Zhang Haoyu

Zhang Haoyu
Hanyang University · Department of Computer Science and Engineering

About

135
Publications
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2,072
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Publications

Publications (135)
Article
Full-text available
Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods Among 106,571 invasive breast c...
Article
Full-text available
Cytochalasans are an important class of fungal metabolites displaying remarkable structural diversity and significant biological activity. Historically, considerable effort has been devoted toward the synthesis of cytochalasans. Comparably, merocytochalasans, an array of more complicated molecules biosynthetically derived from cytochalasans and epi...
Article
In this study, NiTi shape memory alloys were in-situ synthesized by dual-wire-feed electron beam additive manufacturing (dual-wire EBAM), which uses electron beam as energy source working in the vacuum environment, and uses pure Ni and Ti wires as feedstock. Microstructures, chemical composition distribution and mechanical properties of the as-buil...
Preprint
Polygenic risk scores are becoming increasingly predictive of complex traits, but subpar performance in non-European populations raises concerns about their potential clinical applications. We develop a powerful and scalable method to calculate PRS using GWAS summary-statistics from multi-ancestry training samples by integrating multiple techniques...
Article
As a challenging but promising technology, wire-based in-situ additive manufacturing shows great advantages in material preparation and part manufacturing integration. However, compared with single-wire AM technology, it faces a more complex droplet transition pattern, which is closely related to the feeding modes of the elemental wires. In the cur...
Article
Electrons, which carry abundant information, can be used for the in situ monitoring of electron beam additive manufacturing, such as in the emerging electron optics method for monitoring surface morphology. In electron beam directed energy deposition (EB-DED), droplet transfer, which affects the stability and quality of the deposition, is a unique...
Article
The self-imaging effect in a square core fiber has been investigated, and an integrated all-fiber combiner has been proposed based on a large mode area double clad fiber, which can be employed to construct high power coherent beam combining sources in the all-fiber format. The influence of various parameters on beam quality ( M 2 ) and efficiency o...
Article
Full-text available
In this paper, a feedforward control method of droplet transition based on dual beam spot in electron beam freeform fabrication is proposed. A deflection coil is used to form two beam spots on the surface of the workpiece. Images containing the prepositive spot are taken, the height information of the workpiece surface is obtained through image pro...
Article
To consider both high-power handling and blue-extended supercontinuum (SC) generation, a long-tapered photonic crystal fiber is pumped by a high-power laser source. An SC ranging from 390 to 2400 nm with 314.7 W output power is obtained. A spectral component below 960 nm accounts for 36.1% of the total output power, exceeding 113.5 W, with a spectr...
Article
Background: Past history of gallstones is associated with increased risk of gallbladder cancer (GBC) in observational studies. We conducted complementary observational and Mendelian Randomization (MR) analyses to determine whether history of gallstones is causally related to development of GBC in an Indian population. Methods: To investigate ass...
Article
Modern compilers provide a huge number of optional compilation optimization options. It is necessary to select the appropriate compilation optimization options for different programs or applications. To mitigate this problem, machine learning is widely used as an efficient technology. How to ensure the integrity and effectiveness of program informa...
Preprint
State-of-the-art deep learning systems tightly couple model execution with the underlying hardware. This coupling poses important challenges in a world where the scale of deep learning workloads is growing rapidly: workloads with high resource requirements are inaccessible to most users, experimentation on smaller test beds is impossible, and resul...
Article
Full-text available
When dealing with different programs or applications, it is necessary to select the appropriate compilation optimization pass or subsequence for the program. Machine learning is widely used as an efficient technological means of solving this problem. However, the most important problem when using machine learning is the extraction of program featur...
Article
Full-text available
Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and under...
Article
Full-text available
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1–3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel m...
Article
Full-text available
104 W supercontinuum (SC) covering 370 nm-2400 nm is reported. High power visible SC is generated by pumping cascaded photonic crystal fibers (PCF) with 1064 nm picosecond pulse. Cascaded PCFs is fabricated by fusion splicing two different PCFs together with a coupling efficiency of 75%. For the purpose of avoiding fiber fuse phenomenon in PCF, the...
Article
The extended Kalman filter (EKF) is a widely used method in navigation applications. The EKF suffers from noise covariance uncertainty, potentially causing it to perform poorly in practice. This paper attempts to suppress the unfavorable effect of the noise covariance uncertainty to the EKF in the framework of reinforcement learning. The proposed s...
Article
Cancers are routinely classified into subtypes according to various features, including histopathological characteristics and molecular markers. Previous genome-wide association studies have reported heterogeneous associations between loci and cancer subtypes. However, it is not evident what is the optimal modeling strategy for handling correlated...
Article
Full-text available
In the process of electron-beam freeform fabrication deposition, the surface of the deposit layer becomes rough because of the instability of the feeding wire and the changing of the thermal diffusion condition. This will make the droplet transfer distance change in the deposition process, and the droplet transfer cannot always be stable in the liq...
Preprint
Full-text available
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and nov...
Article
Full-text available
In the process of electron beam freeform fabrication (EBF3), due to the continuous change of thermal conditions and variability in wire feeding in the deposition process, geometric deviations are generated in the deposition of each layer. In order to prevent the layer-by-layer accumulation of the deviation, it is necessary to perform online geometr...
Preprint
Full-text available
Background: Genome-wide association studies have identified over 170 common breast cancer susceptibility loci, many of them with differential associations by estrogen receptor (ER). How these variants are related to other tumor features is unclear. Methods: Analyses included 106,571 invasive breast cancer cases and 95,762 controls of European ances...
Conference Paper
In today’s rapid developments of intelligent transportation, voice navigation has been widely used. In order to reduce the risks of traffic safety caused by drivers’ delayed reactions to voice prompts at expressway exits, a simulated driving experiment was designed to study a driver’s auditory reaction characteristics during lane changes. A total o...
Conference Paper
Background: Reproductive factors are reported to be differentially associated with risk of breast cancer (BC) subtypes; however, subtype defining markers are highly correlated and clarifying which markers are sources of heterogeneity is challenging. We aimed to define the association of parity, age at first full-term pregnancy (AFFTP), and breastfe...
Article
Reversible mechanochromic and thermochromic luminescence switching via hydrogen-bonddirected assemblies in a zinc coordination complex
Preprint
Full-text available
In this paper, we propose a novel pretraining-based encoder-decoder framework, which can generate the output sequence based on the input sequence in a two-stage manner. For the encoder of our model, we encode the input sequence into context representations using BERT. For the decoder, there are two stages in our model, in the first stage, we use a...
Chapter
To enhance the traffic safety level of highway, the paper proposes SVM-based highway traffic safety evaluation model. According to the screening principle and grading standard of evaluation index, and establishes road traffic safety evaluation index system including driver, vehicle, road, traffic management and supervision and determines weight of...
Article
In this paper, a parallel model adaptive Kalman filtering algorithm is presented for multiple sensors estimation fusion when the measurement noise statistics are uncertain. As a typical adaptive filtering algorithm, the multiple model adaptive estimation tries to reduce the dependency of the filter on the noise parameters. It utilizes multiple mode...
Article
Full-text available
A finite element model of FRP reinforced concrete frame structure is established to analyze the structural performance of FRP reinforced concrete frame. The load displacement hysteretic curve, skeleton curve and ductility of the AFRP reinforcement, CFRP bar and GFRP reinforced concrete frame model are analyzed. The results show that the bearing cap...
Article
Most common human diseases are a result from the combined effect of genes, the environmental factors and their interactions such that including gene‐environment (GE) interactions can improve power in gene mapping studies. The standard strategy is to test the SNPs, one‐by‐one, using a regression model that includes both the SNP effect and the GE int...
Preprint
Full-text available
A bstract Cancers are routinely classified into subtypes according to various features, including histopathological characteristics and molecular markers. Previous genome-wide association studies have reported heterogeneous associations between loci and cancer subtypes. However, it is not evident what is the optimal modeling strategy for handling c...
Article
An all-fiber supercontinuum source with 215 W of average power and spectra spanning from 480 nm to over 2000 nm is reported. Constructed with a pulsed seed and four stages of amplifiers based on large-mode-area fiber for mitigating nonlinear effects, the pump power of supercontinuum is up scaled to 556 W. A special designed mode field adaptor is de...
Conference Paper
In the presented algorithm, the Gaussian maximum a posteriori (MAP) filter and the traditional extended Kalman filter (EKF) are implemented in parallel to obtain the adaptive ability. One of the elemental filters, the EKF yields high precision in the scenario with low process noise, whereas the other elemental filter, the Gaussian MAP filter is ado...
Article
Full-text available
An ultrasonic method and a tetrahydrofuran-mixed dispersion method were used to synthesize two heat-treated cobalt phthalocyanine catalysts supported on carbon nanotubes, CoPc-CNT-S and CoPc-CNT-R,respectively. The ultrasonic process was that mixing cobalt phthalocyanine and carbon nanotubes in isopropanol under ultrasound condition within 30 min,...
Article
The first total syntheses of asperchalasines A‐E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through a unified approach that hinges on a Diels‐Alder reaction and an RCM reaction. The bioinspired Diels‐Alder reactions of aspochalasin B with different epic...
Article
Full-text available
The first total syntheses of asperchalasines A‐E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through a unified approach that hinges on a Diels‐Alder reaction and an RCM reaction. The bioinspired Diels‐Alder reactions of aspochalasin B with different epic...
Article
Purpose To answer 2 questions: What is the main structure that prevents the superior translation of the humeral head, the supraspinatus or the superior capsule (SC)? And what mechanism does the principal structure rely on to prevent the superior translation of the humeral head, the spacer effect or the tensional hammock effect? Methods Eight shoul...
Article
Full-text available
Electron beam freeform fabrication (EBF3) is one the of rapid manufacturing methods, which produces metal parts using an electron beam and wire feed unit in a layer additive fashion without need of mold or jigs. The main disadvantage of EBF3 is that the process is carried out in a chamber, which not only takes a lot of time to evacuate but also lim...
Article
This paper presents a frequency modulated continuous wave (FMCW) technology-based airborne synthetic aperture radar (SAR) system. This radar system operates on an eight-channel simultaneous dual band (X-and L-bands) in fully polarimetric mode. Compared with the traditional multiband airborne SAR, this radar system features a small size and low powe...
Article
Full-text available
The deep neural named entity recognition model automatically learns and extracts the features of entities and solves the problem of the traditional model relying heavily on complex feature engineering and obscure professional knowledge. This issue has become a hot topic in recent years. Existing deep neural models only involve simple character lear...
Article
Full-text available
Undercoordinated lead cations and halide anions on the surface of perovskite layer can form surface trap states and cause electronic disorders which reduce the performance of perovskite solar cells. Nitrogen-doped carbon dots (NCDs) that have rich nitrogen- and oxygen-containing functional groups can effectively interact with the unsaturated metal...
Article
Full-text available
Determining the validity of knowledge triples and filling in the missing entities or relationships in the knowledge graph are the crucial tasks for large-scale knowledge graph completion. So far, the main solutions use machine learning methods to learn the low-dimensional distributed representations of entities and relationships to complete the kno...
Conference Paper
Full-text available
The rapidly growing size of data and complexity of analytics present new challenges for large-scale data processing systems. Modern systems keep data partitions in memory for pipelined operators, and persist data across stages with wide dependencies on disks for fault tolerance. While processing can often scale well by splitting jobs into smaller t...
Article
A lead-iodide single crystal semiconductor with multi-orientation photoconductive property and broad spectrum absorption has been designed and constructed by crystal engineering technique. Strong charge transfer band is formed via organic-inorganic intermolecular interactions darkening the color of crystal. Electron catcher viologen cations surroun...
Chapter
Full-text available
In modern high-performance computing (HPC) systems, users are usually requested to estimate the job runtime for system scheduling when they submit a job. In general, an underestimation of job runtime will cause the HPC system to terminate the job before its completion. If users could be notified that their jobs may not finish before its allocated t...
Article
Full-text available
Coordination services are a fundamental building block of modern cloud systems, providing critical functionalities like configuration management and distributed locking. The major challenge is to achieve low latency and high throughput while providing strong consistency and fault-tolerance. Traditional server-based solutions require multiple round-...
Article
Full-text available
Training machine learning (ML) models with large datasets can incur significant resource contention on shared clusters. This training typically involves many iterations that continually improve the quality of the model. Yet in exploratory settings, better models can be obtained faster by directing resources to jobs with the most potential for impro...
Conference Paper
The problem of residents’ transfer and short-distance travel can be solved by the urban bus microcirculation system. But passengers and bus companies have different considerations in the setting of bus routes. So, this article planned the profits of passengers and bus companies synthetically and built a bi-level programing model in order to plan an...
Conference Paper
Pure electric vehicles play an important role in green transport. Based on the gasoline car, power system parameters calculated for the power system using the vehicle’s parameters and performance requirements. As a platform of the simulation software ADVISOR, the simulation models of all parts which make up the power system of pure electric vehicle...
Article
Full-text available
Gated recurrent unit (GRU) networks perform well in sequence learning tasks and overcome the problems of vanishing and explosion of gradients in traditional recurrent neural networks (RNNs) when learning long-term dependencies. Although they apply essentially to financial time series predictions, they are seldom used in the field. To fill this void...
Article
Full-text available
In the field of space computing, DSP is more and more used for its high performance. Like other non-radiation-resistant chips, COTS DSP is easily affected by high-energy particle irradiation in the space environment, which can prone to transient faults, also known as soft errors. Soft error is one of the serious problems to the reliability of space...
Article
An Improved Parent’s Crossover Evolutionary Algorithm(IPCEA)is presented to deal with a class of job-shop scheduling optimisation problems in this paper. The considered integrated production process is firstly described as a job-shop model. Based on the model, the active schedules encoding and decoding approaches for production scheduling processes...