Zsuzsa Emri

Zsuzsa Emri
Eszterházy Károly Egyetem · Department of Zoology

PhD

About

51
Publications
4,198
Reads
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2,600
Citations
Additional affiliations
January 2001 - August 2009
Hungarian Academy of Sciences
Position
  • Senior Researcher
January 1994 - December 2001
Hungarian Academy of Sciences
Position
  • Researcher
Education
September 1986 - July 1991
Eötvös Loránd University
Field of study
  • Biology

Publications

Publications (51)
Article
Az autizmus spektrum betegség (ASD) az egyik leggyakoribb, gyógyíthatatlan fejlődési rendellenesség. Legfontosabb megnyilvánulási jegyei a szociális viselkedés zavara, a kommunikációs készségek sérülése és a repetitív mozdulatok és sztereotip viselkedések meg jelenése. Enyhe formáival rendelkező gyerekek integrálhatóak a közoktatásba. Az integráció...
Conference Paper
Full-text available
A hordozható, könnyen használható elektroencefalográfok (EEG) segítségével a kognitív folyamatokat úgy vizsgálhatjuk, hogy a természetes viselkedést alig befolyásoljuk. A hajas fejbőrön mért idegi aktivitás mikrovoltos nagyságrendű, emiatt az izomaktivitásból, szemmozgásból származó műtermékektől meg kell tisztítani. Ezeknek a műtermékeknek a tökél...
Article
A szigorítások ellenére a magyar lakosság, különösen a nők körében a dohányzók aránya magasabb, mint az európai átlag (Eurostat, 2017). A nikotin az egyik legaddiktívabb pszichoaktív drog, a függőség gyorsan kialakul, különösen fiataloknál (Pócs és mtsai, 2018). Gyerekek és serdülők már alkalmi használat alatt függőkké válhatnak, emiatt a gyermekko...
Article
A neuropedagógia kialakulásával megjelent a pedagógiának egy olyan irányzata, amely az oktatási folyamatok ter vezésénél biológiai mérésekre, többek között az elektroenkefalográfiára (EEG) támaszkodik. Kísérletünkben 14 csatornás, vezeték nélküli EEG-készüléket használtunk, és összehasonlítottuk a különböző kognitív igénybevételt jelentő feladatok...
Article
Az indiai kender (Cannabis sativa) fő hatóanyaga a THC, illet ve a szintetikus kannabinoidok az agy CB1 típusú endocannabinoid receptorain fejtik ki hatásukat. A marihuána és a szintetikus kannabinoidok tartós használata függőséghez vezethet, ennek ellenére a fiatalok körében fogyasztásuk egyre népszerűbb, 2018-ban a felnőtt népesség 7,4%-a próbált...
Article
Full-text available
Key points: Sleep spindle frequency positively, duration negatively correlates with brain temperature. Local heating of the thalamus produces similar effects in the heated area. Thalamic network model corroborates temperature dependence of sleep spindle frequency. Brain temperature shows spontaneous microfluctuations during both anesthesia and nat...
Article
Spindle oscillations are generated predominantly during sleep state II, through cyclical interactions between thalamocortical and reticular neurons. Inhibition from reticular cells is critical for this activity; it enables burst firing by the de-inactivation of T-type Ca2+channels. While the effect of different channelopathies on spindling is exten...
Article
Full-text available
The gamma-aminobutyric acid (GABA) metabolite gamma-hydroxybutyric acid (GHB) shows a variety of behavioural effects when administered to animals and humans, including reward/addiction properties and absence seizures. At the cellular level, these actions of GHB are mediated by activation of neuronal GABAB receptors (GABABRs) where it acts as a weak...
Article
Full-text available
Accumulating evidence suggests that different energy metabolites play a role not only in neuronal but also in glial signaling. Recently, astroglial Ca(2+) transients evoked by the major citric acid cycle metabolite succinate (SUC) and gamma-hydroxybutyrate (GHB) that enters the citric acid cycle via SUC have been described in the brain reward area,...
Data
File name: 3-31-29_PM-diff.avi. Ca2+ signaling evoked by GHB and ATP in the acute NAc slice from the rat brain. Movie of time measurement showing GHB (50 μM) and ATP (100 μM) application onto a Fluo-4 AM loaded acute, 300 μm thick NAc slice. GHB was applied between 0 and 2 min in the perfusion buffer. ATP was applied for 60 s starting from 1.5 min...
Data
Ca2+ signalling evoked by ATP in the acute NAc slice from the rat brain. Movie of time measurement showing ATP (100 μM) application onto a Fluo-4 AM loaded acute NAc slice (300 μm). ATP was applied for 60 s (long puff) through a glass micropipette right above the tissue surface. Image acquisition frequency was 2 s in depth of 25 μm from the slice s...
Article
Full-text available
Accumulating evidence suggests that glial signalling is activated by different brain functions. However, knowledge regarding molecular mechanisms of activation or their relation to neuronal activity is limited. The purpose of the present study is to identify the characteristics of ATP-evoked glial signalling in the brain reward area, the nucleus ac...
Article
Primary lens epithelial cell (LEC) cultures derived from newborn (P0) and one-month-old (P30) mouse lenses were used to study GABA (gamma-aminobutyric acid) signaling expression and its effect on the intracellular Ca2+ ([Ca2+]i) level. We have found that these cultures express specific cellular markers for lens epithelial and fiber cells, all compo...
Article
Full-text available
Gamma-amminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system of vertebrates, serves as an autocrine/paracrine signaling molecule during development, modulating a number of calcium (Ca(2+))-dependent processes, including proliferation, migration, and differentiation, acting via 2 types of GABA receptors (GABAR...
Article
Full-text available
Gamma-hydroxybutyric acid (GHB) is an endogenous brain substance that has diverse neuropharmacological actions, including rewarding properties in different animal species and in humans. As other drugs of abuse, GHB affects the firing of ventral tegmental neurons (VTA) in anaesthetized animals and hyperpolarizes dopaminergic neurons in VTA slices. H...
Article
We report on cellular actions of the illicit recreational drug gamma-hydroxybutyrate (GHB) in the brain reward area nucleus accumbens. First, we compared the effects of GHB and the GABA(B) receptor agonist baclofen. Neither of them affected the membrane currents of medium spiny neurons in rat nucleus accumbens slices. GABAergic and glutamatergic sy...
Article
We present data on the antiepileptic potency of 2-methyl-4-oxo-3H-quinazoline-3-acetyl piperidine (Q5) in juvenile (P9-13) rat hippocampal slices and in particular Q5's action mechanism and target. Q5 (200-500 microM), but not alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/Kainate receptor antagonists blocked low-[Mg2+]-induced sei...
Article
Binding of the metabolic gamma-hydroxybutyrate (GHB) precursor succinate to NCS-382-sensitive [3H]GHB-labeled sites in crude synaptosomal or purified synaptic membrane fractions prepared from the human nucleus accumbens (NA), globus pallidus (GP) and rat forebrain has been shown. This site can be characterized by binding of ethyl hemisuccinate and...
Article
Full-text available
Gamma-hydroxybutyric acid (GHB) is a naturally occurring gamma-aminobutyric acid (GABA) metabolite that has been proposed as a neurotransmitter/neuromodulator that acts via its own receptor (GHBR). Its exogenous administration, however, elicits central nervous system-dependent effects (e.g. memory impairment, increase in sleep stages 3 and 4, depen...
Article
Major aspects of temporal lobe epilepsy (TLE) can be reproduced in mice following a unilateral injection of kainic acid into the dorsal hippocampus. This treatment induces a non-convulsive status epilepticus and acute lesion of CA1, CA3c and hilar neurons, followed by a latent phase with ongoing ipsilateral neuronal degeneration. Spontaneous focal...
Article
Full-text available
GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained interictal-like activity in hippocampal slices downregulates KCC2 mRNA and protein expression in CA1 pyramidal neurons, which leads to a reduced capacity for neuronal Cl- extrusion. This effect...
Article
Somatostatin receptor type 1 was modelled based on the atomic structure of bovine rhodopsin. Possible ways of binding interaction between somatostatin receptor type 1 and TT-232, a cycloheptapeptide analogue of somatostatin with broad therapeutic potential, were analysed by molecular docking. The twelve TT-232 conformations, obtained by NMR measure...
Article
High-frequency field potential activity between 50 and 400 Hz occurs throughout seizure-like events recorded from the CA3 region of juvenile rat hippocampal slices under low-[Mg(2+)] condition. Another (400-800 Hz) component occurred mainly during preictal paroxysmal spiking and the onsets of seizure-like events (97%) and less frequently during ton...
Article
Full-text available
Here, we show the modulation of somatostatin functions in the hippocampus by the orally active 'cognition enhancer' GABA(B) receptor antagonist, (3-aminopropyl)n-butylphosphinic acid (CGP-36742), both in vivo and in vitro. Using high-pressure liquid chromatography-coupled electrospray mass spectrometry, we measured a two-fold increase in the extrac...
Article
The spatio-temporal integration of cortical excitatory postsynaptic potentials was investigated in a multi-compartment model of a thalamocortical neurone. Consistent with experimental data, cortical excitatory postsynaptic potentials contained a metabotropic glutamate receptor-mediated component and were generated by synapses located on distal dend...
Article
In vivo electrophysiological recordings of CA1/CA2 pyramidal cells were performed 10-12 months after global forebrain ischemia (four-vessel occlusion, 15 mm) and were compared to levels of calbindin expression. Ischemic animals were subdivided in non-sclerotic ischemic (NSI) and sclerotic ischemic (SI) groups depending on the absence or presence of...
Article
The effects of different dendritic geometries and distal dendritic Na+ current distributions on the propagation of action potentials (APs) and sensory EPSPs were investigated using a multi-compartment model of thalamocortical (TC) neurones where the somatic and proximal dendritic distribution of voltage-gated channels matched the ones measured expe...
Article
To elucidate the role of dendritic morphology in signal transfer, the passive propagation of somatic and dendritic potentials was compared in multi-compartment models of three interneuron subpopulations in the CA1 region. Nine calbindin-, 15 calretinin- and 10 parvalbumin-containing cells were modelled incorporating the detailed geometry, the curre...
Article
Full-text available
The integrative properties of neurons depend strongly on the number, proportions and distribution of excitatory and inhibitory synaptic inputs they receive. In this study the three-dimensional geometry of dendritic trees and the density of symmetrical and asymmetrical synapses on different cellular compartments of rat hippocampal CA1 area pyramidal...
Article
Full-text available
The action of somatostatin on GABA-mediated transmission was investigated in cat and rat thalamocortical neurons of the dorsal lateral geniculate nucleus and ventrobasal thalamus in vitro. In the cat thalamus, somatostatin (10 μM) had no effect on the passive membrane properties of thalamocortical neurons and on the postsynaptic response elicited i...
Article
Uniform and non-uniform somato-dendritic distributions of the ion channels carrying the low-threshold Ca²⁺ current (IT), the hyperpolarization-activated inward current (Ih), the fast Na⁺ current (INa) and the delayed rectifier current (IK) were investigated in a multi-compartment model of a thalamocortical neuron for their suitability to reproduce...
Article
The least known aspect of the functional architecture of hippocampal microcircuits is the quantitative distribution of synaptic inputs of identified cell classes. The complete dendritic trees of functionally distinct interneuron types containing parvalbumin (PV), calbindin D(28k) (CB), or calretinin (CR) were reconstructed at the light microscopic...
Article
To investigate the functional role of dendrites of thalamocortical neurones, we have used our one-compartmental model to construct a multi-compartmental model with dendritic regions chosen according to a representative soma-to-dendritic terminal path of an X cell of the cat dorsal lateral geniculate nucleus. The multi-compartmental model with dendr...
Article
The effect of intrathalamic application of GABA(B) receptor antagonists on the basal excitatory amino-acid levels was studied using microdialysis probes implanted in the dorsal lateral geniculate nucleus and in the ventrobasal complex. In both nuclei, continuous perfusion of the GABA(B) receptor antagonist 3-aminopropyl-(diethoxymethyl)-phosphinic...
Article
TO investigate the functional role of dendrites of thalamocortical neurones, we have used our one-compartmental model to construct a multi-compartmental model with dendritic regions chosen according to a representative soma-to-dendritic terminal path of an X cell of the cat dorsal lateral geniculate nucleus. The multi-compartmental model with dendr...
Article
The effect of gamma-hydroxybutyric acid (GHB) on the excitatory postsynaptic potential (EPSP) evoked in thalamocortical neurones of the rat dorsal lateral geniculate nucleus and ventrobasal thalamus was investigated in vitro. GHB (0.1-5 mM) dose-dependently and reversibly decreased (36-78%) the amplitude of the sensory EPSP. This effect of GHB was...
Article
The presence and role of presynaptic GABAB receptors in the control of excitatory amino acid-mediated transmission were investigated (using sharp electrode recordings) in the rat dorsal lateral geniculate nucleus and ventrobasal thalamus in vitro by comparing the effects of the selective GABAB receptor agonist, (±)-baclofen, and of two antagonists,...
Article
The gamma-aminobutyric acid (GABA)B receptor antagonists 2-OH-saclofen and CGP 35348 were injected in the thalamus of freely moving cats via a microdialysis probe while recording the sleep-walking cycle. The results obtained with the two antagonists were similar: wakefulness and the total sleep time were not affected by the blockade of GABAB recept...
Article
The uptake of gamma-aminobutyric acid (GABA) by glial cells was decreased when 4,5,6,7,-tetrahydroisoxazolo-(4,5-C)-pyridin-3-ol (THPO) was applied in the thalamus of freely moving cats by in vivo microdialysis. A marked reduction in duration of wakefulness and in number of awakenings was obtained during THPO treatment. THPO did not change the rati...
Article
Changes in the sleep-waking cycle of freely moving cats were studied during application of excitatory amino acid antagonists in the ventro-posterolateral thalamic nuclei by microdialysis. dl-2-Amino-5-phosphono-pentanoic acid (APV), a selective (NMDA) receptor antagonist, produced an increase in the deep stages of slow wave sleep and in paradoxical...
Article
The extracellular concentration of γ-aminobutyric acid (GABA) was increased in the ventroposterolateral nucleus of the thalamus in cats using in vivo microdialysis probes. In freely moving cats, the permanent injection of 8 × 10−9 M/mm2 × min GABA induced a significant increase in sleep proportion. The duration of paradoxical sleep was particularly...
Article
Kísérleteinkben kimutattuk az asztrociták részvételét a gamma-hidroxi vajsav (GHB) hatás közvetítésében, GHB adagolásra Ca2+ ion tranziensek léptek fel a nucleus accumbens (NA) asztrocitáiban. A GHB-val kiváltott Ca2+ ion koncentráció növekedést nem lehetett blokkolni a GHB receptor antagonista NCS-382-vel, vagy GABA-A és GABA-B receptor antagonist...

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Projects (2)
Project
The project aims to investigate the role of this complex signaling system during differentiation using the vertebrate lens as a model system.