Zhinuo Jenny Wang

Zhinuo Jenny Wang
University of Oxford | OX · Department of Computer Science

PhD in Biomedical Engineering

About

25
Publications
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227
Citations

Publications

Publications (25)
Article
Full-text available
Models of cardiac mechanics are increasingly used to investigate cardiac physiology. These models are characterized by a high level of complexity, including the particular anisotropic material properties of biological tissue and the actively contracting material. A large number of independent simulation codes have been developed, but a consistent w...
Article
Full-text available
Background: Heart failure (HF) patients present with a spectrum of phenotypes, including preserved ejection fraction (HFpEF) and reduced EF (HFrEF). The underlying mechanisms of HFpEF and HFrEF may be related to mechanical factors such as stiffness and stress. This study aimed to quantify passive mechanical properties in HFrEF and HFpEF patients us...
Article
Full-text available
Models of cardiac mechanics require a well‐defined reference geometry from which deformations, and hence myocardial strain and stress can be calculated. In the in vivo beating heart, the load‐free (LF) geometry generally cannot be measured directly, since, in many cases, there is no stage at which the lumen pressures and contractile state are all z...
Article
Full-text available
Develop, calibrate and evaluate with clinical data a human electromechanical modelling and simulation framework for multiscale, mechanistic investigations in healthy and post-myocardial infarction (MI) conditions, from ionic to clinical biomarkers. Human healthy and post-MI electromechanical simulations were conducted with a novel biventricular m...
Preprint
Full-text available
Aims Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic remodelling, which are reflected as variable phenotypes. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with the post-MI electrophysiological heterogeneities are unknown. We aim to unravel how ph...
Chapter
The helix orientated fibres in the ventricular wall modulate the cardiac electromechanical functions. Experimental data of the helix angle through the ventricular wall have been reported from histological and image-based methods, exhibiting large variability. It is, however, still unclear how this variability influences electrocardiographic charact...
Chapter
Heart failure is known to be associated with substantial changes in the mechanical properties of the heart muscle. Biomechanical parameters, such as myocardial stiffness, have the potential to help clinicians diagnose and determine and monitor treatment options. The impact of inter-observer variability of geometric modelling on the estimation of pa...
Article
Full-text available
The realisation of precision cardiology requires novel techniques for the non-invasive characterisation of individual patients’ cardiac function to inform therapeutic and diagnostic decision-making. Both electrocardiography and imaging are used for the clinical diagnosis of cardiac disease. The integration of multi-modal datasets through advanced c...
Article
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Wellcome Trust Background Sudden cardiac death after a myocardial infarction (MI) was reported in both the acute stage and the chronic stage with the development of heart failure (HF). Around 50% of these deaths were due to ventricular tachyarrhythmia which is re...
Article
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Wellcome Trust Background Sudden cardiac death (SCD) occurs in both acute and chronic stages post myocardial infarction (MI), and the left ventricular ejection fraction (LVEF) and electrocardiogram (ECG) characteristics are important b...
Article
Full-text available
Optical mapping is widely used in experimental cardiology, as it allows visualization of cardiac membrane potential and calcium transients. However, optical mapping measurements from a single heart or cell culture can produce several gigabytes of data, warranting automated computer analysis. Here we present COSMAS, a software toolkit for automated...
Preprint
The realisation of precision cardiology requires novel techniques for the non-invasive characterisation of individual patients' cardiac function to inform therapeutic and diagnostic decision-making. The electrocardiogram (ECG) is the most widely used clinical tool for cardiac diagnosis. Its interpretation is, however, confounded by functional and a...
Article
Full-text available
Human-based computational modelling and simulation are powerful tools to accelerate the mechanistic understanding of cardiac patho-physiology, and to develop and evaluate therapeutic interventions. The aim of this study is to calibrate and evaluate human ventricular electro-mechanical models for investigations on the effect of the electro-mechanica...
Article
Full-text available
The human heart beats as a result of multiscale nonlinear dynamics coupling subcellular to whole organ processes, achieving electrophysiologically-driven mechanical contraction. Computational cardiac modelling and simulation have achieved a great degree of maturity, both in terms of mathematical models of underlying biophysical processes and the de...
Article
The cover image is based on the Original Article Efficient estimation of load‐free left ventricular geometry and passive myocardial properties using principal component analysis. by Zhinuo Jenny Wang, VY Wang, Vijay Rajagopal et al., https://doi.org/10.1002/cnm.3331.
Article
Full-text available
Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular and molecular mechanisms of action are unknown. We tested disopyramide in cardiomyocytes from the septum of surgical myectomy patients: disopyramide inhibits multiple ion channels, leading to lower Ca transients and force, and shortens...
Article
Full-text available
Understanding the aetiology of heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction requires knowledge of biomechanical factors such as diastolic myocardial stiffness and stress. Cine CMR images and intra-ventricular pressure recordings were acquired in 8 HFrEF, 11 HFpEF and 5 control subjects. Diastolic myocardial stiffness w...
Conference Paper
Full-text available
Estimation of the left ventricular load-free geometry in cases of human heart failure has been performed using principal component analysis techniques to represent the cardiac geometry. This novel method allows us to use multiple diastolic deformed geometries to inform the estimation of the load-free geometry. This method has been applied to imagin...
Conference Paper
Full-text available
This paper presents a method to characterise the passive orthotropic and contractile properties of left ventricular (LV) myocar- dial tissue using MRI data of cardiac anatomy, structure and func- tion. Personalised anatomical LV models were fitted to image data from four canine hearts. Diffusion tensor MRI data from the same hearts were parameteris...
Article
Full-text available
The T2R family of bitter taste receptors is expressed in enteroendocrine cells of the gastrointestinal tract where they modulate gastric emptying and satiety. This functionality is mediated by calcium signalling leading to the secretion of hormones involved in nutrient sensing, satiety and the control of gastrointestinal motility. In this work we p...