Zohour Ibrahim Nabil

• Professor at Suez Canal University

Candidasis, an important cause of morbidity and death, has been on the rise globally in the last several decades, particularly among very sick patients. Because of its immunosuppressive effects, the metabolic disease diabetes mellitus (DM) makes patients more likely to contract fungal infections, such as those caused by Candida sp. Only a small num...

Even though kidney stones seem to be one of the oldest disorders recognized by medicine, the exact processes by which they form and grow remain unknown. Significant progress has been achieved in our understanding of the pathophysiology of ten different types of stones, including the most common type, the idiopathic calcium oxalate stone former...

Obesity is a global public health issue. It is associated with a spectrum of liver abnormalities, like nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to investigate the effect of Vitamin D 3 on light microscopic changes in the liver, as well as hematology and some liver enzymes in experimentally overweight albino rats. Five...

Obesity's dangers are becoming more widely recognized around the world. Obese people are more likely to develop a variety of serious diseases, including fatty liver. The purpose of this study was to investigate the effect of Origanum majorana on light microscopic changes in the liver, as well as hematology and some liver enzymes in experimentally o...

To discover potential cytotoxic agents, new semi-synthetic phenoxy acetamide derivatives, compound I and compound II, were synthesized, characterized, and screened for their cytotoxic activity against breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The two compounds were more promising against HepG2 than the MCF-7 cell line according to...

One of the most important health issues facing the world today is obesity. It is an important independent risk factor for developing type 2 diabetes. Harmine offers various pharmacological effects, such as anti-inflammatory and anti-tumor effects. The current study aims to investigate Harmine’s anti-diabetic and anti-adipogenic properties in albino...

Despite advances in understanding the intricate pathophysiological mechanisms underlying peripheral nerve injury, there are still few proven cures. Finding potential alternative therapies is necessary because conventional therapies have associated side effects and poor efficacy. In this regard, a study was conducted that offered substitute therapeu...

forced swim for Depression

Evaluation of the efficacy of ashwagandha root extract to ameliorate the oxidative stress and depression resulting from diabetes in male rats was conducted in the current study. Thirty-six male albino rats were randomly grouped into two main groups: normal (n=18) and diabetic (n=18), diabetes was induced by a single dose of 150 mg/kg BW alloxan inj...

A Review on: Ashwagandha Root Extract Phenolic Compounds Counteract Alloxan's Effects on Oxidative Stress, Inflammation, and Peripheral Nerve Injury

Background: A combination of pharmacological and biomedical assays was applied in this study to examine the bioactivity of Conus virgo crude venom in order to determine the potential pharmacological benefit of this venom, and its in vivo mechanism of action. Methods: Two doses (1/5 and 1/10 of LC50, 9.14 and 4.57 mg/kg) of the venom were used in...

Consumption of plant-derived foods contaminated with afatoxin and their metabolites in animal products or exposure to contaminated mycotoxins air and dust caused kidney and liver damage. The purpose of this study was to evaluate the efect of fenugreek (Trigonella foenum graecum L.) upon afatoxin B1-induced damages to the liver and kidney of male al...

The goal of this study was to investigate the protective effect of licorice supplements in a rat model of Bleomycin-induced lung oxidative damage over a duration of one month. The rats were randomly divided into six groups (n = 10 per group). Control group;. Bleomycin group (B): rats were IP injected with bleomycin 5 mg/kg twice weekly. Licorice gr...

The goal of this study was to investigate the protective effect of licorice supplements in a rat model of Bleomycin-induced lung oxidative damage over a duration of one month. The rats were randomly divided into six groups (n = 10 per group). Control group;. Bleomycin group (B): rats were IP injected with bleomycin 5 mg/kg twice weekly. Licorice gr...

Chlorotoxin (Cltx), a cell-penetrating peptide from the venom of the scorpion Leiurus quinquestriatus has selective activity on a range of neuroectodermal tumours and related cell lines. Although the precise mechanism of Cltx action is not clear, Cltx has been shown to be a useful tumour imaging agent and radiolabelled Cltx has undergone clinical t...

Background Scorpion venom contains various biomolecules with potential therapeutic values against different diseases, including cancer. The present study was carried out to assess the antitumor efficacy of Androctonus australis crude venom using both in vitro and in vivo approaches. Methodology For in vitro assay, the cytotoxic effect of different...

Circadian and stress systems have a crucial role in adaptation of organisms to environmental challenges. This study investigates the ability of Oscillatoria brevis (O. brevis) β-carotene extract (βC) in modulating the circadian alternations of locomotor activity (LA) and serum melatonin (M) rhythms under chronic unpredictable stress (CUS) in rats....

Managing stress can prevent serious health problems. The present study aimed to evaluate the possible protective effect of β-carotene (βC), as a natural cyanobacterial product, against stress-induced alterations in biochemical and hematological circadian patterns. Male albino rats were subjected to chronic unpredictable stress (CUS) for 21 days. Ra...

Managing stress can prevent serious health problems. The present study aimed to evaluate the possible protective effect of β-carotene (βC), as a natural cyanobacterial product, against stress-induced alterations in biochemical and hematological circadian patterns. Male albino rats were subjected to chronic unpredictable stress (CUS) for 21 days. Ra...

Scorpion venom is a complex mixture of components with various pharmacological and toxicological effects. It is characterized by the presence of a large number of toxins that specifically interact with ion channels of excitable cells. The Egyptian scorpion Androctonus bicolor belongs to the family of Buthidae and until now no information is availab...

Stress may be an environmental, physical and/or psychological stimulus that is capable of altering the physiological homeostasis of the body, and hence it is considered as a crucial determinant in health and disease. Circadian rhythms (CRs) are endogenous, about 24-hr oscillations controlling different physiological and behavioural functions of org...

Scorpion venom is a heterogeneous mixture of components with various biochemical and toxicological effects. The Egyptian scorpion Androctonus australis belongs to the family of Buthidae and until now little information is available about the structure and biochemical effects of its venom. The separation of A. australis venom by RP-HPLC resulted in...

Health problems related to stress is a major global issue. The present study aims at evaluating the possible protective effect of β-carotene (βC), as a natural cyanobacterial product, against stress-induced alterations in circadian rhythms of behavioral activities and oxidative markers. Male albino rats were subjected to chronic unpredictable stres...

Health problems related to stress is a major global issue. The present study aims at evaluating the possible protective effect of β-carotene (βC), as a natural cyanobacterial product, against stress-induced alterations in circadian rhythms of behavioral activities and oxidative markers. Male albino rats were subjected to chronic unpredictable stres...

Cyanobacteria or blue green algae have become more world wide spread, Oscillatoria brevis (O. brevis) is one of the most toxic species collected from freshwater Suez canal during algal bloom condition and was grown in blue green medium (BG-11) under laboratory conditions. In vitro assessment of cardio-toxicity of O. brevis was carried out by record...

Resveratrol Therefore, the present study was carried out to investigate the potential protective and therapeutic effects of RES against oxidative stress induced by cadmium. Male albino mice were divided into group, CdCl (10.0 mg/kg) treated group, RES followed by CdCl CdCl2 no toxic effects on the measured parameters, except for inhibition of the a...

Oscillatoria brevis (O. brevis) is known to produce off-flavor problems and toxins in water supply, O. brevis was collected from Suez freshwater canal during algal bloom condition and was grown in blue green medium (BG-11) under laboratory conditions. The adverse physiological effects of cyanobacterial toxin were studied in mice weighing (25-33g)....

Calotropis procera (Ait.) R.Br. (Asclepiadaceae) is a shrub or small tree that grows wild in Egypt. Calotropis acts as a purgative, anthelmintic, anticoagulant, palliative (in problems with respiration, blood pressure), antipyretic, and analgesic, and induces neuromuscular blocking activity. Little research has been done to study the electrophysiol...

Two types of integrative sampling approaches (passive samplers and biomonitors) were tested for their sampling characteristics of selected pollutants. Chemical analysis by gas chromatography with mass spectrometry (GC/MSD) were used to determine the amounts of eight compounds (diuron, γ-HCH, atrazine, irgarol, phenanthrene, dieldrin and two congene...

Amphibian skin secretions are considered a rich source of biologically active compounds and are known to be rich in bufadienolides, peptides and alkaloids. Bufadienolides are cardioactive steroids derived from animals and plants as well. The current study was conducted to investigate the influence of skin secretions of the Egyptian green toad Bufo...

Passive sampling could provide the solution to problems associated with costly and time consuming sampling programmes and biomonitoring. Mussels (Mytilus edulis) and Chemcatcher passive sampler were simultaneously analyzed for sequestered pesticides and polychlorinated biphenyls (PCBs) by gas chromatography with mass spectrometry (GC/MSD). The Chem...

Induction of hyperadrenergic activity was experimentally achieved in urethane-anesthetized rats using epinephrine (adrenaline). Acute administration of epinephrine (100 microg/kg) for 2 hours induced several cardiac disorders and vasomotor dysfunction. Pretreatment with natural wild honey (5 g/kg) for 1 hour prior to the injection with epinephrine...

A study was carried out to evaluate the acute and chronic toxicity of lindane and atrazine in Mytilus edulis . The threshold median lethal dose for lindane was approached at long elapsed times (90 days) when the LC<SUB>50</SUB> was 1.7 mg l<SUP>-1</SUP>. The LT<SUB>50</SUB> at a concentration of 30 mg l<SUP>-1</SUP> was 8.4 days which appears to be...

The present study is a trial to suppress or attenuate the cardiotoxicity of catecholamines, which have been developed synthetically for the treatment of several cardiovascular disorders and conditions such as asthma and nasal congestion. Epinephrine (Adrenaline) is the most commonly available inotrope and in many cases the most appropriate drug t o...

In this study certain activities of solitary wasp venoms collected from the Suez Canal area (Bembix oculata, Dielis collaris, and Scolia erythrocephala) were investigated. The effects of these venoms on different types of muscles were studied, and in addition, the chemical structures were studied by electrophoretic analysis. We found that the venom...

Crude venoms from three highly evolved aculeate species: Apis mellifera (highly social bees), Bombus morrisoni (eusocial bees), and Anthophora pauperata (solitary bees), were used for conducting this study to compare the effects of honey bee, bumble bee, and solitary bee venom on toad cardiac muscle activity. In addition, these venoms were tested o...

Crude venoms from three highly evolved aculeate species: Apis mellifera (highly social bees), Bombus morrisoni (eusocial bees), and Anthophora pauperata (solitary bees), were used for conducting this study to compare the effects of honey bee, bumble bee, and solitary bee venom on toad cardiac muscle activity. In addition, these venoms were tested o...

Crude venoms from three highly evolved aculeate species: Apis mellifera (highly social bees), Bombus morrisoni (eusocial bees), and Anthophora pauperata (solitary bees), were used for conducting this study to compare the effects of honey bee, bumble bee, and solitary bee venom on toad cardiac muscle activity. In addition, these venoms were tested o...

1 The effect of crude honeybee (Apis mellifera)venom on the skeletal, smooth as well as cardiac muscles were studied in this investigation. 2 Perfusion of gastrocnemius-sciatic nerve preparation of frogs with 1 mg/ml venom solution has weakened the mechanical contraction of the muscle without recovery. Blocking of nicotinic receptors with 3 mg/ml f...

1. The effect of crude honeybee (Apis mellifera) venom on the skeletal, smooth as well as cardiac muscles were studied in this investigation. 2. Perfusion of gastrocnemius-sciatic nerve preparation of frogs with 1 microgram/ml venom solution has weakened the mechanical contraction of the muscle without recovery. Blocking of nicotinic receptors with...

Ochratoxin A (OA) is a mycotoxin produced by certain species of storage fungi of the Penicillium and Aspergillus genera. It has been reported that OA is toxic to different animal species. Liver and kidney are the primary target organs for OA toxicity. Its effect on the cardiovascular physiology of animals has not been studied in detail. In this inv...

Chromium is an environmentally significant human carcinogen with a complicated metabolism and an unknown mechan sm of mutagenesis. Chromium (VI) is taken up by cells as anions and is reduced intracellulary via reactive intermediates to stable Cr (III) species. A comparison was made between the effects of Cr (III) and Cr (VI). Two groups of male adu...

The effects of the scorpion Leiurus quinquestriatus (H.&E.) venom on electrocardiogram (ECG) parameters such as P-R and Q-T intervals and R and T wave amplitudes were investigated in anesthetized rats. Venom was administered intramuscularly (i.m.) at three doses (100, 200 and 400 micrograms/kg). ECG limb lead II was recorded for 4-h sessions. Becau...

The effects of scorpion Leiurus quinquestriatus (H&E) venom collected from the South Sinai region, Egypt, on heart rate (HR) and mean arterial pressure (MAP) were studied after intramuscular administration of 3 different doses (100, 200 and 400 micrograms/kg) to anesthetized rats. The effects of adrenergic and cholinergic blocking agents on the ven...

Electrocardiographic and flexible suction electrode techniques were used to investigate the effects of a nutmeg extract on the toad heart. Acute treatment with the extract resulted in a dose-related sinus tachycardia, faster atrioventricular conduction speed and an increased amplitude of ventricular action potential. Chronic treatment resulted in s...

The effects of acute and chronic administration of an extract of Catha edulis on the heart of the toad were investigated. ECG and ventricular action potential were recorded simultaneously from the surface of the heart of spinal pithed toads before and after administration of different doses of khat extract. Acute treatment resulted in a dose-depend...

Changes of the positive chronotropic effect in the frog atrium during stimulation of the extracardiac pathways or of the central end of intracardiac innervation after application of atropin (10(-4)--10(-5) on the sinus node, were studied. The positive chronotropic effects were abolished by the atropin application. The postganglionic impulse activit...