Zahra Lorigooini

Shahrekord University of Medical Sciences · Medical Plants Research Center

A confluence of genetic, environmental, and epigenetic factors shapes autism spectrum disorder (ASD). Early‐life stressors like MS play a contributing role in this multifaceted neurodevelopmental disorder. This research was to explore the efficacy of Ocimum basilicum L. (O.B.) extract in mitigating behaviors reminiscent of autism prompted by matern...

Epilepsy, a widespread neural ailment considered by prolonged neuronal depolarization and repetitive discharge, has been linked to extreme stimulus of N-methyl-D-aspartate receptors (NMDARs). Despite the availability of approved anti-seizure medications (ASMs) in many developed nations, approximately 30% of epilepsy patients continue to experience...

Background Breast cancer remains a significant global health challenge, with thymoquinone showing promise as a therapeutic agent, but hindered by poor solubility. Objective This study aimed to enhance TQ delivery to MCF-7 breast cancer cells using mesitylene- mesoporous silica nanoparticles coated with liposomes, designed for controlled drug relea...

Background and aims: One essential plant-based strategy to deal with infections is antimicrobial synergism, which can make antimicrobials more efficient. The aim of this study was to investigate the interaction between these extracts and two widely used antibiotics, meropenem and gentamicin, on two multidrug-resistant (MDR) bacteria, K. pneumoniae...

Inflammatory bowel disease (IBD) is often accompanied by psychiatric disorders. Emerging evidence suggests that neuroinflammation and oxidative stress contribute to the psychiatric symptoms associated with IBD. Umbelliprenin (UMB) possesses several pharmacological properties, including anti-inflammatory and antioxidant effects. This study aimed to...

The current farming systems strongly depend on chemical fertilizers (CF), which are widely applied to increase crop yield worldwide. However, although CF enhance crop yield in the short term, their excessive and long-term application can have adverse effects on environmental and human health. One of the most important goals of sustainable agricultu...

Microalgae are a high‐potential source of biomolecules. Therefore, extracting bioactive components from microalgae with efficient and green extraction techniques is an important objective in many research. Cavitation‐based extraction is gaining widespread attention as an environmentally friendly method due to its reduced energy and solvent consumpt...

Objective To explore the effect of black radish ( Raphanus sativus L. var niger) root extract on liver enzymes, oxidative stress, and histopathological alterations in mice with sodium valproate-induced hepatotoxicity. Methods Thirty-two mice were divided into four groups: the control group received drinking water by gavage, the second group was ad...

Glutamatergic neurotransmission and oxidative stress are involved in the pathophysiology of seizures. Some anticonvulsants exert their effects through modulation of these pathways. Trigonelline (TRG) has been shown to possess various pharmacological effects like neuroprotection. Therefore, this study was performed to determine TRG’s anticonvulsant...

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with worldwide increasing incidence. Maternal separation (MS) stress at the beginning of life with its own neuroendocrine changes can provide the basis for development of ASD. Rosmarinic acid (RA) is a phenolic compound with a protective effect in neurodegenerative diseases. The aim of...

Background and aims: Due to the high prevalence of gastric cancer and the lack of appropriate prognostic factors, most patients are diagnosed at advanced stages of the disease. Therefore, this study aimed to investigate the relationship between two prognostic factors: neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to pa...

The occurrence of major depressive disorder is widespread and can be observed in individuals belonging to all societies. It has been suggested that changes in the NO pathway and heightened oxidative stress may play a role in developing this condition. Anethole is a diterpene aromatic compound found in the Umbelliferae, Apiaceae, and Schisandraceae...

Epilepsy poses a significant challenge, especially for drug-resistant cases, necessitating novel treatment avenues. This study explores the potential interplay between nitric oxide (NO) and the anticonvulsant effects of betulin, a triterpene with promising neuroprotective properties. While betulin exhibits anticonvulsant effects, the specific invol...

Medicinal plants are widely used in various traditional and modern medical methods due to their therapeutic properties. Drying is a common method used to preserve the biochemical compounds of medicinal plants. Still, conventional drying methods can lead to the loss of active compounds due to exposure to high temperatures. This research aimed to des...

Introduction: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition. Maternal separation (MS) stress is an early-life stress factor associated with behaviors resembling Autism. Both MECP2 and oxidative stress are implicated in the pathophysiology of Autism. Umbelliprenin (UMB) is a coumarin compound with various pharmacological p...

Background and aims: This article was written to better introduce Alcea rosea as a valuable medicinal plant to the medical and pharmaceutical communities and the general public for industrial and traditional uses as a valuable medicinal plant. Methods: The results were gathered from scientific papers and databases to find flavonoids, phenolic acids...

Autism spectrum disorder (ASD) is the fastest‐growing neurodevelopmental disease throughout the world. Neuro‐immune responses from prenatal to adulthood stages of life induce developmental defects in synaptic signaling, neurotransmitter imbalance, and even structural changes in the brain. In this study, we aimed to focus on the possible role of neu...

Objective Numerous therapeutics and pharmacological properties have been reported in syringic acid (SA). In this study, we aimed to evaluate effect of SA in ulcerative colitis (UC) in rats considering effect on TLR4, NF-κB, and INOS pathways. Materials and methods 48 Wistar rats were randomly designated into six groups (n = 8). UC was induced via...

In recent years, there has been a growing trend in the usage of traditional medicine and herbal treatments. However, the misconception that they are completely safe resulted in irreversible complications and damages. The present study was conducted to investigate the potential renal toxicity of a commonly used drug in Iran's traditional medicine an...

Despite tremendous progress in the prevention and treatment of cerebral ischemia, stroke remains one of the major causes of mortality and paralysis among the elderly. The design and study of neuroprotective drugs in vitro, such as in the Serum-Glucose Deprivation (SGD) condition, are proved to be efficient to understand how these drugs defend neuro...

Objective In this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats. Methods Ulcerative colitis (UC) was induced in rats by acetic acid intrarectally, and the protective effects of QA in 10, 30, 60, and 100 mg/kg doses were investigated. Rats...

Background and Aim: Infertility is one year of regular sexual intercourse without a successful pregnancy. The first and most common form of ART is In-vitro fertilization (IVF). In animal studies, royal jelly is the treatment supplementary to improve fertility. Therefore, this study aims to evaluate the effect of royal jelly on the quality of the o...

Introduction Ulcerative colitis is a chronic inflammation of the colon. However, the common treatment for it is accompanied by many complications. Therefore, the present study was aimed to determine the ameliorative effects of ferulic acid on acetic acid-induced colitis in rat. Materials and methods To induce ulcerative colitis, animals received 0...

In spite of the broad biological and also anticarcinogenic effects which have been reported for galbanic acid in various studies, its toxic effects are not still well characterized. The study was accomplished to evaluate the acute oral toxicity of galbanic acid pursuant to Organisation for Economic Co-operation and Development (OECD) TG No. 425. Fe...

Smyrnium is a rich source of isofuranodiene, a bioactive furanosesquiterpenoid. This study evaluated root samples from ten ecotypes of S. cordifolium from southwest Iran and found that their essential oils were predominantly composed of isofuranodiene and curzerene. The principal component analysis identified four chemotypes among the ecotypes, cha...

Echium amoenum is an annual herb native to the northern mountains of Iran which has medicinal application. Petals of Echium amoenum (Gole-Gavzaban) is one of the most valuable medicinal plants in Iranian folk medicine. The dry petals of E. amoenum have long been used as a sedative, tonic, anxiolytic and as a treatment for sore throat, cough and inf...

Background: Epilepsy is one of the major neurological disorders. The inflammatory process and oxidative stress are closely related to seizure progression. Quercetin is a flavonoid with anti-inflammatory and antioxidant properties as well as neuroprotective effects. We aimed to evaluate the effect of quercetin on pentylenetetrazole- (PTZ-) induced...

Background Depression is one of the most common mental illnesses worldwide. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to possess pharmacological effects on neurological diseases. Purpose The present study aimed to investigate the possible role of the NO pathway in Auraptene...

Hyssopus officinalis L. is one of the most important medicinal plants in traditional medicine used to treat seizures. In this study, we assessed the effects of H. officinalis hydroalcoholic extract against pentylenetetrazol (PTZ)-induced seizures in rat. The anti-seizure activity of the extract was assessed in three doses of 25, 50, and 100 mg/kg....

Objective Due to the high side effects of commonly used drugs and according to the pharmacological properties reported for coumaric acid (CA), this study was designed to determine the impact of CA on acetic acid-induced colitis in rats, considering its possible anti-inflammatory, antioxidant, and anti-apoptotic properties. Materials and methods Fo...

Background and aims: The lack of effective antiviral drugs for adenoviruses is one of the most important problems in this area. The aim of this study was to investigate the phytochemical properties and antiviral effect of the green tea extract (GTE) on adenovirus in HEp2 cells in vitro. Methods: In this experimental study, dried leaves of green tea...

Methods: In this experimental study, 64 mice were divided into 8 groups and received the following: normal saline; EA at doses of 6.25, 12.5, and 25 mg/kg; NMDA agonist at a dose of 75 mg/kg; NMDA antagonist (ketamine) at a dose of 0.5 mg/kg; an effective dose of EA plus NMDA agonist; and a subeffective dose of EA plus ketamine. We induced seizure...

Anethole has possessed anti-inflammatory and antioxidant responses in numerous studies. Oxidative stress has a pivotal role in the pathophysiology of colitis. The current study is designed to determine the effect of anethole on acetic acid-induced colitis in mice in view of its possible anti-inflammatory and antioxidant properties. In this study, 4...

Introduction It has been shown that oxidative stress is involved in the pathophysiology of seizure. Current anticonvulsants have side effects, thus further studies are needed to find new agents with low side effects. Anchusa italica Retz. has been suggested to have antioxidant and neuroprotective effects. The present study aimed to determine the an...

Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs. Carvacrol is a phenolic compound with neuroprotective, anti-inflammatory, antioxidant and anticonvulsant effects. The aim of th...

Abstract The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (200 and 400 mg/kg doses, gavage, once daily). Treatm...

Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have...

Background: We examined anti-Toxoplasma effect of hydroalcoholic extract of Terminalia chebula Retz (T. chebula) in cell culture and murine model. Methods: The study was conducted in Shahrekord University of Medical Sciences, Iran in 2017. Half maximal effective (concentration (EC50) of T. chebula extract and pyrimethamine was determined in infe...

Background and aims: Osteoporosis is one of the most common metabolic bone diseases with systemic involvement of the body skeleton. The Peganum harmala seed contains high amounts of carboline alkaloids, which have been shown to have positive effects on bone formation in animal studies. In the present study, the effect of an oral capsule of P. harma...

Rutin is a unique antioxidant flavonoid that is mainly found in fruit, vegetables, cereals, and many other plant-based human diets. This review aims to highlight the in vitro anticancer properties of rutin including combination therapeutic strategies. Literature resources were gathered through PubMed, Scopus, Web of Science, and Google Scholar data...

Objectives Seizures are abnormal discharge of neurons in the brain. Ferulic acid (FA) is a phenolic compound with antioxidant and neuroprotective effects. The present study aimed to investigate the role of the nitrergic system in the anticonvulsant effect of FA in pentylenetetrazol (PTZ)-induced seizures in male mice. Methods 64 male Naval Medical...

It is necessary to seek more effective sources to design new drug against epilepsy. This study aimed to evaluate the effect of hydroalcoholic extract of Artemisia persica on pentylenetetrazole- (PTZ-) induced seizure in male mice by investigating the possible role of the NMDA receptor and antioxidative stress effect. The phenolic profile of A. pers...

A new system for cold atmospheric pressure plasma (CAPP) generation was designed and characterised. The effects of voltage (10, 15, 20 kV), frequency (10, 15, 20 kHz), gas flow rate (3, 5, 7 L min⁻¹) and percentage of oxygen (0%, 0.5%, 1%) on the plasma jet length (PJL) were investigated. Then, different volumes (5, 10, 15 mL) of sour cherry juice...

The cover image is based on the Review Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting) by Sorayya Ghasemi et al., https://doi.org/10.1002/ptr.7059.

Background: The use of natural compounds in relieving pain has been commonplace since ancient times and their use is currently increasing. Objectives: Given that analgesic and anti-inflammatory effects of Kombucha have not been studied, this study was designed to examine these effects in vitro. Methods: In this experimental study, rats were divided...

Early life stress is associated with various complications. Auraptene has significant antioxidant and anti-inflammatory effects. This study aimed to assess the probable underlying mechanisms that mediate changes in the behavior, hippocampus, heart and serum in the mouse model of maternal separation (MS) stress. We evaluated the possible protective...

Background and aims: Depression is one of the most common psychiatric disorders with serious impacts on individuals, and is often associated with physiological symptoms. In this study, we investigated the antidepressant effects of Kelussia odoratissima Mozaffarian extract in male mice. Methods: A total of 56 male mice (weight: 25-35 g; age: 6-8 wee...

Background: Benign prostatic hyperplasia (BPH) is the most prevalent disease of the prostate in elderly men. Since Nigella sativa has been reported to show various pharmacological effects, this study was conducted to examine the effect of N. sativa seed oil on experimental BPH. Methods: The oil was extracted using the cold-pressing method. Fifty...

Epigenetic alterations are one of the main factors that disrupt the expression of genes and consequently, they have an important role in the carcinogenicity and the progression of different cancers. Cancer stem cells (CSCs) are accountable for the recurrence, metastasis, and therapeutic failure of cancer. The noticeable and specific pathways in CSC...

Cornus mas (C. mas) is one of the native horticultural products to Iran that have high pharmaceutical and nutritional values. This study aimed to comparatively investigate different drying methods with ultrasound‐osmotic pretreatment on energy consumption, timing, and qualitative properties of Cornus mas. In this study, C. mas was first dried by th...

It has been well known that anxiety is associated with various complications. The exact underlying bridge between the probable cardiac diseases in anxiety is undetermined. Auraptene has significant antioxidant and anti-inflammatory effects. In this study we aimed to assess the probable underlying mechanisms bridge comorbid cardiac complications wit...

Background: Depression is one of the most common mental illnesses around the world. Nitric oxide (NO) is involved in the pathophysiology of depression. Auraptene (a coumarin derivative) has been shown to have pharmacological effects on neurological diseases. porpuse: The present study aimed to investigate the possible role of NO pathway in Aurapten...

Background: Astragalus fascicolifolius manna is used to treat different diseases. Because pregnant women tend to use Astragalus. fascicolifolius and Iranian traditional medicine emphasizes the abortifacient potential of this plant, this study aimed to investigate Astragalus fascicolifolius manna abortifacient property and effects on estrogen, prog...

Background and Aim: Given the widespread prevalence of seizures worldwide and the low efficacy of synthetic drugs, studies are needed to find new compounds with appropriate efficacy. Ferulic acid (FA) is a phenolic compound with antioxidant and neuroprotective effects. The aim of present study was to investigate the role of nitrergic system in the...

Aim: This study aims to investigate the relationship of two prognostic factors NLR and PLR to patient survival in gastric cancer patients diagnosed before surgery. Background: Due to the high prevalence of gastric cancer and the lack of appropriate prognostic factors, most patients are diagnosed at advanced stages of the disease. Therefore, this st...

Background: Previous studies have shown that seizures can cause cognitive disorders. On the other hand, the Curcuma zedoaria (CZ) has beneficial effects on the nervous system. However, there is little information on the possible effects of the CZ extract on seizures. The aim of this study was to investigate the possible effects of CZ extract on co...

Background: The most important side effects of Cyclophosphamide, as an anticancer broad-spectrum drug, are the negative effects on the reproduction and fertility because of oxidative stress. Considering the antioxidant properties of medicinal plants, especially those of the Allium genus, this paper studied the effect of hydroalcoholic extract of A...