Zehra Ozcan

Ege University · Department of Nuclear Medicine

Objective:Bone metastasis is common in advanced prostate cancer (PCa). Recently, there has been a growing interest in the potential role of inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-to-monocyte ratio (NMR), in predicting advanced disease in patients with solid tumors. In th...

Objectives: Inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been recently introduced as potential biomarkers for tumor pathogenesis, development and prognosis in solid tumors. Our aim was to assess the correlation of clinicopathological features and NLR and PLR in patients with papillar...

Thyroid carcinoma is an uncommon malignancy in children, and metastatic involvement at initial presentation is much more common than adults. The clinical course of the disease is favorable; however, management is challenging due to differences in biologic behavior of the tumor and potential side effects of I-131 in the long-term follow-up. The curr...

Thyroid carcinomas are usually diagnosed in small sizes and accepted as low-risk disease without disease-related mortality. However, there has been still controversy regarding the optimal management of differentiated thyroid carcinoma both in surgical technique and the use of radioactive iodine ablation. Moreover, there is also uncertainty about wh...

During the follow-up of a patient with differentiated thyroid carcinoma, Tg elevation without iodine uptake on WB scan was noted. She received an empiric dose of radioiodine to evaluate the possible Tg production site; however, no evidence of uptake was found. PET/CT scan showed pulmonary nodules, some of which were FDG avid. Finally, sorafenib tre...

Locally advanced disease accounts for 5–15% of the differentiated thyroid cancer (DTC) patients. Although surgical excision of the entire primary lesion is aimed for the optimum disease management, incomplete resections may occur especially in patients having invasions to recurrent laryngeal nerve, respiratory tract, esophagus, or major vessels. Ra...

Medullary thyroid carcinoma is a part of “multiple endocrine neoplasia” syndromes in 25% of the cases. Surgery is the primary curative treatment modality in the management of medullary thyroid carcinoma. Detection of the presence and the extent of the metastatic disease is important for the appropriate therapy planning. The contribution of two nucl...

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer subtype and constitutes 80% of all thyroid malignancies. PTC lesions that are 1 cm or less in size are defined as “papillary thyroid microcarcinoma” (PTMC). The incidence of occult PTC cases detected on autopsy series is very high, ranging from 10 to 35%. With the increased use of...

Objectives: The incidence of papillary microcarcinomas, which are defined as thyroid cancers of <10mm in size, has been increasing in the last decade. Herein, we present internet-based questionnaire results performed by the Turkish Association of Endocrine Surgery with the aim to evaluate the perspective of the management of papillary microcarcino...

Nuclear medicine applications in Turkey started in the early 1950s, grew as an independent medical discipline and finally were recognized by the Ministry of Health in 1973. Later on, the professional organization of nuclear medicine physicians and other related professionals including radiopharmacists and technologists under the Turkish Society of...

Purpose: It is known that the presence of neck lymph node (LN) metastasis is correlated with persistent disease in papillary thyroid carcinoma (PTC) patients. After appropriate therapy, most patients become disease free, whereas some may still have persistent disease. The present study aimed to determine the potential variables affecting the clini...

Radisosynovectomy (RS) is a local form of radionuclide therapy used in various forms of arthritis characterized by synovitis. In hemophilic arthropathy, RS provides removal of inflamed synovium and prevents further joint damage. This review focuses on the practical aspects of radionuclide synovectomy in hemophilic patients and describes the issues...

Objectives: To review the significance of first thyroglobulin (Tg) values at the time of remnant ablation, in assessing the clinical course in patients with differentiated thyroid cancer (DTC) Design: Retrospective study Setting: Faculty of Medicine, Ege University, Turkey Subjects: A total of 474 patients with DTC excluding those with positive thy...

Diffuse hepatic uptake of I-131 either on diagnostic or post-therapeutic scans is a usual finding in patients with differentiated thyroid carcinoma. The aim of this study was to evaluate the frequency and clinical significance of diffuse hepatic uptake of radioiodine on post-therapeutic (PT) and postablative (PA) whole-body scans.A total of 720 PA...

Objectives of this study were to investigate the occurrence and aggressiveness of differentiated thyroid carcinoma (DTC) in patients with hyperthyroidism and to explore the influence of the changes in dietary iodine intake on the association of hyperthyroidism and DTC. Clinical records of 1,800 patients with DTC were reviewed. The characteristics o...

Patients with differentiated thyroid carcinoma (DTC) have long-life expectancy and are at risk for developing a second primary cancer. Aim of this study was to assess the occurrence of DTC in conjunction with other primary neoplasms. It was also aimed to explore the possibility of synchronous or metachronous other malignancies having an impact on c...

Myocardial perfusion scintigraphy (MPS) is an effective tool for early diagnosis of coronary artery disease (CAD) in type II diabetes mellitus (DM). The purpose of this study was to review the comparative findings of Tc-99m MIBI and Tl-201 MPS in defining normal and abnormal myocardial segments, type and extent of the perfusion defects with referen...

Short communication. To report a case with bilateral lower extremity complex regional pain syndrome (CRPS) in a patient with paraplegia occurring following spinal disc herniation surgery, who was treated successfully with pulse radiofrequency (PRF) lumbar sympatholysis. Departments of Physical Medicine and Rehabilitation, Algology Department of Ana...

Dynamic renal scintigraphy plays an important role in the postoperative evaluation of renal transplant function. Scintigraphic evalution is based upon visual analysis and additional quantitative parameters of the renogram. The authors describe the experience obtained in scintigraphic evaluation of two renal transplant cases and underline the import...

In this report, a case of differentiated thyroid carcinoma having false-positive I-131 accumulation due to a large hydatid cyst in the liver is presented. Abdominal sonographic examination of a 37-year-old patient with differentiated thyroid carcinoma demonstrated an ovoid, complex cystic mass containing cystic parts as well as solid-appearing comp...

Despite many animal and clinical studies to date, there is still debate on the effect of internal thoracic artery harvesting on postoperative sternal perfusion and thus healing. We performed a prospective clinical study to assess the postoperative sternal perfusion in patients who underwent surgical coronary revascularization by means of unilateral...

The two methods recommended for estimation of differential renal function (DRF) in the renography guidelines published by the European Association of Nuclear Medicine are the area under the background-subtracted time-activity curves (AUCs) (often called the integral method) and the regression slope of the background-subtracted Rutland/Patlak plot a...

Protein-losing enteropathy is an uncommon syndrome of excessive loss of protein via the gastrointestinal mucosa. 99mTc-dextran scintigraphy was performed on a 42-year-old woman with protein-losing enteropathy. She had secondary amyloidosis due to rheumatoid arthritis. Abnormal leakage of the radiotracer was observed in the mid-abdominal region sugg...

The presence of accessory renal arteries has been considered a relative contraindication in the setting of a live related renal transplant program. Failure to properly anastomose the arteries can cause segmental infarction leading to increased morbidity. The authors describe a transplant patient with a well-defined cortical defect on a Tc-99m DMSA...

Imaging characteristics obtained from serial scintigraphic and ultrasonographic studies in children with the prenatal diagnosis of unilateral pelvic dilatation are presented. Serial ultrasonographic and scintigraphic findings in 101 children with unilateral pelvic dilatation collected during followup were reviewed. Changes in hydronephrotic kidney...

Recombinant human interferon-α has been used successfully in the treatment of patients with chronic active hepatitis. In the current report, a patient presented with fatigue, weight loss, irritability, and palpitation while receiving interferon therapy resulting from chronic hepatitis B infection. Thyroid function tests and scintigraphic findings w...

As calculated from a (99m)technetium (Tc)-mercaptoacetyltriglycine (MAG3) renogram, differential renal function is an important parameter affecting the clinical treatment of children with prenatal unilateral hydronephrosis. We determined whether value is potentially added by calculating a functional image from MAG3 renograms that represents proxima...

Amiodarone hydrochloride, which is used in life-threatening cardiac tachyarrhythmia, has been known to cause amiodarone induced pulmonary toxicity (AIPT) as a complication. In this study we aimed to investigate the clinical value of technetium-99m diethylene triamine penta-acetic acid (DTPA) aerosol lung scintigraphy in patients with AIPT in compar...

Multidrug resistance (MDR) is a major problem in lung cancer. Tc-99m methoxyisobutyl isonitrile (MIBI) has been demonstrated to be a non-invasive marker to diagnose MDRI related P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) expression in various solid tumors. The aim of this study was to evaluate the relationship between th...

The authors describe a neonate with bilateral dysplastic kidneys who underwent Tc-99m DMSA scintigraphy for the assessment of renal cortical functions. Although poor renal uptake was noted on the Tc-99m DMSA scan, an unusual area of soft tissue accumulation was detected in the right hypochondrium. A color Doppler study confirmed the diagnosis of so...

SUMMARY Urinary leakage is a well-recognized complication of renal transplant surgery, which may lead to increased morbidity. In order to define clinical efficacy of renal scintigraphy in urinary leakages, we retrospectively reviewed 82 renal transplant patients with early scintigraphic exams in the current study. The clinical, scintigraphic and ul...