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A polyherbal formulation was designed for alcohol use disorders and an experimental validation of the same was carried out for its hepatoprotective activity against ethanol and paracetamol induced liver damage in swiss albino rats. The rats were divided into four groups of ten animals each with two study groups, one toxic control group and one normal control group. The polyherbal formulation was coded as Sumukti and was prepared in syrup form by combination of 11 drugs. The study groups were fed with Sumukti syrup for 21 days and 31 days respectively along with hepaotoxic drugs like ethanol and paracetamol. Biochemical parameters like Liver function test Histopathological studies of liver cells were carried out. Results were suggestive of hepatoprotective activity of study formulation.
The present study is an effort to develop a polyherbal formulation (Sumukti Syrup) to treat alcohol dependency and its standardization. The compound is prepared with herbs that are nootropic (Medhya), immunomodulators (Rasayana), carminating (Deepana) and with hepatic stimulants (Yakrituttejaka) properties. The ingredients are Kiratatikta (Swertia chirata), Draksha (Vitis vinifera), Katuki (Picrorhiza kurroa), Bhringaraja (Eclipta alba), Mandookaparni (Centella asiatica), Guduchi (Tinospora cordifolia), Hareetaki (Terminalia chebula), Vibhitaki (Terminalia belerica), Amalaki (Emblica officinalis), Ashwagandha (Withania somnifera) and Yastimadhu (Glycyrrhiza glabra) which is prepared in Syrup form following standard protocols. The raw materials were collected, authenticated and standardized as per Department of AYUSH, Ministry of Health & Family welfare, Government of India guidelines. In the present study, the physico-chemical parameters in terms of total ash, acid insoluble ash, water soluble extractive value and alcohol soluble extractive value of the raw materials are comparable with pharmacopeia standards. HPTLC photo documentation of raw materials as well as finished product provided a hint towards isolation of few constituents to the finished product. The results of total solids, total sugar, reducing sugar, non-reducing sugar, specific gravity and refractive index of study formulation can be considered as preliminary standards. Key words: Syrup, Polyherbal, Standardization, HPTLC, Sumukti