Zahida Parveen

Abdul Wali Khan University Mardan · Department of Biochemistry

A novel spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs were synthesized by [3+2] cycloaddition (32CA) reactions in one step process starting from the ethylene-based thiochromene and pyrazole scaffolds with the secondary amino-acids and substituted isatins in high yield. The 32CA reaction of AY 10 with ethylene derivative 6 has a...

Dihydropyrazole (1-22) derivatives were synthesized from already synthesized chalcones. The structures of all of the synthesized compounds were confirmed by elemental analysis and various spectroscopic techniques. Furthermore, the synthesized compounds were screened against α amylase as well as investigated for antioxidant activities. The synthesiz...

Trifolium hybridum L. (Alsike clover), a member of Fabaceae, is mainly used as a fodder crop. However, the related species such as T. repenes, T. arvense, and T. pratense have already been explored for their antioxidant, antiseptic, and anti-inflammatory potentials. As little information was available on T. hybridium, the current study aimed to mon...

Abiotic stressors are global limiting constraints for plant growth and development. The most severe abiotic factor for plant growth suppression is salt. Among many field crops, maize is more vulnerable to salt, which inhibits the growth and development of plants and results in low productivity or even crop loss under extreme salinity. Consequently,...

ABSTRACT:Alzheimer’sdisease(AD)is a neurodegenerativedisorderthat affects35 millionpeopleworldwide.However,nopotentialtherapeuticscurrentlyare availablefor AD becauseof the multiplefactorsinvolvedin it, suchas regulatoryfactorswiththeircandidategenes,factorsassociatedwiththe expressionlevelsof its correspondinggenes,and manyothers.To date,29 novell...

The present study was carried out to determine various phytochemicals from Swertia chirayita and to evaluate antimicrobial and antioxidant properties of the extracted phytochemicals. Phytochemical determination i.e., flavonoids, tannins, β-carotene and lycopene, and alkaloids was carried out using different methods. Among the phytochemicals, flavon...

The intake of various types and amounts of dietary fats influences metabolic and cardiovascular health. Hence, this study evaluated the impact of routinely consumed Pakistani dietary fats on their cardiometabolic impact. For this, we made four groups of mice, each comprising 5 animals: (1) C-ND: Control mice on a normal diet, (2) HFD-DG: High-fat d...

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is considered a global public health concern since it causes high morbidity and mortality. Recently, it has been reported that repurposed anti-COVID-19 drugs might interact with multidrug resistance ABC transporter, particularly ABCB1. In the current study, a series of thiourea derivativ...

Introduction The current study is designed to assess the various risk factors, prevalence, and clinical characteristics of type 2 diabetes (among aged Pakistanis) and gestational diabetes (in pregnant women). Material and methods The statistical analysis of a cross-sectional survey included the data of 1479 adults, aged 18–75 years, living in urba...

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia which affects insulin secretion. Among several approaches to treat diabetes controlling postprandial hyperglycemia is an effective way to manage diabetes type II. In this regard medicinal plants are considered the best source for the provision of new chemical...

Background Solidago virgaurea (Asteraceae), has been used for more than 700 years for treating cystitis, chronic nephritis, urolithiasis, rheumatism, and inflammatory diseases. However, the antidiabetic activity of Solidago virgaurea has been rarely studied. Methods Three extracts of Solidago virgaurea were prepared and their antidiabetic potentia...

Salinity stress has hindered the growth and yield of crops globally. The demands for inducing salt stress tolerance by natural and biological sources with potent antioxidants and growth-promoting metabolites have been the main focus of the recent era. Therefore, the current research was conducted to extract salt stress tolerance-ameliorating metabo...

Morchella conica (M. conica) Pers. belongs to six wild edible mushrooms that are widely used by Asian and European countries for their nutritional value. The low glycemic index of mushrooms makes them the best source for drug development against diabetes. The present study assessed the anti-diabetic potential of M. conica methanolic extract (100 mg...

Persicaria hydropiper (L.) Delarbre (family Polygonacea), commonly known as Polygonum hydropiper, is a popular medicinal plant used in traditional medicine. The plant is indigenous to the tropical northern hemisphere and temperate zone including China, Bangladesh, India, and Japan. The plant is used in folk medicine for numerous ailments such as he...

Several ABC exporters carry a degenerate nucleotide binding site (NBS) that is unable to hydrolyze ATP at a rate sufficient for sustaining transport activity. A hallmark of a degenerate NBS is the lack of the catalytic glutamate in the Walker B motif in the nucleotide binding domain (NBD). The multidrug resistance transporter ABCB1 (P-glycoprotein)...

Polygonum hydropiper L. is a traditionally used medicinal plant. The present study was designed to explore the α-amylase inhibitory, antioxidant, and antimicrobial activities of Polygonum hydropiper L. Polarity-based solvent extracts (n-hexane, acetone, chloroform, methanol, ethanol, and water) of Polygonum hydropiper leaves and stem were used. Ant...

Polygonum hydropiper L. is a traditionally used medicinal plant. The present study was designed to explore the α-amylase inhibitory, antioxidant, and antimicrobial activities of Polygonum hydropiper L. Polarity-based solvent extracts (n-hexane, acetone, chloroform, methanol, ethanol, and water) of Polygonum hydropiper leaves and stem were used. Ant...

Background Human P-glycoprotein (P-gp) is a transmembrane protein that belongs to the ATP-Binding Cassette (ABC) transporters family. Physiologically, it exports toxins out of the cell, however, its over-expression leads to the phenomena of MultidrugResistance (MDR) by exporting a diverse range of compounds, which are structurally and chemically di...

ATP-binding cassette (ABC) transporters form the largest family of transmembrane proteins. They play a vital physiological role in preventing xenotoxic substances from entering the body, thereby shielding it from potentially harmful substances. Among these, ABCB1 is a multidrug resistance ABC transporter which plays a major role in absorption, dist...

The present study was conducted to develop and characterize two polyherbal formulations (S11 and S12) against alpha amylase, intestinal gluco-sidase, Advanced Glycation End-products to find a potential multi-targeted inhibitor. Cytotoxicity was evaluated for ABCB1 (P-glycoprotein) overex-pressing cells. It is a multi-drug resistant ATP-binding cass...

The phytochemical screening, antimicrobial, antioxidant and cytotoxic properties of Camellia sinensis were evaluated in the present study. The phytochemical screening revealed the presence of an applicable amount of lycopene, β-carotenes, flavonoids and tannins in C. sinensis. Among the phytochemicals, tannin was found to be significantly higher in...

The phytochemical screening, antimicrobial, antioxidant and cytotoxic properties of Camellia sinensis were evaluated in the present study. The phytochemical screening revealed the presence of an applicable amount of lycopene, β-carotenes, flavonoids and tannins in C. sinensis. Among the phytochemicals, tannin was found to be significantly higher in...

fish scales converted into water souble protein hydrolysate were fractionated to check the antibacterial activity

Infectious diseases caused by micro-organisms are transmissible and infect a large group of population. Investigations were carried out for studying the phytochemistry and biological potential of the leaves of Acacia modesta. Dried and finely ground leaves were extracted with ethanol. Different fractions were obtained by extracting the crude extrac...

P-glycoprotein (P-gp) is an ATP-dependent multidrug resistance efflux transporter that plays an important role in anticancer drug resistance and in pharmacokinetics of medicines. Despite a large number of structurally and functionally diverse compounds, also flavonoids and chalcones have been reported as inhibitors of P-gp. The latter share some si...

Infection caused by hepatitis virus (HBV) is a global public health issue affecting more than 350 million people. Vertical transmission of HBV infection during the prenatal period is the major cause of HBV transmission in endemic countries such as Pakistan. This study was undertaken to investigate the possible risk factors associated with vertical...

Cardiovascular diseases are the most common cause of death in the world and their prevalence rate is rapidly increasing in developing countries. Blood group is a classification of blood based on the presence or absence of inherited substances on the surface of red blood cells. The most well-known and medically important blood groups are ABO blood t...

The multispecific efflux transporter P-glycoprotein plays an important role in drug disposition. Substrate translocation occurs along the interface of its transmembrane domains. The rotational C2 symmetry of ABC-transporters implies the existence of two symmetry related sets of substrate-interacting amino acids. These sets are identical in homodime...

HM30181, a potent and selective inhibitor of the adenosine triphosphate-binding cassette transporter P-glycoprotein (Pgp), was shown to enhance oral bioavailability and improve antitumour efficacy of paclitaxel in mouse tumour models. In search for a positron emission tomography (PET) radiotracer to visualise Pgp expression levels at the blood-brai...

Background The human genome contains 48 members of the ABC protein family. We focus on the multidrug resistance transporter P-glycoprotein (P-gp, ABCB1), which is expressed at the blood-brain-barrier, in intestine, kidney, liver and macrophages. The first structure of an ABC exporter was from Staphylococcus aureus and showed a twisted architecture....

A series of enantiomerically pure benzopyrano[3,4-b][1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein. Reducing the conformational flexibility of the molecules leads to remarkable differences in the activity of diastereoisomers. Docking studies into a homology model of human P-gp provide first insights into...

The human multispecific drug efflux transporter P-glycoprotein (P-gp) causes drug resistance and modulates the pharmacological profile of systemically administered medicines. It has arisen from a homodimeric ancestor by gene duplication. Crystal structures of mouse MDR1A indicate that P-gp shares the overall architecture with two homodimeric bacter...

The use of leaves and roots of Berberis lycium Royle and Justicia adhatoda against different human infections is common practice in the North East of Pakistan. A study was conducted to evaluate the leaves and roots of Berberis lycium Royle and Justicia adhatoda for active compound alkaloids, flavonoids, saponins, tannins, vitamins (Vit. C, niacin,...

SUMMARY Berberis lyceum is a medicinal shrub used in conventional therapy for a number of diseases including diabetes mellitus. The aim of the present study was to investigate the antihyperglycemic effects of aqueous and ethanol extracts of Berberis lyceum in alloxan induced diabetic and normal rats. Rats were administered 50 and 100 mg/kg of aqueo...