Zohar Arnon

Zohar Arnon
Tel Aviv University | TAU · Department of Molecular Microbiology and Biotechnology

PhD

About

35
Publications
3,835
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
568
Citations

Publications

Publications (35)
Article
Despite the fundamental clinical importance of amyloid fibril formation, its mechanism is still enigmatic. Crystallography of minimal amyloid models was a milestone in understanding of the architecture and biological activities of amyloid fibers. However, the crystal structure of ultimate dipeptide-based amyloids is not yet reported. Herein, we pre...
Article
Despite the fundamental clinical importance of amyloid fibril formation, its mechanism is still enigmatic. Crystallography of minimal amyloid models was a milestone in understanding of the architecture and biological activities of amyloid fibers. However, the crystal structure of ultimate dipeptide‐based amyloids is not yet reported. Herein, we pre...
Article
The self-assembly of peptides is a key direction for fabrication of advanced materials. Novel approaches for fine tuning of macroscopic and microscopic properties of peptide self-assemblies are of a high demand for constructing biomaterials with desired properties. In this work, while studying the kinetics of the Fmoc-Diphenylalanine (Fmoc-FF) dipe...
Article
The self-assembly of peptides is a key direction for fabrication of advanced materials. Novel approaches for fine tuning of macroscopic and microscopic properties of peptide self-assemblies are of a high demand for constructing biomaterials with desired properties. In this work, while studying the kinetics of the Fmoc-Diphenylalanine (Fmoc-FF) dipe...
Article
Full-text available
Supramolecular hydrogels formed by the self-assembly of amino-acid based gelators are receiving increasing attention from the fields of biomedicine and material science. Self-assembled systems exhibit well-ordered functional architectures and unique physicochemical properties. However, the control over the kinetics and mechanical properties of the...
Preprint
Full-text available
Supramolecular architecture formation by the self-assembly of proteins and nucleic acids is well studied. Yet, the spontaneous organization of oligosaccharides, the most common polymers in nature, is less explored. Here, using inulin as a model, we identify the "sweet spot" length for oligosaccharide assembly. Inulin forms discrete spheres in a con...
Article
Full-text available
Biomolecule luminescence in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased empirical insights. Several amino acids, including non-aroma...
Preprint
Full-text available
It has been experimentally observed that various biomolecules exhibit clear luminescence in the visible upon aggregation, contrary their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to provide non-biased insights into this phenomenon. Several amino acids, in...
Article
Full-text available
Supramolecular polymer co‐assembly between diphenylalanine and Fmoc‐diphenylalanine yields branched and curled amyloidogenic aggregates within 3D network of hydrogels, unlike the linear crystalline aggregates obtained from an aqueous solution of diphenylalanine. Theoretical and experimental studies prove the existence of co‐assembly between the dip...
Article
Full-text available
Supramolecular polymer co-assembly is a useful approach to modulate peptide nanostructures. However, the co-assembly scenario where one of the peptide building blocks simultaneously forms a hydrogel is yet to be studied. Herein, we investigated the co-assembly formation of a minimalistic dipeptide, diphenylalanine (FF), and Fmoc-diphenylalanine (Fm...
Article
Supramolecular self-assembly is a key process in natural systems, allowing for the formation of structures across all length-scales with a wide range of functionalities. Notable progress has been made in the bottom-up design and generation of natural and artificial peptides, which through self-assembly provide diverse nano- and micro-scale architec...
Article
Phenylalanine was the minimalistic and first of numerous non-proteinaceous building blocks to be demonstrated to form amy-loid-like fibrils. This unexpected organization of such a simple building block into canonical architecture, which was previously observed only with proteins and peptides, has numerous implications for medicine and supramolecula...
Article
Alzheimer's disease (AD) is the most common cause of dementia. Despite substantial investment in research, there are no current effective treatments to prevent or delay the onset and development of AD and the exact molecular mechanism of AD pathogenesis is still not fully understood. Researchers have long suspected that microbial infections may pla...
Article
The self‐assembly of simple units into well‐ordered supramolecular polymeric structures may give rise to a broad range of desirable attributes. In the field of bionanotechnology, there are two main classes commonly used as building blocks for self‐assembly—amino acids and nucleobases. While protein, peptide, and amino acid building blocks propose b...
Article
Full-text available
Self-assembling peptides and oligonucleotides have given rise to synthetic materials with several applications in nanotechnology. Aggregation of synthetic oligosaccharides into well-defined architectures has not been reported even though natural polysaccharides, such as cellulose and chitin, are key structural components of biomaterials. Here, we r...
Article
The ensemble of native, folded state was once considered to represent the global energy minimum of a given protein sequence. More recently, the discovery of the cross-β amyloid state revealed that deeper energy minima exist, often associated with pathogenic, fibrillar deposits, when the concertation of proteins reaches a critical value. Fortunately...
Article
Molecular self-assembly is a major approach for the fabrication of functional supramolecular nanomaterials. This dynamic, straightforward, bottom-up procedure may result in the formation of various architectures at the nano-scale, with remarkable physical and chemical characteristics. Biological and bio-inspired building blocks are especially attra...
Article
The formation of apoptosis‐inducing amyloidal structures by metabolites has significantly extended the "amyloid hypothesis" to include non‐proteinaceous, single metabolite building blocks. However, detection of metabolite assemblies is restricted, as compared to their larger protein‐based counterparts, due to the hindrance of external labelling and...
Article
The formation of apoptosis‐inducing amyloidal structures by metabolites has significantly extended the "amyloid hypothesis" to include non‐proteinaceous, single metabolite building blocks. However, detection of metabolite assemblies is restricted, as compared to their larger protein‐based counterparts, due to the hindrance of external labelling and...
Article
Molecular self-assembly of short peptide building blocks leads to the formation of various material architectures that may possess unique physical properties. Recent studies had confirmed the key role of biaromaticity in peptide self-assembly, with the diphenylalanine (FF) structural family as an archetypical model. Another significant direction in...
Article
Scanning electron microscopy (SEM) studies of laminated self-assembled N-capped diphenylalanine crystals are presented by Lihi Adler-Abramovich, Ehud Gazit, and co-workers in article number 1704551. These crystals exhibit well-ordered crystal packing and diffraction of sub-Ångstrom resolution, yet display an exceptionally flexible nature. The combi...
Article
Full-text available
The accumulation of various metabolites appears to be associated with diverse human diseases. However, the aetiological link between metabolic alteration and the observed diseases is still elusive. This includes the correlation between the abnormally high levels of homocysteine and quinolinic acid in Alzheimer's disease, as well as the accumulation...
Article
One major challenge of functional material fabrication is combining flexibility, strength, and toughness. In several biological and artificial systems, these desired mechanical properties are achieved by hierarchical architectures and various forms of anisotropy, as found in bones and nacre. Here, it is reported that crystals of N-capped diphenylal...
Article
The phenomenon of protein aggregation into amyloid fibrils is associated with a large number of major diseases of unrelated etiology. Unraveling the mechanism of amyloid self-assembly and identifying therapeutic directions to control this process are of utmost importance. Research in this field has been hampered by several challenges, including rep...
Article
Peptide-based biomaterials are key to the future of diagnostics and therapy, promoting applications such as tissue scaffolds and drug delivery vehicles. To realise the full potential of the peptide systems, control and optimisation of material properties are essential. Here we investigated the co-assembly of the minimal amyloid motif peptide, diphe...
Article
Full-text available
The dynamic nature of supramolecular polymers has a key role in their organization. Yet, the manipulation of their dimensions and polarity remains a challenge. Here, the minimalistic diphenylalanine building block was applied to demonstrate control of nano-assemblies growth and shrinkage using microfluidics. To fine-tune differential local environm...
Data
Supplementary Figures 1-4, Supplementary Discussion, Supplementary Methods and Supplementary References
Article
Full-text available
Molecular self-assembly is pivotal for the formation of ordered nanostructures, yet the structural diversity obtained by the use of a single type of building-block is limited. Multicomponent co-assembly, utilized to expand the architectural space, is principally based on empirical observations rather than rational design. Here we report large scale...
Article
Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric and semiconductive properties. Yet, the control over nanotube length in solution has remained challengin...
Article
The cover picture presents the ultrastructural morphology of tetra-phenylalanine assembly prepared by a solvent-switching technique. Imaging was performed using high-resolution scanning electron microscopy. Read more in the Full Paper by Gazit and co-workers on page 756.
Article
Diphenylalanine peptide (FF) self-assembles into ordered structures of notable physical properties. Moreover, the ability of the phenylalanine amino acid or triphenylalanine to assemble into ordered nanostructures had been demonstrated. Herein, we explored the association potential of larger phenylalanine peptides, tetraphenylalanine, and pentaphen...

Network

Cited By

Projects

Project (1)