Żekanowska Ewa

Żekanowska Ewa
Nicolaus Copernicus University | umk · Department of Pathophysiology

About

134
Publications
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1,011
Citations
Citations since 2017
44 Research Items
699 Citations
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2017201820192020202120222023050100150200
2017201820192020202120222023050100150200

Publications

Publications (134)
Conference Paper
Full-text available
Background Experimental studies conducted over the past few years have shown that factor VII activating protease (FSAP) fulfills a fundamental role in the pathophysiology of ischemic stroke (IS). FSAP deficiency is associated principally with the deterioration of IS outcomes, which was demonstrated in the mouse model of the disease. Consequently, t...
Article
Full-text available
Introduction: Accurately predicting outcomes after acute ischaemic stroke (AIS) is a major clinical goal. The aim of this pilot study was to evaluate the prognostic validity and accuracy of the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) score in predicting symptomatic haemorrhagic transformation (sHT) in patients with AIS who have und...
Chapter
Introduction: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently and rapidly emerged and developed into a global pandemic. Through the renin-angiotensin system, the virus may impact the lung circulation, but the expression on endothelium may conduct to its activation and further systemic damage. While precise...
Article
Full-text available
Intense physical activity contributes to an increased demand for red blood cells, which transport oxygen to working muscles. The purpose of this study was to assess the concentration of erythroferrone (ERFE), the novel marker of erythroid activity in athletes, during the beginning of their training season. The study group consisted of 39 athletes a...
Article
Full-text available
Streszczenie Osteopatia uznaje zależność pomiędzy ciałem, psychiką i umysłem zarówno w stanie zdrowia w stanie choroby. Celem było określenie wpływu technik osteopatycznych czaszkowo - krzyżowych na posturalność ciała i pracę układu autonomicznego. Przebadano 57 klinicznie zdrowych mężczyzn w wieku 21,78±2,11 lat, których, podzielono na dwie grupy...
Article
Full-text available
Viscoelastic methods (VEMs) such as thromboelastography (TEG) and thromboelastometry (TEM) offer a comprehensive assessment of hemostasis, starting with early stages of coagulation, through fibrin clot formation, and ending with fibrinolysis. They offer several advantages compared to the standard coagulation tests i.e. they allow a detailed assessm...
Article
Full-text available
Objective: The aim of this study was to evaluate non-transferrin-bound iron (NTBI) and labile plasma iron (LPI) levels and other parameters of iron metabolism in children undergoing therapy for acute leukemia or after hematopoietic cell transplantation (HCT), in the context of iron overload. Patients: A total number of 85 children were prospecti...
Article
Haemostatic unbalance is often observed in patients with coronavirus disease 2019 (COVID-19), and patients with severe disease are at high risk of developing thromboembolic complications. Viscoelastic methods (VEMs), including thrombelastography (TEG) and thromboelastometry (TEM), provide data on the nature of haemostatic disturbance. In this syste...
Article
Full-text available
Osteopathy recognizes and accepts the relationship between the body, psyche and mind both in the state referred to as health and in the disease state. The aim was to determine the impact of craniosacral osteopathic techniques on body posturality and autonomic system work. 22 healthy men 21.63 ± 1.41 years old were examined and divided into two grou...
Article
Full-text available
Objectives: Symptomatic hemorrhagic transformation (sHT) is a life-threatening complication of acute ischemic stroke (AIS). The early identification of the patients at increased risk of sHT can have clinically relevant implications. The aim of this study was to explore the validity and accuracy of the neutrophil-to-lymphocyte ratio (NLR) in predic...
Article
Full-text available
Osteopathy recognizes and accepts the relationship between the body, psyche and mind both in the state referred to as health and in the disease state. The aim was to determine the impact of craniosacral osteopathic techniques on body posturality and autonomic system work. 22 healthy men 21.63 ± 1.41 years old were examined and divided into two grou...
Article
Full-text available
Infection with severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) is a rapidly spreading and devastating global pandemic. Many researchers are attempting to clarify the mechanisms of infection and to develop a drug or vaccine against the virus, but there are still no proven effective treatments. The present article reviews the common pres...
Article
The association between blood levels of protein Z (PZ) and risk of ischemic stroke remains poorly understood. We aimed to assess this potential relationship through a meta-analysis of case–control studies. PubMed, Scopus, Web of Science Core Collection, and the Cochrane Library were searched from April 1984 to April 2019. We selected case–control s...
Conference Paper
Full-text available
Osteopatia uznaje i akceptuje zależność pomiędzy ciałem, psychiką i umysłem zarówno w stanie określanym jako zdrowie jak i w stanie chorobowym. Celem było określenie wpływu technik osteopatycznych czaszkowo - krzyżowych na posturalność ciała i pracę układu autonomicznego. Przebadano 22 klinicznie zdrowych mężczyzn w wieku 21,63±1,41 lat, których, p...
Article
Background: Type 2 neurological complications of coronary artery bypass grafting (CABG) include postoperative cognitive dysfunction (POCD) and delirium. Although relevant clinically, they are rarely properly recognized outside of dedicated research setting, as their identification is complex and time-consuming. The aim of this study was to examine...
Article
Full-text available
The basis for the application of craniosacral osteopathic techniques is the interdependence of structure and function. The aim of the research was to determine the impact of craniosacral techniques on postural stability. We examined 22 clinically healthy men aged 21.63 ± 1.41 years, divided into two groups (11 people given craniosacral techniques a...
Article
Full-text available
Background and Objectives: Ischaemic stroke (IS) is the leading cause of death and disability worldwide. All stages of cerebral ischaemia, but especially acute phase, are associated with inflammatory response. Recent studies showed that neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) may be used to assess inflammation in...
Article
The function of central nervous system (CNS) processes is highly dependent on iron containing enzymes and proteins. Therefore, even mild iron deficiency (ID) may result in decreased endurance, increased irritability and withdrawal behavior among women. The current study was designed to assess the effects of iron status on perceived energy level alo...
Article
Objectives: The purpose of this study was to explore how osteopathic treatments influence certain measurable aspects of stress performance in male athletes. Design and Participants:Twenty-two (22) healthy male athletes (21,63 ± 1,41 years), participated in the study and were randomly allocated to either a craniosacral therapy or placebo group with...
Chapter
Factor VII blood coagulation plays a key role in the blood coagulation process. Its activation gives rise to a cascade reaction to stimulate further coagulation factors. This glycoprotein, having the proenzyme character, is activated after the formation of the complex with tissue factor (TF). Complex TF:VIIa is not only crucial during the blood coa...
Conference Paper
Influence of cranialsacral techniques of osteopathy and neuromobilization on the values of stress markers Introduction. Osteopathy acknowledges and accepts the relationship between the body, psyche and mind, both in the defined state as health and in the disease. Aim of the study. The aim was to determine the influence of osteopathic craniosacral t...
Article
Full-text available
Background: Considerable attention has been focused over the past several years on the protein Z (PZ) system. However, little is known about the role of auto-antibodies to PZ (anti-PZ) in cardiac surgery patients. Aim: In the present pilot study, we investigated plasma levels of anti-PZ in patients undergoing off-pump coronary artery bypass (OPCAB)...
Article
Full-text available
Background and Objectives: Top-level sports performance places heavy physical and psychological demands on elite-level athletes, which can be a source of increased levels of stress. Therefore, high-level volleyball players may present altered cardiovascular and endocrinological stress response during stressful events. Although many previous studies...
Article
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The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles (EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis. The unique surface antigens of MPs/MVs allow for the identification of their cellular origin as well as its functional characterization. Two basic aspects of MP/MV fun...
Article
Full-text available
Neurological injury is a frequent and important complication of coronary artery bypass grafting (CABG). Several risk factors for this type of sequela have been identified, among them aortic arch atherosclerosis. Our previous study indicated that atherosclerotic burden in coronary arteries may likewise predict postoperative neurological complication...
Article
Full-text available
Iron is one of the most important microelements in the human body. It is a component of haemoglobin, which transports oxygen to all cells in the organism. It is also used in the synthesis of myelin, neurotrans-mitters, and DNA and transfers electrons in biochemical reactions. Iron is also responsible for regular development of the foetus’ central n...
Article
To understand the coagulation changes after off-pump coronary artery bypass (OPCAB) surgery, we evaluated the procoagulant activity of microparticles (MPs) and microparticles exposing tissue factor (MPs-TF), together with the levels of total tissue factor (TF), protein Z (PZ), protein Z-dependent protease inhibitor (ZPI), and factor X (FX) before (...
Article
Intensive genetic selection has improved productive traits in poultry and contributed to changes in systemic metabolism; however, their blood coagulation processes have received little study. The precise physiological mechanisms of haemostasis in birds remain poorly understood, but blood clotting is believed to be governed by an extrinsic tissue fa...
Article
Full-text available
The tissue factor (TF) – tissue factor pathway inhibitor (TFPI) axis plays a major role in hemostasis. Disorders of the coagulation system are commonly diagnosed with the help of screening tests such as prothrombin time (PT), activated partial thromboplastin time (aPTT), and plasma fibrinogen concentration (PFC). However, the effect of prebiotics o...
Article
Derangement of bone morphogenetic protein (BMP) signalling was observed in cardiovascular disorders. The present study assesses the diagnostic and prognostic value of BMP6 plasma concentration in chronic heart failure (CHF). 130 CHF patients and 32 controls participated in the study. BMP6 plasma level was measured at baseline. During 12-month follo...
Article
Background: Although the role of microparticles was recently implicated in stroke pathophysiology, the association between microparticles and inflammation is still not fully understood. The aim of this cohort study of 66 patients was to assess a relation between haemostatic factors, C-reactive protein and clinical outcome of ischaemic stroke. Met...
Article
Full-text available
Aim: The goal of this study was to determine the levels of factor VII (FVII), factor VIIa–antithrombin complexes (FVIIa-AT), total tissue factor (TF), and tissue factor-bearing microparticles (MPs-TF) in patients with acute ischemic stroke. Further, we sought evidence of an association between hemostatic markers, time of blood sampling, type of tre...
Article
Aim: The aim of the study was to assess the blood concentration of orexin and its association with other clinical factors in patients with alcohol dependence. Methods: Thirty-two males hospitalized on an addiction treatment ward due to alcohol dependence and 23 healthy men as a control group were enrolled in the study. The measurement of orexin...
Article
Full-text available
Introduction: Visfatin is a protein which belongs to the adiponectines, and exhibits insulinomimetic properties. A high concentration of visfatin may be directly related to an ongoing inflammatory process in the body. The aim of this study was to assess changes in the concentration of visfatin in relation to the intensity of alcohol craving and sel...
Article
Background Our current understanding of iron balance in acute ischemic stroke (AIS) is still limited. The objective of this study was to evaluate levels of iron homeostasis proteins–hepcidin (25–amino acid form) and soluble hemojuvelin (sHJV) together with hepcidin/sHJV ratio (Hepc/sHJV) and soluble transferrin receptor (sTfR) in patients with AIS....
Article
Full-text available
Background and purposeStroke is an important cause of death and disability throughout the world. Microparticles play a cardinal role in vascular hemostasis. The primary aim of this study was to evaluate the procoagulant activity of microparticles and levels of tissue-factor-bearing microparticles (MPs-TF), tissue factor (TF) and tissue factor pathw...
Article
Background/aim: It is believed that the amniotic fluid-derived TF, in the case of amniotic fluid embolism (AFE), contributes to acute disseminated intravascular coagulation (DIC) and obstetric shock in the mother. However, the role of amniotic fluid-derived contact phase coagulation factors that irrupt into the bloodstream simultaneously with TF i...
Article
Full-text available
Iron is found in almost all foods, so dietary iron intake is related to energy intake. However, its availability for absorption is quite variable, and poor bioavailability is a major reason for the high prevalence of nutritional iron deficiency anaemia. Absorption occurs primarily in the proximal small intestine through mature enterocytes located a...
Article
Unlabelled: The mechanisms contributing to thromboembolic complications in children with acute lymphoblastic leukemia (ALL) are complex, but it is believed that two factors are of critical importance, i.e. increased thrombin generation and decreased antithrombotic potential of the blood plasma. We evaluated generation of thrombin in three periods...
Article
Full-text available
Introduction and objective: The clinical consequences of malnutrition are multi-directional and result in dysfunctions of the majority of internal organs and systems. The results of recent studies suggest that a significant role is played by malnutrition in pathophysiology of iron homeostasis disorders, but the underlying mechanism is unclear. The...
Article
Full-text available
Current knowledge indicates that there is a close connection between being overweight, obesity and iron metabolism disorders,but the underlying mechanism is unclear. Hepcidin could be a major contributor to poor iron status observed in the obese population. The study was performed in 58 obese elderly individuals (F/M 34/24) aged 65-91 (78.92 ± 8.32...
Article
Background and aim: This study was designed to clarify the impact of the short-term consumption of different types of alcoholic beverages on haemostatic factors, C-reactive protein (hsCRP) and endothelin-1 (E-1) plasma levels. Methods: The study group consisted of 57 healthy male volunteers, aged 20-29 years. Subjects were randomised to consume...
Article
Iron is an essential element in human development. It is imperative for oxygen and electron transport and also for DNA and neurotransmitters synthesis. On the other hand, this metal is able to participate in Fenton's reaction that in turn leads to free radical damage. The most toxic fraction of iron - nontransferrin-bound iron and its part desferri...
Article
Full-text available
Introduction: The diagnosis of iron deficiency anemia (IDA) in the context of the anemia of chronic disease (ACD) in elderly patients is often difficult due to the existence of many disorders. Recent studies have shown that hepcidin measurement (combined with the existing diagnostic methods) may possibly help in the differential diagnosis of IDA a...
Article
Full-text available
Hepcydyna jest niewielkim białkiem zaangażowanym w metabolizm żelaza. Poprzez internalizację i degradację ferroportyny, jedynego transportera żelaza z cytoplazmy komórek do krwiobiegu, hepcydyna odpowiedzialna jest za zmniejszenie stężenia tego pierwiastka w surowicy krwi. Wcześniejsze badania dokładnie scharakteryzowały mechanizmy odpowiedzialne z...
Article
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Abstract Objective: To assess the relationship between parameters of iron homeostasis in infants and clinical features characterising newborns and their mothers. Methods: The goal of the present work was to determine nine iron status parameters, i.e. hepcidin, prohepcidin, soluble transferrin receptor, ferritin, total iron binding capacity, unsatur...
Article
Full-text available
Iron is an essential micronutrient for the proper functioning of most organisms. This element is used in oxygen transport, myelin and neurotransmitters synthesis, cell cycle and synthesis of nucleic acids. The importance of iron in the maturation of lymphocytes and proper functioning of the eye is also stressed. Newborns are particularly sensitive...
Article
Background: Hepcidin is a major iron regulatory protein. The aim of this pilot study was to determine hepcidin precursor–prohepcidin and iron metabolism parameters in serum cord blood of infants delivered by gestational diabetes mellitus mothers (GDM). Materials and methods: The study group comprised 12 infants delivered by women diagnosed with GDM...
Article
Full-text available
Non-transferrin bound iron (NTBI) is known to facilitate reactive oxygen species generation which contributes to the development of tissue damage observed in various disorders like hemolytic anemia, hemochromatosis, diabetes mellitus or many forms of neonatal central nervous system damage. Here we are summarizing information about biochemical natur...
Article
Hepcidin is a small protein involved in iron metabolism that also exhibits antibacterial and antifungal activities. Since its discovery in 2000, hepcidin has been extensively studied in many research centers. Usage of natural and synthetic hepcidin inhibitors can be applied as a powerful therapeutic tool that targets multiple types of anemia. In ad...
Article
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Objectives: In the working hypothesis we assumed that the procoagulant activity of microparticles (MPs) is associated with the concentration of tissue factor (TF) and its inhibitor (TFPI), and that these three components together affect fetal hemostasis. The aim of the study was to check whether MPs are present in the cord blood, to compare their c...
Article
Full-text available
To examine the impact of a body fat content on the concentration of a serum prohepcidin, iron metabolism parameters and inflammation markers in elderly patients with microcytic or normocytic anemia. Clinical study with biochemical and anthropometric measurements. Fifty two elderly patients (19 male, 33 female) with anemia, 65-91 years of age. Prohe...
Article
Obesity and overweight have become a global problem affecting not only high income countries but also developing countries. According to the World Health Organization (WHO) more than 1 billion adults are overweight and at least 300 million of them are obese. Experimental and clinical studies indicate that there is a relationship between iron metabo...
Article
Hepcidin is a newly discovered iron metabolism regulator. It decreases iron absorption from the duodenal enterocytes and inhibits its release from the reticuloendothelial macrophages. The experiments on hepcidin and its precursor--prohepcidin seem very promising and underline the need to establish the reference intervals for these proteins and defi...
Article
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Activated protein C (APC) is an important anticoagulant which plays a role in pathophysiology of pregnancy, e.g. in maintenance of the uteroplacental circulation and development of the fetus as well as in pathogenesis of preeclampsia. The study objective was to compare the levels of the respective components of the protein C system (protein C, PC;...
Article
Full-text available
Iron deficiency is a common complication in patients with polycythemia vera (PV). Hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess prohepcidin, a hepcidin precursor, and other iron status parameters in the serum of PV patients. The study was performed in 60 patients (F/M 26/34) aged 38~84 (66+/-10) years. Th...
Article
A high number of blood donations may cause iron depletion. The pathophysiology behind this process may involve hepcidin, a recently discovered peptide that acts by inhibiting iron absorption and promoting iron retention in reticuloendothelial macrophages. The aim of this study was to determine serum pro-hepcidin levels and iron metabolism parameter...
Article
Full-text available
Hepcidin, a small peptide secreted mainly by the liver, plays a central role in iron status regulation. The experiments on hepcidin seemed very promising and gave new life to understanding iron metabolism. Many authors suggest that hepcidin measurement can be used as a clinical tool for the diagnosis and management of a wide range of iron]related...