Yvonne Handajani

• PhD
• Senior Researcher at Atma Jaya Catholic University of Indonesia

Introduction: Sarcopenia has many risk factors and an increased likelihood of adverse effects. However, the exact mechanism of how these risk factors cause sarcopenia remains to be elucidated. This study aimed to evaluate the association between physical components, olfactory function impairment and sarcopenia in urban communities. Methods: This cr...

Objectives: This study aims to investigate the association of global cognitive with chronic conditions, physical impairment, olfactory function, socio-demographics and other factors among older adults in the urban community, West Jakarta. Materials and methods: The cross-sectional study involved 334 older adults aged 60 years and older who resid...

Background Older adults with frailty have an increased risk of multiple negative health outcomes, such as disability, falls, and morbidity when exposed to physical stressors. The present study investigated the prevalence of frailty and associated risk factors among community-dwelling Indonesian older adults in several districts in Jakarta, Indonesi...

Latar Belakang: Peningkatan prevalensi depresi pada lansia dapat berdampak pada tingginya angka morbiditas dan mortalitas. Penelitian ini secara spesifik dilakukan untuk mengetahui persentase depresi beserta hubungannya dengan usia, jenis kelamin, pendidikan, sarkopenia, dan gangguan fungsi kognitif pada lansia yang memiliki latar belakang homogen...

The decline of olfactory function is an early indicator of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. An olfactory function assessment instrument using ten familiar scents with multiple-choice answers has been developed, but several items were inapplicable and had not been standardized. This study aimed to identify var...

Latar Belakang: Peningkatan prevalensi depresi pada lansia dapat berdampak pada tingginya angka morbiditas dan mortalitas. Penelitian ini secara spesifik dilakukan untuk mengetahui persentase depresi beserta hubungannya dengan usia, jenis kelamin, pendidikan, sarkopenia, dan gangguan fungsi kognitif pada lansia yang memiliki latar belakang homogen...

Background and Objective Insomnia can cause impairment in physical, mental, and social functioning, which contributes to considerable healthcare and social challenges. This study aims to investigate various potential associated factors of insomnia among older adults in Indonesia.Methods Publicly available data of the fifth wave of the Indonesia Fam...

Background: Chronic diseases, especially hypertension, dyslipidemia, stroke, as well as sleep impairment, were found as the risk factors of cognitive impairment. However some studies showed conflicting results between some of those factors and cognitive function in older persons. Objective: This study aims to investigate the association between soc...

Introduction: A noteworthy correlation was seen between changes in the gut microbiome and sarcopenia in older adults. Along with increasing research on probiotic supplementation for various medical problems, we aimed to obtain evidence and summarize the effect of probiotic supplementation on sarcopenic indices among older adults. Methods: We utiliz...

Background To support informal dementia carers, the World Health Organization (WHO) developed ‘iSupport for Dementia’ online skills training program, culturally adaptable to local contexts. Several WHO Member States are adapting the program. This study was conducted to draw lessons about iSupport adaptation in Australia, Brazil, Indonesia, New Zeal...

Indonesia, like many rapidly ageing lower-middle-income countries (LMICs), tends to portray older citizens as ‘vulnerable’ and ‘dependent’; yet the country has few public policies to support them. To this discourse, an alternative stereotype is emerging, influenced by notions of ‘successful ageing’, which promotes models of older people as healthy...

Introduction: This study aimed to evaluate the prevalence of frailty and its determinants, especially in relation to chronic disease and lifestyle among elderly individuals. Method: A cross-sectional study was conducted among 278 individuals aged 60 years and over living in Jakarta. All participants underwent assessment, including medical histor...

Background: Currently we see an increase in life expectancy followed by an increase in the number of elderly with various health problems, one of them being hypertension. Moreover, not all patients can control this disease properly. The most difficult challenge is someone's adherence to taking medication. If this is not properly anticipated, it wil...

Background: Arthritis is a highly debilitating disease prevalent in the elderly population. Despite its comparable inflammatory pathophysiology, few studies especially in the Indonesian population have explored the links between arthritis and the ever-increasing metabolic syndrome. Objective: This study aims to analyze the relationship between four...

Background: Hypertension is the leading cause of premature death in the world. The prevalence of hypertension in the elderly in Indonesia was 55,2–69,5% and will increase with advancing age. Objective: This study aimed to determine the relationship between obesity and other risk factors with hypertension in the elderly in Indonesia. Methods: This r...

Background: The life expectancy in Indonesia is increasing. The rising number of the elderly people plays a vital role for a country to achieve development success. However, it has many consequences in the health sector, including a frailty syndrome. This study aimed to explore the association between frailty and related factors. Methods: This cro...

Dementia causes a great burden of disease globally. Volunteers' contributions in caring for older persons with dementia (OPD) are growing. This review aims to evaluate the impact of trained volunteers' involvement in providing care and support for OPD. PubMed, ProQuest, EBSCOHost, and Cochrane Library databases were searched using specific keywords...

Aims This study aimed to evaluate the association between memory impairment and its risk and protective factors, focusing on demographic and health-related variables among older adults in Indonesia. Method The data analyzed were the Indonesian Family Life Survey-5 (IFLS-5) using cross-sectional variables of 4236 older adults aged 60 years and over...

Background Providing care for people with dementia (PwD) without sufficient understanding of the condition might negatively affect the wellbeing of the caregivers, given the lengthy care and progressive nature of the disease. The iSupport for dementia developed by World Health Organization (WHO) is a self-administered training manual for caregivers...

Background : Cardiovascular disease is one of the non-communicable diseases that causes most deaths in Indonesia. According to data from the Ministry of Health, coronary heart disease is the leading cause of all deaths at 26.4%. The rate of heart disease increases at a concerning pace every year, affecting at least 15 in 1000 Indonesians. Objective...

Introduction Recent evidence suggests that there is clear association between microbiota and cognitive functioning, which is known as microbiome-gut-brain axis. Probiotic bacteria consumption can alter human microbiota; therefore, probiotic supplementation might affect the gut microbiota dynamics and influence cognitive function.Methods Three elect...

Introduction: Oral consumption of probiotics can alter Gut Microbiota by causing changes in the production of probiotic derivatives. Therefore, by utilizing Gut-Brain-Axis (GBA), probiotics could provide an opportunity for central nervous system (CNS) modulation, including cognitive function. Tempeh is a traditional Indonesian food rich in probioti...

Background: Depression is one of the most common illnesses worldwide, with a prevalence of 5.7% among older adults aged over 60. Depression is a severe health condition that can significantly affect the quality of life. Objective: The objective of this study is to investigate the determinant factors of depression among older adults in Indonesia....

Introduction: Aging and physical disability are often associated with hypertension, obesity and blood sugar levels which are important factors in the development of metabolic syndrome and cardiovascular disease.This study aims to determine the relationship between obesity, hyperglycemia, hypertension and sarcopenia among the elderly at PUSAKA Kalid...

Dementia prevalence is increasing worldwide and developing countries are expected to carry the highest burden of this. Dementia has high care needs and no current effective long-term treatment. However, factors associated with active ageing (e.g., longer employment; participation in society; independent, healthy and secure living; and enabling envi...

Introduction Cognitive impairment is often associated with aging and a history of cardiovascular disease. This study aims to determine the relationship between hypertension and other risk factors for cognitive disorders in the elderly without diabetes. Methods This study uses secondary data in Atma Jaya Cognitive and Aging studies, 2013–2017 on 71...

Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (member...

Introduction: Tempeh consumption has been linked to the improvement of cognitive function in older people. However, to what extent the amount of microorganism or the size of tempeh serving consumed per day influences the benefit to cognitive functions has not yet been studied. Methods: This experimental study involved a total of 90 respondents,...

RELATIONSHIP OF MARITAL STATUS, APOE ε4, AND TYPES OF PHYSICAL ACTIVITIES ON COGNITIVE DECLINE IN ELDERLY WOMENABSTRACTIntroduction: The number of elderly population in Indonesia continues to increase every year, especially women. Elderly women are at higher risk of experiencing decreased cognitive function.Aims: To determine the relationship betwe...

ABSTRAK Gangguan kognitif merupakan bagian dari proses neurodegeneratif, saat ini belum ada perawatan atau pengobatan untuk mencegah progresifitas. Tujuan penelitian ini adalah untuk mengetahui faktor risiko gangguan kognitif dalam studi prospektif. Penelitian dengan desain studi kohort prospektif pada 110 subjek dengan pengambilan sampel dilakukan...

ABSTRAKGangguan kognitif merupakan bagian dari proses neurodegeneratif, saat ini belum ada perawatan atau pengobatan untuk mencegah progresifitas. Tujuan penelitian ini adalah untuk mengetahui faktor risiko gangguan kognitif dalam studi prospektif. Penelitian dengan desain studi kohort prospektif pada 110 subjek dengan pengambilan sampel dilakukan...

Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer`s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Therefore, we combined individual participant data for 16 cohorts from 15 countries (members of the...

Background and aims: Among older adults, olfactory dysfunction is associated with cognitive impairment, lower quality of life, and increased mortality. While age is a risk factor for olfactory dysfunction, other risk factors are less well understood, and may vary between ethno-regional groups. This study investigated how associations between odour...

CHRONIC DISEASES AND LIFESTYLE IMPACT TO CATEGORY VERBAL FLUENCY PERFORMANCE IN ELDERLYABSTRACTIntroduction: In recent studies, chronic illness and sedentary lifestyle were found to bea risk factors for cognitive impairment. Verbal fluency (VF) is one of the most used instruments.Aim: To determine cognitive impairment using VF and its correlation w...

THE IMPACT OF GRANDPARENTING ACTIVITY ON COGNITIVE FUNCTION IN ELDERLY WOMANABSTRACT Introduction: Cognitive impairment is a neurodegenerative process which often experienced by the elderly. One of the factors associated with cognitive function is grandparenting which is common and has become a social norm in Indonesia.Aims: To determine the associ...

Background: Since the EWGSOP consensus was established, researchers were easier to create a ‘global map’ of sarcopenia, which revealed prevalence ranging from 5 to 33% in the various regions. Sarcopenia appears to be an age-related phenomenon, exacerbated, by a sedentary lifestyle, nutritional factors, and chronic disease. The objective of this stu...

Objective: This study investigated the relationship between sarcopenia and the chronic disease, dietary intake in aging as well as the potential factors. Material And Methods This was a cross-sectional study evaluated one hundred and thirty eight from nursing home elderly. Data were collected during a face to face interview using a standardized que...

BACKGROUND Approximately 10-27% of the population aged >65 years suffers from frailty. The percentage increases with age so that the prevalence of frailty in the population aged >85 years reaches 45%. The objective of this study was to determine the relationship between frailty and quality of life (QOL) in nursing home elderly. METHODS This was...

Aim: Early prediction using cognitive evaluation tools that are less influenced by education level is beneficial for dementia screening. This study investigated the relationship between Word List Memory Immediate Recall (WLM IR) and the Saving Score (SS) with having the APOE ε4 risk allele in the elderly with normal global cognitive assessment. Met...

The International Association of Gerontology and Geriatrics held its first conference on nursing home research in St Louis, MO, in November 2013. This article provides a summary of the presentations.

Background. Amnestic Mild Cognitive Impairment (aMCI) often progresses to Alzheimer's disease. There are clinical markers and biomarkers to identify the degenerative process in the brain. Objectives. To obtain the diagnostic values of olfactory test, pupillary response to tropicamide 0.01%, BDNF plasma level, and APOE ε 4 in diagnosing aMCI. Method...

Background: depression is the most often psychological problem in people living with HIV/AIDS (PLWHA) and occurs greater than not infected people. PLWHA also had decreased quality of life (OQL). Depression is more undiagnosed, untreated, and misinterpreted. Based on that, we want to know depression influence to the QOL in PLWHA who receive antiretr...

Aim: to provide an overview of the quality of life (OQL) for people living with HIV/AIDS (PLWHA) in Jakarta, particularly in the Kramat 128 Hospital, based on CD4 and viral load (VL) levels and the length of antiretroviral (ARV) treatment. Methods: a cross-sectional study performed at Kramat 128 Hospital Jakarta Outpatient Clinic from November 2...

Objective: To acknowledge the development of people with HIV/AIDS (PLWHA) after receiving antiretroviral (ARV) therapy in Jakarta, especially in the Kramat 128 Hospital, based on CD4 and viral load (VL) levels and quality of life (QOL). Methods: A cross-sectional analytic study performed at outpatient clinic of Kramat 128 Hospital Jakarta, througho...

Aim To examine those claims, i.e the effects of oxygenated water on hypertension and Diabetes Mellitus (DM).Methods In this clinical trial, 108 subjects of Diabetes Mellitus were recruited. Each group was divided randomly into 2 subgroups. One subgroup was given oxygenated water and the other subgroup was given non-oxygenated water for 2 period of...