Zesheng Zhang

• Tianjin University of Science & Technology

Aging is a global challenge. Many studies reported that the accumulation of ROS and oxidative stress could be the most important causative factors for aging. Phenolic, flavonoids, and melanoidins possess potent of ROS scavenging ability. In this study, brown black wolfberry (BBW) was prepared via the Maillard Reaction (MR) and its anti-aging potent...

Gymnemic acid (GA) isolated from gymnema sylvestre (Retz.) Schult has been shown to display anti-diabetic activity, however the molecular mechanisms governing these effects are unclear. In this study, GA (40, 80 mg/kg/day) was evaluated by type 2 diabetes mellitus (T2DM) rats to explore its hypoglycemic activity and underlying mechanisms of action....

It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD)...

Gymnemic acid (GA) is a naturally occurring herbal ingredient that is improves glucose metabolism in patients with diabetes mellitus. In this study, we evaluated the ameliorative effects of GA on insulin resistance (IR) and identified the mechanisms in a rat model of type 2 diabetes mellitus (T2DM) and IR HepG2 cells. GA effectively increased gluco...

In this paper, the physical properties of a soluble non-starch polysaccharide (EGSP) from the endosperm of Gleditsia japonica var. delavayi seeds, and its effects on starch digestibility, glucose diffusion and glycemic index (GI) were investigated. EGSP has good acid-base and thermal stability and can form high viscosity solutions at low concentrat...

The water-soluble polysaccharides extracted from endosperm of Gleditsia japonica var. delavayi seeds (EGSP) were identified as galactomannan having the M/G ratio of 2.54–2.66 and a weight average molecular weight (Mw) of 1913 kDa. The molecular structure of EGSP was determined by periodate oxidation, Smith degradation, methylation, FTIR and NMR spe...

Sea buckthorn fruit oil is rich in palmitoleic acid (POA), which has been reported to play roles in many metabolic processes. In this study, a sea buckthorn fruit oil (SBFO) extract was evaluated through in vitro experiments (the does were 50, 100, 200 and 400 μM) and in vivo experiments (the does were 100, 200 and 300 mg/kg·day) to explore its mec...

The rosemary extract is a new natural antioxidant. In this study, the stability of palm oil with rosemary extract during frying and accelerated storage was studied. The antioxidant of palm oil with different concentrations of rosemary ethanol extract were evaluated at 180 °C and 65 °C. The effect of rosemary ethanol extract was also compared with t...

Lotus leaves have been used traditionally as both food and herbal medicine in Asia. Open-field, sodium pentobarbital-induced sleeping and light/dark box tests were used to evaluate sedative-hypnotic and anxiolytic effects of the total alkaloids (TA) extracted from the herb, and the neurotransmitter levels in the brain were determined by ultra fast...

This study investigated the effect of Cordyceps sinensis oral liquid (CSOL) on the lifespan of Drosophila melanogaster (fruit fly). Following the lifelong treatment of fruit flies with CSOL, lifespan was examined. The activity of copper-zinc-containing superoxide dismutase 1 (SOD1), manganese-containing superoxide dismutase 2 (SOD2) and catalase (C...

D-pinitol, a compound isolated from pinaceae and leguminosae plants, has been reported to possess insulin-like properties. Although hypoglycemic activity of D-pinitol was recognized in recent years, the molecule mechanism of D-pinitol in the treatment of diabetes mellitus remains unclear. In this investigation, a model of type 2 diabetes mellitus (...

This study aimed to explore the alliin, saccharides, antioxidant and some other physicochemical changes of black garlic during the thermal processing steps. The contents of alliin and polysaccharides decreased significantly after 10 days of heat treatment, whereas the content of reducing sugars increased correspondingly. The 57.14% of fructose, 6.7...

The objective of this study was to investigate the effects of superfine grinding on the physicochemical and antioxidant properties of Lycium barbarum polysaccharides (LBP). Superfine grinding treatment could decrease the average molecular weight (changed from 834.0, 85.2 and 70.6 to 538.5, 71.2 and 2.1, respectively), the spherical particle’s heigh...

To investigate structure-bioactivity relationship of LBP, Lycium barbarum polysaccharide (LBP) was extracted and separated into five fractions using ultra filtration membrane method. Then the effects of these polysaccharide fractions on human liver cancer cells (SMMC-7721) were observed by MTT assay, LSCM and FCM. And the components, molecular weigh...

To explore the effects of thermal processing on antioxidant activity and the chemical composition of s-alk(en)ylcysteine s-oxides (alliin) extract from garlic, the alliin extract was thermally processed and the chemical constituents were analyzed by HPLC and LC–MS, and antioxidant capacities were investigated by 2,2-Diphenyl-1-picrylhydrazyl (DPPH)...

Extrusion processing is a thermal process applied to food preparation. However, its effects on food ingredients are ambiguous. The aim of this study was to elucidate the effects of extrusion processing on soluble dietary fiber (SDF) in oat bran. The yield, composition, thermal properties, rheological behavior and functionality of SDF in extruded oa...

Hawthorn fruit has long been used as a folk medicine with many medicinal benefits. HPLC analysis revealed that hawthorn fruit extract (HFE) contained 19.86% procyanidin B2, 15.27% epicatechin, 3.10% chlorogenic acid, 2.91% hyperoside, and 1.34% isoquercitrin. Antioxidants are essential for protection of the bodies against the damaging action of fre...

Apple polyphenols are considered as natural antioxidants. The purpose of this paper was to evaluate the cytoprotective effects of apple polyphenols against rat primary hepatocytes oxidative injury induced by carbon tetrachloride in vitro. Some biochemical assays were carried out to determine the cytoprotective effects of apple polyphenols on the he...

Starch is an important ingredient for food and other industries. Modified starch has better properties than natural starch. Phosphorylation is one of the effective techniques to improve the functional properties of starch and to modify its behavior in terms of gelatinization, pasting, and retrogradation. Phosphorus is the effective component of pho...

To evaluate the effects of processes on physicochemical properties of oat bran soluble dietary fiber (OSDF), the oat bran was processed by steam heating, superfine grinding, and extrusion, and extracted to obtain OSDF. The molecular weight distribution, monosaccharide composition, transparency, solubility, structure, and thermal and morphological p...

We investigated the radioprotective activity of betalains from red beets in mice irradiated by a (60)Co gamma (gamma) ray (6.0 Gy, at a dose of 1.5 Gy min(-1)). Mice were randomly divided into five groups, namely the control group and four experimental groups which were given one of four concentrations of betalains from red beets (0, 5, 20 and 80 m...

Hawthorn fruit extract has been shown to have many health benefits including being cardiovascular protective, hypotensive and hypocholesterolemic. The present study was carried out to characterize further the antioxidants of hawthorn fruit and their effect on the oxidation of human low density lipoprotein (LDL) and alpha-tocopherol. The dry hawthor...

This study compared the antioxidative activity of green tea catechin (GTC) extract with that of rosemary extract in canola oil, pork lard, and chicken fat. The GTC extract was obtained from jasmine and longjing green teas and mainly consisted of four epicatechin isomers including (−)epigallocatechin gallate (EGCG), (−)epigallocatechin (EGC), (−)epi...

Green tea catechins (GTCs) as a mixture of (−)-epicatechin (EC), (−)-epicatechin gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin gallate (EGCG) possess a variety of biological activities. We have previously studied the stability of GTCs either as a mixture or as individual epicatechin derivatives in various pH, demonstrating tha...