Zahra Lorigooini

Zahra Lorigooini
Shahrekord University of Medical Sciences · Medical Plants Research Center

Ph.D of Pharmacognosy

About

108
Publications
52,092
Reads
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1,700
Citations
Citations since 2016
102 Research Items
1687 Citations
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
20162017201820192020202120220100200300400
Additional affiliations
December 2014 - present
Shahrekord University of Medical Sciences
Position
  • Professor (Assistant)
January 2008 - present
Position
  • phytochemistry
September 2001 - September 2008
Shiraz University of Medical Sciences
Position
  • Pharm. D Student

Publications

Publications (108)
Article
Full-text available
Background Depression is one of the most common mental illnesses worldwide. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to possess pharmacological effects on neurological diseases. Purpose The present study aimed to investigate the possible role of the NO pathway in Auraptene...
Article
Full-text available
Hyssopus officinalis L. is one of the most important medicinal plants in traditional medicine used to treat seizures. In this study, we assessed the effects of H. officinalis hydroalcoholic extract against pentylenetetrazol (PTZ)-induced seizures in rat. The anti-seizure activity of the extract was assessed in three doses of 25, 50, and 100 mg/kg....
Article
Full-text available
Objective Due to the high side effects of commonly used drugs and according to the pharmacological properties reported for coumaric acid (CA), this study was designed to determine the impact of CA on acetic acid-induced colitis in rats, considering its possible anti-inflammatory, antioxidant, and anti-apoptotic properties. Materials and methods Fo...
Article
Background and aims: The lack of effective antiviral drugs for adenoviruses is one of the most important problems in this area. The aim of this study was to investigate the phytochemical properties and antiviral effect of the green tea extract (GTE) on adenovirus in HEp2 cells in vitro. Methods: In this experimental study, dried leaves of green tea...
Article
Full-text available
Methods: In this experimental study, 64 mice were divided into 8 groups and received the following: normal saline; EA at doses of 6.25, 12.5, and 25 mg/kg; NMDA agonist at a dose of 75 mg/kg; NMDA antagonist (ketamine) at a dose of 0.5 mg/kg; an effective dose of EA plus NMDA agonist; and a subeffective dose of EA plus ketamine. We induced seizure...
Article
Full-text available
Anethole has possessed anti-inflammatory and antioxidant responses in numerous studies. Oxidative stress has a pivotal role in the pathophysiology of colitis. The current study is designed to determine the effect of anethole on acetic acid-induced colitis in mice in view of its possible anti-inflammatory and antioxidant properties. In this study, 4...
Article
Full-text available
Introduction It has been shown that oxidative stress is involved in the pathophysiology of seizure. Current anticonvulsants have side effects, thus further studies are needed to find new agents with low side effects. Anchusa italica Retz. has been suggested to have antioxidant and neuroprotective effects. The present study aimed to determine the an...
Article
Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs. Carvacrol is a phenolic compound with neuroprotective, anti-inflammatory, antioxidant and anticonvulsant effects. The aim of th...
Article
Full-text available
Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have...
Article
Background: We examined anti-Toxoplasma effect of hydroalcoholic extract of Terminalia chebula Retz (T. chebula) in cell culture and murine model. Methods: The study was conducted in Shahrekord University of Medical Sciences, Iran in 2017. Half maximal effective (concentration (EC50) of T. chebula extract and pyrimethamine was determined in infe...
Article
Full-text available
Background and aims: Osteoporosis is one of the most common metabolic bone diseases with systemic involvement of the body skeleton. The Peganum harmala seed contains high amounts of carboline alkaloids, which have been shown to have positive effects on bone formation in animal studies. In the present study, the effect of an oral capsule of P. harma...
Article
Full-text available
Rutin is a unique antioxidant flavonoid that is mainly found in fruit, vegetables, cereals, and many other plant-based human diets. This review aims to highlight the in vitro anticancer properties of rutin including combination therapeutic strategies. Literature resources were gathered through PubMed, Scopus, Web of Science, and Google Scholar data...
Article
Objectives Seizures are abnormal discharge of neurons in the brain. Ferulic acid (FA) is a phenolic compound with antioxidant and neuroprotective effects. The present study aimed to investigate the role of the nitrergic system in the anticonvulsant effect of FA in pentylenetetrazol (PTZ)-induced seizures in male mice. Methods 64 male Naval Medical...
Article
Full-text available
It is necessary to seek more effective sources to design new drug against epilepsy. This study aimed to evaluate the effect of hydroalcoholic extract of Artemisia persica on pentylenetetrazole- (PTZ-) induced seizure in male mice by investigating the possible role of the NMDA receptor and antioxidative stress effect. The phenolic profile of A. pers...
Article
The cover image is based on the Review Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting) by Sorayya Ghasemi et al., https://doi.org/10.1002/ptr.7059.
Article
Full-text available
A new system for cold atmospheric pressure plasma (CAPP) generation was designed and characterized. The effects of voltage (10, 15, 20 kV), frequency (10, 15, 20 kHz), gas flow rate (3, 5, 7 L/min), and percentage of oxygen (0, 0.5, 1%) on the plasma jet length (PJL) were investigated. Then, different volumes (5, 10, 15 mL) of sour cherry juice wer...
Article
Full-text available
Background: The use of natural compounds in relieving pain has been commonplace since ancient times and their use is currently increasing. Objectives: Given that analgesic and anti-inflammatory effects of Kombucha have not been studied, this study was designed to examine these effects in vitro. Methods: In this experimental study, rats were divided...
Article
Early life stress is associated with various complications. Auraptene has significant antioxidant and anti-inflammatory effects. This study aimed to assess the probable underlying mechanisms that mediate changes in the behavior, hippocampus, heart and serum in the mouse model of maternal separation (MS) stress. We evaluated the possible protective...
Article
Background and aims: Depression is one of the most common psychiatric disorders with serious impacts on individuals, and is often associated with physiological symptoms. In this study, we investigated the antidepressant effects of Kelussia odoratissima Mozaffarian extract in male mice. Methods: A total of 56 male mice (weight: 25-35 g; age: 6-8 wee...
Article
Background: Benign prostatic hyperplasia (BPH) is the most prevalent disease of the prostate in elderly men. Since Nigella sativa has been reported to show various pharmacological effects, this study was conducted to examine the effect of N. sativa seed oil on experimental BPH. Methods: The oil was extracted using the cold-pressing method. Fifty...
Article
Epigenetic alterations are one of the main factors that disrupt the expression of genes and consequently, they have an important role in the carcinogenicity and the progression of different cancers. Cancer stem cells (CSCs) are accountable for the recurrence, metastasis, and therapeutic failure of cancer. The noticeable and specific pathways in CSC...
Article
Cornus mas (C. mas) is one of the native horticultural products to Iran that have high pharmaceutical and nutritional values. This study aimed to comparatively investigate different drying methods with ultrasound‐osmotic pretreatment on energy consumption, timing, and qualitative properties of Cornus mas. In this study, C. mas was first dried by th...
Article
It has been well known that anxiety is associated with various complications. The exact underlying bridge between the probable cardiac diseases in anxiety is undetermined. Auraptene has significant antioxidant and anti-inflammatory effects. In this study we aimed to assess the probable underlying mechanisms bridge comorbid cardiac complications wit...
Preprint
Full-text available
Background: Depression is one of the most common mental illnesses around the world. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to have pharmacological effects on neurological diseases. porpuse: The present study aimed to investigate the possible role of NO pathway in Aurapten...
Article
Full-text available
Context: There are numerous pharmacological activities for Ruta graveolens and its bioactive constituent, rutin, on learning and memory. Objective: This study aimed to examine the effect of R. graveolens and rutin on memory in rats. Materials and methods: In this study animals were treated with the hydroalcholic extract of R. graveolens and rutin b...
Article
Background: Astragalus fascicolifolius manna is used to treat different diseases. Because pregnant women tend to use Astragalus. fascicolifolius and Iranian traditional medicine emphasizes the abortifacient potential of this plant, this study aimed to investigate Astragalus fascicolifolius manna abortifacient property and effects on estrogen, prog...
Preprint
Full-text available
Background and Aim: Given the widespread prevalence of seizures worldwide and the low efficacy of synthetic drugs, studies are needed to find new compounds with appropriate efficacy. Ferulic acid (FA) is a phenolic compound with antioxidant and neuroprotective effects. The aim of present study was to investigate the role of nitrergic system in the...
Preprint
Full-text available
Aim: This study aims to investigate the relationship of two prognostic factors NLR and PLR to patient survival in gastric cancer patients diagnosed before surgery. Background: Due to the high prevalence of gastric cancer and the lack of appropriate prognostic factors, most patients are diagnosed at advanced stages of the disease. Therefore, this st...
Article
Full-text available
Background: Previous studies have shown that seizures can cause cognitive disorders. On the other hand, the Curcuma zedoaria (CZ) has beneficial effects on the nervous system. However, there is little information on the possible effects of the CZ extract on seizures. The aim of this study was to investigate the possible effects of CZ extract on co...
Article
Background: The most important side effects of Cyclophosphamide, as an anticancer broad-spectrum drug, are the negative effects on the reproduction and fertility because of oxidative stress. Considering the antioxidant properties of medicinal plants, especially those of the Allium genus, this paper studied the effect of hydroalcoholic extract of A...
Article
Full-text available
Background Today, the attention of researchers has been drawn to the use of medicinal plant for the treatment of kidney stones. The aim of this study was to investigate the effect of five plants used in traditional medicine on the dissolution of calcium oxalate and calcium phosphate stones. Then, the ability of more effective plants to dissolve sto...
Article
Full-text available
This study aimed to assess the effects of 8-week administration of pomegranate peel extract (PPE, ~180 mg ellagic acid) and vitamin E (Vit E, 400 IU) alone and in combination on oxidative stress (OS) and antioxidative capacity of hemodialysis (HD) patients. One hundred HD patients randomly divided in to 4 groups (control, PPE, Vit E, and PPE + Vit...
Article
Full-text available
Background and aim: Anxiety disorders are one of the most common psychiatric disorders worldwide. Common anti-anxiety medications are associated with several side effects. Caffeic acid (CA) is a phenolic compound with several pharmacological effects. The aim of this study was to investigate the anxiolytic-like effect of CA in maternally separated...
Article
Numerous studies have implicated oxidative stress in the development of complications of diabetes. During hyperglycemia, production of oxidant agents such as reactive oxygen species and reactive nitrogen species increases. This process, along with a decrease in the activity of antioxidant enzymes, induces oxidative stress in the body. This redox im...
Article
Full-text available
Background and Aim Anxiety is one of the most common psychiatric disorders that lead to disruption of daily and quality of life. Routine medications have many side effects and cause physical dependence and psychosocial addiction. Diosgenin is a phytosteroid found in a number of herbs. The aim of present study was to investigate the anxiolytic-like...
Article
Full-text available
Background and Aim Depression is a mood disorder with high global prevalence. Depression is associated with a reduction in the hippocampal volume and change in its neurotransmitters function. Trigonelline is an alkaloid with neuroprotective activity. The aim of this study was to investigate the possible role of N-methyl-D-aspartate (NMDA) receptor...
Article
Full-text available
Introduction : Inflammation is one of the body›s natural defence mechanisms alongside the cells or tissues damage due to various stimuli or infections. Pain is one of the greatest common symbols associated with different diseases. Therefore, researchers are trying to find new medications that bring patients relief with fewer side effects. Herbal me...
Article
Full-text available
Polyphenol content and antioxidant activity of flowers and herbage of three species of the genus Alcea were determined. Flowers showed high total phenolic content and yielded values ranging from 26.83 (Alcea aucheri var. lobata) to 82.59 (A. aucheri var. aucheri) mg GAE/g DW. Total anthocyanin content was highest (934.98 mg/ml) in the flowers of A....
Article
Full-text available
Free radicals are constructed by natural physiological activities in the human cells as well as in the environment. They may be produced as a result of diet, smoking, exercise, inflammation, exposure to sunlight, air pollutants, stress, alcohol and drugs. Imbalanced redox status may lead to cellular oxidative stress, which can damage the cells of t...
Article
Objective The aim of this study was to comparatively investigate the effect of the topical 1% Hedera. helix extract gel to 1% diclofenac gel on knee osteoarthritis. Methods A total of 150 patients with primary osteoarthritis were randomly divided into three groups: 1% H. helix gel-treated, 1% diclofenac gel-treated, and placebo-treated. The topica...
Article
Full-text available
Background and aims:Euphorbia helioscopia has multiple pharmacological activities, such as antibacterial, antiviral, antifungal,anticancer and/or antitumor, allelopathic, anti-allergic and anti-asthmatic, antioxidant, antinociceptive effect. The aim of the study was to evaluate the antinociceptive activities of Euphorbia helioscopia extract in Balb...
Article
Full-text available
One of the nonthermal methods is the atmospheric pressure cold plasma (APCP). In this study, the effect of cold plasma on the reduction of Escherichia coli bacteria and qualitative properties of sour cherry juice, including total phenolic content (TPC), total anthocyanin content (TAC), and vitamin C, were investigated. Independent variables include...
Article
Hyssop (Hyssopus offisinalis L.) is a medicinal plant belonging to the Lamiaceae family. Hyssop essential oil has been used as antibacterial, antifungal and as a flavoring in the food industry. The essential oils from shade drying (20-25 °C), sun drying (under direct sunlight at 25-35°C,) oven drying (40, 50 and 60°C), microwave drying (300, 450 an...
Article
Dracocephalum kotschyi Boiss. (D. kotachyi), is an aromatic and perennial plant endemic to Iran. This plant is commonly used for the treatment of headache, congestion, stomach and also liver disorders. Furthermore, antihyperlipidemic, immunomodulatory, antinociceptive, cytotoxic and antispasmodic effects have already been reported for D. kotachyi....
Chapter
Phenolic acids are one of the most pervasive groups of plant phenolic compounds. Due to their significance in plants composition and for human health, a better understanding of phenolic acids concentrations and biological activities can potentially highlight their therapeutic properties and also help predict and control the quality of medicinal her...
Chapter
One of the most diverse and significant terpenoid subdivisions in plants is sesquiterpenoids. In addition to playing physiological roles, they show considerable biological and physicochemical properties making them suitable to be used for cosmetic, medicinal, and agrochemical purposes. To this end, phytochemical analysis contributes fundamentally t...
Article
Full-text available
Pathogenesis of the inflammatory bowel disease (IBD) involves the combination of immunological and inflammatory factors. IBD is associated with several extra-intestinal manifestations. The exact underlying bridge between the probable cardiac diseases in IBD patients is undetermined. Trigonelline is an alkaloid with several therapeutic potential pro...
Article
Full-text available
Background: This study examined the acute and sub-acute toxic effects of Terminalia chebula and Achillea wilhelmsii extracts on the murine model. Methods: In both phases, mice were assigned to intervention and control groups. At the end of study, the liver, kidney, and heart tissues were collected for histopathological studies. Results: In the acut...
Article
Silymarin is a complex extract isolated from the plant Silybum marianum, widely known for its prominent antioxidant and hepatoprotective effects, although increasing evidences have reported extraordinary antiproliferative and apoptotic abilities. As a result, several signaling pathways involved in cell cycle control, cell proliferation, and cell de...
Article
Depression and anxiety are common psychiatric disorders accounting for social and economic burdens. Previous studies have shown that oxidative stress and oxidant/antioxidant imbalance are involved in the pathophysiology of psychiatric disorders. Experiencing early-life adversities (like maternal separation [MS] stress) provoked psychiatric disorder...
Article
Full-text available
Background: Prevalence of migraine, as a chronic neurovascular disorder, was approximately 10.3 and 23.1% among men and women, respectively, mostly in people younger than 40 years old. Migraine is prevalent in different geographic areas worldwide. The present study was designed to compare the impact of intranasal lidocaine 4% and peppermint essent...
Article
Full-text available
Introduction : Ureteral obstruction by stones is one of the most common urological problems. Objectives : This study aimed to investigate the in vitro effects of hydroalcoholic extract of Peganum harmala L. on the contraction of the human ureter. Materials and Methods : In this study, 28 samples of human ureter tissue were studied. Six tissue sampl...
Article
Full-text available
Background: Osteoarthritis is a syndrome characterized by joint pain and reduced performance and efficien- cy in patient. Thymus daenensis has been used since old times for the treatment of bone and joint deformities and pain in traditional medicine. Purpose: This study was conducted to examine traditional usages and pharmacological features of T....
Article
Full-text available
Resumen Context: Breast cancer is one of the most prevalent cancers that causes substantial numbers of deaths among women, worldwide. Medicinal plants can be used for discovering new anti-breast cancer drugs. Aims: To investigate the antioxidant effects of twenty Iranian herbs and their anticancer effects against breast cancer cell lines (i.e. MDA-...
Article
Full-text available
Depression is a common psychiatric disease and one of the main causes of disability worldwide. In spite of certain developments in this field, chemical and synthetic drugs used for the treatment of depression disrupt the treatment process due to numerous side effects and high cost. Today, the goal of using a potential method for treating depression...
Article
Depression is one the common psychiatric disorders through the world. Nitric oxide (NO)and N-methyl-D-aspartate receptor (NMDA-R)are involved in the pathophysiology of depression. Previous studies have been reported various pharmacological properties for ellagic acid (EA). We aimed to evaluate possible involvement of NMDA-NO pathway in the antidepr...