its own energy. This resistant action is a property, is indeed an automatic action of our life-preserving power, which goes by the name of secondary action or counteraction” (Organon of the art of healing, §63). Based on this postulate or “natural law”, homeopathy uses this secondary action of the organism as a therapeutic reaction, administering to sick individuals medicines that cause symptoms similar to their disorders (principle of therapeutic similarity/similitude), stimulating the organism to react against to own diseases. Although little publicized by modern pharmacology, as it contradicts conventional treatment (principle of contrary), this secondary action or homeostatic reaction of the organism is studied and described after the use of several modern classes of palliative drugs (antipathic or enantiopathic), according to the term "rebound effect" of the drugs or "paradoxical reaction" of the organism. In the last decades, we have been systematically studying the rebound effect of modern drugs, scientifically confirming Hahnemann's postulate (primary action of the drug followed by secondary and opposite action of the organism) and the principle of homeopathic cure. Bridging the gap between homeopathic pharmacology (principle of similarity) and modern pharmacology (principle of contrary), we find a multitude of scientific reports, both in pharmacological compendiums and in experiments and clinical trials published in impact scientific journals, which describe an opposite and secondary organism reaction to primary action of the drug, confirming the Hahnemannian theory. To reiterate, this secondary action of the organism, in the sense of maintaining organic homeostasis, is termed as rebound effect or paradoxical reaction according to modern scientific rationality, being used by homeopathy as a therapeutic response.
Desde a Grécia Antiga, Hipócrates já ensinava que existiam duas formas de tratamento: pelo princípio dos contrários e pelo princípio dos semelhantes. O tratamento pelo princípio dos contrários emprega substâncias que agem de forma contrária ou paliativa (“anti-”) aos sintomas da doença (Ex.: anti-inflamatórios, antiácidos, antidepressivos, etc.). Essa é a principal forma de tratamento utilizada pela medicina convencional ou 'alopatia'. O tratamento pelo princípio dos semelhantes, empregado pela homeopatia, utiliza substâncias que causam sintomas semelhantes (“homeo”) aos sintomas das doenças, com o intuito de estimular uma reação do organismo contra os próprios distúrbios ou doenças (Ex.: café que causa insônia é utilizado homeopaticamente para tratar a insônia, camomila que causa cólica é utilizada homeopaticamente para tratar a cólica, beladona que causa febre é utilizada homeopaticamente para tratar a febre, etc.). Ao instituir a homeopatia em 1796, Samuel Hahnemann fundamenta esse princípio homeopático na observação minuciosa do efeito das drogas de sua época no organismo humano, estipulando um “mecanismo universal de ação das drogas”: “Toda força que atua sobre a vida, todo medicamento afeta, em maior ou menor escala, a força vital, causando certa alteração no estado de saúde do Homem por um período de tempo maior ou menor. A isso se chama ação primária. [...] A essa ação, nossa força vital se esforça para opor sua própria energia. Tal ação oposta faz parte de nossa força de conservação, constituindo uma atividade automática da mesma, chamada ação secundária ou reação". (Organon da arte de curar, §63) Embasada nesse postulado ou “lei natural”, a homeopatia utiliza essa ação secundária do organismo como reação terapêutica, administrando aos indivíduos doentes medicamentos que causam sintomas semelhantes ao conjunto dos seus sintomas (princípio da similitude terapêutica), estimulando o organismo a reagir contra a própria doença. Apesar de pouco divulgada pela farmacologia moderna, pois contraria o tratamento convencional (princípio dos contrários), essa ação secundária ou reação homeostática do organismo é estudada e descrita após o uso de inúmeras classes de drogas paliativas (antipáticas ou enantiopáticas) modernas, segundo o termo "efeito rebote" das drogas ou "reação paradoxal" do organismo. Nas últimas décadas, vimos estudando sistematicamente o efeito rebote dos fármacos modernos, confirmando cientificamente o postulado de Hahnemann (ação primária da droga seguida por ação secundária e oposta do organismo) e o princípio de cura homeopático. Realizando a ponte entre a farmacologia homeopática (princípio da similitude) e a farmacologia moderna (princípio dos contrários), encontramos uma infinidade de relatos, tanto em compêndios farmacológicos como em experimentos e ensaios clínicos publicados em periódicos científicos de impacto, que descrevem uma reação do organismo oposta e secundária a uma ação primária da droga, confirmando a teoria hahnemanniana. Reiterando, essa ação secundária do organismo, no sentido de manter a homeostase orgânica, é denominada de efeito rebote ou reação paradoxal segundo a racionalidade científica moderna, sendo usada pela homeopatia como resposta terapêutica.
Marcus Zulian Teixeira
added a research item
In view of homeopathy being based on scientific assumptions different from those employed by conventional medical practice, it is often the target of unfounded criticism spread by individuals who systematically deny the homeopathic principles and any scientific evidence that proves them, because they are wrapped in dogmatic negationism that prevents a correct and prejudice-free analysis. They are ‘pseudosceptics’ disguised as ‘pseudoscientists’. To clarify physicians, researchers, health professionals and the general population, demystifying culturally entrenched dogmatic postures and the pseudosceptic fallacy that “there is no scientific evidence for homeopathy”, in 2017, the Technical Chamber of Homeopathy of the Regional Council of Medicine of the State of São Paulo (CT-Homeopathy, Cremesp) elaborated and published the “Special Dossier: Scientific Evidence for Homeopathy”, freely available in the Revista de Homeopatia (São Paulo), scientific journal of São Paulo Homeopathic Medical Association (Associação Paulista de Homeopatia, APH). Encompassing nine narrative reviews in several lines of homeopathic research (historical-social, medical education, pharmacological, basic, clinical, patient safety and pathogenetic) and two randomized and placebo-controlled clinical trials developed by members of the CT-Homeopathy, containing hundreds of scientific articles published in numerous indexed and peer-reviewed scientific journals, this dossier highlights for the medical and scientific class, as well as for the general public, the ‘state of the art’ of the research in homeopathy. Troubled by the excellence of this vast body of evidence, in November 2020, a group of pseudosceptics who make up the Instituto Questão de Ciência (IQC) published a derisory and fallacious manuscript entitled “Counter-dossier of Evidence on Homeopathy”, in order to evaluate the articles published in the “Special Dossier: Scientific Evidence for Homeopathy” according to “the best scientific rigor” and “inform the population about what science says about the supposed efficacy of homeopathy”. Unfortunately, none of this occurred in the aforementioned manuscript. Unlike the advertised “better scientific rigor” in the analysis of articles, what is observed throughout the text is a set of criticisms based on known “pseudosceptic strategies” to disqualify certain scientific work: tendency to deny, rather than doubt; use of personal attacks; attempt to disqualify proponents of new ideas by pejoratively taxing them from pseudoscientists, promoters or practitioners of pathological science; conducting judgments without a thorough and conclusive investigation; insufficient or unconvincing evidence (absence of evidence); presentation of unsubstantiated or evidence-based evidence based solely on plausibility, rather than based on evidence; tendency to disqualify any and all evidence; suggestion that unconvincing evidence is sufficient to assume that a theory is false; vitrionic, slanderous or derogatory tone in the comments; non-specific and superficial comments; dissemination in mass media (non-scientific); among others. In the current digital book (Falácias pseudocéticas e pseudocientíficas do “Contradossiê das Evidências sobre a Homeopatia” / Pseudosceptic and pseudoscientific fallacies of the “Counter-dossier of Evidence on Homeopathy”), we highlight these pseudosceptic strategies in the counter-dossier and respond to the authors’ criticisms. In view that these indications of pseudoscepticism contaminate the entire manuscript, denoting the despicable scientific quality of the same, we leave it up to each author of the dossier, cited or not in the counter-dossier, the initiative to respond or not to the authors’ criticisms.
Marcus Zulian Teixeira
added 8 research items
Building a bridge between homeopathic pharmacology (principle of similitude) and modern pharmacology, one can find countless reports in pharmacological compendia and clinical and experimental trials published in the scientific media describing the secondary reaction of the organism opposed to the primary action of the drug, which confirm Hahnemann’s theory. Such secondary action of the organism to preserve organic homeostasis is known in modern science as rebound effect or paradoxical reaction, being used by homeopathy as a therapeutic response.
Realizando a ponte entre a farmacologia homeopática (princípio da similitude) e a farmacologia moderna, encontramos uma infinidade de relatos, tanto em compêndios farmacológicos como em experimentos e ensaios clínicos publicados em periódicos científicos, que descrevem uma reação do organismo oposta e secundária a uma ação primária da droga, confirmando a teoria hahnemanniana. Essa ação secundária do organismo, no sentido de manter a homeostase orgânica, é denominada de efeito rebote ou reação paradoxal segundo a racionalidade científica moderna, sendo usada pela homeopatia como resposta terapêutica.
Building a bridge between homeopathic pharmacology (principle of similitude) and modern pharmacology, one can find countless reports in pharmacological compendia and clinical and experimental trials published in the scientific media describing the secondary reaction of the organism opposed to the primary action of the drug, which confirm Hahnemann’s theory. Such secondary action of the organism to preserve organic homeostasis is known in modern science as rebound effect or paradoxical reaction, being used by homeopathy as a therapeutic response.
Marcus Zulian Teixeira
added 4 research items
Seguindo a mesma dinâmica da homeopatia clássica, essa obra sistematiza uma proposta para empregar os fármacos modernos segundo o princípio da similitude terapêutica, estimulando o efeito rebote (reação vital) curativo do organismo através da administração de substâncias (em doses dinamizadas) que despertaram sintomas semelhantes no estado de saúde humano. Vale ressaltar que os efeitos patogenéticos (ações primárias) dos medicamentos homeopáticos clássicos correspondem aos efeitos terapêuticos, adversos e colaterais dos fármacos modernos, os quais devem apresentar uma totalidade sintomática semelhante ao do paciente para estimular a reação vital curativa (efeito rebote curativo), de acordo ao princípio da similitude terapêutica. Para viabilizar essa proposta, foi necessário elaborar uma Matéria Médica Homeopática dos Fármacos Modernos, agrupando os efeitos terapêuticos, adversos e colaterais das drogas conforme a disposição anátomo-funcional dos capítulos das matérias médicas homeopáticas tradicionais, valorizando a frequência de manifestação dos sintomas observadas nas fases de estudo da droga. Como segundo passo, para facilitar a seleção do medicamento individualizado (semelhança com a totalidade de sintomas do paciente) e a aplicação clínica da proposta, foi elaborado um Repertório Homeopático dos Fármacos Modernos, dispondo os sintomas e seus respectivos medicamentos de forma análoga aos repertórios homeopáticos tradicionais, descrito nessa obra.
Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in this work.
Following the pattern of traditional homeopathy, this work proposes to employ modern drugs according to the principle of therapeutic similitude, stimulating the healing rebound effect (vital reaction) of the organism through the administration of substances (in infinitesimal doses) that caused similar symptoms in healthy human. Is worth emphasizing that the pathogenetic effects (primary actions) of classical homeopathic medicines correspond to the therapeutic, adverse and side effects of conventional drugs, which should be similar to totality of the symptoms of the patient to stimulate the curative vital reaction (curative rebound effect) according to the principle of therapeutic similitude. To make this proposal operative, a Homeopathic Materia Medica of Modern Drugs was elaborated, where the therapeutic, adverse and side effects of drugs were grouped following the structure of the traditional homeopathic materia medica, while giving particular value to the frequency of the symptoms observed during the phases of study of the drugs. In order to facilitate the selection of the individualized remedy (i.e., similar to the totality of symptoms of the patient), and thus the clinical application of the present proposal, at a later stage it was also elaborated a Homeopathic Repertory of Modern Drugs, where symptoms and remedies are arranged as in the traditional homeopathic repertories, described in another work.
Marcus Zulian Teixeira
added 5 research items
The principle of the similitude, the basis of homeopathy, has correspondences in the clinical studies of secondary effects of many modern pharmaceutical agents through the observation of the rebound effects of these drugs. Through clinical pharmacology, I proposed a model on which to base the scientificism of the homeopathic model. We have studied the effects of the drugs in the human body using pharmacological compendia and recent scientific works, confirming the mechanism of the homeopathic medicines' action through the verification of the primary action of the drugs and the consequent secondary reaction of the organism in hundreds of pharmaceutical agents. Treatment exploiting the "rebound" effect (curative vital reaction) may also be observed. This work suggests a research methodology to scientifically base the therapeutic principle of similitude.
Marcus Zulian Teixeira
added 7 research items
The homeopathic model of treatment of diseases uses the ‘principle of similarity’ as therapeutic method, employing drugs that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curentur), seeking to stimulate a healing reaction of the organism against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the organism is based on the study of the ‘rebound effect’ of modern drugs, iatrogenic event that can cause serious disorders after the discontinuation of several classes of conventional treatments that use the ‘principle of contraries’ as therapeutic practice (contraria contrariis curentur). Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is unknown by health professionals, depriving the medical class of a necessary and fundamental knowledge to the safe management of drugs. Despite expressing itself in a small proportion of susceptible individuals, the rebound effect assumes epidemiological importance in view of the enormous consumption of drugs by the population and the lack of clarity on the phenomenon. This article presents an updated review on the rebound effect of drugs, relating it to the homeopathic healing principle. RESUMO: O modelo homeopático de tratamento das doenças utiliza o ‘princípio da semelhança’ como método terapêutico, empregando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curentur), com o intuito de estimular uma reação curativa do organismo contra os seus próprios distúrbios. Esta reação secundária (vital, homeostática ou paradoxal) do organismo está fundamentada no estudo do ‘efeito rebote’ dos fármacos modernos, evento adverso que pode causar transtornos graves após a descontinuação de diversas classes de tratamentos convencionais que utilizam o ‘princípio dos contrários’ como prática terapêutica (contraria contrariis curentur). Embora o fenômeno rebote seja um evento adverso estudado pela farmacologia moderna, ele é desconhecido pelos profissionais da saúde, privando a classe médica de um conhecimento necessário e fundamental ao manejo seguro dos fármacos. Apesar de se expressar numa pequena proporção de indivíduos suscetíveis, o efeito rebote assume importância epidemiológica em vista do enorme consumo de medicamentos pela população e da falta de esclarecimentos sobre o fenômeno. Este artigo apresenta uma revisão atualizada sobre o efeito rebote das drogas, relacionando-o ao princípio de cura homeopático.
The homeopathic model applies the secondary action or vital reaction of the organism as a therapeutic method and thus prescribes treatment by similitude, which consists in administering to ill individuals substances that cause similar symptoms in healthy individuals. The vital, homeostatic or paradoxical reaction of the organism might be explained scientifically by means of the rebound effect of modern drugs, which might cause fatal iatrogenic events after discontinuation of antipathic (a term used in alternative medicine for palliative treatment, also known as enantiopathic) treatment. Although the rebound effect is studied by modern pharmacology, it is poorly communicated to and discussed among healthcare professionals, who are thus deprived of information needed for the safe management of modern drugs. This article presents an up-to-date review on the rebound effect of modern drugs that grounds the homeopathic principle of healing and calls the attention of doctors to this type of adverse effect that is usually unnoticed. The rebound effect of modern palliative drugs, which was pointed out by Hahnemann more than two centuries ago, might cause fatal adverse events and is illustrated by the examples of acetylsalicylic acid, anti-inflammatory agents, bronchodilators, antidepressants, statins, proton-pump inhibitors, etc. Although the rebound effect is expressed by a small fraction of (susceptible) individuals and might be avoided by gradual tapering of antipathic drugs, it exhibits epidemiologic importance as a function of the massive use of such palliative drugs and the lack of knowledge in its regard.
Homeopathy is a therapeutic method based on the application of the similitude principle utilizing medicinal substances that awake effects similar to the symptoms being treated. In this process, the organism is stimulated to react against its own disturbances through a vital (secondary or homeostatic) reaction oriented by the primary effects of the drug employed. This effect should have properties similar to the symptom that is being treated and was mentioned by exponents of countless medical schools, along all of the times. Suggested initially by the founder of the Greek medicine, it was enunciated by Hipócrates through the aphorism similia similibus. According to different and peculiar applications, it was mentioned as therapeutic technique by the propagators of the Roman medicine (Erasistrato, Mitridates, Heráclides of Tarento, Nicandro, Celsus, etc.), of the medieval medicine (Basílio Valentino), of the renaissance medicine (Paracelsus) and of the postrenaissance medicine (Sydenham, van Helmont, Stahl, von Haller, Stoerck, Jenner, etc.). At the end of the century XVIII, Hahnemann systematizes the homoeopathic method of treatment of the illnesses in a rational and logical way, that finds, presently, scientific fundamentation in the paradoxical reaction of the classic physiology and in the rebound phenomenon of the modern pharmacology. RESUMO: A homeopatia é um método terapêutico baseado na aplicação do princípio da similitude, utilizando substâncias medicinais que promovem efeitos semelhantes aos sintomas que se deseja tratar. Nesse processo, o organismo é estimulado a reagir contra os seus próprios distúrbios através de uma reação vital (secundária, homeostásica, paradoxal) orientada pelos efeitos primários da droga empregada, com propriedades semelhantes ao mal que se deseja combater. Esse princípio curativo foi citado por expoentes de inúmeras escolas médicas, ao longo de todos os tempos. Sugerido inicialmente pelo fundador da medicina grega, era enunciado por Hipócrates através do aforismo similia similibus. Segundo aplicações distintas e peculiares, foi mencionado como técnica terapêutica pelos propagadores da medicina romana (Erasistrato, Mitridates, Heráclides de Tarento, Nicandro, Celsus, etc.), da medicina medieval (Basilio Valentino), da medicina renascentista (Paracelsus) e da medicina pós-renascentista (Sydenham, van Helmont, Stahl, von Haller, Stoerck, Jenner, etc.). Ao final do século XVIII, Hahnemann sistematiza o método homeopático de tratamento das enfermidades de uma forma lógica e racional, que encontra, atualmente, fundamentação científica na reação paradoxal da fisiologia clássica e no fenômeno rebote da farmacologia moderna.
Marcus Zulian Teixeira
added a research item
Resumo Introdução: O modelo homeopático de tratamento utiliza o ‘princípio dos semelhantes’ como método terapêutico, administrando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curantur), com o intuito de despertar uma reação secundária e curativa do organismo contra os seus próprios distúrbios. Essa reação secundária (vital, homeostática ou paradoxal) do organismo está embasada no ‘efeito rebote’ dos fármacos modernos, evento adverso observado após a descontinuação de diversas classes de drogas que utilizam o ‘princípio dos contrários’ (contraria contrariis curantur) como método terapêutico. Objetivo: Esta revisão visa fundamentar cientificamente o princípio de cura homeopático perante a farmacologia clínica e experimental, através do estudo sistemático do efeito rebote dos fármacos modernos ou reação paradoxal do organismo. Métodos: Empregando como fonte de referência os estudos e revisões sobre o tema que vimos publicando desde 1998, atualizamos os dados acrescentando pesquisas recentes citadas na base de dados PubMed. Resultados: O efeito rebote ocorre após a descontinuação de inúmeras classes de fármacos com ação terapêutica contrária aos sintomas das doenças, exacerbando-os a níveis superiores aos anteriores do tratamento. Independente da doença, da droga, da dose e da duração do tratamento, o fenômeno rebote se manifesta numa pequena proporção de indivíduos suscetíveis. Seguindo as premissas homeopáticas, os fármacos modernos também podem ser utilizados segundo o princípio da similitude terapêutica, empregando o efeito rebote (reação paradoxal) de forma curativa Conclusões: Evidenciado em centenas de estudos que atestam a similaridade de conceitos e manifestações, o efeito rebote dos fármacos modernos fundamenta cientificamente o princípio de cura homeopático. Embora o fenômeno rebote seja um evento adverso estudado pela farmacologia moderna, ele não é conhecido pelos profissionais da saúde, privando a classe médica de um saber indispensável ao manejo seguro dos fármacos. Abstract Introduction: Homeopathy employs the so-called ‘principle of similars’ as therapeutic method, which consists in administering medicines that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curantur)to arouse a secondary and healing reaction by the body against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the body is based on the ‘rebound effect’ of modern drugs, a type of adverse event that occurs following discontinuation of several classes of drugs prescribed according to the ‘principle of contraries’ (contraria contrariis curantur). Aim: The present review sought to scientifically substantiate the homeopathic healing principle vis-à-vis experimental and clinical pharmacology through a systematic study of the rebound effect of modern drugs or paradoxical reaction of the body. Methods: Employing as reference the studies and revisions on the subject that we have published since 1998, we updated the data adding recent studies cited in database PubMed. Results: The rebound effect occurs after discontinuation of several classes of drugs with contrary action to the symptoms of diseases, exacerbating them to levels above the ones present before treatment. Regardless of disease, drug, dose and duration of treatment, the rebound phenomenon manifests in a small proportion of susceptible individuals. Following the homeopathic premises, modern drugs might also be used according to the principle of therapeutic similitude, thus employing the rebound effect (paradoxical reaction) in a curative manner. Conclusions: Evidenced in hundreds of studies that attest to the similarity of concepts and manifestations, the rebound effect of modern drugs scientifically substantiates the principle of homeopathic cure. Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is not known by healthcare professionals, thus depriving doctors of knowledge indispensable for a safe management of drugs.
Marcus Zulian Teixeira
added 3 research items
ABSTRACT: The homeopathic model of treatment of diseases uses the “principle of similarity” as therapeutic proposal, employing drugs that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curentur), seeking to stimulate a healing reaction of the organism against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the organism is based on the study of the ‘rebound effect’ of modern drugs, iatrogenic event that can cause serious disorders after the discontinuation of several classes of conventional treatments that use the “principle of contraries” as therapeutic practice (contraria contrariis curentur). Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is unknown by health professionals, depriving the medical class of a necessary and fundamental knowledge to the safe management of drugs. Despite expressing itself in a small proportion of susceptible individuals, the rebound effect assumes epidemiological importance in view of the enormous consumption of drugs by the population and the lack of clarity on the phenomenon. In addition to substantiate the mechanism of action of homeopathic medicine in the clinical and experimental Pharmacology, the rebound effect of modern drugs can also be used in a curative way, broadening the spectrum of action of homeopathy to numerous diseases and syndromes with hundreds of “new homeopathic medicines”. This proposed use of modern drugs in accordance with the principle of similitude is systematized in a Homeopathic Materia Medica and a Homeopathic Repertory of Modern Drugs, being made available on a bilingual website of free access (www.newhomeopathicmedicines.com). RESUMO: O modelo homeopático de tratamento das doenças utiliza o “princípio da semelhança” como proposta terapêutica, empregando medicamentos que causam determinados sintomas em indivíduos sadios para tratar sintomas semelhantes em indivíduos doentes (similia similibus curentur), com o intuito de estimular uma reação curativa do organismo contra os seus próprios distúrbios. Esta reação secundária (vital, homeostática ou paradoxal) do organismo está fundamentada no estudo do ‘efeito rebote’ dos fármacos modernos, evento adverso que pode causar transtornos graves após a descontinuação de diversas classes de fármacos modernos que utilizam o “princípio dos contrários” como proposta terapêutica (contraria contrariis curentur). Embora o fenômeno rebote seja um evento adverso estudado pela farmacologia moderna, ele é desconhecido pelos profissionais da saúde, privando a classe médica de um conhecimento necessário e fundamental ao manejo seguro das drogas. Apesar de se expressar numa pequena proporção de indivíduos suscetíveis, o efeito rebote assume importância epidemiológica em vista do enorme consumo de medicamentos pela população e da falta de esclarecimentos sobre o fenômeno. Além de fundamentar o mecanismo de ação do medicamento homeopático perante a farmacologia clínica e experimental, o efeito rebote dos fármacos modernos também pode ser empregado de forma curativa, ampliando o espectro de ação da homeopatia perante inúmeras doenças e síndromes modernas com centenas de “novos medicamentos homeopáticos”. Esta proposta de emprego das drogas modernas em conformidade com o princípio da similitude está sistematizada em uma Matéria Médica Homeopática e um Repertório Homeopático dos Fármacos Modernos, sendo disponibilizado num site bilingue de livre acesso (www.novosmedicamentoshomeopaticos.com).
When Samuel Hahnemann systematized the homeopathy and the effects of drugs on the state of human health, he described a primary action of a drug, which is followed by a secondary and opposite action of the organism. Seeking to employ such secondary action or vital reaction of the organism as a therapeutic method, he stipulated the principle of similitude, namely to administer to ill individuals the drugs that cause similar symptoms in healthy individuals (similia similibus curentur). In modern pharmacology, the secondary action (vital reaction) is known as rebound effect or paradoxical reaction of the organism. It has been observed after the discontinuation of several classes of palliative (enantiopathic) drugs, i.e. those that act according to the principle of contrary (contraria contrariis curentur). Besides to being able to cause severe and fatal iatrogenic events when appearing after the palliative use of modern drugs (principle of contrary), the rebound effect might awaken a healing reaction if the very same drugs involved were employed according to the principle of similitude. The validity of the principle of similitude is demonstrated in the scientific evidence of the rebound effect of modern drugs, and it is proposed the homeopathic employment of conventional drugs using their primary actions (therapeutic, adverse and side effects) as pathogenetic manifestations. For this purpose and using as database the monographs described in The United States Pharmacopeia Dispensing Information, it was elaborated a homeopathic materia medica and repertory of 1251 modern drugs, which follow the traditional systematic of the homeopathic model (www.newhomeopathicmedicines.com). In this way, the therapeutic scope of homeopathy is broadened through the addition of thousands of new medicines that can be employed in every kind of disease, including the countless modern clinical syndromes.
Resumo Objetivo: Avaliar a eficácia e a segurança do estrogênio potencializado em comparação com o placebo no tratamento homeopático da dor pélvica associada à endometriose (DPAE). Desenho do estudo: Ensaio randomizado, duplo-cego e placebo-controlado de 24 semanas de duração, que incluiu 50 mulheres com idade entre 18-45 anos de idade, diagnóstico de endometriose infiltrativa profunda com base em ressonância magnética nuclear ou ultrassonografia transvaginal após preparo intestinal e escore ≥ 5 na escala analógica visual (EAV: intervalo de 0 a 10 pontos) para DPAE. Estrogênio potencializado (12cH, 18cH e 24cH) ou placebo foi administrado 2 vezes ao dia por via oral. A medida de desfecho primário foi a mudança na severidade da DPAE com base no escore global e parcial (EAV) entre as semanas 0-24, determinado pela diferença entre a pontuação média de 5 modalidades de dor pélvica crônica (dismenorreia, dispareunia de profundidade, dor pélvica acíclica, dor intestinal cíclica e/ou dor urinária cíclica). Os desfechos secundários foram: diferença nos escores médios para qualidade de vida (SF-36), sintomas de depressão (Inventário de Depressão de Beck, IDB) e sintomas de ansiedade (Inventário de Ansiedade de Beck, IAB). Resultados: O escore global da DPAE (EAV: intervalo de 0 a 50 pontos) diminuiu 12,82 pontos (p< 0,001) no grupo tratado com o estrogênio potencializado (dinamizado) entre as semanas 0-24. O grupo que usou o estrogênio potencializado também exibiu redução nos escores parciais (EAV: intervalo de 0 a 10 pontos) de 3 modalidades de DPAE: dismenorreia (3,28; p< 0,001), dor pélvica acíclica (2,71; p= 0,009) e dor intestinal cíclica (3,40; p< 0,001). O grupo placebo não apresentou quaisquer alterações significativas nos escores global ou parciais da DPAE. Além disso, o grupo com estrogênio potencializado mostrou melhora significativa em 3 dos 8 domínios do SF-36 (dor corporal, vitalidade e saúde mental) e nos sintomas de depressão (IDB). O grupo placebo não mostrou qualquer melhora significativa nesses desfechos secundários. Esses resultados demonstraram a superioridade do estrogênio potencializado em comparação ao placebo. Alguns efeitos adversos foram associados com o estrogênio dinamizado. Conclusões: Estrogênio potencializado (12cH, 18cH e 24cH) na dose de 3 gotas 2 vezes ao dia durante 24 semanas foi significativamente mais eficaz que o placebo na redução da dor pélvica associada à endometriose. Registro do estudo: ClinicalTrials.gov Identificador: NCT02427386. Abstract Objective: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). Study design: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score ≥ 5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI). Results: The EAPP global score (VAS: range 0 to 50) decreased by 12.82 (P < 0.001) in the group treated with potentized estrogen from baseline to week 24. Group that used potentized estrogen also exhibited partial score (VAS: range 0 to 10) reduction in three EAPP modalities: dysmenorrhea (3.28; P < 0.001), non-cyclic pelvic pain (2.71; P = 0.009), and cyclic bowel pain (3.40; P < 0.001). Placebo group did not show any significant changes in EAPP global or partial scores. In addition, the potentized estrogen group showed significant improvement in three of eight SF-36 domains (bodily pain, vitality and mental health) and depression symptoms (BDI). Placebo group showed no significant improvement in this regard. These results demonstrate superiority of potentized estrogen over placebo. Few adverse events were associated with potentized estrogen. Conclusions: Potentized estrogen (12cH, 18cH and 24cH) at a dose of 3 drops twice daily for 24 weeks was significantly more effective than placebo for reducing endometriosis-associated pelvic pain. Trial registration: ClinicalTrials.gov Identifier: NCT02427386. //
Marcus Zulian Teixeira
added a research item
Homeopathy is based on the law of similarity, which tells us that the use of drugs that produce symptoms similar to those of diseases stimulates the body’s reaction to relieve their own ailments. Homeopathic treatment can use all kinds of substances (natural or synthetic, in weight or infinitesimal doses) provided that this principle is respected. Based on the above, since 2003 we have proposed the use of modern drugs according to the homeopathic healing principle both through research and publications in scientific journals, and the development of a Homeopathic Materia Medica Modern Drugs, which includes the primary effects of 1,250 allopathic drugs, and a Homeopathic Repertory of Modern Drugs. These efforts are part of the New Homeopathic Medicine project: Use of Modern Drugs according to the Principle of Similarity, which can be consulted free of charge, in Portuguese and English, on the website www.newhomeopathicmedicines.com. Now, the clinical and scientific validity of this proposal has begun with the performance of a clinical trial to evaluate the efficacy and safety of energized estrogen in the homeopathic treatment of pelvic pain associated with endometriosis. The result has been positive, but it requires doctors, pharmacists and researchers to join this initiative to strengthen it and boost its growth.//////////// Resumen La Homeopatía se fundamenta en la ley de semejanza, la cual nos dice que el empleo de medicamentos que producen síntomas similares a los de las enfermedades estimula la reacción del organismo para aliviar sus propias dolencias. El tratamiento homeopático puede emplear toda clase de sustancias (naturales o sintéticas, en dosis ponderales o infinitesimales) siempre que se respete dicho principio. Con base en lo anterior, desde 2003 hemos propuesto el uso de fármacos modernos según el principio homeopático de curación tanto a través de investigaciones y publicaciones en revistas científicas, como de la elaboración de una Materia Médica Homeopática de Fármacos Modernos, que incluye los efectos primarios de 1,250 fármacos alopáticos, y un Repertorio Homeopático de Fármacos Modernos. Estos esfuerzos forman parte del proyecto Nuevos Medicamentos Homeopáticos: Uso de Fármacos Modernos según el Principio de Semejanza, que puede consultarse de manera gratuita, en portugués e inglés, en el sitio web www.nuevosmedicamentoshomeopaticos. com. Ahora, la validez clínica y científica de esta propuesta ha comenzado con la realización de un ensayo clínico para evaluar la eficacia y la seguridad del estrógeno dinamizado en el tratamiento homeopático del dolor pélvico asociado a la endometriosis. El resultado ha sido positivo, pero se requiere que médicos, farmacéuticos e investigadores se sumen a esta iniciativa para robustecerla e impulsar su crecimiento.
Marcus Zulian Teixeira
added 2 research items
Introduction: Homeopathy employs the so-called ‘principle of similars’ as therapeutic method, which consists in administering medicines that cause certain symptoms in healthy individuals to treat similar symptoms in sick individuals (similia similibus curantur)to arouse a secondary and healing reaction by the body against its own disorders. This secondary (vital, homeostatic or paradoxical) reaction of the body is based on the ‘rebound effect’ of modern drugs, a type of adverse event that occurs following discontinuation of several classes of drugs prescribed according to the ‘principle of contraries’ (contraria contrariis curantur). Aim: The present review sought to scientifically substantiate the homeopathic healing principle vis-à-vis experimental and clinical pharmacology through a systematic study of the rebound effect of modern drugs or paradoxical reaction of the body. Methods: Employing as reference the studies and revisions on the subject that we have published since 1998, we updated the data adding recent studies cited in database PubMed. Results: The rebound effect occurs after discontinuation of several classes of drugs with contrary action to the symptoms of diseases, exacerbating them to levels above the ones present before treatment. Regardless of disease, drug, dose and duration of treatment, the rebound phenomenon manifests in a small proportion of susceptible individuals. Following the homeopathic premises, modern drugs might also be used according to the principle of therapeutic similitude, thus employing the rebound effect (paradoxical reaction) in a curative manner. Conclusions: Evidenced in hundreds of studies that attest to the similarity of concepts and manifestations, the rebound effect of modern drugs scientifically substantiates the principle of homeopathic cure. Although the rebound phenomenon is an adverse event studied by modern pharmacology, it is not known by healthcare professionals, thus depriving doctors of knowledge indispensable for a safe management of drugs.
Objective: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). Study design: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score ≥ 5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI). Results: The EAPP global score (VAS: range 0 to 50) decreased by 12.82 (P < 0.001) in the group treated with potentized estrogen from baseline to week 24. Group that used potentized estrogen also exhibited partial score (VAS: range 0 to 10) reduction in three EAPP modalities: dysmenorrhea (3.28; P < 0.001), non-cyclic pelvic pain (2.71; P = 0.009), and cyclic bowel pain (3.40; P < 0.001). Placebo group did not show any significant changes in EAPP global or partial scores. In addition, the potentized estrogen group showed significant improvement in three of eight SF-36 domains (bodily pain, vitality and mental health) and depression symptoms (BDI). Placebo group showed no significant improvement in this regard. These results demonstrate superiority of potentized estrogen over placebo. Few adverse events were associated with potentized estrogen. Conclusions: Potentized estrogen (12cH, 18cH and 24cH) at a dose of 3 drops twice daily for 24 weeks was significantly more effective than placebo for reducing endometriosis-associated pelvic pain. Trial registration: ClinicalTrials.gov Identifier: NCT02427386.
Marcus Zulian Teixeira
added a research item
The homeopathic treatment is based on the principle of therapeutic similitude, employing medicines that cause certain disorders to treat similar manifestations, stimulating a reaction of the organism against its own ailments. The occurrence of this secondary reaction of the organism, opposite in nature to the primary action of the medicines, is evidenced in the study of the rebound (paradoxical) effect of several classes of modern drugs. In this work, in addition to substantiate the principle of similitude before the experimental and clinical pharmacology, we suggest a proposal to employ hundreds of conventional drugs according to homeopathic method, applying the therapeutic similitude between the adverse events of medicines and the clinical manifestations of patients. Describing existing lines of research and a specific method for the therapeutic use of the rebound effect of modern drugs (http://www.newhomeopathicmedicines.com), we hope to minimize prejudices related to the homeopathy and contribute to a broadening of the healing art.
Marcus Zulian Teixeira
added a research item
Objective: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP). Study design: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score ≥ 5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI). Results: The EAPP global score (VAS: range 0 to 50) decreased by 12.82 (P < 0.001) in the group treated with potentized estrogen from baseline to week 24. Group that used potentized estrogen also exhibited partial score (VAS: range 0 to 10) reduction in three EAPP modalities: dysmenorrhea (3.28; P < 0.001), non-cyclic pelvic pain (2.71; P = 0.009), and cyclic bowel pain (3.40; P < 0.001). Placebo group did not show any significant changes in EAPP global or partial scores. In addition, the potentized estrogen group showed significant improvement in three of eight SF-36 domains (bodily pain, vitality and mental health) and depression symptoms (BDI). Placebo group showed no significant improvement in this regard. These results demonstrate superiority of potentized estrogen over placebo. Few adverse events were associated with potentized estrogen. Conclusions: Potentized estrogen (12cH, 18cH and 24cH) at a dose of 3 drops twice daily for 24 weeks was significantly more effective than placebo for reducing endometriosis-associated pelvic pain. Trial registration: ClinicalTrials.gov Identifier: NCT02427386.
Marcus Zulian Teixeira
added a project goal
The homeopathic method of healing is grounded on the application of the principle of therapeutic similitude (similia similibus curentur) by using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism against its own disturbs. Such vital, homeostatic or paradoxical reaction of the organism can be scientifically explained on the basis of the rebound effect of modern drugs. This work presents the conclusion of a study aiming at a method to use modern drugs with homeopathic criteria. This claim is epistemologically justified by the fact that a definite class of adverse events described by experimental pharmacology represents actual pathogenetic symptoms of drugs. On these grounds it was possible to elaborate a homeopathic materia medica and repertory comprising 1,251 modern drugs to be employed according to the principle of similitude and the individualizing symptomatic totality. Besides supplying a basis for homeopathy as a medical rationality regarding scientific pharmacology, this study makes available a method that may broaden the scope of intervention of homeopathy in present day diseases. Available at: www.newhomeopathicmedicines.com
O método de tratamento homeopático se baseia na aplicação do princípio da similitude (similia similibus curentur), utilizando medicamentos que causam efeitos semelhantes aos sintomas da doença, com o objetivo de estimular uma reação do organismo contra seus próprios distúrbios. Essa reação vital, homeostática ou paradoxal do organismo está cientificamente embasada no estudo do efeito rebote das drogas modernas. Nesse trabalho, estamos concluindo uma proposta antiga, na qual sugerimos um método para a utilização homeopática das drogas modernas. Apoiados na justificativa epistemológica de que determinada classe de eventos adversos descritos na farmacologia experimental são sintomas patogenéticos das substâncias, foi elaborada uma Matéria Médica e um Repertório Homeopático com 1251 drogas modernas, sugerindo sua utilização segundo o princípio da similitude e a totalidade sintomática individualizante. Além de embasar a racionalidade homeopática perante a farmacologia científica, estamos disponibilizando uma metodologia que poderá ampliar o espectro de ação da homeopatia nas doenças atuais. Disponível em: www.novosmedicamentoshomeopaticos.com