Zothan Siama

Mizoram University · Department of Zoology

The synthesis of dihydropyridone derivatives has been reported by ring rearrangement of pyrans using iodine and formic acid as a catalyst separately. Dihydropyridones were crystallized subjected for single-crystal X-ray crystallography to acquire their structural parameters. The different non-covalent interactions involved within the supermolecular...

Background Mussaenda macrophylla is a shrub widely used in Mizo traditional practice for treatment of cancer, fever, cough, ulcer and dysentery. We have previously shown the antioxidant nature of the plant. In this study, we explore the anticancer activity of the aqueous extract of M. macrophylla (MMAE) using Dalton’s lymphoma ascites (DLA) bearing...

Green synthesis of metal nanoparticles is a rapidly growing research area in the field of nanotechnology because of their biomedical applications. This study describes the synthesis of silver nanoparticles (AgNPs) using Spilanthes acmella leaf extract and its ameliorative effects against doxorubicin-induced toxicity. The formation of AgNPs was conf...

Cervical cancer has emerged as a major threat among the tribal communities of Mizoram where literatures on the prevalence of HPV genotypes are scarce. This study aimed to determine the prevalence of HPV in different cytological grades of cervical samples in relation to lifestyle and socio-demographic factors. Sanger sequencing was performed to conf...

This study investigates the phytochemical composition, anti-oxidative potential and anti-cancer activity of silverberry Elaeagnus caudata. The aqueous extract of E. Caudata has higher phenolic content (259.32 ± 5.18 mg GAE/g) and flavonoid content (1869.25 ± 25.9 mg quercetin equivalent/g) than the methanolic extract. The aqueous extract possessed...

This study was designed to investigate the possible effects of exposure to mobile phone base station (MPBS) emits 1800-MHz RF-EMR on some oxidative stress parameters in the brain, heart, kidney and liver of Swiss albino mice under exposures below thermal levels. Mice were randomly assigned to three experimental groups which were exposed to RF-EMR f...

Background The lack of early diagnostic tools and the development of chemoresistance have made ovarian cancer (OC) one of the deadliest gynaecological cancers. The tumour microenvironment is characterised by the extracellular release of high levels of ATP, which is followed by the activation of P1 adenosinergic and P2 purinergic signalling systems....

The toxic side effects of doxorubicin in cancer treatment are well established. Here we show that methanolic extract of the fungus Ganoderma applanatum offers protection against cardio- and hepatotoxicity induced by doxorubicin (DOX) in Dalton’s Lymphoma Ascites (DLA) bearing mice. Treatment of DLA mice with 20 mg/kg of doxorubicin significantly in...

The study aims to evaluate the anticancer activity of Callicarpa arborea in A549 cancer cells.Fresh non-infected leaves of Callicarpa arborea were collected from Serkawn, Lunglei District, Mizoram and various solvents were used for Soxhlet extraction at their respective boiling points. The extracts were concentrated and the anticancer activity was...

This study evaluates the phytochemical constituents, free radical scavenging activities and antioxidative potential of the tuber extracts of Stemona tuberosa (ST). The preliminary phytochemical screening revealed the presence of alkaloids, cardiac glycosides, saponins, steroids, tannins and terpenoids from various solvent extracts of ST. The methan...

The novel coronavirus disease 2019 (COVID -19), a pandemic of global concern, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has severely revealed the need for public monitoring and efficient screening techniques. In spite of the various advancements made in the medical and research field, containment of this...

Qualitative disorders are the type of genetic disorders that arise from change(s) in a single gene leading to suppression or abnormal expression of a gene causing corresponding phenotype with no intermediate form. The phenotypic representations are qualitatively accessible and not quantitatively.

Ovarian cancer (OC) is one of the deadliest cancers among women contributing to high risk of mortality, mainly owing to delayed detection. There is no specific biomarker for its detection in early stages. However, recent findings show that over-expression of specificity protein 1 (Sp1) is involved in many OC cases. The ubiquitous transcription of S...

This study investigates the phytochemical composition, free radical scavenging activities, and antioxidative potential of various extracts of Mussaenda macrophylla. Phytochemicals such as alkaloids, cardiac glycosides, saponins, steroids, tannins, and terpenoids were found to be present in various extracts of M. macrophylla. Aqueous extract of M. m...

Callicarpa arborea (CA) (English - Beautyberry) locally called as ‘Hnahkiah’ is a small evergreen tree of the family Verbanaceae. The study aims to evaluate the effects of Callicarpa arborea on the level of various antioxidants and reproductive integrity in type II Human lung adenocarcinoma (A549). Treatment of A549 cells with different doses of Ca...

Purpose: The regular low dose occupational exposure to ionizing radiation may induce deleterious health effects, which may be of particular interest to medical radiation workers who daily handle X-ray machines. Human peripheral blood lymphocytes are able to retain the signature of radiation-induced DNA damage, therefore present study was undertaken...

The aim of this study was to investigate the phytochemical constituents and therapeutic potential of various solvent extracts of Mallotus roxburghianus both in-vitro and in-vivo. Free radicals scavenging activities of various extracts were determined in a cell free system and the hepatoprotective effects was investigated in doxorubicin induced oxid...

The study was aimed to assess spontaneous food preferences in captive stump-tailed macaques and to correlate it with nutrients availability in the food items eaten by nursing females. The study was conducted at Aizawl Zoological Park where three captive stump-tailed female monkey (Macaca arctoides) with their infants were maintained on routine diet...

Radiofrequency radiations (RFRs) emitted by mobile phone base stations have raised concerns on its adverse impact on humans residing in the vicinity of mobile phone base stations. Therefore, the present study was envisaged to evaluate the effect of RFR on the DNA damage and antioxidant status in cultured human peripheral blood lymphocytes (HPBLs) o...

The present study investigated how the maternal dominance status influences the mother-infant relationship and the interaction of females other than the mother with the group infants in captive stump-tailed macaques (Macaca arctoides). Nine infants were born into the group; observations were made on these infants during their first six months of li...

In order to determine the factors influencing male mating choice in captive stump-tailed macaques (Macaca arctoides), the group composition was manipulated in which confounding social context were controlled. Each adult male was given the opportunity to mate with any of the estrous female during the mating season between September 2010 and February...

In the present paper, we presented the study of complaints on thirteen (13) different health symptoms faced by inhabitants living near mobile tower – Global System for Mobile Communication (GSM 900) and those inhabitants living in the area where there is no mobile tower. The study was conducted in two different localities in Aizawl in the year 20...

The study examines the relationship between male dominance and cost incurred in monopolizing females for copulation in captive stump -tailed macaque (Macaque arctoides). We correlated the influence of inter-male aggression, male courtship behaviour, female sexual proceptivity and the daily activity budget in male for mating success. Majority of the...

Artificial nest boxes were constructed by Biodiversity and Nature Conservation Network (BIOCONE) using an indigenous wood Tetrameles nudiflora (Thingdawl). A total of 140 artificial nest boxes were constructed during the period of 2011 to 2013. The project was funded by the Department of Science and Technology, Government of Mizoram. These artifici...

This paper present the results of the nests survey of the King Cobra in the Aizawl District of Mizoram, India with data collected between the 2009 and 2012 during the nesting seasons. A number of eighteen (18) nests were monitored during this period. Collection on the data of location, elevation, vegetation, nesting materials, nest dimensions, clut...

In this report, nighttime births of 3 stump-tailed macaques observed at the Aizawl Zoological Park, India, are described. Continuous focal observations were collected along with video and still photographs, on the 3 parturitions, from the first observed onset of labour. The average time taken for infant birth, beginning with visibility of the h...

The present study reports infanticide among stump-tailed macaques. The incident was observed when the study group was manipulated by introducing the β-male to the mother–infant pair at the breeding centre. As no copulation was observed between the β-male and the victim’s mother, it was safe to exclude the β-male as the probable father. The infan...

The present study aims to determine whether homosexual behavior in stump-tailed macaque males of different age groups were socio-sexual or sexually motivated. Male homosexual encounters were divided into two categories for analysis; manual genital stimulation and actual mounting. Manual genital stimulation in adult males occurred bidirectional, i...

The present study aims to determine whether homosexual behavior in stump-tailed macaque males of different age groups were socio-sexual or sexually motivated. Male homosexual encounters were divided into two categories for analysis; manual genital stimulation and actual mounting. Manual genital stimulation in adult males occurred bidirectional, i...

The present study represents the unique features ofmale homosexuality in forms and context, and determines whether this behaviour is sexually motivated or sociosexual in function in captive stump-tailed monkeys,Macaca arctoides. Ten incidents of homosexual encounters between α- and β-male were observed. No reciprocal mounting was observed.Every epi...