Zarko Milosevic

Objectives The study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs). Methods Data (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively col...

The aim of this chapter is to describe hologram-based balance physiotherapist software that was developed in the HOLOBALANCE H2020 project ( www.holobalance.eu ). Balance disorders due to age-related progressive loss of functioning of sensory information and the inability to control body movements are considered a global epidemic according to the W...

Atherosclerosis is a disease of arterial blood vessels characterized by the accumulation of lipids in the arterial wall, starting with endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. In this study, using DICOM images, a numerical model of atherosclerosis progression was developed. Fluid domain (blood...

In this chapter we described predictive model for plaque formation and progression in the coronary and carotid artery. A full three-dimensional model for plaque formation and progression, coupled with blood flow and LDL concentration is analysed. The Navier-Stokes equations together with the Darcy law for model blood filtration and Kedem-Katchalsky...

In this study a patient-specific computer model of stent deployment into the human stenosed coronary arteries is developed. The model is also able to predict atherosclerosis growing in the artery after stent deployment. We analyse shape post-implantation, possible damages to the endothelium as well as the effects of the stenting on the vessel wall,...

The inflammation and lipid accumulation in the arterial wall represents a progressive disease known as atherosclerosis. In this study, a numerical model of atherosclerosis progression was developed. The wall shear stress (WSS) and blood analysis data have a big influence on the development of this disease. The real geometry of patients, and the blo...

Atherosclerosis is a leading cause of mortality in the all developed countries. This disease begins with endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. Interaction between the blood and the plaque can lead to plaque rupture. An important hemodynamic parameter in interaction between fluid and vessel...

Atherosclerosis is a disease of arterial blood vessels characterized by the accumulation of lipids in the arterial wall. Mechanical forces such as low shear stress are implicated in plaque formation and development. Using DICOM images, 3D models of human right coronary artery (RCA) were developed. This paper studies influence of wall shear stress (...

In this study we analysed computational model for plaque development and validation with clinical study. Mass transfer within the blood lumen and through the arterial wall was coupled with the blood flow. Plaque progression was modeled using three additional reaction􀀗diffusion partial differential equations. The results for plaque concentration for...

Benign Paroxysmal Positional Vertigo (BPPV) is the most common vestibular disorder. In this paper we tried to investigate a model of the semi-circular canal (SCC) with parametrically defined dimension and full 3D three SCC from patient-specific 3D reconstruction. Full Navier-Stokes equations and continuity equations are used for fluid domain with A...

In this study stent deployment modeling with plaque formation and pro- gression for specific patient in the coronary arteries are described. State of the art method for the reported investigations of blood flow in the stented arteries is described. In the met- hod section, image segmentation method for arteries with stent is shortly described. Bloo...

In this chapter a complex problem of stent deployment with plaque formation and progression for specific patient in coronary arteries is described. Stent enables widening of the stenosed part of the blood vessel. We firstly describe state of the art for blood flow in the stented arteries. Blood flow simulation is described by Navier-Stokes and cont...

Benign Paroxysmal Positional Vertigo (BPPV) is most common vestibular disorder which becomes from the presence of basophilic particles in the semicircular canals (SCC). Three-dimensional biomechanical model of the SCC is described with full 3D fluid-structure interaction of particles, wall, cupula deformation and endolymph fluid flow. The model of...

Atherosclerosis is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall. Determination of plaque location and plaque volume for a specific patient is very important for prediction of atherosclerotic disease progression. In this study coupled computer modeling of at...

In this study computer model of atherosclerosis progression was developed. Additional to mechanics approach with wall shear stress a biomolecular parameters Cholesterol, LDL, HDL and Triglycerides are also included for patient specific analysis. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the inti...

Determination of plaque location and plaque volume for a specific patient is very important for prediction of atherosclerotic disease progression. Atherosclerosis is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall.

In this study we compared computer simulation of plaque development and Fractional Flow Reserve (FFR) with real clinical data from a specific patient. The Navier-Stokes and continuity equations were used for blood flow and pressure distribution for FFR. The Darcy law was used for model blood filtration, Kedem-Katchalsky equations for the solute and...

Introduction Both, open and endovascular, procedures are related to higher complication rate in abdominal aortic aneurysm (AAA) with shorter neck. Previous study showed that long neck AAA might have lower risk of rupture. Estimation of biomechanical forces in AAA improves rupture risk assessment. Aim of this study was to compare morphological featu...

Computational study for plaque formation and development for the patient specific coronary arteries was performed. Transport of macrophages and oxidized LDL distribution for the initial plaque grow model inside the intimal area was implemented. Mass transport of LDL through the wall and the simplified inflammatory process was firstly solved. The Na...

Treatment of Abdominal Aortic Aneurysm (AAA) is a challenge in vascular surgery. Latest methods used for treatment requires implantation of stent graft - particular synthetic blood vessel (graft) combined with armature (stent). We developed our software for surgical planning of implantation of stent graft for AAA. Material properties of the aortic...

Computer simulations based on the finite element method (FEM) represent powerful tools for modeling blood flow through arteries. However, due to its computational complexity, this approach may be inappropriate when results are needed quickly. In order to reduce computational time, in this paper we proposed an alternative machine learning based appr...

In this review we presented scientific results from three EC FP7 projects: ARTREAT, SIFEM and EMBALANCE. The title of FP7 ARTREAT project was: Multi-level patient-specific artery and atherogenesis model for outcome prediction, decision support treatment, and virtual hand-on training. Researchers from University of Kragujevac and BioIRC participated...

Benign paroxysmal positional vertigo (BPPV) is the most common type of vertigo. The symptoms of BPPV typically appear after angular movements of the head. BPPV leads to dizziness, nausea and imbalance. In this study, we examined a model of the semi-circular canal (SCC) with fully 3D three dimensional anatomical data from specific patient. A full Na...

The semicircular canals (SCC) are fluid-filled inner ear structures designed to detect circular or angular motion. In this study we modeled three-dimensional biomechanical model of SCC and compared results with real patient case for the Benign Paroxysmal Positional Vertigo (BPPV) disease. Model consists of full 3D fluid-structure interaction incorp...

Vibration of the skull causes a hearing sensation. We call it Bone Conduction (BC) sound. There are several investigations about transmission properties of bone conducted sound. The aim of this study was to develop a software tool for easy generation of the finite element (FE) model of the human head with different materials based on human head ana...

Benign paroxysmal positional vertigo (BPPV) is the most commonly diagnosed vertigo syndrome that affects 15% of older persons. BPPV is characterized by sudden attacks of dizziness and nausea triggered by changes in head orientation, and primarily afflicts the posterior canal. We are modeling human semicircular canals (SSC) which considers the morph...

Atherosclerosis is a medical condition becoming the number one cause of death worldwide. For this reason, any developement that may help physicians in early diagnostic and selection of the most appropriate treatment strategy is of great importance. In this paper we describe three-dimensional computer model of plaque formation and development for hu...

This study describes computer simulation of blood flow and plaque progression pattern in a patient who underwent surgical treatment for infected carotid prosthetic tube graft using carotid-carotid cross-over bypass. The 3D blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lu...

Vascular endothelial cells are continuously exposed to hemodynamic shear stress. Intensity and type of shear stress are highly relevant to vascular physiology and pathology. Here, we modeled shear stress distribution in a tissue culture well (R = 17.5 mm, fill volume 2 ml) under orbital translation using computational fluid dynamics with the finite...

Cochlea is part of the inner ear. The role of the cochlea is to transform outer acoustic signal into electrical impulse which is further transmitted to the brain. Two important phenomena taking place inside the cochlea: transformation of outer acoustic signal into mechanical vibration and transforming of mechanical vibration into electrical impulse...

In this study we investigated the hot caloric test response in the three semicircular canals using coupled fluid flow, natural convection and fluid-structure interaction with the finite element method. We demonstrated that the temperature distribution of the horizontal canal duct is more dominant and a longer period of irrigation time is required i...

In this chapter we described predictive model for plaque formation and progression in the coronary and carotid artery. A full Three-Dimensional model for plaque formation and progression, coupled with blood flow and LDL concentration is analysed. The Navier-Stokes equations together with the Darcy law for model blood filtration and Kedem-Katchalsky...

The cochlea is the most important part of the hearing system, due to the fact that it receives sound in the form of vibrations and converts these vibrations into nerve impulses in the organ of Corti that sends information about sounds to the brain. Functioning of the cochlea components and behavior is still not investigated completely because of it...

Atherosclerosis is a progressive disease characterized by inflammation, monocyte-macrophage migration, and lipid accumulation in the vascular wall. The three-dimensional blood flow is governed by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the...

Cochlea is important part of the hearing system, and thanks to special structure converts external sound waves into neural impulses which go to the brain. Shape of the cochlea is like snail, so geometry of the cochleamodel is complex. The simplified cochlea coiled model was developed using finite element method inside SIFEM FP7 project. Software ap...

Atherosclerosis is a progressive disease characterized by inflammation, monocyte-macrophage migration, and lipid accumulation in the vascular wall. The three-dimensional blood flow is governed by the Navier–Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the...

Atherosclerosis is a progressive disease characterized by inflammation and lipid accumulation in the vascular wall. In this study, we analysed animal experiments and clinical data for plaque formation and progression. The first animal experiment examined cast model on the carotid artery (Cheng et al., 2006) [21]. The second animal experiment is rel...

Atherosclerosis is becoming the number one cause of death worldwide. Animal experiments are very important to better understand physiological conditions for atherosclerosis development. We here examined influence of wall shear stress (WSS), histological and blood analysis data on the atherosclerosis lesion development for animal model. The histolog...

Atherosclerosis is a progressive disease characterized by inflammation, monocyte-macrophage migration, and lipid accumulation in the vascular wall. In this study, two experiments are calculated numerically. The first is Cheng et al 2006 experiment with cast model on the carotid artery and the second is our pig experiment on the left anterior descen...

The understanding and the prediction of the evolution of atherosclerotic plaques either into vulnerable plaques or into stable plaques are very important for the medical community. Stents in the coronary arteries are routinely used in the management of patients with angina or myocardial infarction where percutaneous coronary intervention is the cli...

Atherosclerosis is a disease of large arteries that is characterized by the accumulation of lipids in the arterial wall. Mechanical forces such as low shear stress are implicated in plaque formation and development. The objective of this work is to examine influence of wall shear stress (WSS) and histological and blood analysis data on the atherosc...

We present a three-dimensional model of plaque formation and progression that was tested in a set of patients who underwent coronary Computed Tomography angiography (CTA) for anginal symptoms. The 3D blood flow is described by the Navier-Stokes equations, together with the continuity equation. Mass transfer within the blood lumen and through the ar...

Atherosclerosis is the number one cause of death worldwide. A three-dimensional computer model of plaque formation and development for artery is described. Stent deployment procedure for a specific patient is adopted and simulation of the temperature distribution for heating stent in the final position is analysed. The three-dimensional blood flow...

Computational fluid dynamics methods based on in vivo 3-D vessel reconstructions have recently been identified the influence of wall shear stress on endothelial cells as well as on vascular smooth muscle cells, resulting in different events such as flow mediated vasodilatation, atherosclerosis, and vascular remodeling. Development of image-based mo...

A method for three-dimensional modeling of coronary arteries fusing X-ray angiography and intra vascular ultrasound (IVUS) imaging modalities is presented. A 3-D IVUS catheter path is reconstructed from a pair of biplane angio images taken from same cardiac moment. Vessel wall is segmented from previously image-based ECG gated IVUS images and fused...

High-gradient magnetic separation (HGMS) has attracted considerable attention in recent time, both experimentally and theoretically. It has established itself as a powerful technique for the manipulation of particles with magnetic properties. In the present study, analytical and numerical analysis of magnetic separation of cardiomyocytes (CMs) is p...

Atherosclerosis is a progressive disease characterized by inflammation, monocyte-macrophage migration, and lipid accumulation in the vascular wall. Atherosclerosis is initially characterized by endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. In this study we investigated our three-dimensional compute...

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium and vasculitis, and accumulation of lipid, cholesterol, and cell elements inside blood vessel wall. In this study, a continuum-based approach for plaque formation and development in...

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in arteries. It is characterized by dysfunction of endothelium, vasculitis and accumulation of lipid, cholesterol and cell elements inside blood vessel wall. In this study a continuum based approach for plaque formation and development in three...