Zsofia Clemens

International Center for Medical Nutritional Intervention

Introduction: Currently, type 1 diabetes mellitus (T1DM) is treated with insulin and a high carbohydrate diet. In literature, there are studies indicating that low carbohydrate diets may be beneficial in reducing hypoglycemic episodes as well as the need for insulin. Previously, we reported a case of a 19-year-old T1DM patient who was successfully...

The objective of this study was to investigate the relation between habitual milk and dairy consumption and brain morphology as assessed by magnetic resonance imaging (MRI) investigations in 119 young healthy university students. MRI measurements were performed on a Siemens Magnetom Trio Tim (3T) system while FreeSurfer software suite was used for...

Purpose: Although the classical ketogenic diet is an effective treatment in childhood epilepsy, it is difficult to maintain on the long term due to side-effects and dislike. Methods: Here we report a case of a child with frequent epileptiform discharges confined to non-rapid-eye-movement (NREM) sleep and extensive cortical malformation. The child w...

Gilbert’s syndrome (GS) is a common hyperbilirubinaemia syndrome caused by reduced conjugation of serum bilirubin by the liver. Although it is considered as a common and harmless condition not requiring treatment symptoms associated with GS may be unfavorable. Here we present a case of GS where high level of total and direct bilirubin, yellowish di...

Introduction: Type 1 diabetes mellitus (T1DM) patients are usually instructed to follow a low fat/high carbohydrate diet. A few studies in literature, however, reported metabolic benefits and sustainability of carbohydrate restricted diets. Case Report: Herein, we present a case of a 19-year-old male with newly diagnosed T1DM. The patient was first...

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells for the two major fermentable fuels: glucose and glutamine. Glucose is a source of carbon and ATP synthesis...

C-peptide is used as a measure of endogenous insulin production. Given that insulin and C-peptide are produced in equal amounts, C-peptide is typically used to differentiate between external and endogenously produced insulin in insulin-treated type 1 diabetes mellitus (T1DM). In a clinical setting, a decline in C-peptide is regarded as a loss of be...

Studies in animal models have suggested that the ketogenic diet may be effective in the treatment of cancer. However, human cohort studies on the ketogenic diet have, thus far, failed to show benefits in cancer survival or in any other hard clinical endpoints of the disease. This paper presents a case report of a patient with glioblastoma multiform...

Существует несколько научных фактов, известные уже давно и подтверждённые исследованиями в недавнем прошлом, которые однако не стали клиничкски руководящими методами. Речь идёт естественно о вопросе распространения и течения инфекционных болезней. Мы не инфектологи, но уже в течении десяти лет мы занимаемся наукой питания и его содействию в борьбе...

Possibilités de réduire la propagation du virus du SRAS-CoV-2 et d'accroître la résistance naturelle à la maladie par une intervention nutritionnelle Nous préconisons un examen approfondi des données médicales suivantes au bénéfice de la population hongroise. L'objectif de ce document est de contribuer à l'efficacité de la lutte contre l'épidémie a...

A magyar lakosság érdekében javasoljuk az alábbi orvostudományi tények alapos és kellően átgondolt vizsgálatát. Írásunk célja előmozdítani a jelenlegi, SARS-CoV-2 vírus okozta járvány eredményes és hatékony leküzdését és a halálos szövődmények számának gyors csökkentését. Van néhány tudományos tény, amely már régebb óta ismert volt, a közelmúlt kut...

Studies in animal models have suggested that the ketogenic diet may be effective in the treatment of cancer. However, human cohort studies on the ketogenic diet have, thus far, failed to show benefits in cancer survival or in any other hard clinical endpoints of the disease. This paper presents a case report of a patient with glioblastoma multiform...

One should only grab a pen or, in this case, a keyboard and write an open letter if they want to make a clear and meaningful point. Competence in the subject is an advantage. We hope we meet both criteria. First of all, please let us express our appreciation for your work in the field of human nutrition science. We particularly appreciate your work...

Healthy nutrition for Homo sapiens. Scientific facts. Anthropological and clinical evidence. The Paleolithic diet which can be used in clinical practice without risks and side effects.

Outlook for cancer patients remains poor despite ”best available treatment” which includes surgery, chemotherapy and radiotherapy in most solid cancers. Genetic profiling, attempts to use matched chemotherapy and the use of high-cost biological therapies, so far, did result in no major breakthrough (1). Metabolic therapies have been suggested as a...

Magnesium plays an essential role in several enzymatic reactions. Its deficiency is known to be widespread and has been associated with a variety of pathological conditions characterized by chronic inflammation and/or oxidative stress. The connection between the metabolism of glucose and magnesium at the cell level is wellestablished. We hypothesiz...

Between 5 and 7 April 2018, we would like to show you what principles we use in our clinical practice as well as the results that we have achieved. We also provide the opportunity to meet our patients personally. Through hard facts and interesting case studies we will demonstrate how there might be a way to achieve a perfect and lasting cure. The P...

Paleolithic ketogenic diet (PKD): A diet covering and limited to our physiological needs We have developed the PKD in 2010-2011. Previously we have been using the paleolithic diet which proved to be ineffective in the vast majority of chronic conditions. We believe that the PKD is the only evolutionary adapted diet for humans. Rehabilitation of chr...

Background: Ketogenic diets have repeatedly been suggested for the treatment of cancer. To date, only a few case studies reporting long term benefits associated with such diets have been published. Case report: Here we present a case where recurrent cervical intraepithelial neoplasia (CIN), a premalignant condition of cervical cancer, was successfu...

Introduction: Prognosis for patients with high-grade brain tumor is poor and survival did neither substantially change with advances in chemotherapy, radiotherapy and molecular profiling. Ketogenic diets have been suggested as a promising alternative therapy. However, group studies in cancer patients with the classical ketogenic diet so far provide...

Background: Ketogenic diets have repeatedly been suggested for the treatment of cancer. Yet, only a few case studies have been published that reported long term benefits associated with such diets. Case report: Here we present a case where rectal cancer was treated with an animal fat-meat based diet, which we refer to as the paleolithic ketogenic d...

Erickson et al. recently published a review on the use of the ketogenic diet in cancer. The authors of this reply are clinicians who bring into play an evolutionary approach in the practice of medicine and specifically have been using the paleolithic ketogenic diet in the treatment of chronic diseases since 2011. We have instituted the paleolithic...

Abnormally high deposition of iron can contribute to neurodegenerative disorders with cognitive impairment. Since previous studies investigating cognition-brain iron accumulation relationships focused on elderly people, our aim was to explore the association between iron concentration in subcortical nuclei and two types of memory performances in a...

http://link.springer.com/article/10.1007/s11682-015-9454-9 Neuroimaging findings suggest that excessive Internet use shows functional and structural brain changes similar to substance addiction. Even though it is still under debate whether there are gender differences in case of problematic use, previous studies by-passed this question by focusing...

Introduction: Crohn’s disease is regarded as having no curative treatment. Previous reports on dietary therapy of Crohn’s disease indicate no major success. Case Report: Here we report a severe case of Crohn’s disease where we successfully applied the paleolithic ketogenic diet. Dietary therapy resulted in resolution of symptoms, normalized labora...

Introduction: Myoepithelial tumor of the soft palate is associated with rapid progression and poor outcome. The standard care includes surgery with optional radiotherapy and/or chemotherapy. Case report: Here we present a case with myoepithelial tumor of the soft palate where the patient denied conventional treatment options. Instead, the patient s...

The objective of this study was to examine the relationship between verbal memory and total cholesterol (TC) levels related to body mass index (BMI) in healthy young women. Verbal memory was assessed using the Rey Auditory-Verbal Learning Test (RAVLT) while total serum cholesterol was measured by enzymatic colorimetric test. In order to analyze the...

The role of vitamin C at the physiological and cellular levels is indisputable. In line with this, blood level of vitamin C is inversely related to disease parameters such as risk of cancer, cardiovascular disease and mortality in prospective cohort and correlational studies. At the same time, adequately powered clinical intervention studies consis...

Although there is evidence that the ratio of 2nd to 4th digit length (2D:4D) correlates with prenatal testosterone level, psychological and health traits only two studies have assessed the relationship with brain morphological features. Here we investigated the association between the 2D:4D ratio and several brain subvolumes. Seventy-five subjects...

Introduction: Metabolic syndrome is a major public health problem affecting at least 20% of the world’s adult population. Components of the metabolic syndrome include obesity, impaired glucose metabolism, hypertension and altered lipid profile. Currently, medical treatment relies on drugs. A major problem is that patients with long-standing disease...

Hippocampal volume loss has been described in several pathological conditions including sleep disorders. Whether differences in normal sleep are associated with differences in hippocampal volume is unknown. Here we designed a study to assess volume of the hippocampus with regard to bedtime, wake up time and sleep duration in 90 healthy university s...

Objective: Vitamin D plays an important role in brain development and functioning. Low levels of vitamin D have been described in several psychiatric and neurologic conditions including autism spectrum disorder. Alexithymia that shows high comorbidity with autism is also present in the general population as well as hypovitaminosis D. Methods: He...

Objectives: Vitamin D is important in normal brain development. In animals low vitamin D level is associated with brain morphological alterations including enlargement of the brain. Whether a similar association exists in humans is unknown. Here we investigated the relationship between vitamin D and total intracranial volume as well as total volum...

A 1-es típusú diabetes mellitus (1TDM) terápiájában eddig nem tudtunk alkalmazni olyan módszert, ami szükségtelenné tette volna az inzulinpótlást. A betegek terápiáját és gondozását diabetológiai központok végzik. A háziorvosi praxisok ezt nem vállalják. Két 1TDM beteg esetét mutatjuk be, akiknél terápiás módszerként a paleo-ketogén étrendet alkalm...

A vastagbéldaganat világszerte az egyik vezető halálok. Előrehaladott esetekben az átlagos túlélési idő 6-12 hónap. A standard terápiának számító műtét és kemoterápia meghosszabbítja a túlélést, de nem biztosítanak gyógyulást. Két áttétes vastagbéldaganattal diagnosztizált beteg esetét mutatjuk be, ahol sikerrel alkalmaztuk a paleo-ketogén étrendet...

Introduction Ketogenic diets have repeatedly been suggested to confer anti-tumor effect. In the literature, however, studies reporting on cancer patients who benefit from the ketogenic diet are sparse. Case Report Here we report a case of recurrent bronchial tumor successfully managed with the paleolithic ketogenic diet. Currently the patient is on...

A paleolit vagy ahhoz közeli táplálkozást folytató nép -csoportoknál ismeretlenek a nyugati civilizációban gyakori betegségek. Staffan Lindeberg epidemio ló -giai és klinikai vizsgálataival igazolta, hogy a Pápua Új-Guineához tartozó Kitava sziget tradicionális táp -lálkozást folytató ôslakosai között nem fordul elô az elhízás, magas vérnyomás, hir...

Az evolúciós orvoslás alapelvként fogadja el, hogy életfolyamatainkat tekintve stabil belsô szabályozási utakkal rendelkezünk. Ide tartoznak a felépítô és le -bontó folyamataink és kivétel nélkül minden bioké -miai rendszerünk. Ezek egymásra épülése és kölcsön -hatásai teszik lehetôvé fiziológiás folyamatainkat, min dennapi életünket. Úgy alakultak...

Summary Several disorders, both systemic and those of the nervous system, have been linked with vitamin D deficiency. Neurological disorders with a vitamin D link include but are not limited to multiple sclerosis, Alzheimer and Parkinson disease as well as cerebrovascular disorders. Epilepsy which is the second leading neurological disorder receive...

Introduction Childhood absence epilepsy is an epilepsy syndrome responding relatively well to the ketogenic diet with one-third of patients becoming seizure-free. Less restrictive variants of the classical ketogenic diet, however, have been shown to confer similar benefits. Beneficial effects of high fat, low-carbohydrate diets are often explained...

Hippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviors and rapid-eye-movement (REM) sleep is a characteristic and well-identifiable oscillatory rhythm in animals. In contrast, controversy surrounds the existence and electrophysiological correlates of this activity in humans. Some argue that the human hippocampal th...

Seasonal variation has been reported for several disorders, including those of the nervous system. This variability is usually regarded as reflecting fluctuations in vitamin D level. Although epilepsy has also been reported to exhibit some seasonal features only one previous study assessed seasonal distribution of the epileptic seizures themselves....

There is growing interest concerning the role of vitamin D in various medical conditions such as diabetes and oncological, cardiovascular and central nervous system disorders. Although vitamin D deficiency is known to be highly prevalent among epilepsy patients, only a single study, published nearly forty years ago, assessed the effect of vitamin D...

Technological advances in digital EEG allowed the recording the full frequency band of the EEG. Activity beyond the traditional 0.3-70 Hz band reflects both physiological and pathological processes. High frequency activity recorded from the epileptic brain has been related to both epileptogenicity and epileptogenesis. The article reviews research a...

Sleep-associated memory consolidation is thought to rely on coordinated information transfer between the hippocampus and neocortex brought about during slow wave sleep (SWS) by distinct local field potential oscillations. Specifically, findings in animals have led to the concept that ripples originating from hippocampus combine with spindles to pro...

Fractal nature of the human sleep EEG was revealed recently. In the literature there are some attempts to relate fractal features to spectral properties. However, a comprehensive assessment of the relationship between fractal and power spectral measures is still missing. Therefore, in the present study we investigated the relationship of monofracta...

To investigate interhemispheric propagation of mesial temporal lobe epilepsy seizures in patients undergoing long-term video-EEG monitoring with combined scalp and foramen ovale electrodes. To reveal possible interhemispheric propagation patterns in mesial temporal lobe epilepsy, to improve presurgical evaluation of temporal epileptic patients. Six...

Fractality is a common property in nature. It can also be observed in time series representing dynamics of complex processes. Therefore fractal analysis could be a useful tool to describe the dynamics of brain electrical activities in physiological and pathological conditions. In this study, we carried out a spatio-temporal analysis of monofractal...

In the human sleep literature there is much controversy regarding the existence and the characteristics of hippocampal rhythmic slow activity (RSA). Generally the human RSA is believed to occur in short bursts of theta activity. An earlier study, however, reported mesiotemporal RSA during rapid-eye-movement (REM) sleep that instead of theta fell in...

Incidental paradoxical antiepileptic effect of levetiracetam has been described. The aim of the present study was to identify the epilepsy patients at risk. We performed a retrospective analysis in 207 patients treated with levetiracetam. This entailed evaluation of patient notes and patient interviews. A paradoxical effect was defined as an increa...

A tanulmány áttekinti azokat az érveket, amelyek szerint az alvás szakaszai sajátos mechanizmust képeznek a tanulási és emlékezeti konszolidáció számára. A REM-alvás szerepéről számos ellentmondó elképzelés született. Ugyanakkor az alvási _

Among the small apes only siamang males are known to display extensive paternal caretaking behaviour. We observed parental behaviour in a captive family group of white handed-gibbons (Hylobates lar). Our results suggest that paternal involvement in infant care may be more variable than previously believed. The pattern of dealing with the infant (ty...

Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel with sleep spindles, ripple activity is suppressed during the hyperpolarized down-state and enhanced during the...

Recent evidence suggests that the sleep-dependent consolidation of declarative memories relies on the non-rapid eye movement (NREM) rather than the rapid eye movement (REM) phase of sleep. Moreover, a few studies both at the cellular and the behavioural levels have suggested the involvement of sleep spindles, the most synchronous oscillatory wavefo...

We wanted to investigate factors that are associated with frequency of interictal epileptiform discharges by investigating 303 patients with temporal lobe epilepsy (TLE). We included all patients who consecutively underwent the adult presurgical evaluation program at our center and who had intractable, medial TLE with complex partial seizures due t...

The usual assessment of general mental ability (or intelligence) is based on performance attained in reasoning and problem-solving tasks. Differences in general mental ability have been associated with event-related neural activity patterns of the wakeful working brain or physical, chemical and electrical brain features measured during wakeful rest...

Despite strong evidence supporting a role for sleep in the consolidation of newly acquired declarative memories, the contribution of specific sleep stages remains controversial. Based on electrophysiological studies in animals, synchronous sleep oscillations have been long proposed as possible origins of sleep-related memory improvement. Neverthele...

The aim of the study was to investigate the influence of different clinical factors on spiking during sleep and wakefulness in temporal lobe epilepsy. The study included 38 temporal lobe epilepsy (TLE) patients who underwent long-term electroencephalography (EEG) monitoring. In addition to traditional sleep scoring, waking was subdivided into eyes...

To correlate the persistence of contralateral spikes during sleep after unilateral surgery with seizure outcome in a temporal lobe epilepsy (TLE) population and to test the existing hypotheses about the origin of the contralateral spikes in temporal lobe epilepsy. In the 19 patients selected for this study unilateral temporal lobe surgery was perfo...

To investigate factors determining the presence of bilateral interictal epileptiform discharges (IEDs) in temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (HS). We analysed data of 243 TLE patients with unilateral HS who had long-term video-EEG. Eighty-one patients (33%) had bitemporal IEDs. We categorised patients into a unilater...

To assess distribution of temporal lobe spikes across different states of sleep and wakefulness in simultaneous scalp and foramen ovale (Fo) recordings. The study included 12 patients with mesial temporal lobe epilepsy (MTLE). As part of their presurgical evaluation, patients underwent long-term video-EEG monitoring with combined scalp and foramen...