Zhaoping Li

Zhaoping Li
University of California, Los Angeles | UCLA · Department of Medicine

MD PHD

About

241
Publications
75,850
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10,326
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Introduction
Zhaoping Li, MD, PhD, is the Lynda and Stewart Resnick Endowed Chair in Human Nutrition and professor of Medicine at David Geffen School of Medicine at UCLA . She current serves as director of the Center for Human Nutrition, chief of the Division of Clinical Nutrition at UCLA . She is also the interim chair of Department of Medicine at the Greater Los Angeles Veterans Administrations (VA) Health System and executive vice chair of Department of Medicine, UCLA

Publications

Publications (241)
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Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital...
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Background: Antioxidant nutrients such as the polyphenols in pomegranate juice may prevent neuronal damage from the free radicals produced during normal metabolism. Previous research in animals and a short-term clinical trial in middle-aged and older adults support the potential memory benefits of pomegranate juice; however, the long-term effects...
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In vitro and animal studies have demonstrated that topical application and oral consumption of pomegranate reduces UVB-induced skin damage. We therefore investigated if oral pomegranate consumption will reduce photodamage from UVB irradiation and alter the composition of the skin microbiota in a randomized controlled, parallel, three-arm, open labe...
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Background Excess visceral adiposity is associated with increased risk of cardiometabolic disorders. Short‐term well‐controlled clinical trials suggest that regular avocado consumption favorably affects body weight, visceral adiposity, and satiety. Methods and Results The HAT Trial (Habitual Diet and Avocado Trial) was a multicenter, randomized, c...
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Objectives We recently demonstrated that the consumption of mixed tree nuts (MTNs) as part of a hypocaloric diet decreased heart rate and increased satiety. MTNs can be categorized as a high tryptophan (Trp) food and disturbed Trp metabolism has been associated with cardiovascular disease. The fiber and polyphenol content of MTNs have been suggeste...
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Objective To examine whether a weight loss intervention program improves rheumatoid arthritis (RA) disease activity and/or musculoskeletal ultrasound synovitis measures in obese RA patients. Methods We conducted a proof-of-concept, 12-week, single-blind, randomized controlled trial of obese RA patients (BMI ≥ 30) with DAS28 ≥ 3.2 and with evidence...
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This interventional pilot study demonstrates that ellagic acid and its metabolites are absorbed by the nursing infant from breast milk, excreted in urine and impact the infant's gut microbiome. Phenolic compounds in breast milk might contribute health benefits to infants.
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Food insecurity in the United States has been exacerbated due to the socioeconomic strain of the coronavirus disease 2019 (COVID-19) pandemic. Populations experiencing poverty and, as a consequence, food insecurity in the United States are disproportionately affected by obesity, which was identified early in the pandemic as a major risk factor for...
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Background Avocados are a rich dietary source of monounsaturated fatty acids, carotenoids, and phenolic compounds. Clinical studies have demonstrated that oral consumption of carotenoids improved skin aging. However, no studies have investigated whether oral intake of avocado will reduce skin aging. Objectives We therefore performed this pilot stu...
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Scope We tested the hypothesis that dietary pomegranate extract (PomX) supplementation attenuates colitis in a Western diet fed IL-10 deficient (IL10-/-) murine model. Methods and Results 4 week old male IL-10-/- mice were randomly assigned to a high fat high sucrose (HFHS) diet or a HFHS diet supplemented with 0.25% PomX for 8 weeks. PomX supplem...
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Background: Completing Patient-Generated Subjective Global Assessment (PG-SGA) questionnaires is time consuming. This study aimed to develop and validate an easy-to-use modified PG-SGA (mPG-SGA) for cancer patients. Methods: Seventy professionals assessed the content validity, comprehensibility, and difficulty of the full PG-SGA. A survey includ...
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Grapes provide a rich source of polyphenols and fibers. This study aimed to evaluate the effect of the daily consumption of 46 g of whole grape powder, providing the equivalent of two servings of California table grapes, on the gut microbiome and cholesterol/bile acid metabolism in healthy adults. This study included a 4-week standardization to a l...
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Individuals with obesity have larger amounts of visceral (VAT) and subcutaneous adipose tissue (SAT) in their body, increasing the risk for cardiometabolic diseases. The reference standard to quantify SAT and VAT uses manual annotations of magnetic resonance images (MRI), which requires expert knowledge and is time-consuming. Although there have be...
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Activation of endothelial cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is thought to be the primary driver for the increasingly recognized thrombotic complications in coronavirus disease 2019 patients, potentially due to the SARS-CoV-2 Spike protein binding to the human angiotensin-converting enzyme 2 (hACE...
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Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of cardiometabolic diseases in overweight individuals. While liver biopsy is the current gold standard to diagnose NAFLD and magnetic resonance imaging (MRI) is a non-invasive alternative still under clinical trials, the former is invasive and the latter costly. We demonstra...
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Pistachio nuts are a nutrient-dense source of good quality plant protein, commonly consumed as a minimally processed snack food or ingredient. The present paper is based on a symposium held during the 13th FENS (Federation of European Nutrition Societies) 2019 conference in Dublin that explored recent research and practical applications of pistachi...
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The COVID-19 pandemic has uncovered the increased susceptibility of individuals with obesity to infection and severe disease leading to hospitalization and death. Studies in New York City demonstrated that after advanced age, obesity was the most common risk factor leading to severe disease and death from COVID-19. While the connection has been rec...
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Excess visceral adiposity is associated with increased risk of diabetes and cardiovascular disease. In the U.S. approximately 60% of adults have visceral obesity. Despite high calorie and fat, small, well-controlled clinical studies suggest that avocado consumption has favorable effects on body weight and visceral adiposity. Additionally, short-ter...
Book
Nutritional Oncology: Nutrition in Cancer Prevention, Treatment, and Survivorship presents evidence-based approaches to the study and application of nutrition in all phases of cancer including prevention, treatment, and survivorship. There is a long history of interest in the role of nutrition in cancer but only in the last 50 years has this inter...
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Background: The microbiome has been shown in pre-clinical and epidemiological studies to be important in both the development and treatment of obesity and metabolic associated fatty liver disease (MAFLD). However, few studies have examined the role of the microbiome in the clinical response to calorie restriction. To explore this area, we performed...
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Aims: The progression of prediabetes to T2DM can be delayed through diet modification and weight management. However, the intensive lifestyle program is often not covered by medical insurance. This retrospective analysis evaluates the association of a patient self-paid weight management program on an improvement of blood sugar in overweight and ob...
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Objectives Avocados are an excellent source of bioactive compounds such as monounsaturated fatty acids, sterols, polyhydroxylated fatty alcohols and carotenoids. A common cause of photoaging is exposure to UV light, as the radiation generates oxidative stress, which leads to inflammation and erythema of the skin. Studies have demonstrated that topi...
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Objectives Almonds are a rich source of phenolic and polyphenolic compounds, which have antioxidant activity. In vitro and in vivo studies have demonstrated that topical application of almond oil and almond skin extract reduces UVB-induced photoaging. Ultraviolet-B (UVB) protection by oral almond consumption has not been previously studied in human...
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Objectives Tree nuts are an excellent dietary source of protein and healthy fat leading to increased satiety. Tree nuts also provide polyphenols, vitamins and minerals supporting the immune response. However, there is a concern that tree nuts are not suitable to be included in a weight loss diet due to their fat content. Therefore, it was the objec...
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Objectives Homeostasis of amino acids (AA) such as branched chain AAs (BCAAs), and aromatic AAs are associated with glucose regulation. Fermentable carbohydrates (FC), such as xylooligosaccharide (XOS), have been shown to improve glucose and lipid metabolism. Therefore, we aim to study the potential of dietary FC to modulate systemic and tissue spe...
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Objectives To evaluate the impact of a dietary supplement within an elderly population who reside in a Community Living Center (CLC; VA Nursing Home), on the number of respiratory tract infections (RTIs) during a 90-day study period. Methods This is a randomized, double-blind, placebo-controlled study to evaluate the impact of bovine Lactoferrin (...
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Objectives Inflammatory bowel disease (IBD) results from a complex interaction among host, microbial and environmental factors. Among these, diet has emerged as an important and actionable modifier of IBD activity. Pomegranate major bioactive metabolites, ellagic acid and urolithins, have been shown to improve symptoms of IBD in chemically induced...
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Mixed tree nuts (MTNs) are an excellent source of protein and healthy fat contributing to satiety. However, their relatively high caloric content might not be beneficial in a weight loss diet. The present study was designed to test whether including MTNs in a weight loss and maintenance program interferes with weight management compared to a refine...
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Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and ra...
Preprint
Aims: The progression of prediabetes to T2DM can be delayed through diet modification and weight management. This retrospective review examines the impact on blood sugar, blood pressure, and fasting lipids of a self-pay weight management program utilizing protein-enriched meal replacements and partial meal replacement diets providing 2.2 grams/kg/d...
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Background Almonds are a rich source of phenolic and polyphenolic compounds, which have antioxidant activity. In vitro and in vivo studies have demonstrated that topical application of almond oil and almond skin extract reduces UVB‐induced photoaging. Ultraviolet‐B (UVB) protection by oral almond consumption has not been previously studied in human...
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Clinical studies and meta-analyses have supported the notion that consuming cinnamon spice long term can have beneficial effects in individuals with normal glucose homeostasis and varying degrees of glucose intolerance including type 2 diabetes. The objective of this study was to evaluate the acute effect of cinnamon on the post-prandial responses...
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Aim: The microbiome has been shown to be pivotal in the development of metabolic associated fatty liver disease (MAFLD). Few have examined the relationship of the microbiome specifically with steatosis grade. Therefore, our aim was to characterize the association of the microbiome with MAFLD steatosis severity while adjusting for metabolic comorbid...
Preprint
Non-alcoholic fatty liver disease (NAFLD) is endemic in developed countries and is one of the most common causes of cardiometabolic diseases in overweight/obese individuals. While liver biopsy or magnetic resonance imaging (MRI) is the current gold standard to diagnose NAFLD, the former is prone to bleeding and the latter is costly. We hereby demon...
Preprint
Non-alcoholic fatty liver disease (NAFLD) is endemic in developed countries and is one of the most common causes of cardiometabolic diseases in overweight/obese individuals. While liver biopsy or magnetic resonance imaging (MRI) is the current gold standard to diagnose NAFLD, the former is prone to bleeding and the latter is costly. We hereby demon...
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It was our hypothesis that foods high in polyphenols and fiber have prebiotic activity. This human intervention study aimed to determine if daily consumption of freeze-dried California strawberry powder (SBP) leads to changes in the intestinal microbiota, fecal cholesterol and bile acid (BA) microbial metabolites. Fifteen healthy adults consumed a...
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Background We showed that pomegranate juice (PomJ) can help to maintain memory in adults aged >50 y. The mechanism for this effect is unknown, but might involve Trp and its metabolites, which are important in brain function. Objectives We aimed to test the hypothesis that PomJ and its metabolites ellagic acid (EA) and urolithin A (UA) affect Trp m...
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Background: High protein calorie restriction diets have shown clinical efficacy for obesity, but the mechanisms are not fully known. The intestinal microbiome is a mediator of obesity and preclinical data support an effect of high protein diet (HPD) on the gut microbiome of obesity, but there are few studies in humans. Methods: To address this,...
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Mol. Nutr. Food Res. 2020, 64, 2000091 DOI: 10.1002/mnfr.202000091 Large inter‐individual variation of microbial conversion of ellagic acid (EA) into urolithin A (UA) is known in humans. EA and UA intake result in differential metabolic benefits and mitochondrial dynamics in insulin resistant mice. These data suggest that individuals capable of UA...
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The potential anti-cancer properties of selenium (Se) and eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) has been documented. However, few studies have been conducted examining anti-tumor effects of nutritional supplements (NS) containing Se and EPA/DHA in combination with anti-cancer agents, such as taxol (Tax), adriamycin (Adr), and avast...
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Bariatric surgery is commonly performed to achieve otherwise refractory weight loss. Outcomes following these procedures depend on the quality of clinical care received after the procedure,¹ although many patients who undergo bariatric surgery do not entirely adhere to the prescribed follow-up regimen. A 2011² study showed that only 7% of the 242 p...
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Scope We aimed at evaluating the effect of dietary ellagic acid (EA) and its microbial metabolite urolithin A (UA) on glucose metabolism and insulin resistance (IR) in mice with diet‐induced IR. Methods and results DBA2J mice were fed a high fat/high sucrose diet (HF/HS) for 8 weeks to induce IR and then 0.1% EA, UA, or EA and UA combined (EA+UA)...
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A 47-year-old male with morbid obesity and progressive pulmonary fibrosis was admitted to the intensive care unit (ICU) with worsening hypoxia and nocturnal ventilator dependence. Due to a significant oxygen requirement, the patient could only safely remain in an acute care setting. Unfortunately, he was not eligible for lung transplantation due to...
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Elafin is an antimicrobial and anti-inflammatory protein. We hypothesize that elafin expression correlates with diabetes. Among non-diabetic and prediabetic groups, men have significantly higher serum elafin levels than women. Men with type 2 diabetes mellitus (T2DM) have significantly lower serum elafin levels than men without T2DM. Serum elafin l...
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Objectives Systemic amino acid (AA) levels are tightly regulated. Homeostasis of certain AAs, such as branched chain AAs (BCAAs), and aromatic AAs are not only associated with impaired glucose control but also important determinants of mood. The health benefits of dietary xylooligosaccharides (XOS) in glucose control have been published. In additio...
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Objectives We recently showed that a single dose of pomegranate juice (PomJ) intake reduced fasting glucose and increased insulin in young healthy subjects. Our study aims to determine the responses of blood glucose as well as principle hormones involved in glucose homeostasis (insulin, C-peptide, glucagon and gastric inhibitory polypeptide (GIP))...
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Objectives Anemia is a frequently observed consequence after bariatric surgery particularly involving patients who have had a malabsorptive procedure. Common causes of anemia in these patients are typically due to iron, folate or vitamin B12 deficiency. This case demonstrates the need to evaluate for less common causes of anemia in patients who hav...
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Objectives Roux-en-y gastric bypass (RYGB) is a surgical procedure for weight loss via volume restriction and malabsorption. Without adequate postoperative nutrition, patients can develop micronutrient deficiencies. Methods A 48-year-old male with a history of RYGB nine years ago presented with lower extremity weakness. Patient lost over 150 lbs a...
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Objectives Based on the polyphenol and fiber content of strawberries (SB), it was our hypothesis that daily consumption of California strawberries will lead to changes in the composition of the intestinal microbiota, and concentration of fecal cholesterol and bile acid (BA) microbial metabolites. Methods We performed a randomized, double blind, pa...
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We evaluated if chronic consumption of quercetin (Q) with green tea extract (GTE) enhances the bioavailability of GT polyphenols (GTPs) and reduces methylation activity as previously observed in mouse xenograft tumors. In this prospective, randomized, parallel design, placebo controlled study, thirty-one men with prostate cancer consumed daily 1 gr...
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A number of recent studies on the loquat (Eriobotrya japonica Lindl.) leaf have demonstrated that loquat leaf extracts exhibited a wide range of pharmacological activities including hypoglycemic, anti-inflammatory, anti-tumor, neuroprotective and enhancement of brain health and liver function in the in vitro and animal models. Consequently, loquat...
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Purpose Cardiorespiratory test (CPX) directly measures cardiorespiratory fitness (CF). CF refers to the ability to supply oxygen to skeletal muscles during sustained exercise and is measured by peak oxygen uptake (VO2) per kg/min body weight. We postulate that impaired CF is associated with pro-inflammatory mechanisms in heart failure (HF). CPX-ind...
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Long-term consumption of pistachios could potentially improves glucose homeostasis. Impaired postprandial glucose, insulin, and glucagon-like peptide-1 (GLP-1) responses have been reported in gestational diabetes mellitus (GDM) patients. The objective of this study was to evaluate the acute effects of two isocaloric test meals, 42 g pistachios and...
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Pomegranates are an excellent source of ellagic acid (EA), ellagitannins (ETs), anthocyanins and other phytochemicals. Health benefits of pomegranate (Pom) have been mainly related to its EA and ET content. The objective of the present study was to determine EA bioavailability and bioactivity form different sources wither pure/free or in natural fo...
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Recent studies implicate a strong association between elevated plasma branched-chain amino acids (BCAAs) and insulin resistance (IR). However, a causal relationship and whether interrupted BCAA homeostasis can serve as a therapeutic target for diabetes remain to be established experimentally. In this study, unbiased integrative pathway analyses ide...