Zoya Gridneva

Zoya Gridneva
University of Western Australia | UWA · School of Molecular Sciences

PhD

About

83
Publications
16,295
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1,219
Citations
Introduction
Zoya Gridneva, PhD is a Research Fellow at the Geddes Hartmann Human Lactation Research Group, UWA (Western Australia). Zoya has a biochemical background with emphasis in proteomics, she utilizes new techniques (ultrasound, bioimpedance) to improve the understanding of human milk composition and its relationship to infant’s growth, appetite control and body composition. Her other interests are the effects of maternal factors on breast anatomy and human milk composition, production and removal.
Additional affiliations
April 2017 - April 2021
University of Western Australia
Position
  • PostDoc Position
September 2012 - March 2017
University of Western Australia
Position
  • PhD Student
October 2004 - February 2011
University of Western Australia
Position
  • Research Officer

Publications

Publications (83)
Article
Full-text available
Background: Whilst it is inconvenient and time-intensive, predominantly (PP) and exclusively pumping (EP) mothers rely on breast expression to provide milk for their infants and to ensure continued milk supply, yet these populations are poorly understood. Methods: We assessed and characterised Western Australian PP mothers (n = 93) regarding 24 h m...
Article
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Background/Objectives: The causes of low milk supply are multifactorial, including factors such as gene mutations, endocrine disorders, and infrequent milk removal. These factors affect the functional capacity of the mammary gland and, potentially, the concentrations of milk components. This study aimed to investigate the differences in milk compos...
Article
Full-text available
Background: Infant growth trajectories reflect current health status and may predict future obesity and metabolic diseases. Human milk is tailored to support optimal infant growth. However, nutrient intake rather than milk composition more accurately predicts growth outcomes. Although the role of protein leverage in infant growth is unclear, protei...
Article
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Background: Maternal breast volume is determined by the quantity of glandular and adipose tissue, and it undergoes significant changes during pregnancy. These changes are intricately linked to the development of glandular tissue, which most likely reflects lactation capacity. Evidence indicates that women with overweight or obesity exhibit larger b...
Article
Full-text available
Human milk (HM) composition, including metabolic hormones and lipids, is influenced by various factors, including lactation stage and, potentially, infant sex, which may affect infant body composition (BC) development. We aimed to: (a) characterize the longitudinal concentration and intake profiles of HM leptin, adiponectin, insulin, and total lipi...
Article
Aims To determine the effect of a two-week reduced fat and sugar and increased fibre maternal dietary intervention on the maternal faecal and human milk (HM) microbiomes. Methods and results Faecal swabs and HM samples were collected from mothers (n = 11) immediately pre-intervention, immediately post-intervention, and 4- and 8-weeks post-interven...
Article
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Limited attention is given to the efficacy of protocols for the estimation of infant intake of milk components when investigating their impact on infant outcomes. We compared the actual measured intake of human milk components with estimations derived from 15 protocols to determine the most reliable approach for estimating intake of HM leptin, adip...
Article
Full-text available
There is an inadequate understanding of the daily variations in hormones and macronutrients in human milk (HM), and sample collection protocols vary considerably from study to study. To investigate changes in these milk components across 24 h, 22 lactating women collected small milk samples before and after each breastfeed or expression from each b...
Article
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Human milk provides all of the elements necessary for infant growth and development. Previous studies have reported associations between breastfeeding and a reduced risk of developing obesity and late-onset metabolic disorders; however, the underlying mechanisms are poorly understood. Recently, intakes of human milk components have been associated...
Article
Full-text available
Citation: Norrish, I.; Sindi, A.; Sakalidis, V.S.; Lai, C.T.; McEachran, J.L.; Tint, M.T.; Perrella, S.L.; Nicol, M.P.; Gridneva, Z.; Geddes, D.T. Relationships between the Intakes of Human Milk Components and Body Composition of Breastfed Infants: A Systematic Review. Nutrients 2023, 15, 2370. https://doi. Abstract: Human milk provides all of the...
Article
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Background & Aims: To improve convenience and maximize flexibility whilst pumping, wearable pumps have been designed however, their performance have not been evaluated. This study aimed to develop the protocol and evaluate the efficacy and comfort of a new hands-free, in-bra, breastmilk collection pump set (IBCPS) connected to a personal use double...
Conference Paper
Full-text available
Human milk (HM) is an important source of nutrition for infants that provides all elements necessary for their growth and development. Previous studies have reported associations between breastfeeding and a reduced risk of developing obesity and late metabolic diseases, such as type 2 diabetes. However, the underlying mechanisms are poorly understo...
Conference Paper
Full-text available
When submitting conference proceedings to the journal, Proceedings, the volume’s editors must notify the publisher that they carried out a peer review of all published papers [...]
Article
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Gestational diabetes mellitus (GDM) is a common pregnancy complication with short- and long-term health consequences for the infant and mother. Breastfeeding is the recommended mode of feeding as it offers an opportunity to reduce the risk of GDM consequences, likely partially mediated through changes in human milk (HM) composition. This review sys...
Article
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We investigated associations between intakes of human milk (HM) components (macronutrients and biologically active molecules) and regional fat depots development in healthy term infants (n = 20) across the first year of lactation. Infant limb (mid-arm and mid-thigh) lean and fat areas were assessed by ultrasound imaging at 2, 5, 9 and 12 months of...
Article
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Human milk is a complex and variable ecosystem fundamental to the development of newborns. This study aimed to investigate relationships between human milk oligosaccharides (HMO) and human milk bacterial profiles and infant body composition. Human milk samples (n = 60) were collected at two months postpartum. Infant and maternal body composition wa...
Article
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Temporal development of maternal and infant microbiomes during early life impacts short- and long-term infant health. This study aimed to characterize bacterial dynamics within maternal faecal, human milk (HM), infant oral, and infant faecal samples during the exclusive breastfeeding period and to document associations between human milk oligosacch...
Article
Humans are exposed to environmental factors at every stage of life including infancy. The aim of this mini‐review was to present a narrative of environmental factors influencing human milk composition. Current literature shows lactation is a dynamic process and is responsive to multiple environmental challenges including geographical location, life...
Article
Full-text available
Human milk (HM) components may influence infant growth and development. This study aimed to investigate relationships between infant body composition (BC) and HM lactose, insulin, and glucose (concentrations and calculated daily intakes (CDI)) as well as 24-h milk intake and maternal BC at 3 months postpartum. HM samples were collected at 2 months...
Article
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This study aimed to investigate relationships between infant abdominal visceral and subcutaneous adiposity and human milk (HM) components and maternal body composition (BC) during first year of lactation. Subcutaneous-abdominal depth (SAD), subcutaneous-abdominal fat area (SFA), visceral depth (VD) and preperitoneal fat area of 20 breastfed infants...
Article
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Researchers have recently called for human lactation research to be conceptualized as a biological framework where maternal and infant factors impacting human milk, in terms of composition, volume and energy content are studied along with relationships to infant growth, development and health. This approach allows for the development of evidence-ba...
Article
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Human milk (HM) contains a wide array of peptide hormones including leptin and adiponectin, which are involved in the regulation of infant growth and development. These essential hormones might play an important role in the regulation of metabolic reprogramming of the new-born infant. However, HM hormone studies are sparse and heterogeneous in rega...
Article
Human milk is a living dynamic fluid that promotes optimal nutrition and development of the infant and impacts health across the lifespan. This review reports on the diverse range of nutrients, immune protection factors, hormones, microbes and metabolites in human milk and their impacts on infant nutrition and health. While many of these components...
Article
Full-text available
Human milk (HM) is a complex and dynamic biological fluid, which contains appreciable concentrations of the glucocorticoids, cortisol and cortisone. Experimental studies in non-human primates suggest the HM glucocorticoids' impact on infant growth and body composition. In this current study, analysis is made of the relationships between HM glucocor...
Article
To investigate relationships between infant body composition (BC) and human milk (HM) immunomodulatory proteins (IMPs) during the first 12 months of lactation. BC of breastfeeding dyads (n = 20) was measured with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers) at 2, 5, 9, and/or 12 months post partum. Breastfeeding fr...
Poster
Full-text available
Maternal stress and anxiety can negatively impact breastfeeding and thus potentially the nutritional intake of the infant which may influence early programming of infant metabolism and gene expression. Inhibition of the milk ejection reflex may also impact autocrine control of milk synthesis leading to downregulation of milk production (MP), result...
Poster
Associations of maternal characteristics with breast anatomy and milk production during the established lactation Gridneva Z1, Gardner H1, Lai CT1, Geddes DT1 1The University of Western Australia, Perth, Australia Presenting Author Email: zoya.gridneva@uwa.edu.au Background/Aims: Animal models show a more rapid mammary gland response and more...
Article
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Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads (n = 20) was determined...
Article
Full-text available
Background Human milk (HM) transforming growth factor beta (TGF‐β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF‐β levels are associated with allergic outcomes. Objective We undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relat...
Article
Human milk (HM) components, such as appetite hormones, proteins and carbohydrates can influence infant feeding behavior, regulation of appetite and body composition (BC). This study investigated associations between breastfed term infant anthropometrics/BC and the concentrations/calculated daily intakes (CDIs) of HM adipokines (adiponectin and lept...
Article
Persistent organic pollutants (POPs), such as pesticides, are released into the environment and bio‐accumulate in human adipose tissue via inhalation, ingestion or dermal adsorption. The presence of pesticides in human milk (HM) is of great concern due to the potential health effects. Longitudinal monitoring of these pesticides in HM is essential t...
Article
Full-text available
Human milk (HM) influences infant feeding patterns and body composition (BC). This small proof-of concept longitudinal study investigated relationships between infant/maternal BC and HM casein, whey and total protein during the first 12 months of lactation. BC of breastfeeding dyads (n = 20) was measured at 2 (n = 15), 5 (n = 20), 9 (n = 19), and/o...
Article
Full-text available
Human milk (HM) adipokines may influence infant feeding patterns, appetite regulation, and body composition (BC). The associations between concentrations/calculated daily intakes (CDI) of HM adipokines in the first 12 months postpartum and maternal/term infant BC, and infant breastfeeding parameters were investigated. BC of breastfeeding dyads (n =...
Article
Full-text available
Breastfeeding has been implicated in the establishment of infant appetite regulation, feeding patterns and body composition (BC). A holistic approach is required to elucidate relationships between infant and maternal BC and contributing factors, such as breastfeeding parameters. Associations between maternal and breastfed term infant BC (n = 20) an...
Article
Background: Preterm infants' meals typically progress to higher volumes over time. Knowledge of gastric emptying (GE) responses to differing meal volumes may inform enteral feeding management. We examined the effect of meal volume and composition on preterm GE. Methods: Forty infants were studied at 33.3±1.4 (29.7-35.6) weeks postmenstrual age w...
Article
Background: Infants breastfed on demand exhibit a variety of feeding patterns and self-regulate their nutrient intake but factors influencing their gastric emptying (GE) are poorly understood. Despite research into appetite regulation properties of leptin, there is limited information about relationships between human milk leptin and infant GE. M...
Article
Full-text available
Human milk (HM) appetite hormones and macronutrients may mediate satiety in breastfed infants. This study investigated associations between maternal adiposity and concentrations of HM leptin, adiponectin, protein and lactose, and whether these concentrations and the relationship between body mass index and percentage fat mass (%FM) in a breastfeedi...
Article
Persistent organic pollutants in human milk (HM) at high levels are considered to be detrimental to the breastfed infant. To determine the pesticide concentration in HM, a pilot cross-sectional study of 40 Western Australian (WA) women was carried out. Gas chromatography-tandem mass spectrometry (GC-MS/MS) with a validated QuEChERS was used for the...
Article
Full-text available
Human milk (HM) components influence infant feeding patterns and nutrient intake, yet it is unclear how they influence gastric emptying (GE), a key component of appetite regulation. This study analyzed GE of a single breastfeed, HM appetite hormones/macronutrients and demographics/anthropometrics/body composition of term fully breastfed infants (n...
Article
Full-text available
The presence of pesticides in human milk (HM) is of great concern due to the potential health effects for the breastfed infant. To determine the relationships between HM pesticides and infant growth and development, a longitudinal study was conducted. HM samples (n = 99) from 16 mothers were collected at 2, 5, 9 and 12 months of lactation. A valida...
Article
Background: Accurate, non-invasive and inexpensive methods are required to measure infant body composition. Ultrasound and bioimpedance spectroscopy (BIS) have been validated in adults and introduced in pediatric populations. The aim of this study was to evaluate the performance of both methods in determining percentage fat mass (%FM) in breastfed...
Article
Full-text available
Human milk (HM) contains a plethora of metabolic hormones, including leptin, which is thought to participate in the regulation of the appetite of the developing infant. Leptin in HM is derived from a combination of de novo mammary synthesis and transfer from the maternal serum. Moreover, leptin is partially lipophilic and is also present in HM cell...
Article
BACKGROUND/OBJECTIVES: Bioimpedance spectroscopy is an accurate non-invasive method for measuring body composition in adults, but in infants it requires further testing and validation. Of the few studies of bioimpedance conducted in infants, none have comprehensively investigated the effect of milk intake volume. This study assessed the effect of t...
Article
Background/objectives: Bioimpedance spectroscopy is an accurate non-invasive method for measuring body composition in adults, but in infants it requires further testing and validation. Of the few studies of bioimpedance conducted in infants, none have comprehensively investigated the effect of milk intake volume. This study assessed the effect of...
Conference Paper
Full-text available
Objective: Epidemiological studies have shown that extended breastfeeding is associated with reduced risk of becoming obese later in life. Infants exclusively breastfed on demand self-regulate their nutrient intake demonstrating a variety of feeding patterns. However, the factors influencing their gastric emptying are not well understood. Despite t...
Conference Paper
Full-text available
Objectives: Breastmilk biochemical components, such as protein, oligosaccharides, cytokines and hormones together with the process of breastfeeding itself can influence infant feeding behavior and regulation of appetite control and growth later in life. The objective of this study was to determine if there is a relationship between concentration of...
Article
Higher breastmilk casein concentration increases gastric emptying in preterm infants, however there are limited information regarding whether casein or other components of breastmilk affect gastric emptying in term infants. In this study we investigated associations of macronutrient and skim milk leptin concentrations with gastric emptying. Term fu...
Article
We evaluated the effects of fortification and composition on gastric emptying and curding in un/fortified pairs of mother's own milk (MOM, n = 17) and pasteurized donor human milk (PDHM, n = 15) in preterm infants. Retained meal proportions (%) and curding were determined from sonography. Immediate and subsequent postprandial % were higher for PDHM...