Yuxiang Liang

Yuxiang Liang
The University of Hong Kong | HKU · State Key Laboratory of Brain and Cognitive Sciences

MD

About

33
Publications
5,425
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,138
Citations
Introduction

Publications

Publications (33)
Article
Full-text available
A Correction to this paper has been published: https://doi.org/10.1038/s41593-018-0090-8.
Article
Full-text available
Newborn microglia rapidly replenish the whole brain after selective elimination of most microglia (>99%) in adult mice. Previous studies reported that repopulated microglia were largely derived from microglial progenitor cells expressing nestin in the brain. However, the origin of these repopulated microglia has been hotly debated. In this study, w...
Article
Full-text available
Microglia are the mononuclear phagocytes with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection model of the retina, the retrograde degeneration of retinal ganglion cells induces microglial activations to a unique morphology termed rod microglia....
Article
Full-text available
Retrograde labelling of retinal ganglion cells with optic nerve transection often leads to degeneration of ganglion cells in prolonged experiments. Here we report that an intact optic nerve could uptake retrograde tracers applied onto the surface of the nerve, leading to high efficiency labelling of ganglion cells in the retina with long-term survi...
Article
Full-text available
Microglia are the resident phagocytic cells with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection (ONT) model in the retina, the retrograde degeneration of retinal ganglion cells (RGCs) induces microglial activations to a unique morphology terme...
Article
Full-text available
Neurovascular niches serve as the hosts for adult neural stem cells in both the hippocampus and subventricular zone. The rostral migratory stream (RMS) vasculature has been found to be important for neuroblast migration, while its roles in hosting putative neural stem cells have not been investigated. Here we investigated the organization of RMS va...
Article
Full-text available
There is no effective treatment for intracerebral hemorrhage (ICH). Intracerebral delivery of nanomaterials into the hemorrhagic lesion may be a new therapeutic strategy. In a rat model of ICH plus ultra-early hematoma aspiration, we found that locally delivered self-assembling peptide nanofiber scaffold (SAPNS) replaced the hematoma, reduced acute...
Article
Full-text available
Adult neurogenesis has been well studied in hippocampus and subventricular zone (SVZ); while this is much less appreciated in other brain regions, including amygdala, hypothalamus, and piriform cortex (PC). The present review aims at summarizing recent advances on the occurrence of new neurons in the PC, their potential origin, and migration route...
Article
Full-text available
Our group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models. Protecting RGCs from secondary degeneration is a promising direction for therapy in glaucoma management. The complete optic nerve transection (CONT) model can be used to study primary de...
Article
Full-text available
A combination of hematoma aspiration and local delivery of chemicals may be more effective than either therapy in intracerebral hemorrhage (ICH). The aim of the present study was to develop a rat model of hematoma aspiration plus intralesional injection after ICH. ICH was induced in adult Sprague-Dawley rats by an intrastriatal injection of bacteri...
Article
Full-text available
The different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: from stage 1A to 6A, the cell body size increased,...
Article
The active components in L. barbarum (wolfberry) include polysaccharide (LBP), zeaxanthin, beta-carotene, betaine, flavonoids, etc. The biological activities of L. barbarům can be summarized into two aspects. The first one is the intercellular effects on neurons. L. barbarum has immune modulation effects and it can activate microglia to an appropri...
Article
To speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the optimal timing and delivery of therapeutics and rehabilitation. It was necessary to develop a chronic animal model with an in vivo measurement tech...
Article
Unlabelled: To speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the optimal timing and delivery of therapeutics and rehabilitation. It was necessary to develop a chronic animal model with an in vivo mea...
Article
Full-text available
Within the emerging field of stem cells there is a need for an environment that can regulate cell activity, to slow down differentiation or proliferation, in vitro or in vivo while remaining invisible to the immune system. By creating a nanoenvironment surrounding PC12 cells, Schwann cells, and neural precursor cells (NPCs), we were able to control...
Article
In traumatic spinal cord injury, loss of neurological function is due to the inability of damaged axons to regenerate across large, cystic cavities. It has recently been demonstrated that a self-assembled nanofiber scaffold (SAPNS) could repair the injured optical pathway and restore visual function. To demonstrate the possibility of using it to re...
Article
Cyclosporine is one of the foremost immunosuppressive agents for cell, tissue, and organ transplantation. Cyclosporine is, however, associated with significant side effects in the host, and may also affect the fate of the donor cells. This study was performed to test whether cyclosporine may change the fate of neural stem cells, as neural stem cell...
Article
After traumatic brain and spinal cord injury several formidable barriers must be overcome, such as scar tissue formation after injury and the failure of many adult neurons to initiate axonal extension. Here we show that a more permissive environment can be created using regenerationenhancing factors (REF), such as scar-reducing materials or chemica...
Article
Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery,...
Article
Full-text available
Nanotechnology is often associated with materials fabrication, microelectronics, and microfluidics. Until now, the use of nanotechnology and molecular self assembly in biomedicine to repair injured brain structures has not been explored. To achieve axonal regeneration after injury in the CNS, several formidable barriers must be overcome, such as sc...
Article
Full-text available
The dependence of visual orienting ability in hamsters on the axonal projections from retina to midbrain tectum provides experimenters with a good model for assessing the functional regeneration of this central nervous system axonal pathway. For reliable testing of this behavior, male animals at least 10-12 weeks old are prepared by regular pretest...
Article
Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery,...
Article
INTRODUCTION: This study aims to employ in vivo proton magnetic resonance spectroscopy (1 H MRS) to evaluate the trans-synaptic effect of acute axonal injury to the superior colliculi (SC) by monitoring longitudinally the metabolic changes in the SC following deafferentation of the optic tract in adult hamsters. In addition, a self-designed, self-a...
Article
Full-text available
INTRODUCTION: Manganese (Mn 2+) has been being used for in vivo axonal tracing of the rodent visual pathways in MRI because of its paramagnetic property and its ability to enter intracellular space as a calcium analogue [1]. Previous studies showed the feasibility for Mn 2+ to detect optic nerve lesions and regeneration by nerve graft implantation...

Network

Cited By

Projects

Project (1)