Project

Genomic Homeopathy: isopathic use of auto-sarcode of DNA (auto-isotherapic of DNA) as homeopathic therapeutic modulator of gene expression in the management of chronic diseases

Goal: The homeopathic philosophical vitalist conception considers vital force dystonia as the primary cause of diseases, while the return to health status would occur by vital rebalancing. The homeopathic model expands understanding of the etiopathogenic dynamics, and also considers the manifestation of chronic miasmas (manifest psora) as a fundamental cause of chronic diseases in general, while health restoration would occur through modulating this miasmatic manifestation (latent psora).
According to the biomedical etiopathogenic process, the primary cause of diseases is the expression of genes responsible for the respective physiological disorders, considering the manifestation of disease-promoting epigenetic alterations as a fundamental cause of chronic diseases in general. The return to health status would occur through modulating these epigenetic manifestations and consequent inhibition of pathological gene expression.
Due to presenting similar characteristics and properties, we have suggested in recent studies the philosophical-scientific correlations between vital force and genome (exome plus epigenome) and between chronic miasms and disease-promoting epigenetic alterations, meaning that the genome would be the biological representation of organic vital force, and disease-promoting epigenetic alterations would be the biological representation of chronic miasms.
The properties and functions of the telomere-telomerase complex expand understanding of the gene expression mechanism at the chromosome level (DNA molecule or genomic unit), and reiterate the philosophical-scientific correlations between the vital principle and the genome in view of its recognized role as a biomarker of cellular vitality, biological aging and the health-disease process. In this context, telomere length would indicate the organic vital force state and could be used in the diagnosis and prognosis of diseases according to the vitalist approach, expanding the spectrum and scope of classical homeopathic semiology.
In accordance with these hypotheses, the isopathic use of auto-sarcode of DNA (auto-isotherapic of DNA) could act on the imbalance of the vital principle or genome and in the chronic miasmas or disease-promoting epigenetic alterations as homeopathic therapeutic modulator of gene expression in the management of chronic diseases.
Available at: https://www.homeozulian.med.br/homeozulian_autoisoterapicos_dna.asp

Date: 28 March 2018

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Marcus Zulian Teixeira
added a research item
The aging process occurs due to the decline of vital physiological functions and adaptability of the body, being influenced by genetics and lifestyle. With advances in genetics, biological aging can be calculated by telomere length. Telomeres are regions at the ends of chromosomes that play a role in the maintenance and integrity of DNA. With biological aging, telomere shortening occurs, causing cellular senescence. Several studies show that shorter telomeres are associated with acute and chronic diseases, stress, addictions, and intoxications. Even in the current COVID-19 pandemic, telomere shortening is proposed as a marker of severity in individuals infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On the other hand, healthy lifestyle habits increase telomere length and balance of various cellular functions, preventing diseases.
Marcus Zulian Teixeira
added a research item
Background: Philosophical–scientific correlations described in previous studies suggest that the genome can be the biological representation of the vital force, whilst the disease-promoting epigenetic alterations would be the biological representation of the chronic miasmas. In this study, we expand the functional correlation between vital force and chromosomes, describing the mechanism of action of the telomere–telomerase complex in the context of physiological balance. Aims: The aim of the work is to study the role of the telomere–telomerase complex in cell vitality, biological aging, and the health-disease process, with the goal of proposing the use of telomere length as a biomarker of the vital force state and the effectiveness of homeopathic treatment. Results: Similar to the vital force, telomere length and telomerase enzyme activity play an important role in maintaining cellular vitality, biological longevity, and physiological homeostasis. Telomere shortening functions as a biomarker of vital imbalance and is associated with numerous diseases and health disorders. On the other hand, health-promotion practices neutralize the pathological shortening of the telomeres, acting therapeutically in diseases or age-dependent health disorders. Conclusions: As a hypothetical biomarker of the vital force state, an intra-individual analysis of the mean leukocyte telomere length before, during, and after homeopathic treatment can be used as a biomarker of therapeutic effectiveness.
Marcus Zulian Teixeira
added 2 research items
Since homeopathy is based on the vitalist medical model, concepts such as vital force, mind, soul, spirit, etc., referring to the immaterial human nature, are frequently cited, making their understanding indispensable. Based on the works of Samuel Hahnemann, founder of homeopathy, including his minor writings and letters, this work seeks to clarify these conceptions, in order to dissolve doctrinal confusions. In this study, the concept of ‘instinctive and irrational vital force’, analogous to the Hippocratic ‘vis medicatrix naturae’, becomes clear, forming a substantial compound with the physical body and a nature distinct from the intelligent spirit. As another entity distinct from the previous ones, Hahnemann also mentions the mind, seat of the soul, as ‘physical organs almost non-material, of higher hierarchy’, attributing to the human psyche the greatest influence in the binomial health-disease, referring to the moral and ethics as preventive and curative factors for diseases that affect humanity. He criticizes scholasticism and the excess of metaphysical speculations, moving away from any philosophical or religious current, offering us universal spiritualist concepts within moral and ethical principles, further enhancing his work and demonstrating that he is a prejudice-free observer. For Hahnemann, the physical body forms a substantial unity with the vital principle, and not with the soul, being commanded by the intelligent spirit that in him dwells. The mind, as a psychic organ, assumes an important role in the relationship between these entities that make up the human being.
Since homeopathy is based on the vitalist medical model, concepts such as vital force, mind, soul, spirit, etc., referring to the immaterial human nature, are frequently cited, making their understanding indispensable. Based on the works of Samuel Hahnemann, founder of homeopathy, including his minor writings and letters, this work seeks to clarify these conceptions, in order to dissolve doctrinal confusions. In this study, the concept of ‘instinctive and irrational vital force’, analogous to the Hippocratic ‘vis medicatrix naturae’, becomes clear, forming a substantial compound with the physical body and a nature distinct from the intelligent spirit. As another entity distinct from the previous ones, Hahnemann also mentions the mind, seat of the soul, as ‘physical organs almost non-material, of higher hierarchy’, attributing to the human psyche the greatest influence in the binomial health-disease, referring to the moral and ethics as preventive and curative factors for diseases that affect humanity. He criticizes scholasticism and the excess of metaphysical speculations, moving away from any philosophical or religious current, offering us universal spiritualist concepts within moral and ethical principles, further enhancing his work and demonstrating that he is a prejudice-free observer. For Hahnemann, the physical body forms a substantial unity with the vital principle, and not with the soul, being commanded by the intelligent spirit that in him dwells. The mind, as a psychic organ, assumes an important role in the relationship between these entities that make up the human being.
Marcus Zulian Teixeira
added a research item
The aging process occurs due to the decline of physiological functions and the ability of the organism to adapt, being influenced by genetics and lifestyle. Currently, with advances in genetics, biological aging can be calculated by the telomere length (‘telomere lenght’). Telomeres are regions at the ends of chromosomes that play a role in the maintenance and integrity of DNA. With biological aging, telomere shortening occurs, causing cellular senescence. Numerous studies show that shorter telomeres are associated with chronic diseases, addictions and intoxications. On the other hand, healthy living habits promote the increase of telomere length and the balance of the different cellular functions, preventing diseases. Thus, telomeres function as a biomarker of the vitality of the organism. // Resumen: El proceso de envejecimiento se produce por la disminución de las funciones fisiológicas y de la capacidad de adaptación del organismo, siendo influenciado por la genética y el estilo de vida. Actualmente, con los avances de la genética, el envejecimiento biológico se puede calcular por la longitud de los telómeros (‘telomere lenght’). Los telómeros son regiones en los extremos de los cromosomas que juegan un papel en el mantenimiento y la integridad del ADN. Con el envejecimiento biológico, se produce el acortamiento de los telómeros, causando la senescencia celular. Numerosos estudios evidencian que telómeros más cortos están asociados a enfermedades crónicas, a vicios y a intoxicaciones. Por otro lado, hábitos de vida saludables propician el aumento de la longitud de los telómeros y el equilibrio de las diversas funciones celulares, previniendo enfermedades. Por lo tanto, los telómeros funcionan como un biomarcador de la vitalidad del organismo.
Marcus Zulian Teixeira
added a research item
Enquanto a epidemiologia estuda a distribuição e os determinantes das doenças ou condições relacionadas à saúde em populações específicas, a epidemiologia clínica se ocupa da prática clínica através do estudo da variação e dos determinantes da evolução da doença. Epidemiologia clínica é uma ciência que visa fazer predições sobre pacientes individuais através de estudos em grupos de pacientes similares, analisando eventos clínicos semelhantes e usando métodos científicos sólidos que assegurem maior veracidade ('certeza') nas conclusões. O objetivo da epidemiologia clínica é desenvolver e aplicar métodos de observação clínica que permitam predições seguras, evitando ser enganado por erros sistemáticos (vieses) ou erros aleatórios (acaso), ajudando o médico a tomar decisões acertadas no cuidado dos pacientes, aperfeiçoando a prática clínica. Nessa primeira palestra, direcionando o estudo para os fundamentos da epidemiologia clínica e sua aplicação no desenho de estudos epidemiológicos em homeopatia, abordamos os seguintes tópicos: - Epidemiologia clínica: premissas para a elaboração de estudos epidemiológicos. - Tipos de estudos epidemiológicos. - Epidemiologia clínica homeopática: premissas para a elaboração de estudos epidemiológicos. - Tipos de estudos epidemiológicos homeopáticos.
Marcus Zulian Teixeira
added a research item
Introduction: In homeopathic philosophy, vital force is a non-material substrate that is responsible for maintaining the body’s sensations and functions and where homeopathic medicines act. In genetics, the body’s vital functions are controlled by biochemical information, which is contained in the cell genome and consists of a protein encoding portion (exome) and another that regulates this encoding scheme (epigenome). Both the philosophical vital force and the genome present properties of complex and dynamic self-organisation systems. Aims: This study aimed to explore and develop a philosophical-scientific correlation between vitalism and genetics according to the complexity paradigm. Results: Vital principle and genome present inseparable composition among distinct existing components that influence one another and form a network of connections that create complex and dynamic self-organisation behaviour. Described in both models, ‘vortex’ indicates the existence of a force coming from within the system that is externalised as an emergent, information-transmitting phenomenon. Supporting this correlation, some experimental studies show that homeopathic medicines act on the genome by modulating gene expression. Conclusions: In line with the similarity of existing characteristics and properties, the genome may be considered as hypothetical biological substrate of organic vital force.
Marcus Zulian Teixeira
added 8 research items
Antropologia é a ciência que tem como objetivo estudar o homem em sua pluralidade de modos de vida e de pensamento, incorporando os diversos aspectos da individualidade às suas modalidades de estudo (biológica, social, cultural e filosófica). Por sua vez, a Antropologia Médica estuda os fatores que influenciam o processo saúde-doença, incluindo os aspectos biossocioculturais e os variados sistemas de saúde. Seguindo o objetivo intrínseco de estudar o homem em sua pluralidade, a Antropologia Médica Vitalista fornece subsídios filosóficos para uma ampliação do entendimento do processo de adoecimento, analisando o mecanismo saúde-doença em conformidade com a estrutura ontológica humana. Fundamentando o diagnóstico e o tratamento das doenças em diversas racionalidades médicas não convencionais (Medicina Tradicional Chinesa, Medicina Tradicional Indiana, Medicina Homeopática e Medicina Antroposófica), a concepção vitalista é uma doutrina filosófica que considera a existência de uma força (princípio) vital responsável pela manutenção da saúde e da vida, unida substancialmente ao corpo físico. Além disso, valorizando a interação de outras instâncias superiores da individualidade humana (mente, alma e espírito) no equilíbrio fisiológico-vital, a concepção vitalista inclui a influência dos pensamentos, sentimentos e emoções na etiopatogenia e na evolução das doenças, aspectos difundidos pela dinâmica psicossomática moderna e pelo recente campo de pesquisas que relaciona a saúde à espiritualidade.
Além da materialidade grosseira do corpo físico, sempre se acreditou na existência de uma natureza imaterial do homem, assumindo várias conotações ao longo das diversas civilizações humanas. Em todas as filosofias e religiões, termos como alma, espírito, mente, força vital, etc. são citados, representando uma entidade energética-espiritual com ascendência sobre a entidade orgânica-material. Além disso, atribui-se ao espírito (alma) uma natureza eterna, imortal, ao contrário da existência limitada e passageira do corpo material. Até o século XIX, existia na medicina a noção de uma força vital responsável pela manutenção do equilíbrio das funções orgânicas e da saúde, sendo substituída, no século XX, pelos princípios cartesianos que localizaram a causa das doenças nos órgãos, nos tecidos e nas células. Dentre as especialidades médicas atuais, a homeopatia apresenta em seu corpo doutrinário a noção de que o binômio saúde-doença se fundamenta num substrato material-energético (força vital, princípio vital). Apesar de utilizar esse conceito filosófico para explicar a gênese profunda das enfermidades, apresenta um modelo terapêutico fundamentado pelos conhecimentos experimentais e científicos da medicina moderna. Nessa obra, buscamos estudar comparativamente as diversas escolas médicas e filosóficas que valorizam os veículos sutis de manifestação da individualidade humana, evidenciando, através das semelhanças conceituais encontradas, que este conhecimento espiritualista provém de uma fonte primordial comum, que remonta ao início da humanidade terrena. Através das inúmeras citações e referências bibliográficas, o leitor poderá se aprofundar no estudo desta natureza imaterial humana, não alimentando esse trabalho qualquer pretensão de esgotar um assunto de tamanha complexidade e importância para o entendimento do homem e de seu papel no atual ciclo de evolução terrena. Principais tópicos: A natureza imaterial do homem ao longo da história da medicina. A natureza imaterial do homem segundo a homeopatia: concepção vitalista de Samuel Hahnemann. O princípio vital homeopático perante a fisiologia humana. A natureza imaterial do homem segundo a medicina tradicional chinesa (acupuntura). A natureza imaterial do homem segundo a medicina âyurveda e a filosofia hindu-tibetana. A natureza imaterial do homem segundo a concepção rosacruz. A natureza imaterial do homem segundo a medicina antroposófica. A natureza imaterial do homem segundo a cabala hebraica. A natureza imaterial do homem segundo a doutrina espírita. Available at: http://www.homeozulian.med.br/homeozulian_visualizarlivroautor.asp?id=4
The diseases genesis, for the Homeopathic Science, comes from the vital force disturbance: the homeopathic treatment aims to balance this vital source. And what is this vital force? It is the spirit, the soul, the mind, or a primordial energy responsible for the human being's life and health care. Many doctrinaire misunderstandings come from the incomprehension of this vital force real meaning; starting from understanding the disease process up to the therapeutic propositions for treating them. This may bring to the homeopathic clinical practice aspirations that this science does not expect to reach. In this work, we stand out the hahnemanniana vital force's main characteristics, making analogies of the same with the several existing medical and philosophic conceptions. This way, we can visualize the several currents that might have influenced Hahnemann during the elaboration of his vitalistic model. According to the several currents studied, it is evident that the disturb responsible for the organic disease genesis is in the vital source, tsri or chi, linga sharira, double electric, vital body or ethereal body, all corresponding to the Hippocratic, instinctive, automatic and unintelligent vis medicatrix naturae which, in its modus operandi, is similar to the neural-immune-endocrine-metabolic system studied by the integrative physiology in the reactions to the stress. RESUMO: Para a Homeopatia, a gênese das doenças situa-se na distonia da força vital: o tratamento homeopático visa reequilibrar este princípio vital. E o que é esta força vital? O espírito, a alma, a mente ou uma energia primordial responsável pela vida e pela preservação da saúde nos seres vivos. Na incompreensão do verdadeiro significado desta força vital, radicam inúmeras confusões doutrinárias, desde o entendimento do processo da doença até as propostas terapêuticas para as mesmas, podendo transmitir à prática clínica homeopática pretensões que ela não se propõe atingir. Neste trabalho, destacamos as principais características da força vital hahnemanniana, traçando analogias da mesma com as diversas concepções médicas e filosóficas existentes. Desta forma, podemos visualizar as diversas correntes que podem ter influenciado Hahnemann na elaboração do seu modelo vitalista. Segundo as diversas linhas de pensamento estudadas, fica evidente que o distúrbio responsável pela gênese das doenças orgânicas localiza-se no princípio vital, tsri ou chi, linga sharira, duplo etérico, corpo vital ou corpo etéreo, todas correspondendo à vis medicatrix naturae hipocrática, instintiva, automática e desprovida de inteligência, que se assemelha em seu modus operandi ao sistema neuro-imuno-endócrino-metabólico estudado pela fisiologia integrativa nas reações ao estresse.
Marcus Zulian Teixeira
added a research item
Introduction: In addition to the four pillars of homeopathy, vitalism and the miasmatic theory are often used to explain the health–disease process. According to Hahnemann's concepts, homeopathic miasms are the main obstacle to the cure of chronic diseases, with psora being the fundamental cause of all forms of diseases. According to modern genetics, the disease-promoting epigenetic alterations are the fundamental cause of the manifestation of chronic diseases. Objective: This article develops a philosophical–scientific correlation between chronic miasms and disease-promoting epigenetic modifications, aiming to justify the isopathic use of auto-sarcode of an individual's DNA as homeopathic medicine. Results: Based on the study of homeopathic doctrine and epigenetics, a conceptual and functional correlation is observed between homeopathic chronic miasms and disease-promoting epigenetic modifications. Additionally, several experimental studies suggest that homeopathy's mechanism of action may be by modulating gene expression. Conclusions: By the philosophical–scientific correlations described, it is inferred that disease-promoting epigenetic alterations are the biological representation of the chronic miasms, suggesting the isopathic use of auto-sarcode of DNA as homeopathic therapeutic modulator of gene expression for the management of chronic diseases.
Marcus Zulian Teixeira
added a project goal
The homeopathic philosophical vitalist conception considers vital force dystonia as the primary cause of diseases, while the return to health status would occur by vital rebalancing. The homeopathic model expands understanding of the etiopathogenic dynamics, and also considers the manifestation of chronic miasmas (manifest psora) as a fundamental cause of chronic diseases in general, while health restoration would occur through modulating this miasmatic manifestation (latent psora).
According to the biomedical etiopathogenic process, the primary cause of diseases is the expression of genes responsible for the respective physiological disorders, considering the manifestation of disease-promoting epigenetic alterations as a fundamental cause of chronic diseases in general. The return to health status would occur through modulating these epigenetic manifestations and consequent inhibition of pathological gene expression.
Due to presenting similar characteristics and properties, we have suggested in recent studies the philosophical-scientific correlations between vital force and genome (exome plus epigenome) and between chronic miasms and disease-promoting epigenetic alterations, meaning that the genome would be the biological representation of organic vital force, and disease-promoting epigenetic alterations would be the biological representation of chronic miasms.
The properties and functions of the telomere-telomerase complex expand understanding of the gene expression mechanism at the chromosome level (DNA molecule or genomic unit), and reiterate the philosophical-scientific correlations between the vital principle and the genome in view of its recognized role as a biomarker of cellular vitality, biological aging and the health-disease process. In this context, telomere length would indicate the organic vital force state and could be used in the diagnosis and prognosis of diseases according to the vitalist approach, expanding the spectrum and scope of classical homeopathic semiology.
In accordance with these hypotheses, the isopathic use of auto-sarcode of DNA (auto-isotherapic of DNA) could act on the imbalance of the vital principle or genome and in the chronic miasmas or disease-promoting epigenetic alterations as homeopathic therapeutic modulator of gene expression in the management of chronic diseases.