Project

Chemoprotection in Gene-Modified HSPC Transplants

Goal: We are exploring genes that confer chemoprotection against cytotoxic agents to increase engraftment in autologous gene-modified non-myeloablative bone marrow transplants.

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Project log

Serhat Gumrukcu
added 3 research items
ALDH1 overexpression promotes increased engraftment of HSPCs in vivo when combined with low dose cyclophosphamide chemoselection.
Overexpression of ALDH1 provided chemoprotection to CD34+ cell line and human stem/progenitor cells when exposed to low dose cyclophosphamide
Serhat Gumrukcu
added a project goal
We are exploring genes that confer chemoprotection against cytotoxic agents to increase engraftment in autologous gene-modified non-myeloablative bone marrow transplants.