(James) Niels Rosenquist

Massachusetts General Hospital | MGH · Department of Psychiatry

Every second, the thoughts and feelings of millions of people across the world are recorded in the form of 140-character tweets using Twitter. However, despite the enormous potential presented by this remarkable data source, we still do not have an understanding of the Twitter population itself: Who are the Twitter users? How representative of the...

Background Recent initiatives in psychiatry emphasize the utility of characterizing psychiatric symptoms in a multidimensional manner. However, strategies for applying standard self-report scales for multiaxial assessment have not been well-studied, particularly where the aim is to support both categorical and dimensional phenotypes. Methods We pr...

Background: Relying on diagnostic categories of neuropsychiatric illness obscures the complexity of these disorders. Capturing multiple dimensional measures of neuropathology could facilitate the clinical and neurobiological investigation of cognitive and behavioral phenotypes. Methods: We developed a natural language processing-based approach t...

The study was designed to validate use of electronic health records (EHRs) for diagnosing bipolar disorder and classifying control subjects. EHR data were obtained from a health care system of more than 4.6 million patients spanning more than 20 years. Experienced clinicians reviewed charts to identify text features and coded data consistent or inc...

Significance Our finding of a significant gene-by-birth-cohort interaction adds a previously unidentified dimension to gene-by-environment interaction research, suggesting that global changes in the environment over time can modify the penetrance of genetic risk factors for diverse phenotypes. This result also suggests that presence (or absence) of...

Supplementary Materials Code.

Supplementary Materials.

The identification of causal peer effects (also known as social contagion or induction) from observational data in social networks is challenged by two distinct sources of bias: latent homophily and unobserved confounding. In this paper, we investigate how causal peer effects of traits and behaviors can be identified using genes (or other structura...

Using nationwide county-level longitudinal data, we show that recent declines in housing prices are associated with an increased utilization of antidepressant prescriptions among the near elderly. Our results persist in difference-in-difference models using either all non-antidepressant drugs or statins as controls.

Background: Population mental health surveillance is an important challenge limited by resource constraints, long time lags in data collection, and stigma. One promising approach to bridge similar gaps elsewhere has been the use of passively generated digital data. Purpose: This article assesses the viability of aggregate Internet search queries...

Prepared by the residents and faculties of the renowned Massachusetts General Hospital and McLean Hospital, this pocket handbook is packed with succinct, practical, accessible information on the diagnosis and treatment of psychiatric disorders. Major sections include psychiatric emergencies, symptom-based diagnosis and treatment, special population...

The costs of comprehensively genotyping human subjects have fallen to the point where major funding bodies, even in the social sciences, are beginning to incorporate genetic and biological markers into major social surveys. How, if at all, should economists use and combine molecular genetic and economic data from these surveys? What challenges aris...

This study presents an overview of the rapidly expanding field of social network analysis, with an emphasis placed on work relevant to behavioral health clinicians and researchers. I outline how social network analysis is a distinct empirical methodology within the social sciences that has the potential to deepen our understanding of how mental hea...

Every second, the thoughts and feelings of millions of people across the world are recorded in the form of 140-character tweets using Twitter. However, despite the enormous potential presented by this remarkable data source, we still do not have an understanding of the Twitter population itself: Who are the Twitter users? How representative of the...

Twin and adoption studies have consistently found that genetic variation is an important source of heterogeneity in economic outcomes such as educational attainment and income. The advent of inexpensive, genome-wide scans is now making it increasingly feasible to directly examine specific genetic variants that predict individual differences. In thi...

Background: Alcohol consumption has important health-related consequences and numerous biological and social determinants. Objective: To explore quantitatively whether alcohol consumption behavior spreads from person to person in a large social network of friends, coworkers, siblings, spouses, and neighbors, followed for 32 years. Design: Long...

Alcohol consumption has important health-related consequences and numerous biological and social determinants. To explore quantitatively whether alcohol consumption behavior spreads from person to person in a large social network of friends, coworkers, siblings, spouses, and neighbors, followed for 32 years. Longitudinal network cohort study. The F...

The etiology of depression has long been thought to include social environmental factors. To quantitatively explore the novel possibility of person-to-person spread and network-level determination of depressive symptoms, analyses were performed on a densely interconnected social network of 12,067 people assessed repeatedly over 32 years as part of...

This paper examines the influence of health conditions on academic performance during adolescence. To account for the endogeneity of health outcomes and their interactions with risky behaviors we exploit natural variation within a set of genetic markers across individuals. We present evidence that specific genetic markers have good statistical prop...

Steve Wozniak co-founded Apple Computer with Steve Jobs in 1976. He is considered the inventor of the personal computer, having created the Apple I and Apple II computers in the mid-1970s. With an engineering background and a mind for discovery, Wozniak and Apple Computer have helped transform our world. Steve has also been a major investor and con...

This thesis has two main foci. First, it seeks to outline how recent findings from the genetics and neuroscience literature can enrich both the empirical and theoretical understanding of economic behavior. Second, it presents models of health/education investment in teens as well as a special case of the Becker-Murphy model of smoking that treats a...

This paper examines the influence of health conditions on academic performance during adolescence. To account for the endogeneity of health outcomes and their interactions with risky behaviors we exploit natural variation within a set of genetic markers across individuals. We present strong evidence that these genetic markers serve as valid instrum...

In this paper we review the available summary measures for the magnitude of socio-economic inequalities in health. Measures which have been used differ in a number of important respects, including (1) the measurement of "relative" or "absolute" differences; (2) the measurement of an "effect" of lower socio-economic status, or of the "total impact"...

Comparison of the evidence summaries presented here reveals considerable general agreement on the effectiveness or ineffectiveness of the interventions reviewed, with only a few instances in which different reviews reached different conclusions.There is uniform agreement on the effectiveness of the clinical interventions, although the magnitude of...

We studied the effects of eccentric auditory cues to clarify the conditions that evoke inhibition of return (IOR). We found that auditory cues positioned 12 degrees to the left or right of midline failed to produce IOR whereas visual cues produced IOR under the same experimental conditions. The eccentric auditory cues elicited automatic orienting a...

Research on temporal-order judgments, reference frames, discrimination tasks, and links to oculomotor control suggest important differences between inhibition of return (IOR) and attentional costs and benefits. Yet, it is generally assumed that IOR is an attentional effect even though there is little supporting evidence. The authors evaluated this...

Abstract We present a model of an adolescent’s use-versus-abstain choice for addictive products. Motivated by an extensive scientic,literature, our model assumes that preferences change discretely (due to neurobiological development) and unpredictably (due to unrevealed ge- netic variation) between late childhood and late adolescence. Our model ill...