
Zeynep Tırmıkçıoğluİzmir Atatürk Eğitim ve Araştırma Hastanesi · Clinical Pharmacology and Toxicology
Zeynep Tırmıkçıoğlu
Associate Professor of Pharmacology
About
49
Publications
32,869
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227
Citations
Introduction
clinical pharmacology& teratology consultant since 2007,
drug use during pregnancy and lactation,
medication& drug exposure during pregnancy and lactation, poison and poisoning, toxicology, medication in elderly patients, drug induced adverse events, philosophy of sciences, history of drugs
Additional affiliations
January 2013 - present
İzmir Atatürk Eğitim ve Araştırma Hastanesi, Izmir Ataturk Research Hospital
Position
- Medical Doctor
Description
- Teratology Information Service, Pharmacology Consultation (adverse effect, toxicology etc.), Pharmacovigilance
Education
September 2024 - September 2028
Kırklareli University
Field of study
- Hukuk (Faculty of Law)
September 2023 - June 2027
Istanbul University (open education)
Field of study
- Sociology
September 2021 - June 2023
Istanbul University (open education second university)
Field of study
- Justice College
Publications
Publications (49)
Leprosy is a chronic disease which primarily affects the skin, mucous membranes and peripheral nerves due to Mycobacterium leprae. It is now infrequent in Europe and is rarely reported during pregnancy. Leprosy can be exacerbated during pregnancy, and without treatment it can permanently damage the skin, nerves, limbs and eyes. Therefore, it is imp...
Passiflora incarnata is marketed in many countries as anxiolytic herbal supplement. Herbal medicines are natural products, but it doesn't mean they are always safe, especially during pregnancy. Passiflora incarnata extract was not teratogenic in experimental studies. However, there are no data available on possible effects on human pregnancy. Here...
Objective
COVID-19 is a rapidly spreading disease and many people have been infected in a short time. Favipiravir is under investigation for the treatment of COVID-19 and given to patients in many countries following emergency use approval. Based on data from animal studies, favipiravir use is contraindicated during pregnancy. Currently, there is n...
Although pain during pregnancy is caused by
physiological changes, it can reach levels that can
affect the daily life activity, sleep and work quality
of the pregnant woman. If the pain lasts for a long
time, it should be treated as it can lead to stress. An
evidence-based approach to drug therapy during
pregnancy is important for choosing the righ...
Isotretinoin has been used to treat severe acne for more than 40 years. There are no accurate data on the absolute risk of potential teratogenicity to all fetuses exposed to isotretinoin. According to current guidelines, isotretinoin should be discontinued at least 1 month before pregnancy. This study enrolled pregnant women who contacted the Clini...
Tırmıkçıoğlu Z, Alyanak A. Gebelikte estetik ve kozmetik uygulamalar güvenli mi? Kelekçi KH, editör. Gebelikte Kozmetik ve Estetik Yaklaşımlar. 1. Baskı. Ankara: Türkiye Klinikleri; 2022. p.36-46.
ABSTRACT
If the procedures to be performed during pregnancy are not necessary, they should be postponed to the second trimester. Due to physiological cha...
Allergy incidence in pregnancy is about 20% and frequently observed as rhinitis and asthma. Asthma often
coexists with allergic rhinitis in adults, and severe nasal findings are present in one out of every three
pregnant women. Asthma and allergic rhinitis may worsen or remain unchanged in pregnancy. Allergic
reactions can also worsen the course of...
EXTENDED ABSTRACT
Serial murder is more common in males, and murder weapons are usually sharp tools. On the other hand,
female serial killers and healthcare serial killers frequently use high doses of drugs and poisons as method of
killing. There are more than 100 healthcare serial killers in the literature, but it is very difficult to identify a...
Objective:Killing with poison or high-dose drug is an uncommon method used in serial murders. Healthcare serial killers differ from classical serial killers because they frequently use high-dose drugs or poison to kill the victims. In the study, it was aimed to create the most up-to-date list of healthcare serial killers and poisons they used.Metho...
A new respiratory tract infection caused by coronaviruses was identified in 2019 and called Coronavirus disease-19 (COVID-19). It has long been known that pregnant women are not more susceptible to viral illness. However, changes to their immune system in pregnancy can be associated with more severe symptoms. Pregnant women do not seem to be at hig...
Elfriede Blauensteiner, known as the "Black Widow", is an Austrian serial killer who poisoned her victims with overdose drugs. It is known that the main cause of her murders was gambling addiction. As a result of the trials in 1997 and 2001, Elfriede Blauensteiner was sentenced to life imprisonment twice. The serial killer, who started to commit he...
Objective: The aim of this presentation is to discuss the possible teratogenic effects of valproate therapy in pregnancy and the transition to breast milk through follow-up of a patient who needs valproate due to epilepsy during pregnancy and breastfeeding, and to present an up-to-date literature on the subject.
Method: 24 years old was admitted t...
Fatih Sultan Mehmed was an Ottoman Sultan who ruled from 1444 to 1446,
and then later from 1451 to 1481. At the age of 21, he conquered Constantinople
(Istanbul) and brought an end to the Byzantine Empire. He had three sons. The first
son was Bayezid II. The second was Mustafa and the third was Cem. There are some
conflicting data regarding dea...
Objective: The aim of this study was to compare the use of poison or high-dose drugs as the cause of death in western and Turkish literature.
Materials and Methods: The works of Agatha Christie and Ahmet Ümit were examined as examples of crime novels. The use of poison or high-dose drugs as the murder weapon and cause of death, the properties of th...
Hekim Lari, Fatih Sultan Mehmed’in Acem hekimi, ölümünün gerçekleştiği sefer sırasında kendisine ilk ilacı veren hekim olarak bilinmektedir. Fatih Sultan Mehmed’in ölümü yüz yıllar sonra da tartışılan bir konu olup yabancı kaynaklarla yerli kaynaklar arasında bazı görüş farklılıkları mevcuttur. Hekim Lari, Fatih Sultan Mehmed’in zehirlenerek öldürü...
Coronaviruses include some of the agents that produce the common cold and some viruses that produce more severe respiratory syndromes. There have been case reports of normal and abnormal pregnancy outcomes after infection with Coronaviruses. Malformations have not been described. A new respiratory tract infection caused by coronaviruses was identif...
INTRODUCTION: The aim of this study was to evaluate the
prescription drugs and reasons for hospital admission among
elderly patients.
METHODS: A single-center, retrospective study between
November 2013 and December 2013 was conducted using the
medical records of elderly patients (≥65 years of age) admitted
to the outpatient clinic. Demographic...
Medication use in pregnancy is a common problem and question. Nearly half of pregnant women (30% -90%) use at least one prescription medication during pregnancy. In addition to prescription drugs, pregnant women use over the counter drugs for which are limited data in pregnancy. Pregnant patients exposed to drugs should be informed about potential...
Bezmialem Science, in press.
Cardiovascular diseases are the most common cause of morbidity and mortality in diabetic patients. Oxidative stress plays an important role in diabetic endothelial dysfunction. Free oxygen radicals may increase insulin resistance and affect pancreatic beta cells under conditions of oxidative stress. Several experimental...
https://actamedica.org/index.php/actamedica/article/view/77/151
A 34-year-old nulliparous woman with an unplanned pregnancy reported
regular smoking herbal products containing synthetic cannabinoid.
Prenatal sonographic examinations at each trimester revealed normal fetal
growth. Detailed anomaly scan findings were normal and compatible with
gesta...
Drugs contraindicated in pregnancy are medicines that should be avoided by pregnant women, since they carry a concern for teratogenicity or there is no indication for their use during pregnancy. It does not mean that exposures to these drugs always cause harm. The aim of the present study was to investigate the risk of adverse outcomes following ma...
INTRODUCTION: The aim of this study was to evaluate the drug utilization by elderly patients over 65 years old and to provide information on polypharmacy.
METHODS: A single-center, retrospective study between January 2013 and December 2013 was conducted using the medical records of elderly patients (≥65 years of age) admitted to the Doganlar Family...
OBJECTIVES: Cardiovascular disorders and medication are highly prevalent in elderly. Due to age-related changes, the elderly are particularly vulnerable to side effects and adverse drug reactions. Some psychotropic drugs are linked with reports of cardiac side effects. The aim of the study was to investigate the prevalence and nature of concomitant...
There is increasing evidence for an interaction between dopaminergic and glutamatergic systems in obsessive-compulsive disorder (OCD). In the present study, it was tested whether group I metabotropic glutamate 5 receptors (mGlu5R) mediate compulsive-like checking behavior in an animal OCD model induced by quinpirole, a dopamine D2/3 receptor agonis...
Bezmialem Science ; : - DOI: 10.14235/bs.2017.1383 . In press.
Objective: Digoxin is widely used in controlling ventricular rhythm in atrial fibrillation and in heart failure. Therapeutic serum levels of digoxin are 0.5- 2 ng/ml. Toxicity may occur after acute accidental or suicidal ingestion or with chronic therapy. In this study, we aimed to dete...
Introduction:
The emergency contraceptive ulipristal acetate (UPA) 30?mg is increasingly used by women, but there is no published data on UPA exposure in pregnancy.
Case report:
Here we describe five cases of unintended pregnancies following the use of UPA for emergency contraception. Of five pregnant women exposed to UPA, one decided to termina...
Postherpetic neuralgia is the most commonly seen complication of herpes zoster, primarily in elderly and immunocompromised patients.
However, motor involvement due to herpes zoster is very rare. A 65-year-old male patient presented with left leg pain, numbness and
difficulty walking. He was diagnosed with having herpes zoster and treated with valac...
Zeynep Ozturk. High-fat diet and low-dose streptozotocin induced type 2 diabetes: a methodological critique. Appl Med Res. Online First: 23 Jun, 2016. doi:10.5455/amr.20160610011150
Objective: The question of harmfulness of the psychiatric drugs creates a major dilemma for pregnant women. The risks associated with prenatal psychotropic drug exposure are often overestimated. It is unclear that psychotropic medication or disorders themselves increase the risk of adverse pregnancy outcomes. The purpose of this study is to generat...
Rodenticides are the most commonly used toxic agents for suicide attempts. A 24-year-old multiparous
and 11 weeks pregnant woman attempted suicide by taking brodifacoum. She had no signs of
hemorrhage. Laboratory test results included hyponatremia, hypocalcemia, slightly lower blood urea
nitrogen (BUN), creatinine levels and shortened activated par...
Coronary heart disease because of atherosclerosis is still the most common cause of mortality. Elevated levels of low-density lipoprotein and total cholesterol are major risk factors for atherosclerotic cardiovascular disease. The aim of this study was to evaluate the effects of the olive leaf extract on serum lipid profile, early changes of athero...
Endothelial dysfunction develops as a result of oxidative stress and is responsible for diabetic vascular complications. We investigated the effects of selenium on endothelial dysfunction and oxidative stress in type 2 diabetic rats. Male Wistar rats were divided into five groups: controls, untreated diabetics, and diabetics treated with 180, 300,...
Aim: The United States Food and Drug Administration (FDA) has established five
categories to indicate the potential of a drug to cause birth defects if used during
pregnancy. The categories are determined by the reliability of documentation and the
risk to benefit ratio. Category X includes drugs in which human and animal studies (or
actual human e...
Lead is an element that has been used by mankind for 6000 years due to its specifications like
softness, high malleability, ductility, low melting temperature and corrosion resistance. Lead
is the second most dangerous element coming after arsenic and its toxic effects on human are
due to causing dysfunction of various organs such as kidney, bones,...
Drug use during pregnancy can prove teratogenicity and cause a permanent abnormality of
structure or function on fetus. The risks for the fetus are various, with the most serious being
congenital defects, growth impairment, fetotoxic effects and fetal death. However, it does not
mean that exposure to a drug will always cause harm. Teratogenic effec...
Digoxin is a cardiac glycoside used to treat congestive heart failure and to slow the heart rate
in patients with atrial fibrillation. Because its therapeutic effect works only within narrow
window (0.5- 2.0 ng/ml), overdose occurs commonly. Therefore it is recommended to keep
the upper value as 0.9 mg/dl and check regularly.
Digoxin toxicity can b...
Medicine use during pregnancy may lead to
teratogenic effects and structural and functional
abnormalities on foetus. There are various risks
including congenital defects, growth retardation,
foetotoxic effects and foetal death. However, this
does not mean that exposure to medicine would be
harmful in all cases. Teratogenic effects of medicine
depen...