Zozan Guleken

Faculty of Medicine

Opioid use disorder (OUD), which is a chronic disease and widespread public health problem results in death of the patient in the early period. The consumption of opioid depending on the use disorder time, affects blood biochemical parameters. OUD diagnosis can be clinically determined from biochemical values and with the screening tools in substan...

Transcranial direct current stimulation (tDCS) method is a noninvasive neuromodulation technique based on weak direct current stimulation through the scalp. Neurofeedback (NFB) is a learning strategy that may help alter to brain wave parameters, by monitoring electroencephalography (EEG) feedback via special programs. We aimed to investigate the su...

Obesity is frequently a significant risk factor for multiple obesity-associated diseases that have been increasing in prevalence worldwide. Anthropometric data such as body mass index, fat, and fat mass values are assessed for obesity. Therefore, we aimed to propose two Fourier transform infrared (FT-IR) spectral regions, 800-1800 cm-1 and 2700- 30...

Oocytes are surrounded by a fluid called follicular fluid, which provides an essential microenvironment for developing oocytes in human fertility. Various molecules exist in antral follicles, including proteins, steroid hormones, polysaccharides, metabolites, reactive oxygen species, and antioxidants. Oxidative stress is involved in the etiology of...

The presented article is focused on developing and validating an efficient, credible, minimally invasive technique based on spectral signatures of blood serum samples in patients with diagnosed recurrent pregnancy loss (RPL) versus healthy individuals who were followed at the Gynecology department. A total of 120 participants, RPL disease (n = 60)...

Colorectal cancer is the second most common cause of cancer-related deaths worldwide. To follow up on the progression of the disease, tumor markers are commonly used. Here, we report serum analysis based on Raman spectroscopy to provide a rapid cancer diagnosis with tumor markers and two new cell adhesion molecules measured using the ELİSA method....

Among the most significant characteristics of human beings is their ability to feel emotions. In recent years, human-machine interface (HM) research has centered on ways to empower the classification of emotions. Mainly, human-computer interaction (HCI) research concentrates on methods that enable computers to reveal the emotional states of humans....

Herein, we examined the modulatory effects of Apocynum (APO) on Monosodium Glutamate (MSG)-induced oxidative damage on the brain tissue of rats after long-term consumption of blood serum components by biochemical assays, Fourier transform infrared spectroscopy (FTIR), and machine learning methods. Sprague-Dawley male rats were randomly divided into...

Background: Alzheimer’s disease (AD) is the most common reason for dementia and is one of the most important causes of morbidity and mortality in the aging population. A crucial component of AD is the brain’s sensitivity to oxidative stress. We aimed to determine the oxidative load of patients with AD who had just been diagnosed and had not yet beg...

The present article is focused on developing and validating an efcient, credible, minimally invasive technique based on spectral signatures of blood samples of women with recurrent miscarriage vs. those of healthy individuals who were followed in the Department of Obstetrics and Gynecology for 2 years. For this purpose, blood samples from a total o...

Objective: Multiple Sclerosis is an autoimmune demyelinating disease that progresses with inflammatory infiltrates in the central nervous system. Dysregulation of the JAK-STAT signaling pathway plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis-induced Multiple Sclerosis models. The aim of this study was to rev...

In this study, International Affective Picture System (IAPS) were used to evoke fear and neutral stimuli using EMOTIV EPOC EEG recognition system (n=15). During the experiments, EEG data were recorded using the Test bench program. To synchronize the EEG records, IAPS pictures were reflected on the screen. A Python script was written in the Open Ses...

This review aims to draw attention to current studies on syndromes related to food eating behavior, including food addiction, and to highlight the neurobiological and neuropharmacological aspects of food addiction toward the development of new therapies. Food addiction and eating disorders are influenced by several neurobiological factors. Changes...

Background: The venous disease of the legs is a common disease among adults that may lead to a deterioration in the structure and concentration of biomolecules. N-Butyl Cyanoacrylate Ablation Surgery (NBCA) or cyanoacrylate embolization (CAE) technique to adhesive the saphenous vein is an alternative method for the treatment of venous disease. Ob...

By in vitro fertilization, oocytes can be removed and the embryo can be cultured, and then trans cervically replaced when they reach cleavage or when the blastocyst stage. The characterization of the follicular fluid is important for the treatment process. Women who applied to the Academic Hospital in vitro fertilization (IVF) Center diagnosed with...

In this research, blood samples of 47 patients infected by COVID were analyzed. The samples were taken on the 1st, 3rd and 6th month after the detection of COVID infection. Total antibody levels were measured against the SARS-CoV-2 N antigen and surrogate virus neutralization by serological methods. To differentiate COVID patients with different an...

Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepatic bile ducts and gallbladder carcinoma. Mostly diagnosed at an advanced stage with a <5%cure chance. Early-stage diagnosis may increase the number of patients who reach curative treatment. Fourier Transform InfraRed (FT-IR) spectroscopy was used to de...

The formation of the uterus lining, i.e. the endometrium, outside the uterus (ex. in the abdominal cavity, ovaries, or anywhere in the body) is called endometriosis. The presence of endometrial tissue present in the ovaries, thickens after menstruation, leading to menstrual-like bleeding and to the formation of chocolate cyst (Endometrioma) because...

The effects of the electromagnetic field on living organisms have been studied for several years. In this article, we showed what kind of cold change an extremely low-frequency electromagnetic field (ELF-MF) exposure 500 μT 50 Hz by using a Meritt Coil System causes in the samples of the brain and liver samples. To measure oxidative load, we measur...

Polycystic ovarian syndrome (PCOS) is a disease, which causes infertility in women. The factors for the development of the disease are still not well understood and diagnostic methods need to be improved. Therefore, in this study, Raman spectroscopy as a potential diagnostic tool, was investigated and spectra of blood serum were collected from PCOS...

Cholangiocarcinoma (CCA) is a type of cancer, which 5-year survival is lower than 20 %, and which is detected mostly in advanced stage of the disease. Unfortunately, there are no diagnostic tools, which could show changes in the body indicating the development of the disease. Therefore, in this study, we investigate Raman spectroscopy as a promisin...

Amaç Teknolojinin gelişmesiyle beraber, günlük hayatımızda evde, işyerinde, okulda elektromanyetik alanlara maruziyetimiz giderek artmaktadır. Kronik olarak maruz kaldığımız 50 Hz frekansa sahip elektromanyetik alanların (çok düşük frekanslı manyetik alan ELF-MF) sağlık üzerine etkileriyle ilgili birçok bilimsel çalışma yapılmıştır. Bu çalışmada, s...

Aims and Objectives: Perception has an important role in managing crisis situations such as pandemics. While studies have been conducted on the risk and stress perceptions of health-care workers, there has not been any study on the stress and risk perceptions of health science students who have not yet started this profession, which was investigate...

Herein, we show differences in blood serum of asymptomatic and symptomatic pregnant women infected with COVID-19 and correlate them with laboratory indexes, ATR FTIR and multivariate machine learning methods. We collected the sera of COVID-19 diagnosed pregnant women, in the second trimester (n = 12), third-trimester (n = 7), and second-trimester w...

Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive processes during economic decisions. In the present study, we investigate peak-to-peak amplitude of task event-related oscillations of healthy subjects during delay discounting task. The study included forty-seven consecutive volunteers with mean 22 age-...

Endometriomas are typically an advanced form of endometriosis that leads to the formation of scar tissue, adhesions, and an inflammatory reaction. There is no certain serum marker for the diagnosis of endometriosis. This study aims to research the correlation between the amount of peaks corresponding to proteins and lipids with the volume of endome...

Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder in reproductive-age women, indeed a multifactorial condition. Cytokines such as TNF-alpha and IL-6 have an influence on several metabolic activities. The increase in dehydroepiandrosterone (DHEA) is thought to play an important role in IL-6-mediated pathogenetic effects in...

Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with metabolic disturbances. Both in the development and improvement of the disease, the structure of phospholipids and proteins in the blood serum plays important role in the treatment of these disease. Herein, to investigate the metabolic process and the variations of biomacro...

Alcohol abuse is the most common and costly form of drug abuse. The disease is a major contributing factor that leads to many disease categories. The main purpose of this study is to identify the effect of chronic alcohol consumptions in the secondary structure of proteins and lipid balance in the blood samples of the patients. To identify the chan...

Electromagnetic (EM) energy that generates extremely low-frequency magnetic fields (ELF-MF) impacts all living organisms' biological systems. To investigate the chronic impact of ELF-MF (50 Hz) we designed an externally applied electric field exposure to rat offspring during intrauterine and after extrauterine life. A total of 18 rat offsprings blo...

Abstract Colon and gastric cancers are the widespread benign types of cancers that are synchronous and metachronous neoplasms. In terms of the progression and progress of the disease, metabolic processes and differentiation in protein structures have an important role in for treatment of the disease. In this study, we proposed to investigate the me...

Diabetic wounds have a slow healing process and easy to be infected. In addition to current drug treatments, supportive approaches are needed for diabetic wound treatment. In this study, we aimed to load Aloe Vera (AV) and Hypericum perforatum oil (HPO) with PCL/Ge (Poly (ɛ-caprolactone)/Gelatine) polymeric biodegradable by electrospinning method i...

The use of electromagnetic (EM) energy that generates extremely low-frequency magnetic fields (ELF-MF) has become widespread with technology-related features and industrialization which has impacts on all living organism’s biological systems. Consequently, we prepared an experimental design with an externally applied electric field exposure to rat...

Harmful illicit drug use, such as opioid use disorder (OUD), causes multiple diseases that result in physiological, pathological, and structural changes in serum biochemical parameters based on the period of use. Fourier-transform infrared (FTIR) spectrometry is a noninvasive optical technique that can provide accurate evidence about the biochemica...

Introduction Transcranial direct current stimulation (tDCS) method is a noninvasive neuromodulation technique based on weak direct current stimulation through the scalp. Neurofeedback (NFB) is a learning strategy which may help to alter brain wave parameters of a person by giving electroencephalography (EEG) feedback via special developed computer...

The 17β-estradiol plays a role in physiology of pancreas and may protect it from inflammation. To examine the possible anti-inflammatory effects of 17β-estadiol in pancreaticobiliary duct ligated (PBDL) acute pancreatitis (AP) model, and the underlying mechanism that 17β-estradiol acts on, via evaluating the direct and the receptor related effects...

It has been shown that estrogens have anti-inflammatory effects in different experimental inflammation models, however the effect of estrogen on acute pancreatitis was not investigated. In the study it is aimed to determine the potential role of estrogen receptor agonists on acute pancreatitis model induced by pancreaticobiliary ligation. In the st...