Zahra Nazari

Zahra Nazari
Golestan University · Biology

PhD

About

22
Publications
4,391
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
237
Citations
Introduction
Zahra Nazari is assistant professor at golestan university. Zahra does research in congenital malformations.
Additional affiliations
September 2019 - present
Golestan University
Position
  • Professor (Assistant)

Publications

Publications (22)
Article
Full-text available
Background The classical renin-angiotensin system (RAS) has an important role in the cardiovascular system and water homeostasis in the body. Recently, the existence of RAS with all of its components has been shown in the mammalian brain. RAS participates in many brain activities, including memory acquisition and consolidation. Since the cholinergi...
Chapter
Gene therapy drugs and products are non-classic bioproducts designed and established for precision and/or personalized medicine. Gene therapy drugs are developed primarily based on the non-viral or modified-viral tools to restore the function of the missing or defective genes in the target cells. To develop genetically modified (GM) cell products,...
Article
Recent progresses in discovery, development and exploitation of gene manipulation and delivery tools have dramatically revolutionized the gene therapy field for modern therapies. Alireza Shahryari, Ingo Burtscher, Zahra Nazari and Heiko Lickert summarize and discuss the advances and barriers of the gene editing platforms, viral gene delivery vehicl...
Article
Full-text available
Currently, 33 gene-therapy drugs/products have been approved in the clinic. Over 3000 completed and ongoing clinical gene therapy trials have been reported worldwide. The development/maturation of tools for gene manipulation and gene delivery, as well as molecular advances in the diagnosis of genetic diseases, have played a central role in gene the...
Article
Full-text available
Objective DNA methylation, a major epigenetic reprogramming mechanism, contributes to the increased prevalence of type 2 diabetes mellitus (T2DM). Based on genome-wide association studies, polymorphisms in CDKN2A/B are associated with T2DM. Our previous studies showed that gestational diabetes mellitus (GDM) causes apoptosis in β-cells, leading to...
Article
Full-text available
The field of gene therapy is striving more than ever to define a path to the clinic and the market. Twenty gene therapy products have already been approved and over two thousand human gene therapy clinical trials have been reported worldwide. These advances raise great hope to treat devastating rare and inherited diseases as well as incurable illne...
Article
Full-text available
Objectives: Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabe...
Article
Gestational diabetes mellitus (GDM) is one form of diabetes affect approximately 7 % of pregnancies. Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that is associated with loss of nerve fibers, myelin abnormalities and significant decrease in the expression of myelin basic protein (MBP) in peripheral nerves. This study wa...
Article
Several studies indicated that pancreatic ß-cell death occurs in both type 1 and type 2 diabetes. This experimental study was designed to determine the effect of gestational diabetes on the ß-cells in 16-week-old rat offspring. By this aim, adult Wistar rats aged 10-12 weeks were randomly allocated in control and diabetic groups. The diabetic group...
Article
Full-text available
Objective(s) The link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (GDM), but the underlying mechanisms for this phenomenon are still not clear. Reduced β-cells mass is a determinant in the development of diabetes (type 1 and ty...
Article
Background: Filgrastim is a granulocyte colony-stimulating factor (G-CSF), which also showed effects on memory and cognation. Although recent studies have begun to explore G-CSF-related mechanisms of action in memory, little is known about its effects on cholinergic system. Since the cholinergic system has a key role in memory and some studies repo...
Article
Background: The classic renin-angiotensin system (RAS) has a role in the cardiovascular system and water homeostasis in the body, but recently, the existences of this system with all of its components including angiotensinogen, angiotensin-converting enzyme (ACE), and angiotensin receptors have been shown in the mammalian brain. Recent clinical stu...
Article
Full-text available
Background: Aquaporins (AQPs) are water channels that play a key role in water transport in many epithelia. Recent studies have shown that AQP1, located in the apical membrane of choroid plexus cells, has an important role in cerebrospinal fluid (CSF) production. However, the mechanism of water transport through the basolateral membrane of choroid...
Article
Full-text available
Although honeybee venom (BV) has been reported to induce apoptosis in different types of cancerous cells, its synergistic effects with customary anti-cancer drugs remain largely unknown. In the present study, we evaluated the cytotoxic effect of BV alone (as a natural product) and the synergistic cytological effects of this component in combination...
Article
Full-text available
Abstract Aquaporin-1 (AQP1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (CP) and thought to be one of the major pathways for the high water permeability of this structure. Blockade of AQP1 in the CP reduce the production of cerebrospinal fluid (CSF). Downregulation of AQP1 might be protective agai...
Article
Full-text available
Background: Bee venom (BV), like many other complementary medicines, has been used for thousands of years for the treatment of a range of diseases. More recently, BV is also being considered as an effective composition for the treatment of cancer. Cancer is a major worldwide problem. It is obvious that the identification of compounds that can ac...
Article
Full-text available
Ovarian cancer is considered to be one of the most important causes of death among women. Cisplatin is one of the oldest chemotherapeutical compounds used for treating ovarian cancer. Previous studies have shown the inhibitory effects of bee venom on certain types of cancer. The aim of the present study was to evaluate the cytotoxic effect of bee v...
Conference Paper
Full-text available
Polycystic Ovarian Syndrome (PCOS) is inflammatory disease characterized by hyperandrogen- emia, hyperthecosis and chronic anovulation. Honey bee venom (HBV) contains a variety of bio- logically active components having various pharmaceutical properties. This study was designed to detect the possibility of HBV application as an anti-inflammatory t...
Article
Turmeric, derived from the plant Curcuma longa, is a gold-colored Spice that has been used as a traditional medicine. Curcumin (CUR), the principal curcuminoid of turmeric, which gives the yellow color to turmeric, is now recognized as being responsible for most of the therapeutic effects. It has been shown to exhibit antioxidant, anti-inflammatory...

Questions

Question (1)
Question
Hi everyone, I am now establishing bisulfite sequencing using manually protocol, can I use pcr purification kit or DNA extraction kit instead of DNA clean-up kit? I have heard that pcr purification kit just can isolate products with 100-5000 bp, and i think bisulfite treated DNA is larger than these. on the other hand, i think DNA extraction kit can not desalt the DNA fragments. 

Network

Cited By