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Introduction: Vegetable leafminer is a polyphagous and cosmopolite insect and one of the most important pests of greenhouse and field crops especially cucumbers and tomatoes. The usual method for controlling this pest is the use of insecticides. The wide use of insecticides has caused development of resistance against many commercial insecticides in this pest. The use of suitable insecticides to control this pest and reduce the incidence of resistance seems to be necessary. Objectives: The objectives of this study were to assess the efficacy of some fairly new insecticides with novel modes of action on L. sativae and their sublethal effects on certain life table parameters of this insect. Materials and methods: The effects of some insect growth regulators namely hexaflumuron, chromafenozide, chlorfluazuron, cyromazine, lufenuron+fenoxycarb and also azadirachtin and chlorantraniliprole on Liriomyza sativae were evaluated. For four of the insecticides which caused higher mortality of the larvae at field recommended doses, Dose-response lines were constructed. The bioassays were based on the method described by Cox et al. (1995). The effects of sublethal doses of these insecticides on mean weight of pupae, adult emergence and sex ratio of the adults were also studied. Results: LC 50 values for chlorantraniliprole, cyromazine, azadirachtin and hexaflumuron were 0.24, 0.49, 8.51 and 67.6 mg ai/l, respectively. For all compounds except chromafenozide, a significant reduction in pupal weight and adult emergence was observed, but the adult sex ratio did not change significantly compared with control. Conclusion: Most of the insecticides used in this study were fairly new compounds with unique modes of action and had considerable lethal and sublethal effects on L. sativae. If these results also hold true in field and greenhouse conditions, these compounds could be considered as suitable candidates in management programs for vegetable leafminer.