Zheng-Yii Lee

Zheng-Yii Lee
University of Malaya | UM · Department of Anesthesiology

BSc (Dietetics); MSc (Clinical Nutrition); PhD

About

33
Publications
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185
Citations
Introduction
Zheng-Yii Lee currently is a postdoctoral researcher at the Department of Anesthesiology, Faculty of Medicine, University of Malaya. Zheng-Yii does research in Critical Care Nutrition.

Publications

Publications (33)
Article
Background and Aims The effect of provision of full feeding or permissive underfeeding on mortality in mechanically ventilated critically ill patients in the intensive care unit (ICU) is still controversial. This study investigated the relationship of energy and protein intakes with 60-day mortality, and the extent to which ICU length of stay and n...
Article
Full-text available
The stress catabolism state predisposes critically ill patients to a high risk of malnutrition. This, coupled with inadequate or delayed nutrition provision, will lead to further deterioration of nutrition status. Preexisting malnutrition and iatrogenic underfeeding are associated with increased risk of adverse complications. Therefore, accurate de...
Article
Background & Aims In critically ill patients, direct measurement of skeletal muscle using bedside ultrasound (US) may identify a patient population that might benefit more from optimal nutrition practices. When US is not available, survey measures of nutrition risk and functional status that are associated with muscle status may be used to identify...
Article
Full-text available
Background: The optimal protein dose in critical illness is unknown. We aim to conduct a systematic review of randomized controlled trials (RCTs) to compare the effect of higher versus lower protein delivery (with similar energy delivery between groups) on clinical and patient-centered outcomes in critically ill patients. Methods: We searched ME...
Article
Full-text available
Background: Parenteral lipid emulsions in critical care are traditionally based on soybean oil (SO) and rich in pro-inflammatory omega-6 fatty acids (FAs). Parenteral nutrition (PN) strategies with the aim of reducing omega-6 FAs may potentially decrease the morbidity and mortality in critically ill patients. Methods: A systematic search of MEDLI...
Article
Full-text available
Background Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and asso...
Article
We thank Vargas et al (1) for their interest in our recently published study in Critical Care Medicine (2). By analyzing the fragility index (FI) of all randomized controlled trials (RCTs) included in our systematic review and performing a trial sequential analysis (TSA) of our meta-analysis of overall mortality, they agreed with our position that...
Preprint
Background: Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and ass...
Article
Full-text available
Predictive equations (PEs) for estimating resting energy expenditure (REE) that have been developed from acute phase data may not be applicable in the late phase and vice versa. This study aimed to assess whether separate PEs are needed for acute and late phases of critical illness and to develop and validate PE(s) based on the results of this asse...
Article
Vitamin C is an essential micronutrient with antioxidant properties and its use in critical illness has gained interest in recent years.1 Four systematic reviews/meta‐analyses (SRMAs) have been published in 2021 alone (see Table 1 summary).2‐5 These 4 SRMAs included between 8‐43 randomized controlled trials evaluating vitamin C with or without thia...
Article
Objectives: To conduct a systematic review and meta-analysis to evaluate the impact of IV vitamin C on outcomes in critically ill patients. Data Sources: Systematic search of MEDLINE, EMBASE, CINAHL, and the Cochrane Register of Controlled Trials. Study Selection: Randomized controlled trials testing IV vitamin C in critically ill patients....
Article
Background: The correlation between gastric residual volumes (GRV) and markers of gastric emptying (GE) in critically ill patients is unclear. This is especially true for ICU surgical patients as they are underrepresented in previous studies. Methods: We conducted a post-hoc analysis of a multicenter trial that investigated the effectiveness of...
Article
Background Nutrition risk, sarcopenia, and frailty are distinct yet inter-related. They may be due to suboptimal or prevented by optimal nutrition intake. The combination of nutrition risk (modified nutrition risk in the critically ill [mNUTRIC]), sarcopenia (SARC-CALF) and frailty (clinical frailty scale [CFS]) in a single score may better predict...
Article
Full-text available
Introduction: This study aimed to compare the nutritional characteristics and clinical outcomes among critically ill patients with diabetes (DM) and without diabetes (WDM). Methods: Mechanically ventilated, critically ill patients who were admitted into the intensive care unit (ICU) within 48 hours and remained in ICU ≥72 hours were prospectively r...
Article
Full-text available
In the previous years, blended tube feeds have been replaced by commercialized feeds; however, literature suggests that blended tube feeds are still being used to feed critically ill patients. Aim of this narrative review is to review the South Asian Critical Care Nutrition Guidelines type of feed recommendations. From the eight South Asian Countri...
Article
Objectives: Several predictive equations have been developed for estimation of resting energy expenditure, but no study has been done to compare predictive equations against indirect calorimetry among critically ill patients at different phases of critical illness. This study aimed to determine the degree of agreement and accuracy of predictive eq...
Poster
Several predictive equations (PEs) have been developed for estimation of resting energy expenditure (REE) but no validity study has been done among mechanically ventilated critically ill patients in Southeast Asian population. This study is aimed at determining validity of eight PEs for prediction of REE among critically ill adult Malaysian patient...
Article
Background: Low muscularity (LM) is associated with high mortality in the Caucasian critically ill population. Muscularity can be accurately measured by the skeletal muscle index (SMI; cm2 /m2 ) generated by computed tomography (CT). This study aimed to establish the overall and sex-specific cutoff values that predict hospital mortality in an Asia...
Article
Background and Aims The use of enteral nutrition (EN) in the intensive care unit (ICU) is subjected to frequent feeding interruption (FI). The prevalence and duration of reason of EN FI was investigated. Methods Reasons for EN FI identified from extensive literature review were prospectively collected in adult mechanically ventilated critically ill...
Article
Full-text available
p>The Intensive Care Unit (ICU) is one of the disciplines in the hospital that provides close monitoring to the seriously ill or injured patients, also known as the critically ill patients. Critically ill patients in the ICU are usually unable to maintain volitional oral nutrition intake and therefore require nutritional therapy. Nutritional therap...
Book
Full-text available
This guideline is intended to guide dietitians involved in providing medical nutrition therapy to critically ill adult patients admitted into the ICU. Best current available evidence and recommendations, expert opinion and clinical practice aspects were reviewed in developing this guideline. Adherence to this guideline alone may not necessarily gua...
Article
Full-text available
: Critically Ill patients with high nutrition risk require optimal amount of nutrition therapy for a better clinical outcome.Objective : The objective of this study was to study EN feeding adequacy among mechanically ventilated critically ill patient with high nutrition risk.Method : A prospective observational study was carried out at General Inte...
Article
Full-text available
Nutrition support is an integral part of care among critically ill patients. However, critically ill patients are commonly underfed, leading to consequences such as increased length of hospital and intensive care unit stay, time on mechanical ventilation, infectious complications, and mortality. Nevertheless, the prevalence of underfeeding has not...

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Projects

Projects (2)
Project
Once again, we’ve systematically reviewed 53 topics on critical care nutrition have posted our updated summaries on our website. We have included all RCTs of nutritional interventions involving critically ill patients examining clinically important outcomes published since 1980. Visit the Critical Care Nutrition website (https://www.criticalcarenutrition.com/systematic-reviews) to access these Systematic Reviews. The included studies have undergone a formal review by our review committee and data have been extracted in duplicate. The updated Systematic reviews are being made available starting in February 2021 and all will hopefully be updated by the end of March 2021. Refer to the topics below for a full list of the topics and for links to the available systematic reviews. We are hoping you find these summaries of evidence updates helpful in your day to day practice. Also, we wanted to offer a thank you to our collaborators who worked on this update. This would not possible without a full team effort. Review Committee: Dr. Daren Heyland, MD Dr Jayshil Patel, MD Dr Aileen Hill, MD Zheng Yii Lee, MSc Cindy Yap, BSc Luis Alfonso Ortiz Reyes, MSc John Clarke, MSc, RKin Rupinder Dhaliwal, RD