Project

GEroNIMO

Goal: Genome and Epigenome eNabled breedIng in MOnogastrics
To face human population growth, increasing environmental constraints and changes in socio-cultural values, animal breeding must evolve toward a more sustainable model that guarantees production while promoting efficient resource use, animal health and welfare, and preserving genetic diversity. Thanks to recent developments in omics
technologies, it is now possible to rethink breeding, taking advantage of improved knowledge on genome-to-phenome relationships that accounts for both genetic and non-genetic mechanisms controlling traits. GEroNIMO will work on chicken and pig, the most used sources of animal protein worldwide, to provide breeders with new knowledge
and tools to promote innovative genome- and epigenome enabled selection methods for traits related to production (quantity and quality), efficiency, productive longevity, fertility, resilience and welfare. A large number of animals from cosmopolitan and local breeds will be characterized phenotypically, genetically and epigenetically under
different environments to i) identify underlying biological mechanisms affecting trait variation, ii) develop methods to improve selection strategies integrating genetic- and non-genetic factors, and iii) propose strategies to optimize the conservation of genetic and epigenetic diversity. GEroNIMO proposes demand-driven innovation employing a multiactor approach through the involvement of breeders, professional associations of animal production, and scientists, engaged from the planning phase to the dissemination of results over Europe. GEroNIMO will build on existing academic and commercial knowledge and will analyze large populations to quantify the contribution of genetic and
epigenetic variation in gene expression, trait variation and trade-offs between traits. GEroNIMO will also propose a comprehensive and enhanced characterization of diversity by integrating epigenetic diversity into conservation purposes, corresponding to a new integrated conservation strategy.

Date: 1 June 2021 - 31 May 2025

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Project log

Cagla Kaya
added an update
We are delighted to invite you to the upcoming GENE-SWitCH and GEroNIMO joint stakeholder event:
"Bitcoin or Genomics: Which brings more?"
The event is hosted as a satellite to WCGALP 2022 in Rotterdam, The Netherlands, preceding the conference itself.
Therefore, no conference registration is needed to attend. However, please note that registration for the stakeholder event is mandatory even though it is a free-of-charge event.
Bitcoin or Genomics: Which brings more?
3rd JULY 2022 – 15.00h-17.00h (CEST)
De Doelen, ROTTERDAM
15:00 Opening and welcome – Çağla Kaya / European Forum of Farm Animal Breeders (EFFAB)
15:05 GENE-SWitCH introduction – Elisabetta Giuffra or Herve Acloque / INRAE
15:15 Showcasing GENE-SWitCH results for stakeholders:
Latest developments on functional annotation: Peter Harrison / EMBL & Marco Bink/Hendrix Genetics
15:35 GEroNIMO introduction – Tatiana Zerjal / INRAE
15:45 Linking GENE-SWitCH and GEroNIMO: New models – Mario Calus / WUR
15:55 The societal context of genetics and animal breeding – Franck Meijboom / UU
16:05 World café setting with 3/4 different tables based on topics and registrants:
“Focused on increasing the impact of project work and uptake of results by the sector companies”
TABLE 1: Development of new genetic models based on GENE-SWitCH & GEroNIMO research - Moderators: Mario Calus / WUR & Marco Bink / Hendrix Genetics
TABLE 2: Uptake of the exploitable results by sector – Moderator: Noelia Vilar / FEUGA
TABLE 3: Ethical and societal aspects of NGTs Moderator: Frank Meijboom / UU
17:05 Table pitches
17:20 Final words & Closing
Join us on the 3rd of July to find out which brings more!
To register for the event please fill in the form
!! We would appreciate it very much if you could also share the invitation within your network and from your social media accounts !!
LinkedIn post
Twitter post
All the best,
Çağla Yüksel Kaya Kuyululu, DVM, PhD
Senior Project Manager
 
Peter Karlskov-Mortensen
added an update
We have a vacant post doc position in the group of Animal Genetics & Breeding at University of Copenhagen. Our new post doc will look into genetic and epigenetic mechanisms that control growth, feed efficiency and other efficient livestock production related traits in pigs.
See our job portal for further information: https://employment.ku.dk/all-vacancies/?show=156343
 
Fábio Pértille
added an update
In 2013, during my PhD at the University of Sao Paulo, Brazil, I began the optimization of a method called genotype-by-sequencing (GBS) in chickens. In 2015, I made my first contact with Carlos Guerrero-Bosagna at Linköping University in Sweden, and we began a collaboration to promote the development of a new method called GBS-MeDIP. This method is based on a combination of GBS (which was initially described in maize1, and employed in chickens for the first time by our group) and methylated DNA immunoprecipitation (MeDIP). GBS-MeDIP is a cost-effective way to address DNA methylation variations in reduced genomes of many animals. The combination of techniques was needed because current methods assessing DNA methylation in reduced genomes are biased towards CpG sites located in CpG-rich regions of the genome. Instead, GBS-MeDIP reduces the genome to approximately 2% of its original size by digesting the genome independently of CpG density. Based on GBS, the fragments (200–500 bp) are then barcoded to later identify individual samples in a pool. Sequencing libraries are then created with DNA pooled from several individuals. This representation is unique since we found regions that had never before been associated with performance traits and feather pecking behavior (non-published data) in chickens. The GBS method has proved to be applicable, in this sense, in a wide range of studies. We have now applied GBS-MeDIP in six peer-reviewed, ISI-indexed publications. Furthermore, it will be the main method employed in a new H2020 consortium project called “Genome and Epigenome Enabled Breeding in Monogastrics” (GEroNIMO), and in two other approved research projects: “Non-genomic inheritance of environmentally-induced traits: deciphering epigenetically-driven genetic variation in mammals” (funded by the Templeton Foundation), and “Factors influencing the behavioral development and variation in movement patterns across laying hens and their association to animals’ health, with a focus on stress exposure early in life”, funded by the Swiss National Science Foundation (SNF). TODAY, I am delighted to communicate that our methodological article, is currently published in Cell STAR Protocols and available online: https://www.sciencedirect.com/science/article/pii/S266616672200082X?via%3Dihub
 
Fábio Pértille
added a research item
The GBS-MeDIP protocol combines two previously described techniques, Genotype-by-Sequencing (GBS) and Methylated-DNA-Immunoprecipitation (MeDIP). Our method allows for parallel and cost-efficient interrogation of genetic and methylomic variants in the DNA of many reduced genomes, taking advantage of the barcoding of DNA samples performed in the GBS and the subsequent creation of DNA pools, then used as an input for the MeDIP. The GBS-MeDIP is particularly suitable to identify genetic and methylomic biomarkers when resources for whole genome interrogation are lacking.
Cagla Kaya
added an update
We have started fast in 2021. We hope we will continue our research with some results in 2022 and more interactions with other projects and stakeholders. We wish you all a relaxing, healthy and happy holiday season with your loved ones.
 
Cagla Kaya
added an update
The PhD will be employed at a newly funded #H2020 project GEroNIMO: “Genome and Epigenome eNabled breeding in MOnogastrics”.
📷Apply before: 27th June 2021 #Genetics #Statistics #dataanalysis
 
Cagla Kaya
added a project goal
Genome and Epigenome eNabled breedIng in MOnogastrics
To face human population growth, increasing environmental constraints and changes in socio-cultural values, animal breeding must evolve toward a more sustainable model that guarantees production while promoting efficient resource use, animal health and welfare, and preserving genetic diversity. Thanks to recent developments in omics
technologies, it is now possible to rethink breeding, taking advantage of improved knowledge on genome-to-phenome relationships that accounts for both genetic and non-genetic mechanisms controlling traits. GEroNIMO will work on chicken and pig, the most used sources of animal protein worldwide, to provide breeders with new knowledge
and tools to promote innovative genome- and epigenome enabled selection methods for traits related to production (quantity and quality), efficiency, productive longevity, fertility, resilience and welfare. A large number of animals from cosmopolitan and local breeds will be characterized phenotypically, genetically and epigenetically under
different environments to i) identify underlying biological mechanisms affecting trait variation, ii) develop methods to improve selection strategies integrating genetic- and non-genetic factors, and iii) propose strategies to optimize the conservation of genetic and epigenetic diversity. GEroNIMO proposes demand-driven innovation employing a multiactor approach through the involvement of breeders, professional associations of animal production, and scientists, engaged from the planning phase to the dissemination of results over Europe. GEroNIMO will build on existing academic and commercial knowledge and will analyze large populations to quantify the contribution of genetic and
epigenetic variation in gene expression, trait variation and trade-offs between traits. GEroNIMO will also propose a comprehensive and enhanced characterization of diversity by integrating epigenetic diversity into conservation purposes, corresponding to a new integrated conservation strategy.