Zhang Shaokun

Zhang Shaokun
Guangxi University

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41
Publications
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Introduction
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Publications

Publications (41)
Article
Full-text available
Polyetheretherketone (PEEK) has gradually become the mainstream material for preparing orthopedic implants due to its similar elastic modulus to human bone, high strength, excellent wear resistance, radiolucency, and biocompatibility. Since the 1990s, PEEK has increasingly been used in orthopedics. Yet, the widespread application of PEEK is limited...
Article
Full-text available
Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability and tends to occur among the young, seriously affecting patients’ lives and quality of life. The key aims of repairing SCI include preventing secondary nerve injury, inhibiting glial scarring and inflammatory response,...
Article
Full-text available
Postoperative infections following implant-related spinal surgery are severe and disastrous complications for both orthopaedic surgeons and patients worldwide. They can cause neurological damage, disability, and death. To better understand the mechanism of these destructive complications and intervene in the process, further research is needed. The...
Article
Full-text available
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on. The pathological changes of...
Article
Full-text available
Objective: To study the effectiveness of a new spinal protection device for preventing and treating osteoporotic vertebral compression fractures (OVCFs) by finite element analysis (FEA). Methods: One healthy volunteer and one patient with 1-segment lumbar vertebral compression fractures were included in this experimental study. The DICOM files o...
Article
Full-text available
Peripheral blood was extracted from a 45-year old female patient clinically diagnosed with Stickler syndrome harboring a heterozygous splicing mutation in COL2A1 (NM_033150, IVS22-1C>T). Induced pluripotent stem cells (iPSC) were reprogrammed by sendai virus encoding Klf-4, c-Myc, Oct-4, and Sox-2. The iPSC line showed pluripotency, which was verif...
Article
Full-text available
Peripheral blood was extracted from a 48-year old healthy male donor. Induced pluripotent stem cells (iPSC) were reprogrammed by sendai virus encoding Klf-4, c-Myc, Oct-4, and Sox-2. The iPSC line showed pluripotency, which was verified by immunofluorescence staining. The iPSC line showed normal karyotype, and could form embryoid bodies in vitro an...
Article
Bacterial infections and antibiotic resistance have become a global healthcare crisis. Herein, we designed and synthesized a series of cationic amphiphilic dendrons with cationic dendrons and hydrophobic alkyl chains for potential antibacterial applications. Our results showed that the antimicrobial activities of the cationic amphiphilic dendrons w...
Article
Full-text available
Low back pain (LBP), a prevalent and costly disease around the world, is predominantly caused by intervertebral disc (IVD) degeneration (IDD). LBP also presents a substantial burden to public health and the economy. IDD is mainly caused by aging, trauma, genetic susceptibility, and other factors. It is closely associated with changes in tissue stru...
Article
Surgical site infections (SSIs) after spinal surgery are one of the serious complications of spinal surgery, which can lead to failure of spinal surgery, central nervous system infection, and even threaten patient lives. Although existing antibiotics can effectively control and treat postoperative infections in the spine, bacterial resistance conti...
Article
A new series of main-chain copolymers constructed by linkage of both soft and rigid cationic rings has been developed. The imidazolium-DABCO copolymers possess good biocompatibility, high antimicrobial activity and lower...
Article
Meningitis and encephalitis caused by bacteria and fungi are among the top 10 lethal types of infectious diseases. The treatment of brain infection is principally limited by the blood-brain barrier (BBB), which restricts the entry of antimicrobial agents to the desired central nervous system (CNS). To address this issue, many different nanoparticle...
Article
Hollow Ag@AgBr nanospheres were prepared by a greener version of microbial process starting with AgCl colloid formation in yeast extract (YE) and peptone solution. The Kirkendall effect has been exploited...
Article
Full-text available
Ganglioneuroma (GN) is a rare benign tumor of neural crest origin usually found in the abdomen, but may occasionally present at uncommon sites including the cervical, lumbar, or sacral spine. However, GNs of thoracic spine are extremely rare. In this report, we describe a 12-year-old girl with giant GN in the thoracic spine, who underwent successfu...
Article
Full-text available
Recent studies suggest that microRNAs (miRNAs) are critical regulators in many types of cancer, including osteosarcoma.miR-342-3p has emerged as an important cancer-related miRNA in several types of cancers. However, the functional significance of miR-342-3p in osteosarcoma is unknown. The aim of this study is to investigate whether miR-342-3p is d...
Article
Full-text available
Peripheral blood was collected from a clinically diagnosed 79-year old male sporadic Parkinson's disease patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staini...
Article
Full-text available
Peripheral blood was collected from a clinically diagnosed 64-year old male multiple schwannoma patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pl...
Article
Full-text available
Peripheral blood was collected from a clinically diagnosed 60-year old female patient with multiple schwannoma. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining...
Article
Full-text available
Peripheral blood was collected from a clinically diagnosed 72-year old male patient with later onset Alzheimer's disease. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescen...
Conference Paper
In order to achieve the real-time of high performance permanent magnet synchronous motor while reducing its software development cycles and enhancing its running speed, the hardware design of a permanent magnet synchronous motor control circuit based on dual-core DSC is presented. Using TI's new 32 bit floating point dual core TMS320F28377D digital...
Article
Full-text available
The limbal epithelial cells can be maintained on 3T3 feeder layer with fetal bovine serum supplemented culture medium, and these cells have been used to successfully treat limbal stem cell deficiency. However, fetal bovine serum contains unknown components and displays quantitative and qualitative lot-to-lot variations. To improve the culture condi...
Article
Silver has widely been used as antimicrobial agent, but there is a long-standing debate over the microbiocidal potency of ionic silver versus colloidal silver. In this study, the minimum inhibitory concentrations (MICs) of AgNO3 against Gram-positive and Gram-negative bacteria were investigated in a variety of microorganism culture broths. Broth- a...
Article
Osteosarcoma is the most bone-associated malignancy with high lethality. The current therapeutic strategy benefits little on the survival of patients. Studies have shown that aberrant activation of Wnt/β-catenin pathway is essential for the progression of osteosarcoma, implying that targeting this signaling may be an effective way of therapeutics....
Conference Paper
In Automatic Switched Optical Network (ASON), the Generalized Mutli-Protocol Lable Switching (GMPLS) Open Shortest Route First-Traffic Engineering (OSPF-TE) is selected as routing protocol. It provides flexible distributing of routing information and automatic resource discovery. The security of GMPLE OSPF-TE is an important component of ASON netwo...
Conference Paper
In the engineering implementation of ASON control plane, RSVP_TE protocol is widely used. Based on the specific analysis of reliability mechanisms of RSVP_TE protocol, Security problems that RSVP_TE protocol may confront with are discussed, and the corresponding countermeasures are proposed in the paper.
Conference Paper
Unique characteristics of a near-leaky wave guide mode closely coupled to an SPP mode in a metal/dielectric structure are studied. Highly efficient optical modulation can be realized by utilizing the extremely sharp resonance of the mode.
Article
Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy. In this paper, core-shell structured titanium dioxide-silica (TiO2-SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicity and photo-killing ability...
Article
Silver-containing antimicrobial agents are used in various medical products. However, their toxicity to mammalian cells has not been sufficiently evaluated. Numerous studies have unveiled evidence of significant antimicrobial properties associated with Ag ions. In cell culture media or human body fluids, the free Ag(+) has rich opportunities to com...
Conference Paper
Automatically Switched Optical Network (ASON) appear as a potential solution to cope with the increasingly growth of data traffic demands on Internet. The paper gives a tutorial overview of the control plane in ASON, concentrating on its architecture, function and security. Different kinds of protocols related to control plane and their flaws are a...
Conference Paper
For the first time, we propose a novel polarization orthogonal modulation format with code-shift keying (CSK) generated by polarization modulator. And we demonstrate a temporal phase encoded OCDMA system using novel polarization CSK (Polm-CSK) data format and balanced detection. The proposed scheme has fixed threshold with variation of users number...
Conference Paper
In this paper we analyze traditional authentication method based on certificate in mobile network environment. This paper proposes a privilege management system based on attribute certificate in mobile network environment. The system uses attribute certificate which is a high security privilege management method to prove user privilege in large sca...
Article
Full-text available
To investigate the distribution of CD44(+)/CD24(-) cells in breast cancers in relation to tumor size before and after the administration of neoadjuvant chemotherapy. CD44(+)/CD24(-) tumor cells obtained from breast cancer specimens were characterized in vivo and in vitro using tumor formation assays and mammosphere generation assays, respectively....
Article
To investigate the mutations of BRCA1 and BRCA2 and determine whether clinic-pathological factors related to BRCA gene mutation. Mastectomy specimens from 360 breast cancers were enrolled and examined in the study. The relationship between BRCA gene mutation and clinic-pathological factors was evaluated. Overall, 280 patients were BRCA negative and...

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