Chemoprotection in Gene-Modified HSPC Transplants

May 13, 2020

Serhat Gumrukcu

added 3 research items

Source

Increased Engraftment of Gene Modified HSPCs Overexpressing ALDH1 In Vivo

Poster

May 2020

Serhat Gumrukcu
Philippe Gallay
Tung X Nguyen
[...]
David Hardy

ALDH1 overexpression promotes increased engraftment of HSPCs in vivo when combined with low dose cyclophosphamide chemoselection.

Source

Gene modified CD34+ cells with increased ALDH1 expression confers in vitro protection against cyclophosphamide

Poster

May 2020

Ramesh Halder
Andrew Davis
Tung X Nguyen
[...]
Serhat Gumrukcu

Overexpression of ALDH1 provided chemoprotection to CD34+ cell line and human stem/progenitor cells when exposed to low dose cyclophosphamide

Source

Glutamate-Cysteine Ligase Modifier Subunit Overexpression Confers Resistance Against Busulfan

Poster

May 2020

Serhat Gumrukcu
Phillip A Musikanth
Tung X Nguyen

Increased expression GCL modifier subunit alone confers substantial chemoprotection against busulfan

May 13, 2020

Serhat Gumrukcu

added a project goal

We are exploring genes that confer chemoprotection against cytotoxic agents to increase engraftment in autologous gene-modified non-myeloablative bone marrow transplants.

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Chemoprotection in Gene-Modified HSPC Transplants

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