Zohreh Yousefi

Mashhad University of Medical Sciences | MUMS · Department of Obstetrics

Purpose Granulosa cell tumors (GCTs) of the ovary are rare but clinically significant malignancies. Despite advances in treatment, recurrence has remained a substantial challenge. This study aimed to identify clinical outcomes and potential prognostic risk factors for recurrence in patients diagnosed with GCTs. Methods In a retrospective cohort st...

Choriocarcinoma usually occurs in the uterine body. Non-gestational choriocarcinoma is an extremely rare malignant tumor with a poor prognosis and is difficult to distinguish from gestational choriocarcinoma. In this case report, we describe a case of pure non-gestational choriocarcinoma. A 35-year-old woman was referred to our academic hospital wi...

Ovarian cancer management during pregnancy is a topic of limited research due to low occurrence rates of malignant adnexal tumors. To shed further light on this issue, we present a case series of 22 pregnant ovarian cancer patients referred to an academic hospital's gynecology oncology department over six years. Data on each patient's demographic a...

Background: Low-risk gestational trophoblastic neoplasia could be cured in the case of appropriate management with single-agent chemotherapy. This study was carried out to compare the efficacy of single-dose methotrexate versus Actinomycin-D in low-risk gestational trophoblastic neoplasia to analyze the most effective agent. Methods: This retros...

Background: The most prevalent type of gynecological cancer is endometrial cancer. Accurate surgical staging is the most important aspect in the management of endometrial cancer. Preoperative evaluation of myometrial invasion and appropriate management could be achieved by transvaginal sonography and pelvic MRI. Methods: A total of 53 patients with...

Introduction Bladder leiomyoma, commonly found in middle-aged females, is a rare, benign, and mesenchymal tumor of the bladder. Its incidence rate is lower than 0.5% of all types of bladder tumors. There are fewer than 250 reports on bladder leiomyoma. Herein, we report a case of bladder leiomyoma in 37 years’ female. Case Presentation A 37-year-o...

Objective: Gestational trophoblastic disease is a term that encompasses a spectrum of disorders all arising from the placenta. Human chorionic gonadotropin (hCG) hormone has an essential role in the diagnosis and management of gestational trophoblastic neoplasia. Measuring beta-hCG (B-hCG) levels is the only standard method of monitoring treatment...

Objective: The presence of a normal fetus with normal karyotype accompanied by molar changes in the placenta is a rare condition, which carries a significant risk to the mother and fetus. There is a controversy regarding the proper management of this condition. Here, we present the case of a singleton pregnancy that showed molar changes in the path...

Introduction: Gynecologic cancers are the important cause of women's mortality in the world. Considering the importance of epidemiological recognition of gynecologic cancers in regional form for planning the preventive measures, this study was performed with aim to assess the epidemiologic characteristics of patients with gynecologic cancers referr...

Screening of cervical cancer is the most common gynecologic cancer in developing countries. Despite being preventable, but we have still some problems with the screening of this cancer. Recently, many studies have been done on immunohistochemistry to improve screening of cervical intraepithelial neoplasia (CIN) as a precancerous lesion. But, the ma...

Objective: A major controversy in sentinel node (SN) biopsy of endometrial cancer is the injection site of mapping material. We compared lymphatic drainage pathways of the uterine cervix and uterine body in the same patients by head-to-head comparison of intracervical radiotracer and fundal blue dye injections. Methods: All patients with patholo...

Squamous cell carcinoma is one of the common malignancies among women, especially in the third and fourth decades of life. Human papillomavirus is the most important cause of squamous cell carcinoma among women worldwide. Early diagnosis and treatment of this carcinoma can prevent disease progression. Herein, we present the case of a pregnant woman...

Placental site trophoblastic tumor is a subtype of gestational trophoblastic neoplasm with unpredictable clinical behavior. Cytoreductive surgery is the cornerstone of treatment. The aim of this article is to present a case with an unusual site of metastases of placental site trophoblastic tumor. A 35-year-old woman was referred to the academic cen...

Introduction: preeclampsia is one of the rare symptoms of molar pregnancy and is more prevalent in pregnancies with large volumes of abnormal trophoblastic tissue. Preeclampsia is associated with hypertension and proteinuria and rarely occurs in patients with Hydatidiform mole. Since in most cases, molar pregnancy is diagnosed by sonography at firs...

Background: Cancer of the endometrium is the most common gynecologic malignancy in western and industrial countries, and is the second most common in developing countries, therefore it is of special importance. Adenocarcinoma of the endometrium is the most common type of uterine cancer. The prevalence of endometrial cancer in young women under the...

Background: Ovarian superovulation and increased follicle-stimulating hormone concentration for infertility treatment may be the risk factors of developed granulosa-cell tumor. The aim of this report is to introduce a case of granulosa-cell tumor which was discovered after ovarian stimulation. Case: A 31-yr-old woman with clinical presentation o...

Cadmium is an important environmental pollutant which genetically, physiologically and biochemically affects the cell. Phytochelatins (PC) are involved in one of the phytoremediation mechanisms, in which they are able to bind heavy metals, such as cadmium. The objective of this study was to evaluate morphometric, antioxidant enzyme activity, and So...

Introduction: Ovarian cancer is a common malignancy in women, the major presentations of which are gastrointestinal symptoms. The intra-abdominal metastasis of ovarian cancer often occurs in the peritoneal cavity, while cervical metastasis has rarely been reported. This study aimed to present the case of a metastatic epithelial ovarian cancer to th...

Introduction: Breast cancer is the most common malignancy and the second leading cause of death due to cancer in women following lung cancer. Ample evidence has shown the antitumor activities of curcumin in breast cancer in preclinical and clinical trials. The anticancer effects of curcumin include the inhibition of cancer cell formation, angiogene...

Introduction: Isolated metastasis of cervical carcinoma to iliopsoas region might be infrequent and its occurrence is a diagnostic challenge. The aim of this study was to report a case of iliopsoas muscle metastasis from cervical carcinoma. Case Presentation: A 52-year-old multiparous females complaining about post menopause bleeding was referred t...

Drying is one of the most important stages of hazelnut processing and its optimization improves the quality of the final product. The quality of hazelnut is dependent on chemical and organoleptic characteristics of fruit that is affected in the drying process. In present research, samples of Gerd cultivar of hazelnut (Corylus avellana) were dried i...

Introduction: Choriocarcinoma is one of the rare diseases of gestational trophoblastic tumor with various and sometimes misleading clinical presentations. Clinical suggestion of the disease and timely diagnosis can be useful. The aim of this study is to report a case of diagnostic medical error in postpartum choriocarcinoma. Case report: A 25-year-...

Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was perf...

Background: The optimal management of highly invasive ovarian cancer has changed from adjuvant chemotherapy after surgery to neoadjuvant chemotherapy followed by interval debulking surgery. Generally, tissue specimen for definitive diagnosis of ovarian malignancy is necessary. However, abdominal wall metastasis is a complication, known as transabdo...

Introduction: Uterine arteriovenous malformation (AVM) following molar pregnancy is a rare condition. The present study aimed at reporting a case of uterine arteriovenous malformation after molar pregnancy. Case Presentation: A 38-year-old woman with repeated heavy vaginal bleeding was referred to oncology department of Ghaem hospital affiliated to...

Background: Pyoderma gangrenosum (PG) (ulcerating neutrophilic dermatosis) is a rare disease that about of half of these patients have a systemic disorder, particularly Crohn's and ulcerative colitis. In addition, inflammatory lesions play key role in its pathogenesis. In early diagnosis of disease, we will further prevent of serious consequences o...

Introduction: Pure non-gestational ovarian choriocarcinoma is a rare malignant condition with aggressive behavior. The tumor arises from germ cells of ovarian. Few cases have been reported in the literature.We present a case of pure ovarian choriocarcinoma with disseminated tumor in pelvic. Case Presentation: A 16-year-old girl was referred to Ghae...

Introduction: Colposcopy examination remains the gold standard in assessment of the patients with abnormal cervical cytology. There is a controversy in performing endocervical curettage (ECC) on satisfactory colposcopy. This study was performed with the aim to investigate the role of ECC as a complementary method, besides colposcopic examination in...

Cervical cancer (CC) is the third most common malignancy in women globally, and persistent infection with the oncogenic human papillomaviruses (HPV) is recognized as the major risk factor. The pathogenesis of CC relies on the interplay between the tumorigenic properties of the HPV and host factors. Host-related genetic factors, including the presen...

Objective: Lymphatic spread is a common feature of ovarian cancer both in early and advanced stages of the disease. There is also a controversial problem of the impact of para-aortic lymph node dissection between gynecologist oncologist experts. The aim of this study is evaluating the effect of Para aortic Lymph node dissection in ovarian cancer pa...

Introduction: Choriocarcinoma is a gestational trophoblastic tumor that mainly affects women of childbearing age and rarely occurs in postmenopausal women especially following a long latent period from previous pregnancies. In this case report, we introduce three cases of postmenopausal choriocarcinoma with different clinical signs and symptoms. Ca...

Background: The most common symptom of patients with gestational trophoblastic neoplasia is abnormal vaginal bleeding. Despite repeated visits of patients with postpartum choriocarcinoma and abnormal postpartum hemorrhage, delayed diagnosis leads to advanced disease with widespread metastasis. Therefore, occurrence of choriocarcinoma with variable...

Background: Cardiovascular diseases alone account for 48% of deaths in the world. There is a high rate of coronary angiography for the early diagnosis of such diseases. Not only do patients suffer from anxiety because of the invasive nature of this procedure but also they experience pain and discomfort for several hours after the procedure. We cond...

Background: Hemodynamic changes are among the side effects of diagnostic cardiovascular procedures. Hypothesizing that the anxiolytic effects of lavender oil inhalation could alleviate anxiety among patients undergoing diagnostic cardiovascular modalities, we conducted the present study on patients undergoing coronary angiography with the aim of as...

Introduction: Being very rare entities, neuroendocrine tumors of the ovary are mostly benign while few types are malignant. Based on the WHO classification, an acceptable categorization is carcinoid, atypical carcinoid, small-, and large-cell neuroendocrine carcinomas which are of low-, intermediate-, and high-grade, respectively. In this study, th...

Today, poor performance in old residential contexts in terms of memorable visual elements reduce the residents’ sense of belonging. The study used a combination of qualitative and quantitative research methods. To meet the needs of residents, a questionnaire was distributed among twenty-five experts. Data analysis was performed using fuzzy logic to...

Background: Surgical staging is the standard treatment of ovarian cancer. Pelvic and para-aortic lymphadenectomy is the important part of the surgery. The aim of this study was to evaluate the effect of para aortic lymph node dissection in early stage of patients with ovarian cancer. Methods: This descriptive cross-sectional cohort study was perfo...

Background Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. Methods Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study. The radiotracer was injected...

Background: Toll like receptor-2 (TLR2) plays an important role in the process of detection and launching the immune response against Candida albicans. Cyclophosphamide is one of the most widely used chemotherapy drugs, which causes severe neutropenia and suppression of the immune system. In this study Balb/c mice were infected to disseminated cand...

Introduction: Peritoneal tuberculosis (PTB) and ovarian cancer have overlapping nonspecific symptoms and signs. No pathog- nomonic clinical features or imaging findings can help to distinguish definite diagnosis of extra pulmonary TB. Peritoneal TB can be easily confused with peritoneal carcinomatosis or advanced ovarian carcinoma; therefore, it is...

Introduction: Gossypiboma is a rare tumor caused by gauze fibers retained during surgery. This medico-legal problem is associated with an increase in patients’ morbidity and mortality. The aim of this study is to report two cases of gossypiboma mimicking the imaging of a malignant tumor. Case Presentation: We report two patients (the first patient...

Background: the most common symptoms experienced by women are Hot flashes are around the time of menopause. Many women are interested in herbal medicines because of fear of side effect of Hormone therapy. Objective: In this study, we seek to assess the effectiveness of herbal medicine on the recurrence of hot flash in menopausal women. Methods: T...

Today, poor performance in old residential contexts in terms of memorable visual elements reduce the residents’ sense of belonging. The study used a combination of qualitative and quantitative research methods. To meet the needs of residents, a questionnaire was distributed among twenty-five experts. Data analysis was performed using fuzzy logic to...

Background: Swyer syndrome is a type of hypogonadism with 46,XY karyotype. This syndrome was named by Gerald Swyer, an endocrinologist. It leads to a female with normal internal genitalia (uterus, fallopian tubes, cervix, vagina), but instead of ovaries, they have non functional ovary (streak gonads). Also, they have absence of puberty because of g...

Despite the advances in the modern surgery techniques and the variety of new chemotherapy regimens, survival of patients with the ovarian cancer does not have improved. The lack of a system to predict the likelihood of recurrence of this cancer can be felt. Predicting the likelihood of cancer recurrence helps to plan the controlling of this disease...

Introduction: Gestational trophoblastic neoplasms have highly been malignant potential, which usually occurred in child-bearing age women. Unusual feature of this malignancy would be rare, it was important to take in mind the possibility of GTN in different manifestation. Based on the above mentioned, the aim of this presentation would be the mana...

Background Breastfeeding is a natural way to provide nutrients required for proper growth and development of infants. In view of that, it is of great importance to enhance the knowledge of mothers on exclusive breastfeeding in the first six months after birth and the time of starting complementary feeding. This study aimed to assess the training ne...

Background and Aim: Uterine arteriovenous malformation (AVM) is one of the complications of cesarean section and uterine curettage which is life-threatening. The aim of this case report was to assess medical treatment of a symptomatic case of AVM as uncommon cause of vaginal bleeding. Case Report: A 24-year-old female with an episode of heavy vagin...

Background & aim: Ovarian torsion is one of the most common causes of emergency surgery in gynecology, with a tendency to occur in postmenopausal women. The aim of this study was to provide information concerning the clinical presentations, surgical management, pathological findings and risk of malignancy in postmenopausal women with ovarian torsio...

Background: Standard treatment of Gestational Trophoblastic Disease (GTD) is chemotherapy. Single-agent chemotherapy regime including Methotrexate (MTX) or Actinomycin. Single-agent is widely used in treatment of persistent trophoblastic disease. We reported an uncommon toxicity of low-dose single-agent methotrexate in a patient. Case Presentation:...

Introduction: The majority of adnexal tumors in pregnancy are benign. It is important to distinguish between benign and malignant ovarian tumors. Due to the sensitivity of pregnancy, especially malignant adnexal masses in pregnancy and the lack of accurate information from the prevalence of this malignancy, this study was performed with aim to eval...

Uterine sarcoma is a rare tumor of mesodermal origin, accounting for 2-6% of uterine malignancies. Leiomyosarcoma (LMS) has been reported in only 1% of all uterine malignancies and is regarded as the most common primary uterine sarcoma. Herein, we present a case of LMS with unusual macroscopic features. The patient was a 61-years-old woman with LMS...

We reviewed the available literature on the accuracy of sentinel node mapping in the lymph nodal staging of uterine cervical cancers. MEDLINE and Scopus were searched by using "sentinel AND (cervix OR cervical)" as key words. Studies evaluating the accuracy of sentinel node mapping in the lymph nodal staging of uterine cervical cancers were include...

Vulvar cancer is a rare gynecological malignancy with mainly lymphatic spread. Sentinel node mapping plays an important role in the management of this gynecological malignancy. In the current study, we reported our experience in sentinel node mapping of vulvar cancer and review the literature accordingly. Since the introduction of sentinel node map...

Pyometra is an accumulation of purulent material or pus in the uterine cavity. Spontaneous perforation of uterus by pyometra is rare. This is a clinical presentation and management of a spontaneous perforation of uterine caused by pyometra. This is a case report on spontaneously perforated associated with pyometra secondary to cervical malignancy....

Introduction Basic treatment of patients with cervical intraepithelial neoplasia is prevention of regress to invasive carcinoma. One of the treatment methods of these patients is conization. This study was performed with the aim to evaluate the related factors of remained dysplasia after treatment of cervical intraepithelial neoplasia (CIN) by cold...

BACKGROUND: The aim of this study was to evaluate the feasibility and accuracy of sentinel lymph node (SLN) detection using preoperative lymphoscintigraphy and intra-operative gamma probe/blue dye for endometrial cancer patients. MATERIAL AND METHODS: Twenty four consecutive patients with endometrial cancer were recruited. All patients underwent l...

cBackground: Choriocarcinoma is a highly malignant form of gestational trophoblastic disease. It is characterized by metastatic potential, rapid growth and deeply invasion into blood vessel and then widespread dissemination metastasis. However, the most common sites of metastatic choriocarcinoma are lung, vagina, liver, and brain. But, metastatic c...

Herein, we report a case of sentinel lymph node mapping in a uterine cervix cancer patient, referring to the nuclear medicine department of our institute. Lymphoscintigraphy images showed inappropriate intra‐cervical injection of radiotracer. Blue dye technique was applied for sentinel lymph node mapping, using intra‐cervical injection of methylene...

Introduction: In the current study we evaluated the incremental value of lateral pelvic lymphoscintigraphy imaging of endometrial or cervical cancer patients who underwent sentinel node mapping. Methods: Operable endometrial and cervical cancer patients without clinical or paraclinical evidence of lymph node involvement were included in the study....

The primitive neuroectodermal tumor (PNET) belongs to a group of highly malignant tumors and is composed of small round cells of a neuroectodermal origin. Categorized in the same tumor family as Ewing sarcoma, the PNET is most likely to occur in bones and soft tissues. However, a small number of PNET cases arising in the pelvis have been reported a...

Introduction: Primary ovarian non- Hodgkin lymphoma especially T-cell type is a very rare disease which is classified in the group of malignant small round cell tumors. In these tumors, for detection of primary tumor type, it is very crucial to perform more evaluation of the patient and disease, and also using of further pathologic cytologic method...

Objective: The pressures resulting from physical, mental and social fluctuations play a significant role in causing depression and decreasing the happiness in the elderly. The percieved social support and religious beliefs are among some parameters which influence their life satisfaction. Taking this into account, this study intends to examine the...

Effective managers are those who use their emotional capabilities well and make efficient and constructive relationships. In fact, successful managers emphasize the improvement of emotional intelligent and growth of emotional capabilities, which enable them to become an entrepreneur manager. Development of entrepreneurs' success is one of the funda...

Introduction: Cervical cancer is the most common gynecological cancer. Due to the effect of radiation on cervical mucosa, evaluation of response to radiotherapy with pap smear is controversial. This study was performed with the aim to evaluate the value of post-radiation pap smear as a predictive factor of tumor response.

Methods: in this narrative review article, the most recent research, reviews, guideline articles and current evidences were selected and reviewed with the main keywords of pregnancy, cancer, cervical, diagnosis, chemotherapy, radiation and surgery and its equivalents; then, the most important and strongest diagnostic and therapeutic recommendations...

Introduction: Vaginal bleeding is the common sign of clinical manifestation of late vaginal bleeding of postpartum and choriocarcinoma. Choriocarcinoma grows rapidly and metastases and damage vessels and result bleeding. We have described a case of postpartum hemorrhage with metastatic choriocarcinoma. Case report: A 34 year old woman with vaginal...

Introduction: Ovarian cancer is one of the most common gynecological malignancies with high mortality rate. This high mortality rate may be due to delay in diagnosis. Using tumor-specific markers that are sensitive in the early stages of cancer is very effective to improve results of therapy. The aim of this study was evaluation of the diagnostic v...

Globalization is one of the most discussable problems; this phenomenon has played a leading role in economic, social and cultural activities and decisions of human beings. It also minimizes the geographical borders and has intermingled people's and countries' benefits and has facilitated the exchange of goods, services, thoughts and knowledge witho...

We reported an unusual visualization of a pelvic kidney on the lymphoscintigraphy images of a patient with uterine cervix cancer, which was mistaken with para-aortic sentinel nodes. Delayed imaging clearly showed the nature of this activity. Our case underscores the importance of delayed pelvic lymphoscintigraphy imaging in the sentinel node mappin...

Purpose: Sentinel lymph node biopsy is a fairly new approach for staging of gynecological malignancies. In the current study, the authors comprehensively reviewed the available reports on sentinel node biopsy of endometrial cancer. Materials and methods: The authors searched Medline, SCOPUS, ISI web of knowledge, Science Direct, Springer, OVID S...

Fluorine 18 fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging has been used for staging of endometrial cancer. In the current study, we systematically searched the available literature on the accuracy of F-FDG PET imaging for staging of endometrial cancer. PubMed, SCOPUS, ISI Web of Knowledge, Science Direct, and Springer were sea...

Objective: The aim of this study was to evaluate the feasibility and accuracy of sentinel lymph node detection using preoperative lymphoscintigraphy and intra operative gamma probe/blue dye for endometrial cancer patients. Methods: Twenty four consecutive patients with endometrial cancer were recruited. All patients underwent lymphatic mapping and...

Surgery in cervical cancer should be used with intention of cure. Radical abdominal trachelectomy is a feasible operation for selected patients with stage Iα-1β cervical cancer which fertility can be preserved. A 30-years-old woman with squamous cell cervical cancer stage (1 A II) diagnosed at September 2011 expressed a wish for fertility-sparing t...

Objectives: We reviewed the available literature on the accuracy of sentinel node (SN) mapping in the inguinal lymph node staging of vulvar squamous cell carcinoma (SCC). Methods: Medline and SCOPUS were searched by using "sentinel AND vulv*" as key words. Studies evaluating the accuracy of SN mapping in the inguinal lymph node staging of vulvar...

Introduction: A perimortem cesarean section is advised in cases of cardiopulmonary arrest after all other resuscitative measures had failed or in conditions that ongoing pregnant maternal death with gestational age older than 28 weeks. It may result in fetal salvage. Case presentation: We report the case of a 32 weeks pregnant woman with brain tumo...