Project

Influence of whole-body cryostimulation on homeostatis of patients with ankylosing spodnylitis

Updates
0 new
0
Recommendations
0 new
0
Followers
0 new
10
Reads
0 new
89

Project log

Agata Stanek
added a research item
Objective The aim of the study was to estimate the impact of whole body cryotherapy (WBC) on oxidative stress when performed in a closed cryochamber on patients with ankylosing spondylitis (AS). Material and methods The effect of ten WBC procedures lasting 3 minutes a day with a subsequent 60-minute session kinesiotherapy on oxidative stress in male AS patients (WBC group n = 16) was investigated. To assess the disease activity, the Bath Ankylosing Spondylitis Diseases Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were calculated. The WBC group was compared to the kinesiotherapy only (KT; n = 16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) were estimated one day before the beginning and one day after the completion of the research program. Results After the completion of the treatment in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant status were observed. The erythrocyte activity of glutathione peroxidase, glutathione reductase decreased significantly in both groups, but the differences of activity of that enzymes prior to post treatment values (Δ) in the KT group were significantly higher as compared to the WBC group. The activity of erythrocyte catalase and plasma ZnCu isoenzyme of superoxide dismutase showed a decreased tendency; erythrocyte total superoxide dismutase activity showed an increased tendency in the WBC group after the completion of the treatment. The BASDAI and BASFI decreased significantly in both groups, but the differences of value indexes prior to post treatment (Δ) were significantly higher in the WBC than KT group. Conclusion WBC performed in a closed cryochamber decreases oxidative stress and improves BASDAI and BASFI indexes in male patients during the active phase of ankylosing spondylitis.
Tomasz Wielkoszyński
added 2 research items
Background. Whole-body cryostimulation (WBC) is the therapeutic exposure of the total human body (without underwear) to a very low temperature (below –100°C) for 120–180 s. Currently, WBC is used more frequently not only in the treatment of patients suffering from various diseases, but also by healthy people as a wellness method. Objectives. The aim of this research is to evaluate the impact of WBC procedures on oxidative stress parameters in healthy men. Material and Methods. The study involved 32 healthy male subjects who were randomly divided into 2 groups: 16 men exposed to WBC procedures with subsequent kinesiotherapy (WBC group) and 16 men exposed only to kinesiotherapy procedures (KT group). Depending on the group, the subjects were exposed to 10 daily WBC procedures lasting 3 min, with a subsequent 60-min of kinesiotherapy, or exclusively to kinesiotherapy. In subjects from both groups, a day before the beginning of a cycle of treatment and a day after its completion, the level of selected indicators of oxidative stress and non-enzymatic antioxidants, as well as the activity of antioxidant enzymes in serum, plasma and erythrocyte lysates were determined. Results. In the WBC group subjects, we recorded a statistically significant decrease in the concentrations of most of the parameters of oxidative stress with an accompanying increase in plasma concentrations of non-enzymatic antioxidants (total antioxidant status and uric acid). We recorded no significant changes in the activities of antioxidant enzymes (plasma total superoxide dismutase (SOD) and its isoenzymes SOD-Mn and SOD-ZnCu, erythrocyte catalase, glutathione peroxidase and glutathione reductase). Conclusions. The results we obtained confirmed that WBC decreases oxidative stress in healthy men.
Objective The primary aim of the study was to assess levels of oxidative stress markers, soluble CD40 ligand (sCD40L), serum pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF) as well as carotid intima-media thickness (IMT) in patients with ankylosing spondylitis (AS) with active phase without concomitant classical cardiovascular risk factors. Material and methods The observational study involved 96 male subjects: 48 AS patients and 48 healthy ones, who did not differ significantly regarding age, BMI, comorbid disorders, and distribution of classical cardiovascular risk factors. In both groups, we estimated levels of oxidative stress markers, lipid profile, and inflammation parameters as well as sCD40L, serum PAPP-A, and PlGF. In addition, we estimated carotid IMT in each subject. Results The study showed that markers of oxidative stress, lipid profile, and inflammation, as well as sCD40L, PlGF, and IMT, were significantly higher in the AS group compared to the healthy group. Conclusion Our results demonstrate that ankylosing spondylitis may be associated with increased risk for atherosclerosis.
Agata Stanek
added 3 research items
Abstract: The aim of this study was to estimate the influence of whole-body cryotherapy on blood morphology parameters in patients with ankylosing spondylitis and healthy volunteers exposed to cryotherapy as a method of biological restitution. Subjects from both groups were exposed to a cycle of 10 daily, 2 minute-lasting whole-body cryotherapy procedures (at a temperature of -120ºC) with subsequent 60 minute-lasting kinesitherapy. A day before the beginning of cryotherapy procedures and once more after the end therapeutic cycle the following parameters of blood cell count were estimated: leukocytes count with differential cell count, erythrocytes count, platelets count, hemoglobin concentration, hematocrit value and erythrocyte indexes (MCV, MCH, MCHC). In patients with ankylosing spondylitis after the end of a cycle of whole-body cryotherapy a significant decrease in hematocrit value and MCV as well as an increase in MCHC were observed. On the other hand in healthy volunteers a significant increase in erythrocytes, hemoglobin concentration, hematocrit value and MCV, decrease in MCHC as well as an increase in platelets count and proportion of monocytes in differential cell count. On the basis of obtained results it was concluded that whole-body cryotherapy evokes only a slight changes in blood morphology parameters within the range of reference values, different in patients with ankylosing spondylitis and healthy volunteers. In patients with ankylosing spondylitis it seems to be a safe method leading to improvement of rheologic properties of blood.
Background. The aim of this study was to estimate the influence of whole-body cryotherapy on some selected parameters of the circulatory system. Material and methods. The investigation involved 7 male patients with ankylosing spondylitis. They were exposed to a cycle of 10 everyday 2 minute-lasting procedures of whole-body cryotherapy at a temperature of-130°C which was followed by subsequent kinesitherapy. Patients treated with drugs influencing the circulatory system and suffering from circulation and hormonal system disorders were excluded. During the day preceding the beginning ď cryotherapy procedures and once more, after finishing whole-body cryotherapy cycle, echocardiography with calculation of left ventricle ejection fraction (LVET), record and analysis of heart rate variability (HRV), late ventricular potentials and QT dispersion were made. Results. No significant differences between ejection fraction, late ventricular potentials, QT dispersion values before and afler the end of cryotherapy cycle were found. Whole-body cryotherapy evoked increase in total heart rate variability, which was statistically significant for most ofthe parameters in time analysis. Spectrum analysis showed statistically insignificant increase in spectrum power in the full range of analyzed frequencies. Conclusions. Long-lasting whole-body cryotherapy does not influence ejection fraction, late ventricular potentials and QT dispersion in patients without significant pathology of circulation. Cryogenic temperatures applied on the whole-body exerts beneficial influence of whole-body cryotherapy on adaptive processes of vegetative nervous system.
Objective The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion WBC appears to be a useful method of atherosclerosis prevention in AS patients.
Agata Stanek
added 2 research items
In recent years whole-body cryotherapy is considered as one of effective methods of physical medicine in the treatment of many diseases, especially of locomotory system. In this paper the recapitulation of own studies dealing with the effect of cryogenic temperatures in the form of whole-body application in patients with ankylosing spondylitis is presented.
Background. The aim of our study was to assess the impact of whole-body cryotherapy with subsequent kinesitherapy on spinal mobility parameters in patients with ankylosing spondylitis. Material and methods. We enrolled 32 men with ankylosing spondylitis in a clinical trial. The subjects were randomly divided into 2 groups consisting of 16 persons, with no significant differences in age, duration, or stage of disease, treated with a cycle of 10 whole-body cryotherapy procedures with subsequent kinesitherapy or kinesitherapy alone, respectively. Routine spinal mobility parameters were determined for all patients before and after the end of the therapeutic cycle. Results. Significant improvement of spinal mobility was observed in both groups of patients, but in patients exposed to whole-body cryotherapy with subsequent kinesitherapy the percentage changes in the values of particular parameters were more distinct as compared to patients in whom kinesitherapy alone was used, mainly in respect to lumbar and thoracic spinal mobility. Conclusion. The use of whole-body cryotherapy as a component of comprehensive therapy in patients with ankylosing spondylitis produces significant improvements in spinal mobility parameters as compared to patients in whom kinesitherapy alone is used.
Agata Stanek
added a research item
Background. Currently, one of the therapeutic methods of physical medicine applied in physiotherapeutic treatment of patients with ankylosing spondylitis is the whole-body cryotherapy - the short appliance of temperatures lower than -100°C in order to trigger physical reactions in response to cold as an adjunctive method in better preparation of patients for kinesiotherapy. The aim of the study was to assess the analgesic effect of the whole-body cryotherapy in patients with ankylosing spondylitis. Material and methods. 32 males with ankylosing spondylitis were subjected to the trial, who were divided randomly into two 16-person groups, which did not different significantly with regard to age, duration and severity of the disease. The groups underwent ten whole-body cryotherapy with subsequent kinesiotherapy procedures or only 10 kinesiotherapy procedures, respectively. On the first day before the treatment cycle beginning and the first day after treatment completion the patients assess the pain intensity by means of 10-point visual analogue scale (VAS). Results. In patients with ankylosing spondylitis after the completion of a cycle of whole-body cryotherapy procedures the significant reduction of pain intensity amounted to 46% in average (p<0,05) was observed. Conclusion. Whole-body cryotherapy procedures demonstrate a significant analgesic effect in patients with ankylosing spondylitis
Agata Stanek
added 6 research items
Background. Whole-body cryotherapy with subsequent kinesiotherapy evokes the positive anti-inflammatory effect in case of patients with locomotor system inflammatory disorders, however the mechanism of this effect has not been satisfactory explained so far. One of the essential laboratory indicators of the inflammatory process activity is the distribution of the serum protein fractions. The aim of the study was to determine the influence of the whole-body cryotherapy on proteinogram parameters in the patients with ankylosing spondylitis. Material and methods. 32 males with ankylosing spondylitis were subjected to the trial, who were divided randomly into two 16-person groups, which did not different significantly with regard to age, duration and severity of the disease. The groups underwent ten whole-body cryotherapy with subsequent kinesiotherapy procedures or only 10 kinesiotherapy procedures, respectively. On the first day before the treatment cycle beginning and the first day after treatment completion the blood samples were collected from the patients in order to determine the total protein concentrations and share of particular protein fractions in serum. Results. in patients with ankylosing spondylitis after the completion of a cycle of whole-body cryotherapy treatment a statistically significant increase in alpha2-globulins share and decrease in beta1-globulins share in serum proteinogram were observed. Conclusions. In patients with ankylosing spondylitis whole-body cryotherapy treatment corrects the proteinogram differently from kinesitherapy. The changes of share of particular proteinogram fractions in patients subjected to cryotherapy are the most probably related to anti-inflammatory and anti-oxidative action of cryogenic temperatures.