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Article Effects of exercise and diet-induced weight loss on markers of inflammation II: impact on microRNA 21 and microRNA 146a expression and their regulatory role

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Background Obesity has been associated with inflammation. However, the mechanisms are not well understood. The purpose of this study was to determine if exercise and diet-induced weight loss would affect markers of inflammation via the Phosphatase and Tensin homologue Deleted from Chromosome-10 (PTEN), TNF receptor-associated factor 6 (TRAF6), Phosphatidylinositol-3-kinase (PI3k), Protein Kinase B (AKT or PKB), Nuclear Factor kappa Beta (NF-kB) signaling pathway through the regulation of microRNA 21 and microRNA 146a expression. Methods