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Antidiabetic Investigation on Morinda citrifolia

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Khamsah Mohd
added 4 research items
Background: Ayurveda deals with the propensity of the herb to bestow upon the body enhanced capacity of warding off infections and delaying the ageing progression. Ethnic natural products have become the substitute way to switch the synthetic medicine. Aim: An endeavor has been made to evaluate the phytochemicals and free radical scavenging efficacy of different parts of Malaysian Mengkudu using different solvent extracts. Methods: The herbal powder obtained from various parts of Mengkuduplant i.e. dry leaves, dry fruits and fresh fruits were extracted with various solvents. The extracts were analyzed for phytochemicals and antioxidants, carotenoids, ascorbic acid, tocopherol, total phenol, proteins, reducing sugars and sterols. Antioxidant activity was reconnoiteredin terms of superoxideradical scavenging assay and reducing power assay. Result: Phytochemical characterization of thedifferent extracts revealed the presence of the phytochemicals-alkaloids, coumarin, phenols, flavonoids, sterol, saponin glycosides, reducing sugars, proteins, cardio active aglycones and cardinolides. Discussion: Excellent superoxide radical scavenging ability found in almost all extracts of Malaysian Mengkudu. In the present study superoxide radical reduces nitroblue tetrazolium(NBT) to a blue colored formazan that is measured at 560 nm. Antioxidant activity has been reported to be concomitant with development of reducing power. This shows that extracts might comprise reductones like ascorbic acid, reducing sugar, thiol group encompassing protein which could react with free radicals to alleviate and sack the radical chain reaction. Conclusion: These outcomes propose that the guaranteeing phytonutrients of the plant could be subjugated against oxidative stress, cancer, ageing, ischemic heart disease in dissolving thrombus, microbial infections and hormone replacementtherapy (HRT) justifying their use in conventional medicine as nutraceuticals.
Peptic ulcer is a disease of the Gastro-intestinal tract (GIT), which includes both gastric and duodenal ulcers. The occurrence of peptic ulcer disease has been attributed to the imbalance between aggressive factors like acid, pepsin, and Helicobacter infection on one hand and the local mucosa defenses like bicarbonate and mucus secretion and prostaglandins synthesis on the other hand. The most serious complications of peptic ulcer disease include hemorrhage, perforation, penetration, and gastric outlet obstruction. Ulcerative colitis is a form of inflammatory bowel disease (IBD). It is a form of colitis, a disease of the colon that includes characteristic ulcers, or open sores. IBD is often confused with irritable bowel syndrome. Ulcerative colitis is associated with a general inflammatory process that affects many parts of the body. Sometimes these associated extra-intestinal symptoms are the initial signs of the disease, such as painful arthritic knees in a teenager and may be seen in adults also. Several classes of pharmacological agents have proved to be effective in the management of the acid peptic disorders viz., antacids, acid suppressive agents, anticholinergic, cytoprotective agents, etc. A widespread search has been launched to identify new anti-ulcer therapies from natural sources to replace currently used drugs of doubtful efficacy and safety. Herbs, medicinal plants, spices, vegetables and crude drug substances are considered to be a potential source to control various diseases including gastric ulcer and ulcerative colitis. In the scientific literature, a large number of medicinal plants and their secondary metabolites with anti-ulcer potential have been reported. As the gastro protective effect can be linked to different mechanisms, once demonstrated the activity, the extracts and more appropriately the active compounds should be assessed for action mechanisms to elucidate their mode of action. Besides, new action mechanisms may be discovered.
Aim: An endeavor has been organized to screen the secondary metabolite, comparative superoxide radical scavenging and reducing potency of Mengkudu (Morinda citrifolia) using aqueous and organic solvent extracts. Methods: The herbal powder obtained from plant part-dry fruit were extracted with aqueous and organic solvents. The extracts were analysed for secondary metabolite and antioxidants. Free radical scavenging capacity was analysed in terms of superoxide radical scavenging assay and reducing power assay. Result: Phytochemical characterization of the different solvent extracts exposed the existence of the secondary metabolites, viz. alkaloids, phenols, flavonoids, sterol, saponin glycosides, reducing sugars, proteins, cardia active agiycones and cardinolides. Excellent superoxide radical scavenging propensity established in almost all solvent extracts of Mengkudu. Discussion: In the contemporary study, the superoxide radical reduces nitro blue tétrazolium (NBT) to a blue coloured formazan that is measured at 560 nm. Antioxidant activity has been recounted to be concomitant with improvement of reducing power. This confirms that extracts might contain reductones like ascorbic acid, reducing sugar, thiol group containing protein which could react with free radicals to stabilize and terminate radical chain reaction. Conclusion: These outcomes advocate that the guaranteeing phytonutrients of the fruit could be intimidated against oxidative stress, cancer, ageing, ischemic heart disease in dissolving thrombus, microbial infections and hormone replacement therapy extenuating their consumption in conventional medicine as nutraceuticals. © 2014 Japan Health Sciences University & Japan International Cultural Exchange Foundation.