Zoltán Lelkes

Zoltán Lelkes
University of Szeged · Department of Physiology

About

17
Publications
272
Reads
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170
Citations
Citations since 2017
3 Research Items
34 Citations
201720182019202020212022202302468
201720182019202020212022202302468
201720182019202020212022202302468
201720182019202020212022202302468

Publications

Publications (17)
Article
Sleep disturbances are common findings in bipolar affective disorder (BD), and they may be related to the pathophysiology of the disease. REM sleep deprivation, which has an antidepressant effect, increases Na–K-ATPase (NKA) activity. NKA might be involved in the induction of rebound sleep. Decrements in NKA are thought to be implicated in the path...
Article
The cholinergic basal forebrain contributes to cortical activation and receives rich innervations from the ascending activating system. It is involved in the mediation of the arousing actions of noradrenaline and histamine. Glutamatergic stimulation in the basal forebrain results in cortical acetylcholine release and suppression of sleep. However,...
Article
Cholinergic basal forebrain structures are implicated in cortical arousal and regulation of the sleep-wake cycle. Cholinergic neurones are innervated by noradrenergic terminals, noradrenaline excites them via alpha-1 receptors and microinjection of noradrenaline into the basal forebrain enhances wakefulness. However, it is not known to what extent...
Article
The basal forebrain (BF) is involved in the regulation of sleep-wake activity. Cholinergic BF structures contribute to cortical activation. These cholinergic neurons receive noradrenergic input and noradrenalin (NA) excites them via alpha-1 receptors. NA microinjection into the BF enhances wakefulness. Cholinergic BF neurons may be involved in the...
Article
A study was carried out on the effects on sleep of rolipram, an antidepressant that increases the availability of cAMP by inhibiting a phosphodiesterase isoenzyme. Rats were treated with rolipram (0.1 or 1 mg/kg) twice a day (at light and dark onset) for 11 days, after a chronic period of injection of physiological saline for habituation purposes....
Article
A study was carried out on the effects on sleep of rolipram, an antidepressant that increases the availability of cAMP by inhibiting a phosphodiesterase isoenzyme. Rats were treated with rolipram (0.1 or 1 mg/kg) twice a day (at light and dark onset) for 11 days, after a chronic period of injection of physiological saline for habituation purposes....
Article
Rats were treated with trazodone (2.5 or 10 mg kg-1) twice a day (at light and dark onset) for 11 days, after chronic injection of physiological saline. The sleep-wake activity was recorded for 24 h on the baseline day (saline), on trazodone days 1, 5 and 11, and also on day 12, when physiological saline was injected again (withdrawal day). Trazodo...
Article
We studied the effect of alternating 45-min light-dark (L-D) cycles on sleep in rats. Introduction of short L-D cycles did not abolish the normal circadian rhythm of sleep-wake activity. The amount of non-REM sleep was however increased in the L and decreased in the D 45-min periods. REM was promoted in the D and inhibited in the L 45-min periods....
Article
1. After the chronic administration of saline, rats were treated with nomifensine (0.1 or 1.0 mg/kg, twice a day, at light and dark onset) for 11 days. The sleep-wake activity was recorded for 24 h on the baseline day (saline), on nomifensine days 1, 5 and 11, and also on day 12, when saline was injected again (withdrawal day). Another group of rat...
Article
The effect of morphine pretreatment on kainic acid-induced seizures in rats was investigated by electroencephalographic recording. Seizure activity was quantified by counting the number of spikes in the EEG of freely-moving rats during 2 min periods at 30 min intervals after the intraperitoneal administration of 8, 10 or 12 mg/kg kainic acid. Pretr...
Article
The effect of morphine pretreatment on kainic acid-induced seizures in rats was investigated by electroencephalographic recording. Seizure activity was quantified by counting the number of spikes in the EEG of freely-moving rats during 2 min periods at 30 min intervals after the intraperitoneal administration of 8, 10 or 12 mg/kg kainic acid. Pretr...
Article
The alterations in the water, sodium (Na) and potassium (K) contents of the frontoparietal cortex, hippocampus and thalamus as well as the protein permeability of the blood-brain barrier were investigated in rats 4 h after systemic kainic acid administration. Increases in the water and Na contents and a decrease in the K content were observed toget...
Article
Amitriptyline (1, 5 or 15 mg/kg intraperitoneally, twice a day) was administered to rats and the sleep-wake activity was recorded for either 24 hr (1 mg/kg) or 12 hr (5 or 15 mg/kg) on the day before treatment with amitriptyline, on days 1 and 5 of the treatment and on day 6, when the drug was withdrawn. In the first 3 hr amitriptyline increased no...
Article
In acute immobilized rats, the effect on the EEG of thermal and chemical (capsaicin microinjection) stimulation of the warm sensors in the preoptic region, mid-hypothalamic area and posterior hypothalamus were studied. Both localized heating and capsaicin resulted in a sleep-like EEG with spindles and slow waves. Stimulation of the posterior hypoth...

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